IκB/IKK

BMS-066 is an IKK/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.

IMD-0560 is a novel inhibitor of IB kinase .

TBK1/IKK-IN-1 is a dual inhibitor of TBK1 and IKK (IC50s of <100 nM).

Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of …

Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum …

IKK-IN-1 is an inhibitor of IKK.

Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKK.

LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM); IC50 for IKK1 …

GSK319347A is a TBK1 and IKK dual inhibitor (IC50s: 93 nM and 469 nM, respectively). …

ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK- inhibitor (IC50: 8.5 …

BAY 11-7085 can irreversibly inhibit the IB phosphorylation induced by TNF (IC50: 10 μM).

(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.

BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's …

TBK1/IKK-IN-5 is a dual TBK1 and IKK inhibitor(IC50 of 1 nM and 5.6 nM, respectively).

BI605906 is an inhibitor of IKK. When assayed at 0.1 mM ATP, the IC50 value …

INH14 is a novel inhibitor of the IKK/-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for …

Dehydrocostus shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.

GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .

TBK1/IKK-IN-2 is a dual inhibitor of TBK1 and IKK.

Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKK.

MLN120B is a selective and ATP competitive IKK inhibitor (IC50: 60 nM).

BAY 11-7082, a NF-B inhibitor, inhibits TNF-induced IB phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 …

SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-B-dependent gene expression.

BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKK …

WS6, a cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IB kinase pathway.

Bardoxolone Methyl, an IKK inhibitor, exhibits effective proapoptotic and anti-inflammatory activities.

MRT67307 is a kinase inhibitor of TBK1, MARK1-4, IKK, and NUAK1 (IC50: 19, 27-52, 160, …

Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation.

PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.

TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), …

BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with …

IKK-16 (IKK Inhibitor VII) is a selective IB kinase (IKK) inhibitor for IKK-2, IKK complex …

TPCA-1 is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over …

IMD-0354 is an IKK inhibitor and inhibits IB phosphorylation in NF-B pathway.

AZD3264 is a new type IKK2 inhibitor.

WS3, a cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IB kinase pathway.

Olivetol (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is …

BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM …

Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant …

Physalin O possesses anti-inflammatory activity, it exhibited conjugating abilities with GSH and also showed significant …

JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of …

GS143 is a selective IB ubiquitination inhibitor with an IC50 of 5.2 μM for SCFTrCP1-mediated …