
Endocrinology/Hormones
Endocrinology/hormone inhibitors are compounds that block the action of hormones or interfere with hormone signaling pathways. These inhibitors are essential for studying the regulation of endocrine systems and for developing treatments for hormone-related diseases, such as diabetes, thyroid disorders, and hormone-dependent cancers. By modulating hormone activity, these inhibitors can help elucidate the complex interactions within the endocrine system. At CymitQuimica, we offer a wide range of high-quality endocrinology/hormone inhibitors to support your research in endocrinology, pharmacology, and medical sciences.
Subcategories of "Endocrinology/Hormones"
- Androgen Receptor(208 products)
- Annexin A(11 products)
- Aromatase(20 products)
- Estrogen/progestogen Receptor(48 products)
- GPR(1 products)
- Glucocorticoid Receptor(153 products)
- LHRH(1 products)
- Opioid Receptor(297 products)
- Prostaglandin Receptor(119 products)
- RAAS(86 products)
- Reductase(52 products)
- Somatostatin(46 products)
- Thyroid hormone receptor(THR)(26 products)
- Vasopressin Receptor(44 products)
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Found 3180 products of "Endocrinology/Hormones"
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(S)-MCOPPB
CAS:<p>(S)-MCOPPB is the S-enantiomer of MCOPPB, an orally active selective agonist for the Nociceptin/Orphanin FQ-Receptor. It inhibits signal transduction in mouse brain NOP receptors and is utilized in anxiety disorder research.</p>Formula:C26H40N4Color and Shape:SolidMolecular weight:408.623L162389
CAS:<p>L162389 is an angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor and stimulates the conversion of phosphatidylinositol.</p>Formula:C31H38N4O4SPurity:99.11% - 99.57%Color and Shape:SolidMolecular weight:562.72PD 134922
CAS:<p>PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.</p>Formula:C37H61N5O7SPurity:98%Color and Shape:SolidMolecular weight:719.97NSC 645827
CAS:<p>NSC 645827 is an inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), with an IC50 of 0.7 μM.</p>Formula:C17H17N5O2Color and Shape:SolidMolecular weight:323.349J-113397
CAS:<p>J-113397 is a potent and selective NOP receptor antagonist (IC50 = 2.3 nM).</p>Formula:C24H37N3O2Purity:98%Color and Shape:SolidMolecular weight:399.57SC13
CAS:<p>SC13, a novel mitragynine analog, exhibits low-efficacy agonism at Mu opioid receptors and provides antinociception while minimizing adverse effects.</p>Formula:C26H30N2O5Color and Shape:SolidMolecular weight:450.53AR antagonist 4
<p>AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist that acts on wild-type AR (IC50: 246.6 nM).</p>Formula:C29H36N4OColor and Shape:SolidMolecular weight:456.62ERα degrader 5
<p>ERα degrader 5 is an orally active, selective estrogen receptor (ER) reducer that acts on ERα (EC50: 1.1 nM). ERα degrader 5 shows anti-tumour effects in vivo.</p>Formula:C29H25F4N3O2SColor and Shape:SolidMolecular weight:555.595α-reductase-IN-1
CAS:<p>5α-reductase-IN-1 is a potent inhibitor of the enzyme 5α-reductase.</p>Formula:C31H37NO5Purity:98%Color and Shape:SolidMolecular weight:503.63Anticancer agent 257
CAS:<p>Anticanceragent 257 (compound of formula (I)) is an anticancer agent that regulates Nur77 and Nurr1.</p>Formula:C15H9Cl2N3Color and Shape:SolidMolecular weight:302.158JTP-117968
CAS:<p>JTP-117968: Non-steroidal SGRM, glucocorticoid receptor modulator, IC50 = 6.8 nM, offers better inhibitory/activatory balance.</p>Formula:C31H31F3N2O2Color and Shape:SolidMolecular weight:520.59TD-0212 TFA
CAS:<p>TD-0212 TFA is an oral AT1 receptor antagonist & NEP inhibitor with pKi 8.9 & pIC50 9.2.</p>Formula:C30H35F4N3O6SPurity:98%Color and Shape:SolidMolecular weight:641.67L 365209
CAS:<p>L 365209 is an oxytocin antagonist.</p>Formula:C40H50N8O6Purity:98%Color and Shape:SolidMolecular weight:738.88Mu opioid receptor antagonist 3
<p>Potent, selective MOR antagonist (compound 26); crosses blood-brain barrier. Ki: 0.24 nM, EC50: 0.54 nM; for studying OUD.</p>Formula:C25H28N2O4SColor and Shape:SolidMolecular weight:452.57Mepixetil
<p>Mepixetil is a potent angiotensin II receptor antagonist[1].</p>Formula:C12H18N2O3Color and Shape:SolidMolecular weight:238.28Mopivabil
<p>Mopivabil is the angiotensin II receptor antagonist[1].</p>Formula:C14H20O3Color and Shape:SolidMolecular weight:236.31GPR84 antagonist 1
<p>GPR84 antagonist 1 is a highly selective, high-affinity competitive antagonist of human GPR84.</p>Formula:C26H22N4O2Color and Shape:SolidMolecular weight:422.48AT1R antagonist 2
<p>AT1R antagonist 2 is a potent AT1R selective ligand with good AT1R affinity (Ki: 26 nM).</p>Formula:C29H37N5O4S2Color and Shape:SolidMolecular weight:583.77Mu opioid receptor antagonist 5
<p>Compound NAP: MOR antagonist, crosses blood-brain barrier, EC50: 1.14 nM, Ki: 0.37 nM, useful for OUD research.</p>Formula:C26H29N3O4Color and Shape:SolidMolecular weight:447.53DS34942424
<p>DS34942424 is an orally potent analgesic which did not exhibit mu opioid receptor agonist activity.</p>Formula:C15H17FN2OColor and Shape:SolidMolecular weight:260.31GNTI dihydrochloride
CAS:<p>κ opioid receptor antagonist</p>Formula:C27H30ClN5O3Purity:98%Color and Shape:SolidMolecular weight:508.01A4B17
<p>A4B17 is an inhibitor of androgen receptor N-terminal with potential for androgen-responsive prostate cancer treatment.</p>Formula:C14H7F4NSColor and Shape:SolidMolecular weight:297.27KR31173
CAS:<p>KR31173 is an AT1 antagonist with an IC50 of 3.27 nM. When labeled with the 11C isotope, KR31173 can be used as a tracer for positron emission tomography (PET). In mice, KR31173 exhibits favorable biodistribution and pharmacological characteristics. It selectively binds to organs in CD-1 mice known to have a high density of AT1 angiotensin receptors.</p>Formula:C31H30N8O2Color and Shape:SolidMolecular weight:546.626β-Naltrexol
CAS:<p>6β-Naltrexol is a peripherally selective opioid antagonist that reduces constipation from opioids while minimizing central nervous system effects.</p>Formula:C20H25NO4Purity:99.933%Color and Shape:SolidMolecular weight:343.42ER degrader 10
CAS:<p>ER degrader 10 (Compound 51) is an orally active estrogen receptor (ER) selective degrader and antagonist, with a DC50 of 0.43 nM and an IC50 of 0.56 nM. It inhibits the proliferation of ER-positive cells, with an IC50 ranging from 0 to 15 nM. ER degrader 10 exhibits weak inhibitory activity on the hERG channel, with an IC50 greater than 40 μM. It has blood-brain barrier permeability, with a brain/plasma ratio (Kp) of 3.05. In mouse models, ER degrader 10 demonstrates antitumor activity.</p>Formula:C28H29F2NO3SColor and Shape:SolidMolecular weight:497.597Mu opioid receptor antagonist 8
CAS:<p>Muopioid Receptor Antagonist 8 (368) serves as an antagonist to the μ-opioid receptor, significantly inhibiting the activation of Gi induced by met-enkephalin at the µOR.</p>Formula:C36H35N3O4SColor and Shape:SolidMolecular weight:605.75Riminkefon
CAS:<p>Riminkefon is a kappa opioid receptor agonist .</p>Formula:C38H57N7O6Color and Shape:SolidMolecular weight:707.9(Rac)-Fidarestat
CAS:<p>(Rac)-Fidarestat ((Rac)-SNK 860) is the racemic form of Fidarestat, functioning as a potent inhibitor of the enzyme aldose reductase.</p>Formula:C12H10FN3O4Color and Shape:SolidMolecular weight:279.224Amoitone B
CAS:<p>Amoitone B, a cystosporone B derivative, functions as an NR4A1 agonist and exhibits anticancer activity [1].</p>Formula:C22H34O5Color and Shape:SolidMolecular weight:378.5BU72
CAS:<p>BU72 is a potent, long-lasting agonist for μ and κ opioid receptors, with partial agonistic activity at the δ opioid receptor (EC50 values of 0.054, 0.033, and 0.58 nM, respectively). It provides strong, enduring analgesic effects primarily mediated through μ opioid receptors. BU72 also exhibits a prolonged duration of activity and can partially reverse morphine-induced analgesia. It is applicable in studies of opioid dependence.</p>Formula:C28H32N2O2Color and Shape:SolidMolecular weight:428.57Allyphenyline oxalate
CAS:<p>The pKi values of Allyphenyline oxalate (compound 9) for the α2-adrenergic receptor subtypes α2A, α2B, and α2C are 7.24, 6.47, and 7.07, respectively.</p>Formula:C16H20N2O5Color and Shape:SolidMolecular weight:320.34OSU-ERb-12
CAS:<p>OSU-ERb-12 is an ERβ agonist that suppresses ovarian cancer cell proliferation both in vitro and in vivo, and decreases the expression of Snail [1] [2].</p>Formula:C15H30B10O2Color and Shape:SolidMolecular weight:350.51Androgen receptor ligand 1
CAS:<p>Androgen receptorligand 1 is a ligand for the androgen receptor (AR). It interacts with the CRBN E3 ligase via a linker to form an AR-PROTAC degrader. This compound is useful in prostate cancer research.</p>Formula:C19H16F4N2OColor and Shape:SolidMolecular weight:364.34BU09059
CAS:<p>BU09059 is a potent, selective, short-acting antagonist of the κ-opioid receptor (KOR).</p>Formula:C28H37N3O5Purity:98%Color and Shape:SolidMolecular weight:495.61σ1 Receptor/μ Opioid receptor modulator 2
CAS:<p>Compound 4x, also known as σ1 Receptor/μOpioid receptormodulator 2, acts as a μOR agonist and a σ1R antagonist, exhibiting a potent μOR EC50 of 0.6 nM and strong σ1R inhibitory activity (Ki: 363.7 nM). It demonstrates significant analgesic effects in various pain models.</p>Formula:C23H31N3OMolecular weight:365.51Daeatal
CAS:<p>Dynorphin A ethylamide (1-9), the opioid activities were examined in the bioassays.</p>Formula:C56H93N19O10Purity:98%Color and Shape:SolidMolecular weight:1192.46OT-R agonist 1 TFA
CAS:<p>OT-R agonist 1 TFA (compound 5) is an oxytocin receptor (OT-R) agonist with an EC50 value of 0.39 nM. It exhibits V1A antagonist activity, with an EC50 value of 2432 nM, and can be utilized in studies related to central nervous system diseases.</p>Formula:C37H40F3N7O7SColor and Shape:SolidMolecular weight:783.82MB-07344 sodium
<p>"MB-07344 sodium is a TR-β agonist with a 2.17 nM Ki, boosts Atorvastatin's cholesterol-lowering effects in various animals."</p>Formula:C19H25NaO5PPurity:98%Color and Shape:SolidMolecular weight:387.3621-Deacetoxy deflazacort
CAS:<p>21-Deacetoxy deflazacort is a dehydrogenated derivative of Deflazacort, which is a glucocorticoid. As an inactive precursor, Deflazacort rapidly converts into the active metabolite, 21-Desacetyldeflazacort. This compound serves as both an anti-inflammatory and immunosuppressive agent.</p>Formula:C23H29NO4Color and Shape:SolidMolecular weight:383.48BNTX maleate
CAS:<p>δ1 opioid receptor antagonist</p>Formula:C31H31NO8Purity:98%Color and Shape:SolidMolecular weight:545.58EN171
CAS:<p>EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol.</p>Formula:C17H22N2OColor and Shape:SolidMolecular weight:270.37Dazucorilant
CAS:<p>Dazucorilant (CORT113176), a selective non-steroidal GR modulator, has high affinity with a K i <1 nM, useful for neurological research.</p>Formula:C29H22F4N4O3SColor and Shape:SolidMolecular weight:582.57LNS8801
CAS:<p>LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.</p>Formula:C21H18BrNO3Color and Shape:SolidMolecular weight:412.277GPR81 agonist 2
CAS:<p>GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.</p>Formula:C26H27ClN6O5S2Color and Shape:SolidMolecular weight:603.11C108297
CAS:<p>C108297: glucocorticoid modulator, combats diet obesity/inflammation, reduces appetite/lipid storage, boosts fat burn.</p>Formula:C30H36FN3O4SPurity:98%Color and Shape:SolidMolecular weight:553.69LX1
CAS:<p>LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.</p>Formula:C22H15F6NO2Color and Shape:SolidMolecular weight:439.35Androgen receptor antagonist 11
CAS:<p>Androgen receptor antagonist 11 (compound N29) is a selective, orally available antagonist.</p>Formula:C20H19F3N4O3SColor and Shape:SolidMolecular weight:452.45FSH receptor antagonist 1
CAS:<p>FSH receptor antagonist 1 (compound 10) is a potent antagonist of the G(s) protein-coupled human follicle-stimulating hormone (FSH) receptor. It exhibits an IC50 value of 28 nM in cell lines expressing the human FSH receptor. This compound significantly inhibits follicle growth and ovulation in in vitro mouse models.</p>Formula:C33H32N2O2Color and Shape:SolidMolecular weight:488.619ZD 7155 hydrochloride
CAS:<p>ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.</p>Formula:C26H27ClN6OPurity:99.8%Color and Shape:SolidMolecular weight:474.98Cort108297
CAS:<p>Cort108297: selective GR modulator/antagonist, high GR affinity (Ki: 0.45nM), no other steroid receptor affinity.</p>Formula:C26H25F4N3O3SPurity:98.36% - 99.94%Color and Shape:SolidMolecular weight:535.55GLPG0974
CAS:<p>GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.</p>Formula:C25H25ClN2O4SPurity:99.8%Color and Shape:SolidMolecular weight:484.99Nalmefene
CAS:<p>Nalmefene (ORF 11676) is a μ-opioid antagonist and partial κ agonist used in the study of opioid overdose and alcohol dependence.</p>Formula:C21H25NO3Purity:99.86%Color and Shape:SolidMolecular weight:339.43L-371,257
CAS:<p>L-371,257 is a competitive antagonist of oxytocin receptor with pA2 of 8.4 and Ki of 19 nM. L-371,257 shows a Ki of 3.7 nM for vasopressin receptor 1a.</p>Formula:C28H33N3O6Purity:99.79%Color and Shape:SolidMolecular weight:507.58(E/Z)-GSK5182
CAS:<p>GSK5182 is a racemic mix of (E/Z) isomers, a selective ERRγ inverse agonist (IC50: 79 nM), and induces ROS in liver cancer.</p>Formula:C27H31NO3Purity:97.58%Color and Shape:SolidMolecular weight:417.54LSZ-102
CAS:<p>LSZ-102 is an effective and selective degrader of estrogen receptor (IC50 = 0.2 nM) and can be used in studies about ERα positive breast cancer.</p>Formula:C25H17F3O4SPurity:98.56%Color and Shape:SolidMolecular weight:470.46PSN632408
CAS:<p>PSN632408 is an optimized agonist of GPR119 receptors that display similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50: 5.6 and 7.9 uM, respectively).</p>Formula:C18H24N4O4Purity:98%Color and Shape:SolidMolecular weight:360.41ML314
CAS:<p>ML314 is a brain-permeable nonpeptide β-inhibin-biased neurotensin NTR1 receptor agonist (EC50: 1.9 μM), a biased neurotensin receptor ligand for methamphetamine abuse that inhibits NTR2 and GPR35.</p>Formula:C24H28N4O3Purity:99.52%Color and Shape:SolidMolecular weight:420.504Mapracorat
CAS:<p>Mapracorat (ZK-245186, BOL-303242X) is a selective glucocorticoid receptor agonist,anti-inflammatory agent for atopic dermatitis and allergic conjunctivitis.</p>Formula:C25H26F4N2O2Color and Shape:SolidMolecular weight:462.48(S)-Mapracorat
CAS:<p>(S)-Mapracorat is a selective and less active agonist of the glucocorticoid receptor.</p>Formula:C25H26F4N2O2Color and Shape:SolidMolecular weight:462.48ZK 216348
CAS:<p>ZK 216348 also binds to Progesterone and mineralocorticoid receptors (IC50s: 20.4 nM and 79.9 nM, respectively). ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist (IC50: 20.3 nM). ZK 216348 has an anti-inflammatory activity similar to</p>Formula:C24H23F3N2O5Purity:98%Color and Shape:SolidMolecular weight:476.45Exemestane
CAS:<p>Exemestane (EXE) is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.</p>Formula:C20H24O2Purity:99.35% - 99.35%Color and Shape:White To Light Yellow Crystal PowderMolecular weight:296.4Budesonide
CAS:<p>Budesonide (Pulmicort), an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Budesonide has extensively inhibitory effects against multiple cells types and mediators referred to allergic and nonallergic-mediated inflammatory. What's more, the anti-inflammatory action of budesonide has been revealed to contribute to the effectiveness of asthma.</p>Formula:C25H34O6Purity:99.03% - 99.72%Color and Shape:Crystals SolidMolecular weight:430.53Relacorilant
CAS:<p>Relacorilant is an oral glucocorticoid receptor antagonist with Ki of 7.2 nM, potential for treating Cushing's syndrome.</p>Formula:C27H22F4N6O3SPurity:98.53% - 99%Color and Shape:SolidMolecular weight:586.56L-372662
CAS:<p>L-372662 is bioactive chemical.</p>Formula:C33H38N4O6Color and Shape:SolidMolecular weight:586.68AZD9496 maleate
CAS:<p>AZD9496 maleate is a highly potent and selective antagonist of the estrogen receptor alpha (ERα), exhibiting an IC50 value of 0.28 nM. This compound, AZD9496 maleate, is an orally bioavailable selective estrogen receptor degrader (SERD).</p>Formula:C29H29F3N2O6Color and Shape:SolidMolecular weight:558.554PF-998425
CAS:<p>non-steroidal androgen receptor (AR) antagonist</p>Formula:C14H14F3NOPurity:98%Color and Shape:SolidMolecular weight:269.26ERB-196
CAS:<p>Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.</p>Formula:C17H10FNO2Purity:98%Color and Shape:SolidMolecular weight:279.27GPR109 receptor agonist-2
CAS:<p>Compound 5, a selective GPR109a agonist, exhibits a pEC50 value of 5.53 [1].</p>Formula:C7H10N2O2Color and Shape:SolidMolecular weight:154.1721-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
<p>21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is a valuable organic compound for life sciences research [Catalog No.: T67476, CAS No.: 37413-91-5].</p>Formula:C23H26O4Color and Shape:SolidMolecular weight:366.457Phosphoramidon Disodium
CAS:<p>Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.</p>Formula:C23H34N3Na2O10PPurity:98%Color and Shape:SolidMolecular weight:588.48Cebranopadol
CAS:<p>Cebranopadol (GRT6005) is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP)</p>Formula:C24H27FN2OPurity:98.32% - 99.78%Color and Shape:SolidMolecular weight:378.48Pamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Formula:C23H16O6Purity:99.99%Color and Shape:Fine Yellow PowderMolecular weight:388.37YK11
CAS:<p>YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM, with osteogenic activity.</p>Formula:C25H34O6Purity:98.91%Color and Shape:SoildMolecular weight:430.53SR17018
CAS:<p>SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM.</p>Formula:C19H18Cl3N3OPurity:99.89%Color and Shape:SolidMolecular weight:410.72Bromadoline maleate
CAS:<p>Bromadoline is an opioid analgesic selective for the μ-opioid receptor.</p>Formula:C19H25BrN2O5Purity:98%Color and Shape:SolidMolecular weight:441.322Ceronapril
CAS:<p>Ceronapril (SQ 29852) is an orally active and potent angiotensin-converting enzyme (ACE) inhibitor (IC50 : 36 nM) for the study of dementia and hypertension.</p>Formula:C21H33N2O6PPurity:97.94%Color and Shape:SolidMolecular weight:440.47Ref: TM-T25226
Discontinued productSR14150
CAS:<p>SR14150 is a partial agonist of high-affinity NOP receptor.</p>Formula:C21H30N2OPurity:98%Color and Shape:SolidMolecular weight:326.48MOR agonist-1
CAS:<p>MOR Agonist-1 is a μ-opioid receptor (MOR) agonist noted for its potent analgesic properties and is utilized in research concerning pain and associated</p>Formula:C22H26ClFN2O2Purity:98%Color and Shape:SolidMolecular weight:404.91Estrogen receptor modulator 8
CAS:<p>Estrogen Receptor Modulator 8 (compound 4) is an orally active inhibitor targeting Estrogen Receptor/ERR α with potent efficacy (IC50 = 0.437 nM in MCF-7 cells</p>Formula:C25H24F4N2O2Purity:98%Color and Shape:SolidMolecular weight:460.46ALS-I-41
CAS:<p>ALS-I-41 is a novel, potent and selective antagonist of oxytocin receptor.</p>Formula:C30H38FN3O6SPurity:98%Color and Shape:SolidMolecular weight:587.7

