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CCR

CCR

C-C chemokine receptors (CCRs) are a group of GPCRs that respond to chemokines, which are signaling molecules that guide the migration of immune cells to sites of inflammation or infection. CCRs play crucial roles in immune responses, inflammation, and the development of various diseases, including autoimmune disorders and cancer. Modulation of CCR activity is being explored as a therapeutic strategy for conditions such as rheumatoid arthritis, multiple sclerosis, and HIV infection. At CymitQuimica, we provide a range of high-quality CCR modulators to support your research in immunology, inflammation, and therapeutic development.

Found 136 products of "CCR"

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  • J-113863
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    J-113863

    CAS:
    <p>J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM).</p>
    Formula:C30H37Cl2IN2O2
    Purity:95.11%
    Color and Shape:Solid
    Molecular weight:655.44

    Ref: TM-T11699

  • CCR2-RA-[R]
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    CCR2-RA-[R]

    CAS:
    <p>CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).</p>
    Formula:C18H19ClFNO3
    Purity:99.7%
    Color and Shape:Solid
    Molecular weight:351.8

    Ref: TM-T14900

  • RS102895 hydrochloride
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    RS102895 hydrochloride

    CAS:
    <p>RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).</p>
    Formula:C21H22ClF3N2O2
    Purity:98.95%
    Color and Shape:Solid
    Molecular weight:426.86

    Ref: TM-T12773

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    Leronlimab

    CAS:
    <p>Leronlimab (PRO 140), a humanized IgG4 monoclonal antibody, targets CCR5 to combat HIV and cancer.</p>
    Purity:SDS-PAGE:95.0%;SEC-HPLC:99.6%
    Color and Shape:Liquid
    Molecular weight:146.66 kDa

    Ref: TM-T77059

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    Mogamulizumab

    CAS:
    <p>Mogamulizumab is a monoclonal antibody targeting CC chemokine receptor 4 with anticancer effects, used in ATLL and CTCL studies.</p>
    Purity:SDS-PAGE:97.3%;SEC-HPLC:99.4%
    Color and Shape:Liquid
    Molecular weight:146.43 kDa

    Ref: TM-T76782

  • ML604086
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    ML604086

    CAS:
    <p>ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.</p>
    Formula:C27H32N4O4S
    Purity:99.91%
    Color and Shape:Solid
    Molecular weight:508.63

    Ref: TM-T16111

  • INCB-9471
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    INCB-9471

    CAS:
    <p>INCB-9471 is a CCR5 antagonist with anti-HIV activity and inhibits the interaction between HIV-1 gp120.</p>
    Formula:C30H40F3N5O2
    Purity:98.80%
    Color and Shape:Solid
    Molecular weight:559.666

    Ref: TM-T71665

  • MK-0812 Succinate
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    MK-0812 Succinate

    CAS:
    <p>MK-0812 Succinate is an effective and selective CCR2 antagonist.</p>
    Formula:C28H40F3N3O7
    Purity:98.62% - 99.93%
    Color and Shape:Solid
    Molecular weight:587.63

    Ref: TM-T16091

  • CCX140
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    CCX140

    CAS:
    <p>CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.</p>
    Formula:C20H13ClF3N5O3S
    Purity:99.66% - 99.95%
    Color and Shape:Solid
    Molecular weight:495.86

    Ref: TM-T14909

  • AZ084
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    AZ084

    CAS:
    <p>AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.</p>
    Formula:C26H34N4O2
    Purity:97.12%
    Color and Shape:Solid
    Molecular weight:434.57

    Ref: TM-T10425

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    CKLF1-C27 TFA

    <p>CKLF1-C27 peptide activates ERK1/2 via CCR4, competes with CKLF1, promotes HUVEC growth, and has psoriasis research potential.</p>
    Formula:C153H244F3N39O39
    Color and Shape:Solid
    Molecular weight:3310.8

    Ref: TM-T76245L

  • BMS-753426
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    BMS-753426

    CAS:
    <p>BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .</p>
    Formula:C25H33F3N6O2
    Color and Shape:Solid
    Molecular weight:506.574

    Ref: TM-T38397

  • SQA1
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    SQA1

    CAS:
    <p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>
    Formula:C22H26N4O5
    Color and Shape:Solid
    Molecular weight:426.47

    Ref: TM-T88146

  • PF-232798
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    PF-232798

    CAS:
    <p>PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.</p>
    Formula:C29H40FN5O2
    Color and Shape:Solid
    Molecular weight:509.66

    Ref: TM-T28381

  • INCB 3284 dimesylate
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    INCB 3284 dimesylate

    CAS:
    <p>INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.</p>
    Formula:C28H39F3N4O10S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:712.76

    Ref: TM-T11647

  • MLN-3897 TFA
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    MLN-3897 TFA

    <p>MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.</p>
    Formula:C32H32ClF3N2O6
    Purity:98.62%
    Color and Shape:Solid
    Molecular weight:633.05

    Ref: TM-T28072L

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    Zn-DPA-maytansinoid conjugate 1

    <p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>
    Formula:C115H145ClN18O31S2Zn2
    Color and Shape:Solid
    Molecular weight:2505.83

    Ref: TM-T74975

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    Bertilimumab

    CAS:
    <p>Bertilimumab (CAT 213; iCo-008), a human monoclonal antibody that targets eotaxin-1 (CCL11), shows promise in the research of allergic disorders [1].</p>
    Color and Shape:Liquid

    Ref: TM-T76928

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    Met-RANTES,human,acetate

    <p>Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200698

  • CCR4 antagonist 3
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    CCR4 antagonist 3

    CAS:
    <p>Orally active CCR4 antagonist with piperidinyl-azetidine; IC50: 22 nM (calcium flux), 50 nM (CTX); antitumor effects.</p>
    Formula:C24H27Cl2N7O
    Color and Shape:Solid
    Molecular weight:500.43

    Ref: TM-T39661