TLR
Toll-like receptors (TLRs) are a class of proteins that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. TLRs are involved in detecting a wide range of pathogens, including bacteria, viruses, and fungi, and are essential for the activation of inflammatory signaling pathways. Dysregulation of TLR signaling is associated with chronic inflammatory diseases, autoimmune disorders, and cancer. At CymitQuimica, we offer a variety of high-quality TLR modulators to support your research in innate immunity, inflammation, and infectious disease.
Found 74 products of "TLR"
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BMS-905
CAS:BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.Formula:C23H29N3Purity:99.94%Color and Shape:SoildMolecular weight:347.5CU-T12-9
CAS:CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).Formula:C17H13F3N4O2Purity:99.84%Color and Shape:SolidMolecular weight:362.31Ref: TM-T15017
1mg50.00€5mg105.00€10mg160.00€25mg268.00€50mg409.00€100mg583.00€1mL*10mM (DMSO)117.00€CU-CPT17e
CAS:CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).Formula:C27H24N2O8Purity:98.49%Color and Shape:SolidMolecular weight:504.49CU-CPT22
CAS:CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).Formula:C19H22O7Purity:98.66% - 99.80%Color and Shape:SolidMolecular weight:362.37Ref: TM-T15020
1mg52.00€2mg70.00€5mg99.00€10mg168.00€25mg313.00€50mg469.00€100mg682.00€200mg938.00€1mL*10mM (DMSO)114.00€IAXO-102
CAS:IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.Formula:C35H71NO5Purity:98.17%Color and Shape:SolidMolecular weight:585.94TLR7/8 agonist 3
CAS:TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
Formula:C17H23N5OPurity:99.84%Color and Shape:SolidMolecular weight:313.4ODN 4084-F
CAS:ODN 4084-F, a class B ('broadly-active') inhibitory ODN, is a potent inhibitor of TLR9-induced B cells and macrophages.Color and Shape:SolidCU-115
CAS:CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively.
Formula:C21H11F7INO2Purity:99.96%Color and Shape:SolidMolecular weight:569.21Pam3CSK4-Biotin
CAS:Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.Formula:C103H192N14O17S2Purity:98%Color and Shape:SolidMolecular weight:1962.85Pam2CSK4
CAS:TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.Formula:C65H126N10O12SPurity:98%Color and Shape:SolidMolecular weight:1271.83Atibuclimab
CAS:Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region.Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:145.28 kDaCRX 527
CAS:CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.Formula:C81H151N2O19PColor and Shape:SolidMolecular weight:1488.04MTvkPABC-P5 TFA
MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).Color and Shape:Odour SolidRKH acetate
RKH acetate offers protective effects against mortality and organ damage caused by sepsis. It can directly bind to Toll-like receptor 4 (TLR4) and inhibit TLR4 signaling in immune cells.Formula:C18H33N9O4·xC2H4O2TLR7/8 agonist 12
TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.
Formula:C29H38N6O3Color and Shape:SolidMolecular weight:518.65MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA
MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA is the trifluoroacetate form of MC-Val-Cit-PAB-Amide-TLR7 agonist 4,a HER2-TLR7 and HER2- TLR8 immune agonist complexes.Formula:C54H73F3N12O13Purity:99.67%Color and Shape:SolidMolecular weight:1155.22Ref: TM-T74468L
1mg190.00€5mg471.00€10mg663.00€25mg1,036.00€50mg1,429.00€100mg1,830.00€200mg2,498.00€IPH33
IPH33 is a human monoclonal antibody (mAb) targeting TLR3/CD283. It is useful for research in cancer and inflammation.Color and Shape:Odour LiquidRKH
PKH is a TLR4 antagonist, and it is a new tripeptide derived from Akkermansia muciniphila. PKH reduces inflammation-related cell activation and the overproduction of pro-inflammatory factors induced by sepsis.Formula:C18H33N9O4Molecular weight:439.26555L07-2
CAS:L07-2 (Compound 6) is an active scaffold that includes a TLR7/8 agonist. It is suitable for the synthesis of immune-stimulating antibody conjugates (ISACs) used in cancer research.Formula:C56H83N15O14Color and Shape:SolidMolecular weight:1190.35Tilsotolimod sodium
CAS:Tilsotolimod sodium, a synthetic Toll-like receptor 9 (TLR9) agonist, has shown antitumor activity in preclinical models.Formula:C223H262N74Na22O115P22S22Color and Shape:SolidMolecular weight:7711.51PVP-037.2
CAS:PVP-037.2 is a TLR7/8 agonist that acts as an adjuvant to enhance vaccine-induced TH1 immune responses and boost the production of antigen-specific antibodies IgG1 and IgG2c.Formula:C23H20F3N5OColor and Shape:SoildMolecular weight:439.43(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 serves as the E3 ubiquitin ligase ligand and linker for PROTAC(R)-NX-2127, utilized in cancer research.Formula:C29H33N5O4Color and Shape:SolidMolecular weight:515.6Ezeprogind
CAS:Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can TrustFormula:C25H44N6Purity:99.28%Color and Shape:SolidMolecular weight:428.66TLR8 agonist 8
CAS:TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.Formula:C53H63N11O10Color and Shape:SolidMolecular weight:1014.14TLR8 agonist 7
CAS:TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.Formula:C54H63N9O16Color and Shape:SolidMolecular weight:1094.13TLR7 agonist 17
CAS:TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].Formula:C25H37N7O3Color and Shape:SolidMolecular weight:483.61TLR7 agonist 24
TLR7 agonist24 (Compound 21) is an agonist of TLR7 with an EC50 of 3.72 μM. When combined with Aluminum Hydroxide, it can be employed as a vaccine adjuvant to enhance the immune response to antigens from SARS-CoV-2 and hepatitis B.Color and Shape:Odour SolidPam3CSK4
CAS:Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.Formula:C81H156N10O13SPurity:98%Color and Shape:SolidMolecular weight:1510.23TLR7 agonist 3
CAS:TLR7 agonist 3 is a Toll-like receptor 7 (TLR7) agonist that has anticancer activity and is used in the study of diseases of the immune system.
Formula:C18H24N4OPurity:99.27%Color and Shape:SolidMolecular weight:312.41Toll-like receptor modulator
CAS:Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.Formula:C15H13F5N2O2Purity:98%Color and Shape:SolidMolecular weight:348.27Neoseptin-3
CAS:Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.Formula:C29H34N2O4Purity:98%Color and Shape:SolidMolecular weight:474.59Motolimod
CAS:Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.Formula:C28H34N4O2Purity:97.43% - 99.66%Color and Shape:SolidMolecular weight:458.6TLR7 agonist 2
CAS:TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
Formula:C17H16N6O2Purity:99.33%Color and Shape:SolidMolecular weight:336.35TLR7/8 agonist 1
CAS:TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.Formula:C22H25N5Purity:99.4%Color and Shape:SolidMolecular weight:359.47Telratolimod
CAS:Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.Formula:C36H59N5O2Purity:98.61%Color and Shape:SolidMolecular weight:593.89Enpatoran
CAS:Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM).Formula:C16H15F3N4Purity:97.08% - 99.38%Color and Shape:SolidMolecular weight:320.31Ref: TM-T9570
1mg113.00€5mg222.00€10mg334.00€25mg552.00€50mg782.00€100mg1,054.00€200mg1,414.00€1mL*10mM (DMSO)161.00€CU-CPT-8m
CAS:CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)Formula:C14H12N4OPurity:99.00%Color and Shape:SolidMolecular weight:252.27SM-324405
CAS:SM-324405 is an agonist of TLR7.Formula:C19H23N5O4Purity:97.83%Color and Shape:SolidMolecular weight:385.42Ref: TM-T7860
2mg34.00€5mg52.00€10mg84.00€25mg138.00€50mg215.00€100mg306.00€200mg427.00€1mL*10mM (DMSO)57.00€CU-CPT9b
CAS:CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).Formula:C16H13NO2Purity:98.1%Color and Shape:SolidMolecular weight:251.28Ref: TM-T7302
1mg49.00€5mg92.00€10mg152.00€25mg245.00€50mg340.00€100mg504.00€200mg717.00€1mL*10mM (DMSO)105.00€MD2-IN-1
CAS:MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM for the recombinant human MD2 (rhMD2).Formula:C20H22O6Purity:99.87%Color and Shape:SolidMolecular weight:358.39C29
CAS:C29 inhibits TLR2/1 and TLR2/6 in human cells, but only TLR2/1 in mouse macrophages.Formula:C16H15NO4Purity:96.34% - 97.37%Color and Shape:SolidMolecular weight:285.29TLR3-IN-1
CAS:TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the TNF-α and IL-1β.Formula:C18H13ClFNO3SPurity:98.56%Color and Shape:SolidMolecular weight:377.82Ref: TM-T22698
1mg52.00€5mg103.00€10mg168.00€25mg353.00€50mg504.00€100mg708.00€1mL*10mM (DMSO)113.00€RS09 2TFA (1449566-36-2 free base)
RS09 2TFA is a TLR4 agonist enhancing NF-κB and cytokines in macrophages; it's an adjuvant that boosts X-15 antibodies.Formula:C35H51F6N9O13Purity:>99.99%Color and Shape:SolidMolecular weight:919.82CU-CPT-9a
CAS:CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-Formula:C17H15NO2Purity:99.01%Color and Shape:SolidMolecular weight:265.31Ref: TM-T7317
1mg38.00€2mg50.00€5mg84.00€10mg119.00€25mg225.00€50mg409.00€100mg605.00€1mL*10mM (DMSO)93.00€TLR7/8/9-IN-1
CAS:TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.Formula:C27H37N3O2Purity:99.56%Color and Shape:SolidMolecular weight:435.6Ref: TM-T39669
1mg49.00€2mg70.00€5mg111.00€10mg178.00€25mg290.00€50mg424.00€100mg577.00€200mg825.00€1mL*10mM (DMSO)166.00€Pam3CSK4 TFA (112208-00-1 free base)
CAS:Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2.Cost-effective and quality-assured.
Formula:C87H159F9N10O19SPurity:96.4% - 99.01%Color and Shape:SolidMolecular weight:1852.33TLR4-IN-C34
CAS:TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitisFormula:C17H27NO9Purity:99.69%Color and Shape:SolidMolecular weight:389.4Bropirimine
CAS:Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.Formula:C10H8BrN3OPurity:99.01%Color and Shape:SolidMolecular weight:266.091V209
CAS:1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.Formula:C16H17N5O5Purity:99.61%Color and Shape:SolidMolecular weight:359.34TLR7/8 agonist 1 dihydrochloride
CAS:TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.Formula:C22H27Cl2N5Purity:98.33%Color and Shape:SolidMolecular weight:432.39Ref: TM-T5561
1mg57.00€5mg120.00€10mg187.00€25mg406.00€50mg630.00€100mg898.00€200mg1,216.00€1mL*10mM (DMSO)133.00€Robinin
CAS:Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.Formula:C33H40O19Purity:98.78% - 99.13%Color and Shape:SolidMolecular weight:740.66Paridiprubart
CAS:Paridiprubart (NI-0101) is a humanised monoclonal antibody targeting TLR4, ameliorative effects in COVID-19 patients with ARDS and rheumatoid arthritis.Purity:95% - 96.9% (SDS-PAGE); 98.5% (SEC-HPLC)Color and Shape:LiquidMolecular weight:145.16 kDaTLR7 agonist 1
CAS:TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).Formula:C21H25N5OPurity:98%Color and Shape:SolidMolecular weight:363.46AXC-715 trihydrochloride
CAS:AXC-715 trihydrochloride is a TLR7/8 agonist used to make PD-L1 adjuvanted antibody immunocouplings.Formula:C18H28Cl3N5Purity:99.87%Color and Shape:SolidMolecular weight:420.81CL264
CAS:CL264, a selective agonist of TLR7, can be used in studies about innate immune signals.Formula:C19H23N7O4Purity:98.01% - 99.87%Color and Shape:SolidMolecular weight:413.43Ref: TM-T10833
1mg49.00€5mg110.00€10mg182.00€25mg289.00€50mg399.00€100mg530.00€200mg715.00€1mL*10mM (DMSO)122.00€DSR-6434
CAS:DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.Formula:C19H28N8O2Purity:99.78%Color and Shape:SolidMolecular weight:400.48AZD8848
CAS:AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.Formula:C29H43N7O5Color and Shape:SolidMolecular weight:569.7TLR7/8-IN-1
CAS:TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research.Cost-effective and quality-assured.Formula:C29H40N8O2Purity:99.99%Color and Shape:SolidMolecular weight:532.68M62812
CAS:TLR4 inhibitor blocks LPS-induced NF-κB (IC50=2.4μg/mL), cytokines in PBMCs/HUVECs, and extends life in septic shock mice.Formula:C13H13Cl2N3OSPurity:99.07%Color and Shape:SolidMolecular weight:330.23AT791
CAS:AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.Formula:C23H31N3O3Purity:99.88%Color and Shape:SolidMolecular weight:397.51Ref: TM-T61882
1mg72.00€5mg156.00€10mg235.00€25mg378.00€50mg540.00€100mg747.00€200mg1,035.00€1mL*10mM (DMSO)167.00€BBIQ
CAS:BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1Formula:C21H22N4Purity:99.71%Color and Shape:SolidMolecular weight:330.43SM360320
CAS:SM360320 (CL-087) is a selective TLR7 agonist that blocks HCV replication in hepatocytes and aids immunology research.
Formula:C15H17N5O3Purity:99.13%Color and Shape:SolidMolecular weight:315.33Rabeximod
CAS:Rabeximod, an immunomodulator, eases autoimmune diseases, inhibits arthritis, and aids brain recovery post-injury by blocking inflammation.Formula:C22H24ClN5OPurity:99.99%Color and Shape:SolidMolecular weight:409.91TLR7 agonist 23
CAS:TLR7 agonist23 (compound 12b) is a potent agonist of Toll-like receptor-7 (TLR7), with an EC50 value of 0.15 uM. It is suitable for research in immune diseases.Formula:C21H22N4O2Color and Shape:SolidMolecular weight:362.42TLR9-IN-1
CAS:TLR9-IN-1: selective, potent human TLR9 inhibitor (IC50: 7 nM), useful for researching immune-related diseases.Formula:C23H31N7OColor and Shape:SolidMolecular weight:421.541Z105
CAS:1Z105, an orally active TLR4/MD2 ligand, facilitates dendritic cell maturation and antigen presentation, thereby preventing arthritis.Formula:C25H26N4O2SColor and Shape:SolidMolecular weight:446.57CU-CPD107
CAS:CU-CPD107 selectively activates TLR8 and ssRNA, inhibits TLR8 with R848 (IC50=13.7 μM), and coactivates with ssRNA.Formula:C16H21IN2O2Purity:98%Color and Shape:SolidMolecular weight:400.25ABR-238901
CAS:ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end productsFormula:C11H9BrClN3O4SPurity:98.71% - 99.04%Color and Shape:SolidMolecular weight:394.63Ref: TM-T39115
1mg116.00€5mg281.00€10mg447.00€25mg710.00€50mg973.00€100mg1,333.00€1mL*10mM (DMSO)310.00€Creatine ethyl ester
CAS:Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.Formula:C6H13N3O2Color and Shape:SolidMolecular weight:159.186SARM1-IN-5
CAS:SARM1-IN-5 (compound 1-23-a) is an inhibitor of SARM1, useful for researching diseases related to axonal degeneration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).Formula:C18H17FN6OColor and Shape:SolidMolecular weight:352.37LHC-165
CAS:LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.Formula:C29H32F2N3O7PPurity:98%Color and Shape:SolidMolecular weight:603.55SARM1-IN-4
CAS:SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.Formula:C13H17F2N3O2Color and Shape:SolidMolecular weight:285.29TLR7 agonist 28
CAS:TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.Formula:C26H25N9O7Color and Shape:SolidMolecular weight:575.533TLR7/8/9 antagonist 2
CAS:TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.Formula:C23H31N7Purity:98%Color and Shape:SoildMolecular weight:405.54
