Endocrinology/Hormones

Ota-vasotocin is a ligand utilized in quantitative receptor autoradiography for oxytocin receptors.

Naldemedine (S 297995), developed by Shionogi, is a drug for opioid side effects like constipation. It's well tolerated with minor GI issues.

Potent GPR171 agonist (EC50 = 1.6 nM). ProSAAS-derived peptide. Regulates body weight in mice and promotes the outgrowth of neurites in Neuro2A cells.

TRV055: Gq-biased AT1R ligand, stimulates Gq signaling, aids Gq-biased agonist development.

ER degrader 5: potent ER degrader, anti-cancer, for breast cancer research.

Premarin (Estrone 3-sulfate) is an an estrogen sulfate with neuroprotective actions during traumatic brain injury.

[Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity.

Morphiceptin is a synthetic tetrapeptide with morphinelike activities, highly specific for morphine receptors, but not for enkephalin receptors.

CNP, from natriuretic family, first in pigs, now in other species, processes into CNP-22/CNP-53, similar to ANP/BNP, with varying potencies.

<p>AT-121 hydrochloride: dual nociception/mu-opioid agonist, Ki 3.67/16.49 nM, safe, non-addictive pain reliever with analgesic effects.</p>

Detrothyronine is a biochemical.

RLA-5331: iron activator with anti-androgen properties; inhibits mCRPC cell proliferation.

PD 123177 is an inhibitor of Nonpeptide angiotensin AII-2.

AKR1Cs-IN-1 (Compound 29) is an effective and broad-spectrum inhibitor of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). It achieves subtype inhibition by simultaneously binding to the SP2 and SP3 pockets, thereby blocking metabolic pathways related to drug resistance. In enzyme assays, AKR1Cs-IN-1 exhibits significant inhibitory activity with IC50 values of 0.09, 0.28, 0.05, and 0.51 µM for AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. The compound shows excellent resensitizing effects in doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, effectively enhancing the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on breast cancer resistance.

<p>Dermorphin is agonist of μ-opioid receptor (MOR) agonist.</p>

Benazeprilat(CGS 14831) is an orally active active metabolite of Benazepril.Benazeprilat has potent antihypertensive activity and can be used in combination

Ripafollitropin alfa (bovine) is a fusion protein that combines recombinant follicle-stimulating hormone with chorionic gonadotropin [1].

Biotin-Oxytocin (Biotin-α-Hypophamine; Biotin-Oxytocic hormone) is a biologically active peptide. It is oxytocin labeled with biotin at the N-terminus.

<p>[Orn8]-Urotensin II acetate is a Urotensin receptor ligand and a partial agonist at Urotensin receptors.</p>

[Asp5]-Oxytocin acetate: a biologically active neurohypophyseal hormone analogue, inducing uterine contractions, effects magnified by Mg2+.