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Sirtuin

Sirtuin

Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.

Found 88 products of "Sirtuin"

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  • SIRT6-IN-3
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    SIRT6-IN-3

    CAS:
    <p>SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts</p>
    Formula:C21H30Br3ClN6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:673.73

    Ref: TM-T79689

  • SIRT-IN-6
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    SIRT-IN-6

    CAS:
    <p>SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of &gt;50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.</p>
    Formula:C7H4ClN3OS
    Color and Shape:Solid
    Molecular weight:213.644

    Ref: TM-T204971

  • SIRT1-IN-5
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    SIRT1-IN-5

    CAS:
    <p>SIRT1-IN-5 (215) is a modulator of the NAD-dependent protein deacetylase SIRT1.</p>
    Formula:C21H17N3O3S
    Color and Shape:Solid
    Molecular weight:391.443

    Ref: TM-T204465

  • MC3138
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    MC3138

    CAS:
    <p>MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.</p>
    Formula:C25H25NO6
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:435.47

    Ref: TM-T88662

  • Sirtuin-IN-2
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    Sirtuin-IN-2

    <p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>
    Formula:C28H46N8O6S
    Color and Shape:Solid
    Molecular weight:622.78

    Ref: TM-T201797

  • SIRT6 activator 2
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    SIRT6 activator 2

    CAS:
    <p>SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.</p>
    Formula:C23H23N3O6
    Color and Shape:Solid
    Molecular weight:437.45

    Ref: TM-T200625

  • DCHC
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    DCHC

    CAS:
    <p>DCHC is an activator of SIRT1, but it does not induce SIRT1 expression. This compound can be utilized in studies related to mitochondrial damage.</p>
    Formula:C15H8Cl2O3
    Color and Shape:Solid
    Molecular weight:307.128

    Ref: TM-T204498

  • MDL-811
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    MDL-811

    CAS:
    <p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>
    Formula:C25H25BrCl2FN3O5S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:681.42

    Ref: TM-T81831

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