CCR
C-C chemokine receptors (CCRs) are a group of GPCRs that respond to chemokines, which are signaling molecules that guide the migration of immune cells to sites of inflammation or infection. CCRs play crucial roles in immune responses, inflammation, and the development of various diseases, including autoimmune disorders and cancer. Modulation of CCR activity is being explored as a therapeutic strategy for conditions such as rheumatoid arthritis, multiple sclerosis, and HIV infection. At CymitQuimica, we provide a range of high-quality CCR modulators to support your research in immunology, inflammation, and therapeutic development.
Found 165 products for "CCR".
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Denrakibart
Denrakibart is a humanized antibody targeting CCL17 for exploratory research on CCL17/CCR4 immune signaling.Purity:95%Color and Shape:Odour LiquidMolecular weight:~148 kDaDenikitug
Denikitug (GS-1811) is an Fc-optimized humanized anti-CCR8 antibody that can bind human CCR8 and antagonize CCL1 signaling, and induces NK-dependent ADCC against CCR8-high-expressing cells, facilitating tumor immunology research centered on Tregs.Purity:95%Color and Shape:Odour LiquidMolecular weight:~148 kDaLanerkitug
Lanerkitug (BAY3375968) is a fully humanized anti-CCR8 IgG1 mAb that depletes CCR8+ Tregs via ADCC and ADCP, with potential in solid tumor therapy.Purity:95%Color and Shape:Odour LiquidMolecular weight:~148 kDaNebokitug
Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Color and Shape:Odour LiquidCafelkibart
Cafelkibart is a chimeric IgG1κ monoclonal antibody targeting CCR8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Color and Shape:Odour LiquidMLN3126
CAS:MLN3126: Oral CCR9 blocker, hinders CCL25-triggered chemotaxis/thymocyte calcium influx, IC50 of 6.3 nM.Formula:C21H19ClN2O5SColor and Shape:SolidMolecular weight:446.904S-531011
S-531011 is a human IgG1 monoclonal antibody that targets CCR8. It reduces tumor-infiltrating CCR8+ Tregs and exhibits antitumor activity in CT26.WT and EMT6 tumor-bearing mouse models. S-531011 is useful for cancer immunotherapy research. The recommended isotype control is HumanIgG1kappa, Isotype Control.AT008
AT008 is a monoclonal antibody that targets GPCR and inhibits the binding of chemokine ligands to their cell surface receptor, CCR4. [AT008] is applicable in the study of certain hematological cancers and solid tumors.Anti-Human CCR8 Antibody (10A11)
Anti-CCR8 Antibody (10A11) is a humanized IgG1 monoclonal antibody targeting CCR8.HGS004
HGS004 is a humanized IgG4 monoclonal antibody inhibitor targeting CCR5. It exhibits potent antiviral activity against various CCR5-tropic HIV-1 strains, including those resistant to other treatments (such as Maraviroc-resistant strains). HGS004 is applicable for research in HIV-1 infection.Color and Shape:Odour LiquidCCR1 antagonist 7
CAS:CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1].Formula:C21H24ClN5O3SPurity:98%Color and Shape:SolidMolecular weight:461.96BMS-457
CAS:BMS-457 is a potent, CCR1-selective antagonist.Formula:C24H35ClN2O4Purity:98%Color and Shape:SolidMolecular weight:451JNJ-27141491
CAS:JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.Formula:C17H15F2N3O3SPurity:98%Color and Shape:SolidMolecular weight:379.38TAK-220
CAS:TAK-220: Oral CCR5 antagonist. IC50: 3.5 nM (RANTES), 1.4 nM (MIP-1α).Formula:C31H41ClN4O3Purity:98%Color and Shape:SolidMolecular weight:553.135AZD-1678
CAS:AZD-1678 is a potent CCR4 receptor antagonist.Formula:C11H8Cl2FN3O3SColor and Shape:SolidMolecular weight:352.17ALK4290
CAS:ALK4290 (AKST4290), a potent oral CCR3 inhibitor with a Ki of 3.2 nM, may treat macular degeneration and Parkinsonism.Formula:C27H34ClN5O3Color and Shape:SolidMolecular weight:512.044RPT193
CAS:RPT193 is an oral CCR4 inhibitor reducing Th2 cell migration in atopic dermatitis, asthma, and allergies.Formula:C27H34Cl3N5O2Color and Shape:SolidMolecular weight:566.95CCR2 antagonist 3
CAS:CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.Formula:C17H25FN2O2Purity:99.87%Color and Shape:SolidMolecular weight:308.391PNU-177864 hydrochloride
CAS:PNU-177864 hydrochloride is a potent, selective and orally active antagonist of dopamine D3 receptor.Formula:C18H22ClF3N2O3SPurity:99.95%Color and Shape:SolidMolecular weight:438.89PNU-177864
CAS:PNU-177864 is a selective dopamine D3 receptor antagonist.Formula:C18H21F3N2O3SPurity:99.92%Color and Shape:SolidMolecular weight:402.431
