CCR
C-C chemokine receptors (CCRs) are a group of GPCRs that respond to chemokines, which are signaling molecules that guide the migration of immune cells to sites of inflammation or infection. CCRs play crucial roles in immune responses, inflammation, and the development of various diseases, including autoimmune disorders and cancer. Modulation of CCR activity is being explored as a therapeutic strategy for conditions such as rheumatoid arthritis, multiple sclerosis, and HIV infection. At CymitQuimica, we provide a range of high-quality CCR modulators to support your research in immunology, inflammation, and therapeutic development.
Found 136 products of "CCR"
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IPG7236
CAS:<p>IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancer</p>Formula:C23H31N3O3SPurity:98%Color and Shape:SolidMolecular weight:429.58(1S)-CCR2 antagonist 1
CAS:<p>(1S)-CCR2 antagonist 1, a left-handed chiral form of CCR2 antagonist 1, exhibits high affinity and a long residence time as a CCR2 antagonist, with an inhibition constant (K i) of 2.4 nM [1].</p>Formula:C28H32BrF3N2OColor and Shape:SolidMolecular weight:549.47MLN-3897
CAS:<p>MLN-3897 is an oral CCR1 antagonist, Ki 2.3 nM, blocks 125I-MIP-1α binding, and inhibits Akt signaling in MM cells.</p>Formula:C30H31ClN2O4Purity:98.62%Color and Shape:SolidMolecular weight:519.03AZD2423
CAS:<p>AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for</p>Formula:C20H29ClFN5O2Purity:98%Color and Shape:SolidMolecular weight:425.93SB-649701
CAS:<p>SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].</p>Formula:C27H28N4O3Purity:98%Color and Shape:SolidMolecular weight:456.54cis-J-113863
CAS:<p>Cis-J-113863 is a competitive antagonist for the chemokine receptor 1 (CCR1), demonstrating inhibitory concentration 50 (IC50) values of 0.9 nM for human CCR1 receptors and 5.8 nM for mouse CCR1 receptors, respectively [1].</p>Formula:C30H37Cl2IN2O2Color and Shape:SolidMolecular weight:655.44PF-04634817
CAS:<p>PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.</p>Formula:C25H36F3N5O3Purity:98%Color and Shape:SolidMolecular weight:511.58(Rac)-PF-4136309(1341224-83-6 Free base)
CAS:<p>PF-4136309 (INCB8761, PF-04136309) is a highly effective and selective oral CCR2 antagonist with good bioavailability, with an IC50 value of 5.2 nM for human</p>Formula:C29H31F3N6O3Color and Shape:SolidMolecular weight:568.59CMPD167
CAS:<p>CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].</p>Formula:C35H47FN4O2Purity:98%Color and Shape:SolidMolecular weight:574.77RP-23618
CAS:<p>RP-23618 is a non-peptidic antagonist of RANTES.</p>Formula:C30H35N5O3S2Purity:98%Color and Shape:SolidMolecular weight:577.76trans-J-113863
CAS:<p>Trans-J-113863 serves as a potent antagonist of chemokine receptors CCR1 and CCR3, effectively inhibiting MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants, with respective half-maximal inhibitory concentrations (IC50) of 9.57 nM and 93.8 nM [1] [2].</p>Formula:C30H37Cl2IN2O2Color and Shape:SolidMolecular weight:655.44BMS-639623
CAS:<p>BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.</p>Formula:C25H32FN7O2Color and Shape:SolidMolecular weight:481.57LMD-009
CAS:<p>LMD-009 is a non-peptide, selective CCR8 agonist that mediates chemotaxis, inositol phosphate accumulation, and calcium release, with an EC50 of 11–87 nM.</p>Formula:C29H33N3O3Purity:98%Color and Shape:SolidMolecular weight:471.59K777
CAS:<p>K777: Oral cysteine protease inhibitor, CYP3A4 blocker (IC50=60 nM), CCR4 antagonist, anti-Trypanosoma cruzi, antiviral, halts EBOV/SARS-CoV entry (IC50<1 nM).</p>Formula:C32H38N4O4SPurity:98.43% - 99.14%Color and Shape:SolidMolecular weight:574.73CCR3 antagonist 1
CAS:<p>CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.</p>Formula:C19H21Cl2N3O4S2Purity:98.28%Color and Shape:SolidMolecular weight:490.42INCB3344
CAS:<p>INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8</p>Formula:C29H34F3N3O6Purity:98% - 98.2%Color and Shape:SolidMolecular weight:577.59CP-865569
CAS:<p>CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.</p>Formula:C22H26ClFN2O5SColor and Shape:SolidMolecular weight:484.969Aplaviroc
CAS:<p>Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.</p>Formula:C33H43N3O6Purity:97.98% - 98.26%Color and Shape:SolidMolecular weight:577.71CCR5 antagonist 1
CAS:<p>CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.</p>Formula:C39H46ClF2N5O3SPurity:98%Color and Shape:SolidMolecular weight:738.33CXCR2/CCR7 antagonist-1
CAS:<p>CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.</p>Formula:C23H27N3O5Color and Shape:SolidMolecular weight:425.48
