CCR
C-C chemokine receptors (CCRs) are a group of GPCRs that respond to chemokines, which are signaling molecules that guide the migration of immune cells to sites of inflammation or infection. CCRs play crucial roles in immune responses, inflammation, and the development of various diseases, including autoimmune disorders and cancer. Modulation of CCR activity is being explored as a therapeutic strategy for conditions such as rheumatoid arthritis, multiple sclerosis, and HIV infection. At CymitQuimica, we provide a range of high-quality CCR modulators to support your research in immunology, inflammation, and therapeutic development.
Found 154 products for "CCR".
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RP-23618
CAS:RP-23618 is a non-peptidic antagonist of RANTES.Formula:C30H35N5O3S2Purity:98%Color and Shape:SolidMolecular weight:577.76VCH-286
CAS:VCH-286 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist.Formula:C34H50F2N4O3Purity:98%Color and Shape:SolidMolecular weight:600.78K777
CAS:K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).Formula:C32H38N4O4SPurity:98.43% - 99.14%Color and Shape:SolidMolecular weight:574.73(1S)-CCR2 antagonist 1
CAS:(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].Formula:C28H32BrF3N2OColor and Shape:SolidMolecular weight:549.47(Rac)-PF-4136309(1341224-83-6 Free base)
CAS:PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for humanFormula:C29H31F3N6O3Color and Shape:SolidMolecular weight:568.59SB-649701
CAS:SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].Formula:C27H28N4O3Purity:98%Color and Shape:SolidMolecular weight:456.54PF-04634817 succinate
CAS:PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.Formula:C29H42F3N5O7Purity:98%Color and Shape:SolidMolecular weight:629.67CMPD167
CAS:CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].Formula:C35H47FN4O2Purity:98%Color and Shape:SolidMolecular weight:574.77cis-J-113863
CAS:Cis-J-113863 is a competitive antagonist for the chemokine receptor 1 (CCR1), demonstrating inhibitory concentration 50 (IC50) values of 0.9 nM for human CCR1 receptors and 5.8 nM for mouse CCR1 receptors, respectively [1].Formula:C30H37Cl2IN2O2Color and Shape:SolidMolecular weight:655.44CCR4 antagonist 4
CAS:CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].Formula:C24H27Cl2N7OColor and Shape:SolidMolecular weight:500.42CCR3 antagonist 1
CAS:CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.Formula:C19H21Cl2N3O4S2Purity:99.02%Color and Shape:SolidMolecular weight:490.42Ref: TM-T10156
1mg96.00€5mg178.00€1mL*10mM (DMSO)212.00€10mg289.00€25mg462.00€50mg622.00€100mg837.00€INCB3344
CAS:INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8Formula:C29H34F3N3O6Purity:98% - 98.19%Color and Shape:SolidMolecular weight:577.59Ref: TM-TQ0103
1mg66.00€5mg144.00€1mL*10mM (DMSO)178.00€10mg230.00€25mg358.00€50mg512.00€100mg707.00€200mg973.00€CP-481715
CAS:CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.Formula:C26H31FN4O4Color and Shape:SolidMolecular weight:482.55BI 639667
CAS:BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).Formula:C22H18FN5O3SPurity:99.86%Color and Shape:SolidMolecular weight:451.47Aplaviroc
CAS:Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.Formula:C33H43N3O6Purity:98.26% - 99.47%Color and Shape:SolidMolecular weight:577.71YM-344031
CAS:YM-344031 is an orally administered antagonist targeting CCR3. It effectively inhibits the binding of Eotaxin-1 and RANTES to CCR3, with IC50 values of 3.0 and 16.3 nM, respectively. YM-344031 also suppresses ligand-induced increases in intracellular Ca [2+] levels and chemotaxis, alters eosinophil morphology induced by eotaxin-1 in macaque blood, and prevents allergic skin reactions in a mouse allergy model.Formula:C29H31FN4O3Molecular weight:502.58CP-865569
CAS:CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.Formula:C22H26ClFN2O5SColor and Shape:SolidMolecular weight:484.969MK-0812
CAS:MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Formula:C24H34F3N3O3Purity:98%Color and Shape:SolidMolecular weight:469.54Nifeviroc
CAS:Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.Formula:C33H42N4O6Purity:98.14%Color and Shape:SolidMolecular weight:590.71CCR3 antagonist 2
CAS:CCR3 antagonist2 (example 66) is a CCR3 antagonist useful for researching inflammatory or allergic diseases, particularly those affecting the respiratory tract, such as inflammatory or obstructive airway conditions.Formula:C21H28ClN5O3Color and Shape:SolidMolecular weight:433.93
