CCR
C-C chemokine receptors (CCRs) are a group of GPCRs that respond to chemokines, which are signaling molecules that guide the migration of immune cells to sites of inflammation or infection. CCRs play crucial roles in immune responses, inflammation, and the development of various diseases, including autoimmune disorders and cancer. Modulation of CCR activity is being explored as a therapeutic strategy for conditions such as rheumatoid arthritis, multiple sclerosis, and HIV infection. At CymitQuimica, we provide a range of high-quality CCR modulators to support your research in immunology, inflammation, and therapeutic development.
Found 165 products for "CCR".
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CB-0821
CAS:CB-0821 is a high-affinity CCR5 inhibitor with a Ki of 0.04 nM. It effectively binds to the hydrophobic pocket of the CCR5 protein, hindering the interaction between viral proteins and CCR5, thereby blocking virus entry. CB-0821 holds potential for anti-HIV research.Formula:C35H24N8Color and Shape:SolidMolecular weight:556.62CCL17-IN-2
CAS:CCL17-IN-2 (Compound Ex.128) is a CCL17 secretion inhibitor with an EC50 of 0.3 nM. CCL17-IN-1 is applicable for research into autoimmune diseases, dermatological conditions, and respiratory disorders.Formula:C29H38N8O3Molecular weight:546.66CCR1 antagonist 11 hydrochloride
Oral CCR1 antagonist A1B1 targets h/m/rCCR1 (IC50: 0.03/0.58/0.32 μM), potential for treating inflammatory diseases.Color and Shape:SolidPF-07054894
CAS:PF-07054894: potent CCR6 antagonist, targets GPCR, for inflammatory bowel disease research.Formula:C24H30N6O4Color and Shape:SolidMolecular weight:466.53BMS-741672
CAS:BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain.Formula:C25H33F3N6O2Color and Shape:SolidMolecular weight:506.56Aplaviroc
CAS:Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist. With IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.Formula:C33H43N3O6Purity:98.26% - 99.47%Color and Shape:SolidMolecular weight:577.71CCR5 antagonist 1
CAS:CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication.Formula:C39H46ClF2N5O3SPurity:98%Color and Shape:SolidMolecular weight:738.33BAY-3153
CAS:BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) .Formula:C25H29Cl2N3O4Purity:98%Color and Shape:White SolidMolecular weight:506.42INCB-9471 dihydrochloride
CAS:INCB-9471 HCl: a potent CCR5 antagonist, blocks monocyte migration & HIV-1.Formula:C30H42Cl2F3N5O2Purity:98%Color and Shape:SolidMolecular weight:632.59CCR7 Ligand 1
CAS:CCR7-Cmp2105 is a thiadiazole-dioxide allosteric antagonist for CCR7 with a Kd of 3 nM and IC50 of 7.3 μM against arrestin binding.Formula:C22H29N5O5SColor and Shape:SolidMolecular weight:475.561MK-0812
CAS:MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Formula:C24H34F3N3O3Purity:98%Color and Shape:SolidMolecular weight:469.5403CP-865569
CAS:CP-865569 is a CCR1 antagonist useful in the research of inflammatory and autoimmune diseases, including conditions such as rheumatoid arthritis and multiple sclerosis.Formula:C22H26ClFN2O5SColor and Shape:SolidMolecular weight:484.969CXCR2/CCR7 antagonist-1
CAS:CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.Formula:C23H27N3O5Color and Shape:SolidMolecular weight:425.48BI 639667
CAS:BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).Formula:C22H18FN5O3SPurity:99.86%Color and Shape:SolidMolecular weight:451.473YM-344031
CAS:YM-344031 is an orally administered antagonist targeting CCR3. It effectively inhibits the binding of Eotaxin-1 and RANTES to CCR3, with IC50 values of 3.0 and 16.3 nM, respectively. YM-344031 also suppresses ligand-induced increases in intracellular Ca [2+] levels and chemotaxis, alters eosinophil morphology induced by eotaxin-1 in macaque blood, and prevents allergic skin reactions in a mouse allergy model.Formula:C29H31FN4O3Molecular weight:502.58Nifeviroc
CAS:Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.Formula:C33H42N4O6Purity:98.14%Color and Shape:SolidMolecular weight:590.7098CCR2 antagonist 6
CAS:CCR2 antagonist6 (Example 98) is a CCR2 antagonist with a Kb value of 0.215 μM for CCR2 and 0.174 μM for hCCR2B. It is utilized in research pertaining to inflammation and autoimmune diseases.Formula:C33H36F3N3OMolecular weight:547.65CP-481715
CAS:CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases.Formula:C26H31FN4O4Color and Shape:SolidMolecular weight:482.55CH-0076989
CAS:CH-0076989 is a chemokine receptor CCR3 agonist.Formula:C24H22Br2N2O2Color and Shape:SolidMolecular weight:530.25CCR3 antagonist 2
CAS:CCR3 antagonist2 (example 66) is a CCR3 antagonist useful for researching inflammatory or allergic diseases, particularly those affecting the respiratory tract, such as inflammatory or obstructive airway conditions.Formula:C21H28ClN5O3Color and Shape:SolidMolecular weight:433.93
