NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Found 398 products of "NF-κB"
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1,3-Dibenzyl-5-fluorouracil
CAS:1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor that suppresses the formation of osteoclasts, functioning by downregulating the signaling pathways of nuclear factor κB ligand receptor activator (Receptor activator of NF-κB ligand, RANKL) and macrophage colony-stimulating factor (M-CSF). This compound is used in the research of metabolic bone diseases.Formula:C18H15FN2O2Color and Shape:SolidMolecular weight:310.32Tamtuvetmab
CAS:Tamtuvetmab (AT-005), a caninised version of blontuvetmab targeting CD52, enhances progression-free survival (PFS) and demonstrates in vivo efficacy forColor and Shape:LiquidKamebakaurin
CAS:Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.Formula:C20H30O5Purity:98.05%Color and Shape:SolidMolecular weight:350.45E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formula:C21H30O6Purity:99.52%Color and Shape:SolidMolecular weight:378.46HE 3286
CAS:Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.Formula:C21H30O3Color and Shape:SolidMolecular weight:330.46NF-κB-IN-3
CAS:NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.Formula:C24H18ClF3N2O2Color and Shape:SolidMolecular weight:458.86BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Formula:C10H7NO3Purity:96.48% - 97%Color and Shape:Yellow Crystalline PowderMolecular weight:189.17APC-0576
CAS:APC-0576, an (S,S)-isomer, blocks NF-kappaB gene activation and may reduce inflammation in human cells.Formula:C23H27N3O3Color and Shape:SolidMolecular weight:393.48IMD-biphenylB
CAS:IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.Formula:C35H33N5O3Purity:98%Color and Shape:SolidMolecular weight:571.67PHA-408
CAS:PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.Formula:C29H27ClFN7O2Purity:98%Color and Shape:SolidMolecular weight:560.02TRAF-STOP inhibitor 6877002
CAS:TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.Formula:C17H17NOPurity:99.76%Color and Shape:SolidMolecular weight:251.32Bay 65-1942 free base
CAS:Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H25N3O4Purity:98%Color and Shape:SolidMolecular weight:395.45Xanthine oxidase-IN-6
Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.Formula:C29H34N2O15Color and Shape:SolidMolecular weight:650.58Sul-121 HCl
CAS:Sul-121 HCl combats COPD by reducing inflammation and AHR via oxidative stress inhibition.Formula:C18H27ClN2O3Purity:98%Color and Shape:SolidMolecular weight:354.87Edasalonexent
CAS:Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.Formula:C31H42N2O3Purity:99.13% - >99.99%Color and Shape:SolidMolecular weight:490.68Ref: TM-T15198
1mg94.00€2mg137.00€5mg222.00€10mg356.00€25mg640.00€50mg1,009.00€1mL*10mM (DMSO)240.00€HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Formula:C19H16ClN3O3SPurity:98.07% - 98.17%Color and Shape:SolidMolecular weight:401.87Ref: TM-T11573
2mg137.00€5mg222.00€10mg356.00€25mg708.00€50mg1,063.00€100mg1,603.00€200mg2,187.00€1mL*10mM (DMSO)245.00€NF-κB-IN-11
CAS:NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.Formula:C19H18O5Purity:98%Color and Shape:SolidMolecular weight:326.34ABD-350
CAS:ABD-350 is ligand-induced inhibitor of nuclear factor kappaB phosphorylation.Formula:C19H22F2O2Color and Shape:SolidMolecular weight:320.37CID-2858522
CAS:CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).Formula:C28H39N3O3Purity:96.12%Color and Shape:SolidMolecular weight:465.63IT-901
CAS:IT-901: Oral NF-κB c-Rel inhibitor, IC50 0.1 µM. Blocks c-Rel/DNA binding, IC50 3 µM. Antitumor naphthalene derivative for lymphoma/myeloma therapy.Formula:C17H14N2O4SPurity:98.06%Color and Shape:SolidMolecular weight:342.37MHY884
CAS:MHY884 inhibits tyrosinase and UVB-triggered NF-κB activation by reducing oxidative stress.Formula:C15H14ClNO3SPurity:98%Color and Shape:SolidMolecular weight:323.79NF-κB-IN-2
CAS:NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.Formula:C15H18O3Color and Shape:SolidMolecular weight:246.3IMD-catechol
CAS:IMD-catechol: an imidazoquinolinone-based dimer with NF-κB activity; improves CT26 cancer treatment, low toxicity.Formula:C31H34N6O3Purity:98%Color and Shape:SolidMolecular weight:538.64DMX-129
CAS:DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].Formula:C19H17FN8Color and Shape:SolidMolecular weight:376.39Asperbisabolane L
Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.Formula:C12H14O3Color and Shape:SolidMolecular weight:206.24TNF-α-IN-18
CAS:TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.Formula:C16H7ClF2O4Purity:99.77%Color and Shape:SolidMolecular weight:336.67Gue1654
CAS:Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Formula:C23H17N3OS3Purity:98.02% - 98.04%Color and Shape:SolidMolecular weight:447.6Anti-inflammatory agent 21
CAS:Compound 9o: orally active, low-toxicity anti-inflammatory; inhibits NO (IC50: 0.76 μM), blocks NF-κB/MAPK, reduces arthritis symptoms.Formula:C24H21FO6Color and Shape:SolidMolecular weight:424.42Bay 65-1942 hydrochloride
CAS:Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H26ClN3O4Color and Shape:SolidMolecular weight:431.91HSR1304
CAS:HSR1304 (5d) inhibits NFκB, key in diseases like cancer, offering research potential.Formula:C24H21ClN2O3Color and Shape:SolidMolecular weight:420.89Avenanthramide-C methyl ester
CAS:Avenanthramide-C methyl ester blocks IKK/IκB phosphorylation, inhibits NF-κB, and reduces IL-6, IL-8, MCP-1 in endothelial cells (IC50 ~40 μM).Formula:C17H15NO6Color and Shape:SolidMolecular weight:329.31-Dehydro-[10]-gingerdione
CAS:1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.Formula:C21H30O4Color and Shape:SolidMolecular weight:346.46IMD-ferulic
IMD-ferulic, a compound that forms covalent bonds, acts as an NF-κB modulator, enhancing the adjuvanticity of small molecule immune potentiators.Formula:C36H41N7O4Color and Shape:SolidMolecular weight:635.76Ro 106-9920
CAS:Inhibitor of NF-κB activationFormula:C10H7N5OSPurity:98%Color and Shape:SolidMolecular weight:245.26GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formula:C22H19N3O5S2Purity:98.42%Color and Shape:SolidMolecular weight:469.53NF-κB/PON1-IN-1
CAS:NF-κB/PON1-IN-1 (Compound 16) is an NF-κB/PON1 pathway inhibitor with antioxidant activity (IC50: 45.76 μM) and hepatoprotective activity.Formula:C20H16N6O4S2Color and Shape:SolidMolecular weight:468.51TBK1/IKKε-IN-4
CAS:TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nMFormula:C28H35N7O4Color and Shape:SolidMolecular weight:533.62DHMEQ racemate
CAS:DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Formula:C13H11NO5Purity:98%Color and Shape:SolidMolecular weight:261.23NF-κB-IN-8
CAS:NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.Formula:C24H21N3O3Purity:98%Color and Shape:SolidMolecular weight:399.44CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Formula:C22H21N3O6S2Color and Shape:SolidMolecular weight:487.55IKKβ-IN-1
CAS:IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).Formula:C31H30N4O4SColor and Shape:SolidMolecular weight:554.66XT2
CAS:XT2 is a potent, oral NF-κB-inducing kinase (NIK) inhibitor with an IC50 of 9.1 nM, reduces ALT levels, and curbs immune cell liver infiltration.Formula:C19H14FN5OSColor and Shape:SolidMolecular weight:379.41IMD-biphenylA
CAS:IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immuneFormula:C35H33N5O2Purity:98%Color and Shape:SolidMolecular weight:555.67IRAK4-IN-20
CAS:IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Formula:C22H25F3N4O3Purity:98.09%Color and Shape:SolidMolecular weight:450.45HS271
CAS:HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).Formula:C21H24F3N5O2Purity:98.79%Color and Shape:SolidMolecular weight:435.44Ref: TM-T37082
1mg62.00€2mg89.00€5mg135.00€10mg212.00€25mg368.00€50mg510.00€100mg695.00€200mg937.00€1mL*10mM (DMSO)149.00€NFATc1-IN-1
CAS:NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.Formula:C13H8F2INO2Purity:99.98%Color and Shape:SolidMolecular weight:375.11Zabedosertib
CAS:Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.
Formula:C20H21F3N4O4SPurity:98.54%Color and Shape:SolidMolecular weight:470.47Zharp2-1
CAS:Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).
Formula:C19H18N3O2PSPurity:99.41%Color and Shape:SolidMolecular weight:383.4B022
CAS:B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.Formula:C19H16ClN5OSPurity:99.74%Color and Shape:SolidMolecular weight:397.88SP-100030
CAS:SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.Formula:C14H5ClF9N3OPurity:99.79%Color and Shape:SolidMolecular weight:437.65Ref: TM-T24816
1mg34.00€5mg70.00€10mg99.00€25mg230.00€50mg358.00€100mg513.00€500mgTo inquire1mL*10mM (DMSO)78.00€RIPK1-IN-9
CAS:RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).Formula:C26H25FN6O2Purity:99.74%Color and Shape:SolidMolecular weight:472.51Ref: TM-T63055
1mg148.00€5mg344.00€10mg474.00€25mg705.00€50mg944.00€100mg1,283.00€200mg1,710.00€1mL*10mM (DMSO)399.00€PF-184
PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.Formula:C32H32ClFN6O4Color and Shape:SolidMolecular weight:619.09IMD-vanillin
CAS:IMD-vanillin is a novel compound characterized as an imidazoquinolinone-derived dimer with NF-κB immunomodulatory properties.Formula:C37H45N7O4Purity:98%Color and Shape:SolidMolecular weight:651.8ACHP Hydrochloride
CAS:ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Formula:C21H25ClN4O2Purity:99.83%Color and Shape:SolidMolecular weight:400.9Ref: TM-T10237
1mg66.00€5mg144.00€10mg227.00€25mg375.00€50mg540.00€100mg777.00€500mg1,549.00€1mL*10mM (DMSO)159.00€Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formula:C42H70O12Purity:98.46% - 99.13%Color and Shape:SolidMolecular weight:767.00IMD-biphenylC
CAS:IMD-biphenylC: New, dual-action imidazoquinolinone dimer; inhibits tumor growth, low inflammation/toxicity.Formula:C35H33N5O3Purity:98%Color and Shape:SolidMolecular weight:571.67Glabrescone C
CAS:Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.
Formula:C19H22O7Color and Shape:SolidMolecular weight:362.37GGTI 2147
CAS:GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.Formula:C28H30N4O3Purity:98.24%Color and Shape:SolidMolecular weight:470.56(Rac)-BAY-985
CAS:(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Formula:C27H30F3N9OPurity:98%Color and Shape:SolidMolecular weight:553.58GSK840
CAS:GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinaseFormula:C21H23N3O3Purity:99.7%Color and Shape:SolidMolecular weight:365.43Dimethoxycurcumin
CAS:Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.Formula:C23H24O6Purity:99.87%Color and Shape:SolidMolecular weight:396.43Ref: TM-T19853
5mg52.00€10mg77.00€25mg133.00€50mg225.00€100mg330.00€200mg470.00€1mL*10mM (DMSO)52.00€RIPK1-IN-16
CAS:RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.Formula:C20H19N5O2SPurity:98%Color and Shape:SolidMolecular weight:393.46PK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Formula:C22H24N4O3SPurity:98.09% - 99.64%Color and Shape:SolidMolecular weight:424.52Ref: TM-T12493
1mg81.00€5mg170.00€10mg274.00€25mg518.00€50mg747.00€100mg938.00€1mL*10mM (DMSO)188.00€NF-κB-IN-13
CAS:NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1Formula:C20H20O5Purity:98%Color and Shape:SolidMolecular weight:340.37CGA-JK3
CAS:CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.Formula:C15H19NO3Purity:98%Color and Shape:SolidMolecular weight:261.32IKK-IN-4
CAS:IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].Formula:C18H19N5SColor and Shape:SolidMolecular weight:337.44IRAK inhibitor 3
CAS:IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator.Formula:C21H21N5O4SPurity:98.86%Color and Shape:SolidMolecular weight:439.49Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurity:99.18%Color and Shape:SolidMolecular weight:512.46TBK1-IN-1
CAS:TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formula:C27H37N7O2Purity:99.81% - >99.99%Color and Shape:SolidMolecular weight:491.63IKK-IN-1
CAS:IKK-IN-1 is an inhibitor of IKK.Formula:C22H26ClN3O4Purity:98%Color and Shape:SolidMolecular weight:431.91IR-Crizotinib
CAS:IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranialFormula:C53H57Cl2FIN7OPurity:98%Color and Shape:SolidMolecular weight:1024.88Bay 65-1942 (R form)
CAS:Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.Formula:C22H25N3O4Purity:98%Color and Shape:SolidMolecular weight:395.45RIPK1-IN-4
CAS:RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s
Formula:C23H23N5O2Purity:99.94%Color and Shape:SolidMolecular weight:401.46oxLig-1
CAS:OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).Formula:C36H58O5Color and Shape:SolidMolecular weight:570.84Anti-osteoporosis agent-11
CAS:Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent effect by inhibiting osteoclast differentiation, with an IC50 value of 0.36 μM. Additionally, Anti-osteoporosis agent-11 suppresses osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking the RANKL-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.Formula:C23H17NO2Se2Color and Shape:SolidMolecular weight:497.31AS2690168 hydrochloride
CAS:AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Formula:C17H15Cl2F3N4OColor and Shape:SolidMolecular weight:419.228NF-κB-IN-6
NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent that works by reducing the protein expression of iNOS and COX-2 by suppressing the NF-κB signalingFormula:C14H20N2O3Color and Shape:SolidMolecular weight:264.32NIK-IN-2
CAS:NIK-IN-2 (compound 1) is an effective inhibitor of NF-κB inducing kinase (NIK), exhibiting a pIC50 of 7.4. It plays a crucial role in cancer research.Formula:C20H22N4O3Color and Shape:SolidMolecular weight:366.41TBK1/IKKε-IN-1
CAS:TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).Formula:C28H26N4O5Purity:98%Color and Shape:SolidMolecular weight:498.53Anti-inflammatory agent 6
Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.Formula:C22H20O12Color and Shape:SolidMolecular weight:476.39GTCpFE
CAS:GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formula:C22H20O8Color and Shape:SolidMolecular weight:412.39RIPK2-IN-6
CAS:RIPK2-IN-6 (Compound 15a) is an inhibitor of RIPK that specifically targets the phosphorylation of RIPK2, thereby suppressing the NF-κB and MAPK signaling pathways. It has demonstrated anti-inflammatory and anti-fibrotic activities in a mouse model of colitis induced by Dextran sodium sulfate.Formula:C26H21NO3Color and Shape:SolidMolecular weight:395.45TNFα activity modulator 3
CAS:TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.Formula:C27H24F2N6O2Color and Shape:SolidMolecular weight:502.52MAY0132
CAS:MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.Formula:C16H15ClF3NColor and Shape:SolidMolecular weight:313.745DBMB
CAS:DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.Formula:C24H22N4OColor and Shape:SolidMolecular weight:382.458TLR4/NF-κB/MAPK-IN-1
CAS:TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways.Formula:C19H25BrO6Color and Shape:SolidMolecular weight:429.3NLRP3-IN-78
CAS:NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.Formula:C12H5Cl2N3O4S2Color and Shape:SolidMolecular weight:390.222K-14585
CAS:K-14585 blocks PAR(2), reduces NFkappaB activity, and IL-8 response, but alone can boost IL-8.Formula:C51H56Cl2N8O4Color and Shape:SolidMolecular weight:915.95AS2690168 (free base)
CAS:AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.Formula:C17H13F3N4OColor and Shape:SolidMolecular weight:346.306UBS109
CAS:UBS109, a curcumin analog, is a DNA demethylating agent in pancreatic cancer that promotes osteoblast differentiation and mineralization.Formula:C18H17N3OPurity:99.48%Color and Shape:SolidMolecular weight:291.35Ref: TM-T88314
2mg37.00€5mg54.00€10mg87.00€25mg157.00€50mg241.00€100mg369.00€200mg536.00€1mL*10mM (DMSO)59.00€Antiproliferative agent-22
CAS:Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.Formula:C17H13N3O3Purity:99.20% - 99.27%Color and Shape:SolidMolecular weight:307.3HOIPIN-8 sodium
CAS:HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.Formula:C23H15F2N4NaO3Purity:97.34%Color and Shape:SolidMolecular weight:456.38Ref: TM-T62826
1mg66.00€5mg145.00€10mg224.00€25mg358.00€50mg512.00€100mg707.00€200mg973.00€1mL*10mM (DMSO)146.00€2,3-Bis(3-indolylmethyl)indole
CAS:2,3-Bis(3-indolylmethyl)indole exhibits a concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.Formula:C26H21N3Color and Shape:SolidMolecular weight:375.475Tripeptide-41
CAS:Tripeptide-41 (CG-Lipoxyn) is a bioactive peptide known for its ability to reduce fat accumulation.Formula:C29H30N4O5Purity:98%Color and Shape:SolidMolecular weight:514.57ALPK1-IN-1
CAS:ALPK1-IN-1 (A001) strongly inhibits ALPK1, key for innate immunity & NF-κB signaling via TIFA/TRAF.
Formula:C25H32N6O2SColor and Shape:SolidMolecular weight:480.63ALPK1-IN-2
CAS:ALPK1-IN-2 is a potent inhibitor of ALPK1 (α-kinase 1) (IC50: 95 nM). ALPK1-IN-2 inhibits NF-κB (IC50: 1.31 μM).
Formula:C20H18F2N4O2SColor and Shape:SolidMolecular weight:416.44ALPK1-IN-3
CAS:ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-induced
Formula:C20H16F2N4OSPurity:98%Color and Shape:SolidMolecular weight:398.43
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