DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
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UNC0638
CAS:1255580-76-7
UNC0638 inhibits G9a and GLP lysine methyltransferases with IC50 <15 nM and 19 nM, respectively, …
Formula:
C30H47N5O2
Purity:
99.53%
Color and Shape:
Solid
Molecular weight:
509.73
Ref: TM-T3257
| 5mg | 59.00 € | ||
| 10mg | 88.00 € | ||
| 25mg | 143.00 € | ||
| 50mg | 252.00 € | ||
| 100mg | 382.00 € | ||
| 1mL*10mM (DMSO) | 65.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
JQEZ5
CAS:1913252-04-6
JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).
Formula:
C30H38N8O2
Purity:
98.14% - ≥98%
Color and Shape:
Solid
Molecular weight:
542.68
Ref: TM-T7305
| 2mg | 35.00 € | ||
| 5mg | 49.00 € | ||
| 10mg | 72.00 € | ||
| 25mg | 126.00 € | ||
| 50mg | 181.00 € | ||
| 100mg | 263.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
CPI-1205
CAS:1621862-70-1
CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : …
Formula:
C27H33F3N4O3
Purity:
98.71% - 99.7%
Color and Shape:
Solid
Molecular weight:
518.57
Ref: TM-T8510
| 1mg | 92.00 € | ||
| 2mg | 119.00 € | ||
| 5mg | 208.00 € | ||
| 10mg | 307.00 € | ||
| 25mg | 519.00 € | ||
| 50mg | 731.00 € | ||
| 1mL*10mM (DMSO) | 447.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
GSK126
CAS:1346574-57-9
GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).
Formula:
C31H38N6O2
Purity:
98% - 99.67%
Color and Shape:
Solid
Molecular weight:
526.67
Ref: TM-T2079
| 2mg | 43.00 € | ||
| 5mg | 64.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 148.00 € | ||
| 50mg | 222.00 € | ||
| 100mg | 342.00 € | ||
| 200mg | 445.00 € | ||
| 1mL*10mM (DMSO) | 75.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
UNC6934
CAS:2561494-77-5
UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.
Formula:
C24H21N5O4
Purity:
99.81%
Color and Shape:
Solid
Molecular weight:
443.45
Ref: TM-T9584
| 1mg | 85.00 € | ||
| 2mg | 111.00 € | ||
| 5mg | 179.00 € | ||
| 10mg | 280.00 € | ||
| 25mg | 452.00 € | ||
| 50mg | 641.00 € | ||
| 100mg | 875.00 € | ||
| 500mg | 1,745.00 € | ||
| 1mL*10mM (DMSO) | 187.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
Lomeguatrib
CAS:192441-08-0
Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase …
Formula:
C10H8BrN5OS
Purity:
99.08% - 99.62%
Color and Shape:
Solid
Molecular weight:
326.17
Ref: TM-T2495
| 5mg | 51.00 € | ||
| 10mg | 58.00 € | ||
| 25mg | 92.00 € | ||
| 50mg | 156.00 € | ||
| 100mg | 276.00 € | ||
| 500mg | 690.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
DCLX069
CAS:792946-69-1
DCLX069: PRMT1 inhibitor, IC50=17.9µM, targets SAM pocket, inhibits breast/liver cancer, and AML cell growth.
Formula:
C20H25N3O2
Purity:
98.06%
Color and Shape:
Solid
Molecular weight:
339.43
Ref: TM-T27133
| 1mg | 38.00 € | ||
| 2mg | 49.00 € | ||
| 5mg | 80.00 € | ||
| 10mg | 112.00 € | ||
| 25mg | 187.00 € | ||
| 50mg | 307.00 € | ||
| 100mg | 489.00 € | ||
| 500mg | 1,012.00 € | ||
| 1mL*10mM (DMSO) | 93.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
MRTX-1719
CAS:2630904-45-7
MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value …
Formula:
C23H18ClFN6O2
Purity:
98.27% - 99.18%
Color and Shape:
Solid
Molecular weight:
464.88
Ref: TM-T40254
| 1mg | 369.00 € | ||
| 5mg | 720.00 € | ||
| 10mg | 979.00 € | ||
| 25mg | 1,636.00 € | ||
| 50mg | 2,292.00 € | ||
| 100mg | 3,347.00 € | ||
| 1mL*10mM (DMSO) | 739.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
BIX-01294 trihydrochloride
CAS:1392399-03-9
BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM …
Formula:
C28H38N6O2·3HCl
Purity:
98.98% - 99.95%
Color and Shape:
Solid
Molecular weight:
600.02
Ref: TM-T1959
| 1mg | 43.00 € | ||
| 2mg | 55.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 108.00 € | ||
| 25mg | 192.00 € | ||
| 50mg | 274.00 € | ||
| 100mg | 493.00 € | ||
| 500mg | 1,084.00 € | ||
| 1mL*10mM (DMSO) | 140.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
EPZ004777 hydrochloride
CAS:1380316-03-9
EPZ004777 hydrochloride (EPZ004777 HCl) is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
Formula:
C28H42ClN7O4
Color and Shape:
Solid
Molecular weight:
576.13
Ref: TM-T3081L
| 2mg | 73.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
Metoprine
CAS:7761-45-7
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
Formula:
C11H10Cl2N4
Purity:
98.42%
Color and Shape:
Solid
Molecular weight:
269.13
Ref: TM-T8548
| 5mg | 59.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 153.00 € | ||
| 50mg | 246.00 € | ||
| 100mg | 371.00 € | ||
| 500mg | 848.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
UNC0379
CAS:1620401-82-2
UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.
Formula:
C23H35N5O2
Purity:
94.41% - 99.97%
Color and Shape:
Solid
Molecular weight:
413.56
Ref: TM-T1841
| 5mg | 56.00 € | ||
| 10mg | 91.00 € | ||
| 25mg | 147.00 € | ||
| 50mg | 236.00 € | ||
| 100mg | 352.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
EPZ005687
CAS:1396772-26-1
EPZ005687 is a potent and selective inhibitor of EZH2.
Formula:
C32H37N5O3
Purity:
98% - 99.66%
Color and Shape:
Solid
Molecular weight:
539.67
Ref: TM-T1905
| 5mg | 57.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 133.00 € | ||
| 50mg | 193.00 € | ||
| 100mg | 343.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
XY1
CAS:1624117-53-8
XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of …
Formula:
C17H19N3O2
Purity:
97.2% - 97.74%
Color and Shape:
Solid
Molecular weight:
297.35
Ref: TM-T7157
| 2mg | 38.00 € | ||
| 5mg | 56.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 167.00 € | ||
| 50mg | 301.00 € | ||
| 100mg | 498.00 € | ||
| 500mg | 1,072.00 € | ||
| 1mL*10mM (DMSO) | 62.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
BAY-598
CAS:1906919-67-2
BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over …
Formula:
C22H20Cl2F2N6O3
Purity:
98.68% - 99.18%
Color and Shape:
Solid
Molecular weight:
525.34
Ref: TM-T7403
| 1mg | 51.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 138.00 € | ||
| 25mg | 245.00 € | ||
| 50mg | 401.00 € | ||
| 100mg | 605.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
PFI-2 hydrochloride
CAS:1627607-87-7
PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase …
Formula:
C23H26ClF4N3O3S
Purity:
98.04% - 99.91%
Color and Shape:
Solid
Molecular weight:
535.98
Ref: TM-T4583
| 1mg | 40.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 115.00 € | ||
| 25mg | 207.00 € | ||
| 50mg | 371.00 € | ||
| 100mg | 541.00 € | ||
| 500mg | 1,147.00 € | ||
| 1mL*10mM (DMSO) | 127.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
5-Fluoro-2'-deoxycytidine
CAS:10356-76-0
5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .
Formula:
C9H12FN3O4
Purity:
97.91%
Color and Shape:
Fine White Powder
Molecular weight:
245.21
Ref: TM-T7718
| 2mg | 35.00 € | ||
| 5mg | 50.00 € | ||
| 10mg | 67.00 € | ||
| 25mg | 94.00 € | ||
| 50mg | 143.00 € | ||
| 100mg | 206.00 € | ||
| 200mg | 308.00 € | ||
| 500mg | 514.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
Zebularine
CAS:3690-10-6
Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.
Formula:
C9H12N2O5
Purity:
100% - 99.84%
Color and Shape:
Solid
Molecular weight:
228.2
Ref: TM-T2169
| 5mg | 45.00 € | ||
| 10mg | 63.00 € | ||
| 25mg | 122.00 € | ||
| 50mg | 214.00 € | ||
| 100mg | 276.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
PF-06726304
CAS:1616287-82-1
PF-06726304: potent EZH2 inhibitor, effective against tumors, Kis at 0.7 nM (wild-type) and 3.0 nM …
Formula:
C22H21Cl2N3O3
Purity:
98.19% - 98.3%
Color and Shape:
Solid
Molecular weight:
446.33
Ref: TM-T12428L
| 1mg | 39.00 € | ||
| 2mg | 50.00 € | ||
| 5mg | 80.00 € | ||
| 10mg | 123.00 € | ||
| 25mg | 273.00 € | ||
| 50mg | 495.00 € | ||
| 100mg | 713.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
UNC0642
CAS:1481677-78-4
UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
Formula:
C29H44F2N6O2
Purity:
98.75% - 99.5%
Color and Shape:
Solid
Molecular weight:
546.7
Ref: TM-T4166
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 128.00 € | ||
| 25mg | 226.00 € | ||
| 50mg | 369.00 € | ||
| 100mg | 557.00 € | ||
| 200mg | 806.00 € | ||
| 1mL*10mM (DMSO) | 94.00 € |
Estimated delivery in United States, on Thursday 12 Dec 2024
