DNA Methyltransferase
DNA methyltransferases (DNMTs) are enzymes that catalyze the addition of methyl groups to cytosine residues in DNA, leading to gene silencing. Aberrant DNA methylation is associated with various diseases, including cancer. DNMT inhibitors block the activity of these enzymes, leading to the reactivation of silenced genes and induction of apoptosis in cancer cells. DNMT inhibitors are widely used in epigenetic research and cancer therapy. At CymitQuimica, we provide a range of high-quality DNMT inhibitors to support your research in epigenetics, DNA methylation, and cancer biology.
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EEDi-5285
CAS:2488952-40-3
EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.
Formula:
C24H22FN5O3S
Purity:
100%
Color and Shape:
Solid
Molecular weight:
479.53
Ref: TM-T22322
| 1mg | To inquire | ||
| 5mg | 1,546.00 € | ||
| 10mg | 1,859.00 € | ||
| 25mg | 2,377.00 € | ||
| 50mg | 3,128.00 € | ||
| 1mL*10mM (DMSO) | 1,746.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
SW2_110A
CAS:2579696-95-8
SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.
Formula:
C42H60N6O7
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
760.96
Ref: TM-T36798
| 1mg | 106.00 € | ||
| 5mg | 270.00 € | ||
| 25mg | 744.00 € | ||
| 50mg | 1,057.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
iso-Azalansta
CAS:143393-29-7
(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study …
Formula:
C22H24ClN3O2S
Purity:
100% - 99.40%
Color and Shape:
Soild
Molecular weight:
429.96
Ref: TM-T25127L
| 1mg | 187.00 € | ||
| 5mg | 462.00 € | ||
| 10mg | 661.00 € | ||
| 25mg | 1,031.00 € | ||
| 50mg | 1,423.00 € | ||
| 100mg | 1,881.00 € | ||
| 200mg | 2,568.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
WDR5-47
CAS:1422389-91-0
WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value …
Formula:
C19H20ClFN4O3
Purity:
98.08%
Color and Shape:
Soild
Molecular weight:
406.84
Ref: TM-T67697
| 1mg | 112.00 € | ||
| 5mg | 249.00 € | ||
| 10mg | 365.00 € | ||
| 25mg | 547.00 € | ||
| 50mg | 765.00 € | ||
| 100mg | 1,044.00 € | ||
| 200mg | 1,404.00 € | ||
| 1mL*10mM (DMSO) | 271.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Tulmimetostat
CAS:2567686-02-4
Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in …
Formula:
C28H36ClN3O5S
Purity:
98.04%
Color and Shape:
Liquid
Molecular weight:
562.12
Ref: TM-T40199
| 1mg | 36.00 € | ||
| 5mg | 68.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 180.00 € | ||
| 50mg | 270.00 € | ||
| 100mg | 532.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
EZH2-IN-15
CAS:2098545-98-1
A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.
Formula:
C32H44N4O4
Purity:
98.85%
Color and Shape:
Liquid
Molecular weight:
548.72
Ref: TM-T67883
| 1mg | 154.00 € | ||
| 5mg | 339.00 € | ||
| 10mg | 515.00 € | ||
| 25mg | 816.00 € | ||
| 50mg | 1,103.00 € | ||
| 100mg | 1,476.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
DC-S239
CAS:303141-21-1
Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.
Formula:
C15H15N3O5S
Purity:
99.36%
Color and Shape:
Liquid
Molecular weight:
349.36
Ref: TM-T60002
| 1mg | 95.00 € | ||
| 5mg | 232.00 € | ||
| 10mg | 373.00 € | ||
| 25mg | 622.00 € | ||
| 50mg | 887.00 € | ||
| 100mg | 1,201.00 € | ||
| 500mg | 2,385.00 € | ||
| 1mL*10mM (DMSO) | 243.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
MS8511 HCl
MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the …
Formula:
C28H42ClN5O3
Purity:
97.83% - 98.90%
Color and Shape:
Liquid
Molecular weight:
532.12
Ref: TM-T63351L
| 1mg | 182.00 € | ||
| 5mg | 449.00 € | ||
| 10mg | 645.00 € | ||
| 25mg | 1,026.00 € | ||
| 50mg | 1,415.00 € | ||
| 100mg | 1,871.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
MAK-683 hydrochloride
CAS:2170606-94-5
MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, …
Formula:
C20H18ClFN6O
Purity:
100% - 99.72%
Color and Shape:
Liquid
Molecular weight:
412.85
Ref: TM-T9681
| 1mg | 182.00 € | ||
| 5mg | 407.00 € | ||
| 10mg | 611.00 € | ||
| 25mg | 928.00 € | ||
| 50mg | 1,332.00 € | ||
| 100mg | 1,798.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 …
Formula:
C29H43Cl3N4O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
602.04
Ref: TM-T10840
| 5mg | 211.00 € | ||
| 10mg | 327.00 € | ||
| 50mg | 917.00 € | ||
| 100mg | 1,249.00 € | ||
| 200mg | To inquire | ||
| 500mg | To inquire | ||
| 1mL*10mM (DMSO) | 279.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.
Formula:
C15H26Cl2N2O
Purity:
99.9%
Color and Shape:
Solid
Molecular weight:
321.28
Ref: TM-T4393
| 2mg | 38.00 € | ||
| 5mg | 51.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 157.00 € | ||
| 50mg | 288.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Dihydro-5-azacytidine
CAS:62488-57-7
Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It …
Formula:
C8H14N4O5
Purity:
100%
Color and Shape:
Liquid
Molecular weight:
246.22
Ref: TM-T40713
| 25mg | 1,422.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Tazemetostat trihydrochloride
CAS:1403255-00-4
Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in …
Formula:
C34H47Cl3N4O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
682.12
Ref: TM-T15240
| 100mg | To inquire | ||
| 500mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
UNC6852
CAS:2688842-08-0
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and …
Formula:
C43H48N10O6S
Purity:
≥98%
Color and Shape:
Liquid
Molecular weight:
832.97
Ref: TM-T13954
| 1mg | 130.00 € | ||
| 5mg | 270.00 € | ||
| 10mg | 446.00 € | ||
| 25mg | 737.00 € | ||
| 50mg | 1,003.00 € | ||
| 100mg | 1,380.00 € | ||
| 1mL*10mM (DMSO) | 375.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Isomaltotriose
CAS:3371-50-4
Isomaltotriose is a sugar compound derived from the enzymic hydrolyzates of dextran obtained from the …
Formula:
C18H32O16
Purity:
98%
Color and Shape:
Lyophilized Powder
Molecular weight:
504.44
Ref: TM-T19383
| 50mg | To inquire | ||
| 100mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
Nanaomycin A
CAS:52934-83-5
Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).
Formula:
C16H14O6
Purity:
98%
Color and Shape:
Solid
Molecular weight:
302.28
Ref: TM-T16269
| 1mg | 351.00 € | ||
| 5mg | 1,309.00 € | ||
| 10mg | 2,276.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
EPZ020411 hydrochloride
CAS:2070015-25-5
EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value …
Formula:
C25H39ClN4O3
Purity:
100%
Color and Shape:
Solid
Molecular weight:
479.05
Ref: TM-T22325
| 1mg | 60.00 € | ||
| 5mg | 129.00 € | ||
| 10mg | 210.00 € | ||
| 25mg | 362.00 € | ||
| 50mg | 551.00 € | ||
| 100mg | 793.00 € | ||
| 1mL*10mM (DMSO) | 145.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
CARM1 degrader-1
PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the …
Formula:
C71H98N12O8S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
1279.68
Ref: TM-T79741
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
EPZ020411 2HCl (1700663-41-7(free base))
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
Formula:
C25H40Cl2N4O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
515.51
Ref: TM-T4334
| 2mg | 106.00 € | ||
| 5mg | 182.00 € | ||
| 10mg | 289.00 € | ||
| 25mg | 603.00 € | ||
| 1mL*10mM (DMSO) | 289.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
EML734
CAS:3031795-11-3
EML734 is a potent, selective inhibitor of PRMT7 and PRMT9, demonstrating inhibitory concentration 50 (IC50) …
Formula:
C27H32N10O7
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
608.61
Ref: TM-T79614
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
