Sirtuin
Sirtuins are a family of NAD+-dependent deacetylases that play a critical role in regulating cellular processes such as DNA repair, aging, metabolism, and stress resistance. Sirtuins influence DNA repair by deacetylating proteins involved in the repair pathways, thereby modulating their activity. Sirtuin inhibitors and activators are valuable tools in research on aging, cancer, and metabolic diseases, where the regulation of DNA repair and cellular longevity is of interest. At CymitQuimica, we offer a range of high-quality sirtuin modulators to support your research in DNA repair, cellular aging, and metabolic regulation.
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CAY10602
CAS:374922-43-7
CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.
Formula:
C22H15FN4O2S
Purity:
98.87%
Color and Shape:
Solid
Molecular weight:
418.44
Ref: TM-T4062
| 5mg | 51.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 94.00 € | ||
| 50mg | 170.00 € | ||
| 100mg | 302.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 25 Feb 2025
SIRT7 inhibitor 97491
CAS:1807758-81-1
SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 …
Formula:
C15H12ClN3O
Purity:
99.79%
Color and Shape:
Solid
Molecular weight:
285.73
Ref: TM-T39233
| 1mg | 94.00 € | ||
| 5mg | 230.00 € | ||
| 10mg | 347.00 € | ||
| 25mg | 584.00 € | ||
| 50mg | 833.00 € | ||
| 100mg | 1,138.00 € | ||
| 1mL*10mM (DMSO) | 257.00 € |
Estimated delivery in United States, on Tuesday 25 Feb 2025
Splitomicin
CAS:5690-03-9
Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, …
Formula:
C13H10O2
Purity:
98.64% - 99.11%
Color and Shape:
Solid
Molecular weight:
198.22
Ref: TM-T6678
| 5mg | 48.00 € | ||
| 10mg | 63.00 € | ||
| 25mg | 115.00 € | ||
| 50mg | 173.00 € | ||
| 100mg | 326.00 € | ||
| 200mg | 472.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Tuesday 25 Feb 2025
Tenovin-6 Hydrochloride
CAS:1011301-29-3
Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.
Formula:
C25H35ClN4O2S
Purity:
100%
Color and Shape:
Solid
Molecular weight:
491.09
Ref: TM-T8480
| 1mg | 39.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 139.00 € | ||
| 50mg | 224.00 € | ||
| 100mg | 372.00 € | ||
| 1mL*10mM (DMSO) | 73.00 € |
Estimated delivery in United States, on Tuesday 25 Feb 2025
SRT 1460
CAS:925432-73-1
SRT 1460 is a SIRT1 activator.
Formula:
C26H29N5O4S
Purity:
97.62%
Color and Shape:
Solid
Molecular weight:
507.6
Ref: TM-T8346
| 2mg | 59.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | 114.00 € | ||
| 25mg | 170.00 € | ||
| 50mg | 247.00 € | ||
| 100mg | 370.00 € |
Estimated delivery in United States, on Tuesday 25 Feb 2025
Cambinol
CAS:14513-15-6
Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and …
Formula:
C21H16N2O2S
Purity:
98.21% - 98.47%
Color and Shape:
Solid
Molecular weight:
360.43
Ref: TM-T4019
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 122.00 € | ||
| 25mg | 214.00 € | ||
| 50mg | 344.00 € | ||
| 100mg | 512.00 € | ||
| 500mg | 1,110.00 € | ||
| 1mL*10mM (DMSO) | 67.00 € |
Estimated delivery in United States, on Tuesday 25 Feb 2025
Sirtinol
CAS:410536-97-9
Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
Formula:
C26H22N2O2
Purity:
99.52% - 99.96%
Color and Shape:
Solid
Molecular weight:
394.47
Ref: TM-T6671
| 2mg | 42.00 € | ||
| 5mg | 57.00 € | ||
| 10mg | 92.00 € | ||
| 25mg | 176.00 € | ||
| 50mg | 335.00 € | ||
| 100mg | 499.00 € | ||
| 500mg | 1,095.00 € | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Tuesday 25 Feb 2025
B2
CAS:115687-05-3
B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease …
Formula:
C20H17ClN4O3
Purity:
99.14%
Color and Shape:
Solid
Molecular weight:
396.83
Ref: TM-T22595
| 1mg | 45.00 € | ||
| 2mg | 62.00 € | ||
| 5mg | 89.00 € | ||
| 10mg | 141.00 € | ||
| 25mg | 230.00 € | ||
| 50mg | 328.00 € | ||
| 100mg | 475.00 € | ||
| 200mg | 634.00 € |
Estimated delivery in United States, on Tuesday 25 Feb 2025
SIRT2-IN-9
CAS:522650-91-5
SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.
Formula:
C21H22N6OS2
Purity:
99.5%
Color and Shape:
Liquid
Molecular weight:
438.57
Ref: TM-T62515
| 5mg | 74.00 € | ||
| 10mg | 114.00 € | ||
| 25mg | 230.00 € | ||
| 50mg | 364.00 € | ||
| 100mg | 546.00 € |
Estimated delivery in United States, on Tuesday 8 Apr 2025
SIRT5 inhibitor 1
CAS:2166487-21-2
SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked …
Formula:
C31H39FN6O6S2
Purity:
98.06%
Color and Shape:
Solid
Molecular weight:
674.81
Ref: TM-T12921
| 1mg | 145.00 € | ||
| 2mg | 206.00 € | ||
| 5mg | 351.00 € | ||
| 10mg | 527.00 € | ||
| 25mg | 927.00 € | ||
| 50mg | 1,333.00 € | ||
| 100mg | 1,782.00 € | ||
| 1mL*10mM (DMSO) | 463.00 € |
Estimated delivery in United States, on Tuesday 8 Apr 2025
RK-9123016
CAS:955900-27-3
RK-9123016 is a SIRT2 inhibitor.
Formula:
C16H18N6O3S
Purity:
100%
Color and Shape:
Solid
Molecular weight:
374.42
Ref: TM-T28543
| 5mg | 54.00 € | ||
| 10mg | 81.00 € | ||
| 25mg | 124.00 € | ||
| 50mg | 179.00 € | ||
| 100mg | 267.00 € | ||
| 200mg | 401.00 € |
Estimated delivery in United States, on Tuesday 8 Apr 2025
Sirt2-IN-1
CAS:1862238-00-3
Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).
Formula:
C28H27N7O2S2
Purity:
99.05% - 99.15%
Color and Shape:
Solid
Molecular weight:
557.69
Ref: TM-T12920
| 1mg | 103.00 € | ||
| 5mg | 210.00 € | ||
| 10mg | 333.00 € | ||
| 25mg | 531.00 € | ||
| 50mg | 719.00 € | ||
| 100mg | 917.00 € | ||
| 500mg | 1,838.00 € | ||
| 1mL*10mM (DMSO) | 265.00 € |
Estimated delivery in United States, on Tuesday 8 Apr 2025
SIRT5 inhibitor 5
CAS:2883730-60-5
SIRT5 Inhibitor 5 is a potent substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 0.21 …
Formula:
C21H14ClN3O3S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
423.87
Ref: TM-T72637
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Tuesday 8 Apr 2025
SIRT5 inhibitor 6
CAS:2834736-82-0
SIRT5 Inhibitor 6 is a potent, selective, and substrate-competitive inhibitor of SIRT5, exhibiting an IC50 …
Formula:
C21H28N6O4S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
460.55
Ref: TM-T78802
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Tuesday 8 Apr 2025
SIRT6-IN-5
CAS:891002-11-2
SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, …
Formula:
C19H14N2O6
Purity:
98.84%
Color and Shape:
Solid
Molecular weight:
366.32
Ref: TM-T24793
| 1mg | 55.00 € | ||
| 5mg | 118.00 € | ||
| 10mg | 184.00 € | ||
| 25mg | 371.00 € | ||
| 50mg | 732.00 € | ||
| 100mg | 998.00 € | ||
| 500mg | 1,986.00 € |
Estimated delivery in United States, on Tuesday 8 Apr 2025
SPC-180002
CAS:2170274-53-8
SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 …
Formula:
C18H23NO4
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
317.38
Ref: TM-T79601
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Tuesday 8 Apr 2025
SIRT6-IN-3
CAS:3023471-40-8
SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of …
Formula:
C21H30Br3ClN6S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
673.73
Ref: TM-T79689
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 22 Apr 2025
MDL-811
CAS:2275619-98-0
MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine …
Formula:
C25H25BrCl2FN3O5S2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
681.42
Ref: TM-T81831
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Sirt1/2-IN-3
CAS:301313-42-8
Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 …
Formula:
C17H14ClNO4S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
363.82
Ref: TM-T79564
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 22 Apr 2025
SRT3657
CAS:1383551-17-4
SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
Formula:
C40H54N8O6S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
774.97
Ref: TM-T13001
| 25mg | 1,827.00 € | ||
| 50mg | 2,412.00 € | ||
| 100mg | 3,178.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
