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NF-κB

NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.

Found 444 products of "NF-κB"

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  • IMD-vanillin
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    IMD-vanillin

    CAS:
    <p>IMD-vanillin is a novel compound characterized as an imidazoquinolinone-derived dimer with NF-κB immunomodulatory properties.</p>
    Formula:C37H45N7O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:651.8

    Ref: TM-T72926

  • Bay 65-1942 (R form)
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    Bay 65-1942 (R form)

    CAS:
    <p>Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.</p>
    Formula:C22H25N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:395.45

    Ref: TM-T10472

  • IMD-biphenylC
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    IMD-biphenylC

    CAS:
    <p>IMD-biphenylC: New, dual-action imidazoquinolinone dimer; inhibits tumor growth, low inflammation/toxicity.</p>
    Formula:C35H33N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:571.67

    Ref: TM-T72871

  • IRAK4-IN-28
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    IRAK4-IN-28

    CAS:
    <p>IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme.</p>
    Formula:C27H31N9O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:529.59

    Ref: TM-T79337

  • ACHP Hydrochloride
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    ACHP Hydrochloride

    CAS:
    <p>ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.</p>
    Formula:C21H25ClN4O2
    Purity:99.83%
    Color and Shape:Solid
    Molecular weight:400.9

    Ref: TM-T10237

  • IR-Crizotinib
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    IR-Crizotinib

    CAS:
    <p>IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial</p>
    Formula:C53H57Cl2FIN7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1024.88

    Ref: TM-T82049

  • Ginsenoside Rk1
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    Ginsenoside Rk1

    CAS:
    <p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>
    Formula:C42H70O12
    Purity:98.46% - 99.13%
    Color and Shape:Solid
    Molecular weight:767

    Ref: TM-T4S1499

  • Glabrescone C
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    Glabrescone C

    CAS:
    <p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>
    Formula:C19H22O7
    Color and Shape:Solid
    Molecular weight:362.37

    Ref: TM-T72899

  • Dimethoxycurcumin
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    Dimethoxycurcumin

    CAS:
    Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.
    Formula:C23H24O6
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:396.43

    Ref: TM-T19853

  • RIP1 kinase inhibitor 4
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    RIP1 kinase inhibitor 4

    CAS:
    <p>RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].</p>
    Formula:C23H23N5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:369.46

    Ref: TM-T79041

  • IKK-IN-4
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    IKK-IN-4

    CAS:
    <p>IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].</p>
    Formula:C18H19N5S
    Color and Shape:Solid
    Molecular weight:337.44

    Ref: TM-T61059

  • IKK-IN-1
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    IKK-IN-1

    CAS:
    IKK-IN-1 is an inhibitor of IKK.
    Formula:C22H26ClN3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:431.91

    Ref: TM-T11633

  • PK68
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    PK68

    CAS:
    <p>PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.</p>
    Formula:C22H24N4O3S
    Purity:98.09% - 99.64%
    Color and Shape:Solid
    Molecular weight:424.52

    Ref: TM-T12493

  • LTβR-IN-1
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    LTβR-IN-1

    CAS:
    <p>LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor.</p>
    Formula:C18H16N4O2
    Purity:98.93%
    Color and Shape:Solid
    Molecular weight:320.35

    Ref: TM-T11886

  • RIPK1-IN-4
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    RIPK1-IN-4

    CAS:
    <p>RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s</p>
    Formula:C23H23N5O2
    Purity:99.94%
    Color and Shape:Solid
    Molecular weight:401.46

    Ref: TM-T12730

  • Oditrasertib
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    Oditrasertib

    CAS:
    <p>Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.</p>
    Formula:C14H15F2N3O2
    Purity:98.65% - 99.65%
    Color and Shape:Solid
    Molecular weight:295.28

    Ref: TM-T69726

  • Supercinnamaldehyde
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    Supercinnamaldehyde

    CAS:
    <p>Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ion</p>
    Formula:C12H11NO2
    Purity:98.89%
    Color and Shape:Solid
    Molecular weight:201.22

    Ref: TM-T78082

  • Ocadusertib
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    Ocadusertib

    CAS:
    <p>Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).</p>
    Formula:C25H25N5O4
    Color and Shape:Solid
    Molecular weight:459.50

    Ref: TM-T201183

  • DBMB
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    DBMB

    CAS:
    <p>DBMB is a spleen tyrosine kinase (Syk) inhibitor that significantly suppresses Syk enzyme activity. It possesses anti-inflammatory properties by inhibiting NF-κB signaling, thereby reducing the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). DBMB can be utilized in research on inflammatory diseases.</p>
    Formula:C24H22N4O
    Color and Shape:Solid
    Molecular weight:382.458

    Ref: TM-T204568

  • NLRP3-IN-78
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    NLRP3-IN-78

    CAS:
    <p>NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.</p>
    Formula:C12H5Cl2N3O4S2
    Color and Shape:Solid
    Molecular weight:390.222

    Ref: TM-T206735