Androgen Receptor
The androgen receptor (AR) is a nuclear hormone receptor that is activated by binding to androgens, such as testosterone and dihydrotestosterone. This receptor plays a crucial role in the development and maintenance of male characteristics, as well as in the regulation of several physiological processes, including muscle growth, libido, and bone density. Androgen receptor inhibitors are widely studied in the context of prostate cancer, where AR signaling is often upregulated. At CymitQuimica, we offer a range of high-quality androgen receptor modulators to support your research in endocrinology, cancer biology, and hormone regulation.
Found 229 products of "Androgen Receptor"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
BWA-6047
BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM; AR-V7: DC50= 3.0 nM; GSPT1: DC50= 1.2 nM). It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.Formula:C42H46ClN5O7Color and Shape:SolidMolecular weight:767.308582-sec-Butylphenol
CAS:2-sec-Butylphenol is an inhibitor of the androgen receptor and P450 aromatase, and can be used in research and experiments in the field of life sciences.Formula:C10H14OColor and Shape:SolidMolecular weight:150.22ARD-266
CAS:ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase that induces the degradation of AR proteins and is useful in prostate cancer research.Formula:C52H59ClN6O7Purity:99.89%Color and Shape:SolidMolecular weight:915.513-Cl-Pyridine-amide-acrylaldehyde-piperazine
3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.Color and Shape:Odour SolidARD-69
ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ cell lines, and suppresses AR gene expression.Formula:C62H74ClFN8O7SColor and Shape:SolidMolecular weight:1129.83TD-802
CAS:TD-802, an AR-targeting PROTAC with microsomal stability, shows promise for castration-resistant prostate cancer.Formula:C52H61ClN10O6Color and Shape:SolidMolecular weight:957.56ARD-2051
CAS:ARD-2051 is a potent, orally active proteolysis-targeting chimera degrader of the androgen receptor (AR), exhibiting DC50 values of 0.6 nM in degrading ARFormula:C43H45ClN8O5Purity:98%Color and Shape:SolidMolecular weight:789.32Galloylalbiflorin
CAS:Galloylalbiflorin, an AR antagonist with IC50 53.3μM, is sourced from Paeonia lactiflora roots, exhibiting anti-androgenic properties.Formula:C30H32O15Color and Shape:SolidMolecular weight:632.57RLA-5331
RLA-5331: iron activator with anti-androgen properties; inhibits mCRPC cell proliferation.Formula:C40H43F3N6O7SColor and Shape:SolidMolecular weight:808.87PROTAC AR-V7 degrader-1
CAS:Potent, oral AR-V7 degrader (Compound 6); DC50: 0.32µM; targets AR-DBD via VHL E3; EC50: 0.88µM in 22Rv1 cells.Formula:C41H52N6O6S2Color and Shape:SolidMolecular weight:789.02Ludaterone
CAS:Ludaterone is an antiandrogen agent, with potent antiandrogenic activity.Formula:C20H25ClO5Color and Shape:SolidMolecular weight:380.86Tibolone
CAS:Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for theFormula:C21H28O2Purity:99.70% - 99.71%Color and Shape:White To Off-White Crystalline PowderMolecular weight:312.45ARCC-4
CAS:ARCC-4: A VHL-recruiting, low-nanomolar (DC50=5nM) AR degrader; outshines enzalutamide; degrades AR mutants resistant to therapy.Formula:C53H56F3N7O7S2Purity:98%Color and Shape:SolidMolecular weight:1024.18Adrenocorticotropic hormone
CAS:ACTH, a polypeptide, is secreted by the pituitary gland and regulates cortisol and androgen.Color and Shape:SolidARD-61
CAS:ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.Formula:C61H71ClN8O7SColor and Shape:SolidMolecular weight:1095.82-Ethylhexyl trans-4-methoxycinnamate
CAS:2-Ethylhexyl trans-4-methoxycinnamate is a sunscreen agent.Formula:C18H26O3Purity:98.92%Color and Shape:Pale Yellow LiquidMolecular weight:290.4PROTAC AR Degrader-9
PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]Formula:C43H49ClN6O5Color and Shape:SolidMolecular weight:765.339Cl-4AS-1
CAS:steroidal androgen receptor agonistFormula:C26H33ClN2O2Purity:98%Color and Shape:SolidMolecular weight:441.01VAL-201
CAS:VAL-201, an androgen receptor antagonist, is used potentially for the treatment of prostate cancer.Formula:C55H87N19O11Color and Shape:SolidMolecular weight:1190.4TLB 150 Benzoate
CAS:TLB 150 Benzoate (RAD150) is a modulator of the androgen receptor with an IC50 value of 0.13 μM.Formula:C27H20ClN5O3Color and Shape:SolidMolecular weight:497.93
