CCR
C-C chemokine receptors (CCRs) are a group of GPCRs that respond to chemokines, which are signaling molecules that guide the migration of immune cells to sites of inflammation or infection. CCRs play crucial roles in immune responses, inflammation, and the development of various diseases, including autoimmune disorders and cancer. Modulation of CCR activity is being explored as a therapeutic strategy for conditions such as rheumatoid arthritis, multiple sclerosis, and HIV infection. At CymitQuimica, we provide a range of high-quality CCR modulators to support your research in immunology, inflammation, and therapeutic development.
Found 154 products for "CCR".
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AZD-1678
CAS:AZD-1678 is a potent CCR4 receptor antagonist.Formula:C11H8Cl2FN3O3SColor and Shape:SolidMolecular weight:352.17BI-6901
CAS:BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.Formula:C23H27N5O3SPurity:99.83% - 99.98%Color and Shape:White SolidMolecular weight:453.56Ref: TM-T36478
1mg117.00€5mg281.00€1mL*10mM (DMSO)310.00€10mg447.00€25mg827.00€50mg1,108.00€100mg1,494.00€ALK4290
CAS:ALK4290 (AKST4290), a potent oral CCR3 inhibitor with a Ki of 3.2 nM, may treat macular degeneration and Parkinsonism.Formula:C27H34ClN5O3Color and Shape:SolidMolecular weight:512.04AF-399/42018025
CAS:AF-399/42018025 is a small-molecule CCR4 antagonist applied to investigate chemokine-mediated immune cell trafficking and inflammatory disease mechanisms.Formula:C26H16ClN3O4S3Purity:99.96%Color and Shape:Yellow SolidMolecular weight:566.07CCR2 antagonist 5
CAS:JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.Formula:C22H25F3N4O3SPurity:99.98%Color and Shape:SolidMolecular weight:482.52BMS CCR2 22
CAS:BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.Formula:C28H34F3N5O4SPurity:99.65%Color and Shape:SolidMolecular weight:593.66Ref: TM-T14688
1mg55.00€5mg110.00€1mL*10mM (DMSO)141.00€10mg173.00€25mg349.00€50mg532.00€100mg718.00€200mg964.00€Ancriviroc
CAS:Ancriviroc (SCH-351125) is an orally bioavailable small molecule chemokine receptor CCR5 antagonist.Cost-effective and quality-assured.Formula:C28H37BrN4O3Purity:99.76% - 99.82%Color and Shape:SolidMolecular weight:557.533SB 328437
CAS:SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).Formula:C21H18N2O5Purity:99.54%Color and Shape:SolidMolecular weight:378.38Ref: TM-T23321
1mg39.00€1mL*10mM (DMSO)69.00€5mg82.00€10mg123.00€25mg250.00€50mg394.00€100mg618.00€200mg874.00€CCR1 antagonist 6
CAS:CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM).Formula:C21H23ClN4O3SPurity:99.15% - 99.92%Color and Shape:SolidMolecular weight:446.95Tanimilast
CAS:Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Formula:C30H30Cl2F2N2O8SPurity:99.18%Color and Shape:SolidMolecular weight:687.54Cosalane
CAS:Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.Formula:C45H60Cl2O6Purity:99.53% - 99.78%Color and Shape:White SolidMolecular weight:767.86GSK2239633A
CAS:GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.Formula:C24H25ClN4O5S2Purity:99.82%Color and Shape:White SolidMolecular weight:549.06Ref: TM-T11481
500mgTo inquire1mg35.00€5mg79.00€1mL*10mM (DMSO)87.00€10mg118.00€25mg245.00€50mg355.00€100mg515.00€BMS-817399
CAS:BMS-817399: oral CCR1 antagonist with binding and chemotaxis inhibition IC50s, potential for rheumatoid arthritis research.Formula:C23H36ClN3O4Purity:99.7%Color and Shape:SolidMolecular weight:454Ref: TM-T26861
1mg92.00€5mg192.00€1mL*10mM (DMSO)215.00€10mg290.00€25mg462.00€50mg622.00€100mg837.00€PF-04634817
CAS:PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.Formula:C25H36F3N5O3Purity:98%Color and Shape:SolidMolecular weight:511.58BMS-639623
CAS:BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.Formula:C25H32FN7O2Color and Shape:SolidMolecular weight:481.57MLN-3897
CAS:MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.Formula:C30H31ClN2O4Purity:98.62%Color and Shape:SolidMolecular weight:519.03AZD2423
CAS:AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM forFormula:C20H29ClFN5O2Purity:98%Color and Shape:SolidMolecular weight:425.93trans-J-113863
CAS:Trans-J-113863 serves as a potent antagonist of chemokine receptors CCR1 and CCR3, effectively inhibiting MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, with respective half-maximal inhibitory concentrations (IC50) of 9.57 nM and 93.8 nM [1] [2].Formula:C30H37Cl2IN2O2Color and Shape:SolidMolecular weight:655.44LMD-009
CAS:LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.Formula:C29H33N3O3Purity:98%Color and Shape:SolidMolecular weight:471.59CCR2 antagonist 4
CAS:CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nMFormula:C21H21ClF3N3O2Purity:99.86%Color and Shape:SolidMolecular weight:439.86
