NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.
Found 398 products of "NF-κB"
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1,3-Dibenzyl-5-fluorouracil
CAS:1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor that suppresses the formation of osteoclasts, functioning by downregulating the signaling pathways of nuclear factor κB ligand receptor activator (Receptor activator of NF-κB ligand, RANKL) and macrophage colony-stimulating factor (M-CSF). This compound is used in the research of metabolic bone diseases.Formula:C18H15FN2O2Color and Shape:SolidMolecular weight:310.32Tamtuvetmab
CAS:Tamtuvetmab (AT-005), a caninised version of blontuvetmab targeting CD52, enhances progression-free survival (PFS) and demonstrates in vivo efficacy forColor and Shape:LiquidKamebakaurin
CAS:Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.Formula:C20H30O5Purity:98.05%Color and Shape:SolidMolecular weight:350.45E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formula:C21H30O6Purity:99.52%Color and Shape:SolidMolecular weight:378.46HE 3286
CAS:Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.Formula:C21H30O3Color and Shape:SolidMolecular weight:330.46NF-κB-IN-3
CAS:NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.Formula:C24H18ClF3N2O2Color and Shape:SolidMolecular weight:458.86BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Formula:C10H7NO3Purity:96.48% - 97%Color and Shape:Yellow Crystalline PowderMolecular weight:189.17APC-0576
CAS:APC-0576, an (S,S)-isomer, blocks NF-kappaB gene activation and may reduce inflammation in human cells.Formula:C23H27N3O3Color and Shape:SolidMolecular weight:393.48IMD-biphenylB
CAS:IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.Formula:C35H33N5O3Purity:98%Color and Shape:SolidMolecular weight:571.67PHA-408
CAS:PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.Formula:C29H27ClFN7O2Purity:98%Color and Shape:SolidMolecular weight:560.02TRAF-STOP inhibitor 6877002
CAS:TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.Formula:C17H17NOPurity:99.76%Color and Shape:SolidMolecular weight:251.32Bay 65-1942 free base
CAS:Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H25N3O4Purity:98%Color and Shape:SolidMolecular weight:395.45Xanthine oxidase-IN-6
Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.Formula:C29H34N2O15Color and Shape:SolidMolecular weight:650.58Sul-121 HCl
CAS:Sul-121 HCl combats COPD by reducing inflammation and AHR via oxidative stress inhibition.Formula:C18H27ClN2O3Purity:98%Color and Shape:SolidMolecular weight:354.87Edasalonexent
CAS:Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.Formula:C31H42N2O3Purity:99.13% - >99.99%Color and Shape:SolidMolecular weight:490.68Ref: TM-T15198
1mg94.00€2mg137.00€5mg222.00€10mg356.00€25mg640.00€50mg1,009.00€1mL*10mM (DMSO)240.00€HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Formula:C19H16ClN3O3SPurity:98.07% - 98.17%Color and Shape:SolidMolecular weight:401.87Ref: TM-T11573
2mg137.00€5mg222.00€10mg356.00€25mg708.00€50mg1,063.00€100mg1,603.00€200mg2,187.00€1mL*10mM (DMSO)245.00€NF-κB-IN-11
CAS:NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.Formula:C19H18O5Purity:98%Color and Shape:SolidMolecular weight:326.34ABD-350
CAS:ABD-350 is ligand-induced inhibitor of nuclear factor kappaB phosphorylation.Formula:C19H22F2O2Color and Shape:SolidMolecular weight:320.37CID-2858522
CAS:CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).Formula:C28H39N3O3Purity:96.12%Color and Shape:SolidMolecular weight:465.63IT-901
CAS:IT-901: Oral NF-κB c-Rel inhibitor, IC50 0.1 µM. Blocks c-Rel/DNA binding, IC50 3 µM. Antitumor naphthalene derivative for lymphoma/myeloma therapy.Formula:C17H14N2O4SPurity:98.06%Color and Shape:SolidMolecular weight:342.37MHY884
CAS:MHY884 inhibits tyrosinase and UVB-triggered NF-κB activation by reducing oxidative stress.Formula:C15H14ClNO3SPurity:98%Color and Shape:SolidMolecular weight:323.79NF-κB-IN-2
CAS:NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.Formula:C15H18O3Color and Shape:SolidMolecular weight:246.3IMD-catechol
CAS:IMD-catechol: an imidazoquinolinone-based dimer with NF-κB activity; improves CT26 cancer treatment, low toxicity.Formula:C31H34N6O3Purity:98%Color and Shape:SolidMolecular weight:538.64DMX-129
CAS:DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].Formula:C19H17FN8Color and Shape:SolidMolecular weight:376.39Asperbisabolane L
Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.Formula:C12H14O3Color and Shape:SolidMolecular weight:206.24TNF-α-IN-18
CAS:TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.Formula:C16H7ClF2O4Purity:99.77%Color and Shape:SolidMolecular weight:336.67Gue1654
CAS:Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Formula:C23H17N3OS3Purity:98.02% - 98.04%Color and Shape:SolidMolecular weight:447.6Anti-inflammatory agent 21
CAS:Compound 9o: orally active, low-toxicity anti-inflammatory; inhibits NO (IC50: 0.76 μM), blocks NF-κB/MAPK, reduces arthritis symptoms.Formula:C24H21FO6Color and Shape:SolidMolecular weight:424.42Bay 65-1942 hydrochloride
CAS:Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H26ClN3O4Color and Shape:SolidMolecular weight:431.91HSR1304
CAS:HSR1304 (5d) inhibits NFκB, key in diseases like cancer, offering research potential.Formula:C24H21ClN2O3Color and Shape:SolidMolecular weight:420.89Avenanthramide-C methyl ester
CAS:Avenanthramide-C methyl ester blocks IKK/IκB phosphorylation, inhibits NF-κB, and reduces IL-6, IL-8, MCP-1 in endothelial cells (IC50 ~40 μM).Formula:C17H15NO6Color and Shape:SolidMolecular weight:329.31-Dehydro-[10]-gingerdione
CAS:1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.Formula:C21H30O4Color and Shape:SolidMolecular weight:346.46IMD-ferulic
IMD-ferulic, a compound that forms covalent bonds, acts as an NF-κB modulator, enhancing the adjuvanticity of small molecule immune potentiators.Formula:C36H41N7O4Color and Shape:SolidMolecular weight:635.76Ro 106-9920
CAS:Inhibitor of NF-κB activationFormula:C10H7N5OSPurity:98%Color and Shape:SolidMolecular weight:245.26GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formula:C22H19N3O5S2Purity:98.42%Color and Shape:SolidMolecular weight:469.53NF-κB/PON1-IN-1
CAS:NF-κB/PON1-IN-1 (Compound 16) is an NF-κB/PON1 pathway inhibitor with antioxidant activity (IC50: 45.76 μM) and hepatoprotective activity.Formula:C20H16N6O4S2Color and Shape:SolidMolecular weight:468.51TBK1/IKKε-IN-4
CAS:TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nMFormula:C28H35N7O4Color and Shape:SolidMolecular weight:533.62DHMEQ racemate
CAS:DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Formula:C13H11NO5Purity:98%Color and Shape:SolidMolecular weight:261.23NF-κB-IN-8
CAS:NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.Formula:C24H21N3O3Purity:98%Color and Shape:SolidMolecular weight:399.44CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Formula:C22H21N3O6S2Color and Shape:SolidMolecular weight:487.55IKKβ-IN-1
CAS:IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).Formula:C31H30N4O4SColor and Shape:SolidMolecular weight:554.66XT2
CAS:XT2 is a potent, oral NF-κB-inducing kinase (NIK) inhibitor with an IC50 of 9.1 nM, reduces ALT levels, and curbs immune cell liver infiltration.Formula:C19H14FN5OSColor and Shape:SolidMolecular weight:379.41IMD-biphenylA
CAS:IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immuneFormula:C35H33N5O2Purity:98%Color and Shape:SolidMolecular weight:555.67IRAK4-IN-20
CAS:IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Formula:C22H25F3N4O3Purity:98.09%Color and Shape:SolidMolecular weight:450.45HS271
CAS:HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).Formula:C21H24F3N5O2Purity:98.79%Color and Shape:SolidMolecular weight:435.44Ref: TM-T37082
1mg62.00€2mg89.00€5mg135.00€10mg212.00€25mg368.00€50mg510.00€100mg695.00€200mg937.00€1mL*10mM (DMSO)149.00€NFATc1-IN-1
CAS:NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.Formula:C13H8F2INO2Purity:99.98%Color and Shape:SolidMolecular weight:375.11Zabedosertib
CAS:Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.
Formula:C20H21F3N4O4SPurity:98.54%Color and Shape:SolidMolecular weight:470.47Zharp2-1
CAS:Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).
Formula:C19H18N3O2PSPurity:99.41%Color and Shape:SolidMolecular weight:383.4B022
CAS:B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.Formula:C19H16ClN5OSPurity:99.74%Color and Shape:SolidMolecular weight:397.88SP-100030
CAS:SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.Formula:C14H5ClF9N3OPurity:99.79%Color and Shape:SolidMolecular weight:437.65Ref: TM-T24816
1mg34.00€5mg70.00€10mg99.00€25mg230.00€50mg358.00€100mg513.00€500mgTo inquire1mL*10mM (DMSO)78.00€
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