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Endocrinology/Hormones

Endocrinology/Hormones

Endocrinology/hormone inhibitors are compounds that block the action of hormones or interfere with hormone signaling pathways. These inhibitors are essential for studying the regulation of endocrine systems and for developing treatments for hormone-related diseases, such as diabetes, thyroid disorders, and hormone-dependent cancers. By modulating hormone activity, these inhibitors can help elucidate the complex interactions within the endocrine system. At CymitQuimica, we offer a wide range of high-quality endocrinology/hormone inhibitors to support your research in endocrinology, pharmacology, and medical sciences.

Subcategories of "Endocrinology/Hormones"

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Found 3178 products of "Endocrinology/Hormones"

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  • Androgen receptor-IN-5
    Targetmol
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    Androgen receptor-IN-5

    CAS:
    <p>Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties.</p>
    Formula:C22H10Cl2F4N4OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:525.31

    Ref: TM-T79024

  • A81988
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    A81988

    CAS:
    <p>A81988 is an antagonist of angiotensin AT1 receptors.</p>
    Formula:C23H22N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:414.46

    Ref: TM-T14079

  • Trimegestone
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    Trimegestone

    CAS:
    <p>Trimegestone, a highly effective oral progestogen, is used for endometrial protection, all doses inducing secretory endometrial transformation.</p>
    Formula:C22H30O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:342.47

    Ref: TM-T20755

  • RU 59063
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    RU 59063

    CAS:
    <p>RU 59063 is a prototype of a new class of high-affinity nonsteroidal androgen receptor (AR) ligands.</p>
    Formula:C17H18F3N3O2S
    Purity:99.09%
    Color and Shape:Solid
    Molecular weight:385.4

    Ref: TM-T20761

  • GW-803430
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    GW-803430

    CAS:
    <p>GW-803430: potent MCH R1 antagonist, pIC50=9.3, orally effective against obesity in animals.</p>
    Formula:C25H24ClN3O3S
    Purity:98.07%
    Color and Shape:Solid
    Molecular weight:481.99

    Ref: TM-T15450

  • MB-07811
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    MB-07811

    CAS:
    <p>MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity.</p>
    Formula:C28H32ClO5P
    Purity:99.74% - 99.94%
    Color and Shape:Solid
    Molecular weight:514.98

    Ref: TM-T16018

  • CO23
    Targetmol
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    CO23

    CAS:
    <p>CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.</p>
    Formula:C19H18I2N2O4
    Purity:98.08%
    Color and Shape:Solid
    Molecular weight:592.17

    Ref: TM-T10855

  • Rovatirelin
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    Rovatirelin

    CAS:
    <p>Rovatirelin (S-0373) is a TRH analog that improves motor dysfunction in a rat model of cytosine arabinoside-induced spinal cerebellar degeneration.</p>
    Formula:C16H22N4O4S
    Purity:99.59%
    Color and Shape:Solid
    Molecular weight:366.43

    Ref: TM-T34399

  • Giredestrant tartrate
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    Giredestrant tartrate

    CAS:
    <p>Giredestrant tartrate: a new oral, selective non-steroidal ER antagonist, inhibits ER-mediated gene activation and degrades ER protein, treating tumors.</p>
    Formula:C31H37F5N4O7
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:672.64

    Ref: TM-T11236

  • Baxdrostat
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    Baxdrostat

    CAS:
    <p>Baxdrostat is an aldosterone synthase inhibitor.</p>
    Formula:C22H25N3O2
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:363.45

    Ref: TM-T61373

  • DS08210767
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    DS08210767

    CAS:
    <p>DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.</p>
    Formula:C31H39N5O2
    Purity:98.79%
    Color and Shape:Solid
    Molecular weight:513.67

    Ref: TM-T11101

  • AMG 837 calcium hydrate
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    AMG 837 calcium hydrate

    CAS:
    <p>AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM.</p>
    Formula:C52H44CaF6O8
    Purity:98.07%
    Color and Shape:Solid
    Molecular weight:950.97

    Ref: TM-TQ0020

  • OSU-ERb-12
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    OSU-ERb-12

    CAS:
    <p>OSU-ERb-12 is an ERβ agonist that suppresses ovarian cancer cell proliferation both in vitro and in vivo, and decreases the expression of Snail [1] [2].</p>
    Formula:C15H30B10O2
    Color and Shape:Solid
    Molecular weight:350.51

    Ref: TM-T87077

  • Opioid receptor antagonist 1
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    Opioid receptor antagonist 1

    CAS:
    <p>Opioid receptor antagonist 1 (Compound 10) is an Orvinol-based antagonist of opioid receptors. It exhibits activity as an antagonist against the analgesic properties of morphine.</p>
    Formula:C24H29ClF3NO4
    Color and Shape:Solid
    Molecular weight:487.94

    Ref: TM-T204656

  • Isotodesnitazene
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    Isotodesnitazene

    CAS:
    <p>Isotodesnitazene is an opioid compound that primarily targets the μ-opioid receptor (MOR). It exhibits EC50 values of 34.8 nM and 142 nM for MOR-βarr2 and MOR-mini-Gi, respectively. Isotodesnitazene can be utilized for research in opioid drugs.</p>
    Formula:C23H31N3O
    Color and Shape:Solid
    Molecular weight:365.51

    Ref: TM-T201840

  • LIT-001 free base
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    LIT-001 free base

    CAS:
    <p>LIT-001, a nonpeptide OT-R agonist, enhances mouse autism-like behavior, with EC50=55 nM and Ki=226 nM.</p>
    Formula:C28H33N7O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:531.67

    Ref: TM-T11856

  • GC 14
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    GC 14

    CAS:
    <p>GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively.</p>
    Formula:C26H27NO6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:449.5

    Ref: TM-T11376

  • Metahexestrol
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    Metahexestrol

    CAS:
    <p>Metahexestrol is an inhibitor of the estrogen receptor (E2R) with antitumor activity. It significantly inhibits the proliferation of estrogen receptor-positive MCF-7 human breast cancer cell line with an ED50 of 1.0 μM. Additionally, Metahexestrol shows inhibitory activity in estrogen receptor-negative MDA-MB-231 cell lines, and its antiproliferative effect is not reversed by estrogen, suggesting that its mechanism may be partially independent of the E2R pathway. Metahexestrol is applicable in research on estrogen-dependent breast cancer.</p>
    Formula:C18H22O2
    Color and Shape:Solid
    Molecular weight:270.366

    Ref: TM-T206528

  • BMS-248360
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    BMS-248360

    CAS:
    <p>BMS-248360: Oral dual hAT1/hETA antagonist with Kis of 10nM &amp; 1.9nM, respectively; treats hypertension.</p>
    Formula:C36H45N5O5S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:659.84

    Ref: TM-T14672

  • GDC-0927 Racemate
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    GDC-0927 Racemate

    CAS:
    <p>GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM.</p>
    Formula:C28H28FNO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:461.52

    Ref: TM-T13700

  • ID11916
    Targetmol
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    ID11916

    CAS:
    <p>ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.</p>
    Formula:C29H27F3N8O3S
    Color and Shape:Solid
    Molecular weight:624.637

    Ref: TM-T206742

  • ERRα antagonist-2
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    ERRα antagonist-2

    CAS:
    <p>ERRα antagonist-2 is an estrogen-related receptor α inverse agonist, inhibiting migration and invasion in ER-negative MDA-MB-231,breast cancer.</p>
    Formula:C19H16N2O6S
    Purity:99.26%
    Color and Shape:Solid
    Molecular weight:400.41

    Ref: TM-T61923

  • BU72
    Targetmol
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    BU72

    CAS:
    <p>BU72 is a potent, long-lasting agonist for μ and κ opioid receptors, with partial agonistic activity at the δ opioid receptor (EC50 values of 0.054, 0.033, and 0.58 nM, respectively). It provides strong, enduring analgesic effects primarily mediated through μ opioid receptors. BU72 also exhibits a prolonged duration of activity and can partially reverse morphine-induced analgesia. It is applicable in studies of opioid dependence.</p>
    Formula:C28H32N2O2
    Color and Shape:Solid
    Molecular weight:428.57

    Ref: TM-T207187

  • CH5447240
    Targetmol
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    CH5447240

    CAS:
    <p>CH5447240: potent hPTHR1 agonist, treats Hypoparathyroidism, EC50 12 nM, 55% oral bioavailability, raises rat serum calcium.</p>
    Formula:C26H39N5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:517.68

    Ref: TM-T25234

  • 22-Thiocyanatosalvinorin A
    Targetmol
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    22-Thiocyanatosalvinorin A

    CAS:
    <p>22-Thiocyanatosalvinorin A (RB-64) is a potent selective agonist for the kappa-opioid receptor, exhibiting an EC50 value of 0.077 nM.</p>
    Formula:C24H27NO8S
    Color and Shape:Solid
    Molecular weight:489.54

    Ref: TM-T201845

  • Novokinin
    Targetmol
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    Novokinin

    CAS:
    <p>Angiotensin AT2 receptor agonist</p>
    Formula:C39H61N11O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:795.97

    Ref: TM-T23077

  • Anilopam
    Targetmol
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    Anilopam

    CAS:
    <p>Anilopam is an opioid analgesic belonging to the benzazepine class and acts as an agonist at opioid receptors.</p>
    Formula:C20H26N2O
    Color and Shape:Solid
    Molecular weight:310.43

    Ref: TM-T201609

  • 5′-Guanidinonaltrindole
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    5′-Guanidinonaltrindole

    CAS:
    <p>5′-Guanidinonaltrindole (GNTI) is a selective antagonist of the kappa opioid receptor.</p>
    Formula:C27H29N5O3
    Color and Shape:Solid
    Molecular weight:471.551

    Ref: TM-T204552

  • Naldemedine tosylate
    Targetmol
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    Naldemedine tosylate

    CAS:
    <p>Naldemedine (S-297995) tosylate, a PAMORA, targets μ-, δ-, κ-opioid receptors, aiding OIC research, may bind to SARS-CoV2's 3CL pro.</p>
    Formula:C39H42N4O9S
    Color and Shape:Solid
    Molecular weight:742.84

    Ref: TM-T70929

  • CymitQuimica logo
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    DS34942424

    <p>DS34942424 is an orally potent analgesic which did not exhibit mu opioid receptor agonist activity.</p>
    Formula:C15H17FN2O
    Color and Shape:Solid
    Molecular weight:260.31

    Ref: TM-T60415

  • KR31173
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    KR31173

    CAS:
    <p>KR31173 is an AT1 antagonist with an IC50 of 3.27 nM. When labeled with the 11C isotope, KR31173 can be used as a tracer for positron emission tomography (PET). In mice, KR31173 exhibits favorable biodistribution and pharmacological characteristics. It selectively binds to organs in CD-1 mice known to have a high density of AT1 angiotensin receptors.</p>
    Formula:C31H30N8O2
    Color and Shape:Solid
    Molecular weight:546.62

    Ref: TM-T207150

  • 6β-Naltrexol
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    6β-Naltrexol

    CAS:
    <p>6β-Naltrexol is a peripherally selective opioid antagonist that reduces constipation from opioids while minimizing central nervous system effects.</p>
    Formula:C20H25NO4
    Purity:99.933%
    Color and Shape:Solid
    Molecular weight:343.42

    Ref: TM-T85517

  • Mu opioid receptor antagonist 8
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    Mu opioid receptor antagonist 8

    CAS:
    <p>Muopioid Receptor Antagonist 8 (368) serves as an antagonist to the μ-opioid receptor, significantly inhibiting the activation of Gi induced by met-enkephalin at the µOR.</p>
    Formula:C36H35N3O4S
    Color and Shape:Solid
    Molecular weight:605.75

    Ref: TM-T88728

  • Riminkefon
    Targetmol
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    Riminkefon

    CAS:
    <p>Riminkefon is a kappa opioid receptor agonist .</p>
    Formula:C38H57N7O6
    Color and Shape:Solid
    Molecular weight:707.9

    Ref: TM-T69851

  • (Rac)-Fidarestat
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    (Rac)-Fidarestat

    CAS:
    <p>(Rac)-Fidarestat ((Rac)-SNK 860) is the racemic form of Fidarestat, functioning as a potent inhibitor of the enzyme aldose reductase.</p>
    Formula:C12H10FN3O4
    Color and Shape:Solid
    Molecular weight:279.224

    Ref: TM-T207035

  • EN171
    Targetmol
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    EN171

    CAS:
    <p>EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol.</p>
    Formula:C17H22N2O
    Color and Shape:Solid
    Molecular weight:270.37

    Ref: TM-T200403

  • Bromadoline
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    Bromadoline

    CAS:
    <p>Bromadoline is an opioid compound that exhibits anti-nociceptive properties in rodents.</p>
    Formula:C15H21BrN2O
    Color and Shape:Solid
    Molecular weight:325.244

    Ref: TM-T204210

  • Estrogen receptor modulator 11
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    Estrogen receptor modulator 11

    CAS:
    <p>Estrogen receptor modulator11 (Compound 27) is a tetrahydroisoquinoline derivative. It exhibits affinity for the estrogen receptor (ER), with IC50 values of 285 nM for ERα and 421 nM for ERβ. Estrogen receptor modulator11 does not demonstrate antagonist activity in MCF-7 cell assays.</p>
    Formula:C21H18FNO
    Color and Shape:Solid
    Molecular weight:319.372

    Ref: TM-T205569

  • Triisopropyl phosphate
    Targetmol
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    Triisopropyl phosphate

    CAS:
    <p>Triisopropyl phosphate inhibits TFF1 and EGR3 gene expression and exhibits anti-estrogenic activity by suppressing Estradiol-induced proliferation of MCF-7 cells, with an EC50 of 341 μM. Additionally, Triisopropyl phosphate reduces estrogen response element (ERE)-stimulated luciferase activity in MVLN cells, with an EC50 of 900 μM.</p>
    Formula:C9H21O4P
    Color and Shape:Solid
    Molecular weight:224.234

    Ref: TM-T205125

  • PBPE hydrochloride
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    PBPE hydrochloride

    CAS:
    <p>PBPE hydrochloride is a derivative of tamoxifen and functions as a selective ligand for antiestrogen binding sites (AEBS). The binding affinity (Ki) of PBPE hydrochloride and MBPE to AEBS is 8.79 nM and 17.57 nM, respectively.</p>
    Formula:C19H24ClNO
    Color and Shape:Solid
    Molecular weight:317.853

    Ref: TM-T204972

  • AR antagonist 10
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    AR antagonist 10

    CAS:
    <p>AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.</p>
    Formula:C18H17ClN4O3S
    Color and Shape:Solid
    Molecular weight:404.871

    Ref: TM-T205420

  • KNT-127
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    KNT-127

    CAS:
    <p>KNT-127 is an agonist of δ-Opioid receptor.</p>
    Formula:C24H24N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:372.46

    Ref: TM-T25583

  • EN1441
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    EN1441

    CAS:
    <p>EN1441 is a covalent degrader that targets the androgen receptor (AR) with an EC50 value of 4.2 μM, as well as its truncated variant AR-V7. It selectively and effectively degrades AR and AR-V7 in androgen-independent prostate cancer cells. EN1441 holds potential for research into androgen-independent prostate cancer.</p>
    Formula:C13H13ClN2O2
    Color and Shape:Solid
    Molecular weight:264.708

    Ref: TM-T206982

  • AP5
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    AP5

    CAS:
    <p>AP5: GPR40 agonist, positive allosteric modulator; rat hIP1 EC50: 0.49 nM.</p>
    Formula:C28H28FNO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:461.52

    Ref: TM-T13550

  • Glucocorticoid receptor activator 1
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    Glucocorticoid receptor activator 1

    CAS:
    <p>Glucocorticoid Receptor Activator 1, a phenyl nitrogen-heterocyclic precursor, acts as an activator of the glucocorticoid receptor (GR). By activating GR, it downregulates the expression of pro-inflammatory genes stimulated by TNF, making it useful for inflammation research.</p>
    Formula:C11H15Cl2NO2
    Color and Shape:Solid
    Molecular weight:264.15

    Ref: TM-T201578

  • Androgen receptor antagonist 12
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    Androgen receptor antagonist 12

    CAS:
    <p>Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.</p>
    Formula:C12H8F3N3O2
    Color and Shape:Solid
    Molecular weight:283.21

    Ref: TM-T201604

  • Naltrindole 5′-isothiocyanate
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    Naltrindole 5′-isothiocyanate

    CAS:
    <p>Naltrindole 5′-isothiocyanate (5'-NTII) is an irreversible delta opioid receptor antagonist that counters the analgesic effects induced by DSLET without altering the effects caused by DPDPE.</p>
    Formula:C27H25N3O3S
    Color and Shape:Solid
    Molecular weight:471.571

    Ref: TM-T205509

  • LEO 134310
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    LEO 134310

    CAS:
    <p>LEO 134310: Selective, non-steroidal GR agonist with 14 nM EC50, for topical skin disease treatment.</p>
    Formula:C34H40N2O8
    Color and Shape:Solid
    Molecular weight:604.69

    Ref: TM-T69930

  • 6:2 Cl-PFAES
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    6:2 Cl-PFAES

    CAS:
    <p>6:2 Cl-PFAES exhibits reproductive toxicity by elevating the levels of serum estradiol and vitellogenin in adult males, which can harm the embryonic development of offspring.</p>
    Formula:C8ClF16KO4S
    Color and Shape:Solid
    Molecular weight:570.67

    Ref: TM-T201602

  • Urotensin-II receptor antagonist-1
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    Urotensin-II receptor antagonist-1

    CAS:
    <p>Urotensin-II receptor antagonist-1 (compound 1) is a human Urotensin II receptor antagonist with low oral bioavailability (F=0-3% in rats) and a Ki of 16 nM in HEK293 cells expressing human recombinant UT receptors. It inhibits cytochrome P450 enzymes (IC50=0.75 μM for CYP2D6; 1.4 μM for CYP3A4), suppresses κ opioid receptors (EC50=3.2 μM), and targets cardiac sodium channels (Ki=2.5 μM).</p>
    Formula:C25H31Cl2N3O
    Color and Shape:Solid
    Molecular weight:460.439

    Ref: TM-T205347