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NF-κB

NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, cell survival, and proliferation. NF-κB is activated in response to various stimuli, including cytokines, pathogens, and stress signals. Dysregulation of NF-κB signaling is associated with chronic inflammatory diseases, cancer, and autoimmune disorders. At CymitQuimica, we offer a comprehensive selection of NF-κB pathway modulators to support your research in inflammation, oncology, and immune regulation.

Found 445 products of "NF-κB"

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  • IRAK4-IN-28
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    IRAK4-IN-28

    CAS:
    <p>IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme.</p>
    Formula:C27H31N9O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:529.59

    Ref: TM-T79337

  • NF-κB-IN-13
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    NF-κB-IN-13

    CAS:
    <p>NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1</p>
    Formula:C20H20O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:340.37

    Ref: TM-T79999

  • (Rac)-BAY-985
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    (Rac)-BAY-985

    CAS:
    <p>(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.</p>
    Formula:C27H30F3N9O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:553.58

    Ref: TM-T12659

  • ACHP Hydrochloride
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    ACHP Hydrochloride

    CAS:
    <p>ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.</p>
    Formula:C21H25ClN4O2
    Purity:99.83%
    Color and Shape:Solid
    Molecular weight:400.9

    Ref: TM-T10237

  • RIPK2-IN-3
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    RIPK2-IN-3

    CAS:
    <p>RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor with anti-inflammatory and anticancer activities, useful for research on immune diseases and cancer.</p>
    Formula:C25H22N4O2
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:410.47

    Ref: TM-T78597

  • IR-Crizotinib
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    IR-Crizotinib

    CAS:
    <p>IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial</p>
    Formula:C53H57Cl2FIN7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1024.88

    Ref: TM-T82049

  • Trovafloxacin mesylate
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    Trovafloxacin mesylate

    CAS:
    <p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>
    Formula:C21H19F3N4O6S
    Purity:99.18%
    Color and Shape:Solid
    Molecular weight:512.46

    Ref: TM-T13231L

  • IKK-IN-4
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    IKK-IN-4

    CAS:
    <p>IKK-IN-4 is a potent and selective inhibitor of IkappaB kinase 2 with IC 50 values of 45 and 650 nM against IKKβ and IKKα, respectively [1].</p>
    Formula:C18H19N5S
    Color and Shape:Solid
    Molecular weight:337.44

    Ref: TM-T61059

  • Bay 65-1942 (R form)
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    Bay 65-1942 (R form)

    CAS:
    <p>Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor.</p>
    Formula:C22H25N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:395.45

    Ref: TM-T10472

  • GGTI 2147
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    GGTI 2147

    CAS:
    <p>GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.</p>
    Formula:C28H30N4O3
    Purity:98.69%
    Color and Shape:Solid
    Molecular weight:470.56

    Ref: TM-T25450

  • IKK-IN-1
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    IKK-IN-1

    CAS:
    <p>IKK-IN-1 is an inhibitor of IKK.</p>
    Formula:C22H26ClN3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:431.91

    Ref: TM-T11633

  • Glabrescone C
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    Glabrescone C

    CAS:
    <p>Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.</p>
    Formula:C19H22O7
    Color and Shape:Solid
    Molecular weight:362.37

    Ref: TM-T72899

  • Dimethoxycurcumin
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    Dimethoxycurcumin

    CAS:
    <p>Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.</p>
    Formula:C23H24O6
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:396.43

    Ref: TM-T19853

  • Supercinnamaldehyde
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    Supercinnamaldehyde

    CAS:
    <p>Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ion</p>
    Formula:C12H11NO2
    Purity:98.89%
    Color and Shape:Solid
    Molecular weight:201.22

    Ref: TM-T78082

  • Oditrasertib
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    Oditrasertib

    CAS:
    <p>Oditrasertib, a RIPK1 inhibitor characterized by an IC50 value below 100 nM, is employed in inflammation research.</p>
    Formula:C14H15F2N3O2
    Purity:98.65% - 99.65%
    Color and Shape:Solid
    Molecular weight:295.28

    Ref: TM-T69726

  • LTβR-IN-1
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    LTβR-IN-1

    CAS:
    <p>LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor.</p>
    Formula:C18H16N4O2
    Purity:98.93%
    Color and Shape:Solid
    Molecular weight:320.35

    Ref: TM-T11886

  • RIPK1-IN-4
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    RIPK1-IN-4

    CAS:
    <p>RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s</p>
    Formula:C23H23N5O2
    Purity:99.94%
    Color and Shape:Solid
    Molecular weight:401.46

    Ref: TM-T12730

  • MAY0132
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    MAY0132

    CAS:
    <p>MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. It significantly inhibits the replication of HMPV, AdV, and RSV, reduces cytokine/chemokine production induced by viral infections, and suppresses NF-κB activation. MAY0132 exhibits antiviral activity and can be used in respiratory virus infection research.</p>
    Formula:C16H15ClF3N
    Color and Shape:Solid
    Molecular weight:313.745

    Ref: TM-T204630

  • AS2690168 (free base)
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    AS2690168 (free base)

    CAS:
    <p>AS2690168 freebase is an orally active inhibitor of RANKL signaling, capable of suppressing RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.</p>
    Formula:C17H13F3N4O
    Color and Shape:Solid
    Molecular weight:346.306

    Ref: TM-T204137

  • SBI-0640726
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    SBI-0640726

    CAS:
    <p>SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.</p>
    Formula:C23H15ClN2O2
    Color and Shape:Solid
    Molecular weight:386.83

    Ref: TM-T89836