TLR

Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic …

Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.

SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.

CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It …

Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine …

PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to …

TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.

CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 …

Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like …

CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).

Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) …

IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 …

Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.

AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for …

3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is …

LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.

BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and it is a …

Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the …

TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).

CL264, a selective agonist of TLR7, can be used in studies about innate immune signals.

LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM).

TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits …

Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in …

CU-115 is a selective antagonist of TLR8 with IC50s of 1.04 µM and >50 µM …

Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammatory …

BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 …

SM360320 is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes …

TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in …

Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of …

CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages …

Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R …

Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to …

GS-9620 is an effective and specific orally active agonist of Toll-like receptor 7.

1V209 is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.

C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial …

Afimetoran is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory …

Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer …

Motolimod (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), …

Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory …

CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). …

Poly (I:C) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts …

TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).

SM 324405 is an agonist of TLR7.

Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates …

Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.

Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran …

Sophocarpine has anti-cancer, anti-inflammatory, anti-nociceptive, and antivirus activities, it can prevent implant loosening through inhibiting …

Schaftoside has antioxidant and anticancer activity.

TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 …

Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.

Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal …

Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin …

1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, …

TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 …

TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and …

RS09 2TFA is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion …

Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO …

Bropirimine (U-54461) is a biological response modifier that is thought to act through the induction …

MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM …

CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits …

TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.