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NF-κB

NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.

Found 444 products of "NF-κB"

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  • RIPK1-IN-9
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    RIPK1-IN-9

    CAS:
    <p>RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).</p>
    Formula:C26H25FN6O2
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:472.51

    Ref: TM-T63055

  • SP-100030
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    SP-100030

    CAS:
    SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.
    Formula:C14H5ClF9N3O
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:437.65

    Ref: TM-T24816

  • Zharp2-1
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    Zharp2-1

    CAS:
    <p>Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).</p>
    Formula:C19H18N3O2PS
    Purity:99.41%
    Color and Shape:Solid
    Molecular weight:383.4

    Ref: TM-T79600

  • IRAK4-IN-20
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    IRAK4-IN-20

    CAS:
    <p>IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).</p>
    Formula:C22H25F3N4O3
    Purity:98.09%
    Color and Shape:Solid
    Molecular weight:450.45

    Ref: TM-T62714

  • Zabedosertib
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    Zabedosertib

    CAS:
    <p>Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.</p>
    Formula:C20H21F3N4O4S
    Purity:98.54%
    Color and Shape:Solid
    Molecular weight:470.47

    Ref: TM-T37076

  • HS271
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    HS271

    CAS:
    <p>HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM).</p>
    Formula:C21H24F3N5O2
    Purity:98.79%
    Color and Shape:Solid
    Molecular weight:435.44

    Ref: TM-T37082

  • B022
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    B022

    CAS:
    <p>B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.</p>
    Formula:C19H16ClN5OS
    Purity:99.74%
    Color and Shape:Solid
    Molecular weight:397.88

    Ref: TM-T14491

  • IRAK inhibitor 3
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    IRAK inhibitor 3

    CAS:
    <p>IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator.</p>
    Formula:C21H21N5O4S
    Purity:98.86%
    Color and Shape:Solid
    Molecular weight:439.49

    Ref: TM-T11670

  • Trovafloxacin mesylate
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    Trovafloxacin mesylate

    CAS:
    <p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>
    Formula:C21H19F3N4O6S
    Purity:99.18%
    Color and Shape:Solid
    Molecular weight:512.46

    Ref: TM-T13231L

  • CGA-JK3
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    CGA-JK3

    CAS:
    <p>CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.</p>
    Formula:C15H19NO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:261.32

    Ref: TM-T26989

  • TBK1-IN-1
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    TBK1-IN-1

    CAS:
    <p>TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.</p>
    Formula:C27H37N7O2
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:491.63

    Ref: TM-T73322

  • GGTI 2147
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    GGTI 2147

    CAS:
    <p>GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.</p>
    Formula:C28H30N4O3
    Purity:98.69%
    Color and Shape:Solid
    Molecular weight:470.56

    Ref: TM-T25450

  • PF-184
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    PF-184

    <p>PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma &amp; COPD research. IC50: 37 nM.</p>
    Formula:C32H32ClFN6O4
    Color and Shape:Solid
    Molecular weight:619.09

    Ref: TM-T73470

  • WEHI-345
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    WEHI-345

    CAS:
    <p>WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.</p>
    Formula:C22H23N7O
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:401.46

    Ref: TM-T3997

  • (Rac)-BAY-985
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    (Rac)-BAY-985

    CAS:
    <p>(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.</p>
    Formula:C27H30F3N9O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:553.58

    Ref: TM-T12659

  • RIPK1-IN-16
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    RIPK1-IN-16

    CAS:
    <p>RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.</p>
    Formula:C20H19N5O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:393.46

    Ref: TM-T81269

  • GSK840
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    GSK840

    CAS:
    <p>GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase</p>
    Formula:C21H23N3O3
    Purity:99.7%
    Color and Shape:Solid
    Molecular weight:365.43

    Ref: TM-T11501

  • RIPK2-IN-3
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    RIPK2-IN-3

    CAS:
    <p>RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor with anti-inflammatory and anticancer activities, useful for research on immune diseases and cancer.</p>
    Formula:C25H22N4O2
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:410.47

    Ref: TM-T78597

  • NF-κB-IN-13
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    NF-κB-IN-13

    CAS:
    <p>NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1</p>
    Formula:C20H20O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:340.37

    Ref: TM-T79999

  • PF 184
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    PF 184

    CAS:
    <p>IKKβ inhibitor</p>
    Formula:C32H32ClFN6O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:619.09

    Ref: TM-T23137