TLR
Toll-like receptors (TLRs) are a class of proteins that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. TLRs are involved in detecting a wide range of pathogens, including bacteria, viruses, and fungi, and are essential for the activation of inflammatory signaling pathways. Dysregulation of TLR signaling is associated with chronic inflammatory diseases, autoimmune disorders, and cancer. At CymitQuimica, we offer a variety of high-quality TLR modulators to support your research in innate immunity, inflammation, and infectious disease.
Found 66 products of "TLR"
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TLR7/8 agonist 3
CAS:<p>TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.</p>Formula:C17H23N5OPurity:99.84%Color and Shape:SolidMolecular weight:313.4CU-T12-9
CAS:<p>CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).</p>Formula:C17H13F3N4O2Purity:99.84%Color and Shape:SolidMolecular weight:362.31CU-CPT17e
CAS:<p>CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).</p>Formula:C27H24N2O8Purity:98.49%Color and Shape:SolidMolecular weight:504.49IAXO-102
CAS:<p>IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.</p>Formula:C35H71NO5Purity:98.17%Color and Shape:SolidMolecular weight:585.94BMS-905
CAS:<p>BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.</p>Formula:C23H29N3Purity:99.94%Color and Shape:SoildMolecular weight:347.5CU-CPT22
CAS:<p>CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).</p>Formula:C19H22O7Purity:98.66% - 99.8%Color and Shape:SolidMolecular weight:362.37TLR7/8 agonist 12
<p>TLR7/8 agonist 12 (compound 9) is a human TLR7/8 agonist with EC50 values of 11 nM for hTLR7 and 150 nM for hTLR8, indicating its potential for immune modulation.</p>Formula:C29H38N6O3Color and Shape:SolidMolecular weight:518.65Ezeprogind
CAS:<p>Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can Trust</p>Formula:C25H44N6Purity:99.28%Color and Shape:SolidMolecular weight:428.66TLR7 agonist 17
CAS:<p>TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].</p>Formula:C25H37N7O3Color and Shape:SolidMolecular weight:483.61TLR8 agonist 7
CAS:<p>TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.</p>Formula:C54H63N9O16Color and Shape:SolidMolecular weight:1094.13TLR8 agonist 8
CAS:<p>TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.</p>Formula:C53H63N11O10Color and Shape:SolidMolecular weight:1014.14Tomaralimab
CAS:<p>Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS).</p>Purity:100% (SEC-HPLC) - > 95%Color and Shape:LiquidMolecular weight:145.32 kDaCU-115
CAS:<p>CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively.</p>Formula:C21H11F7INO2Purity:99.96%Color and Shape:SolidMolecular weight:569.21Pam3CSK4-Biotin
CAS:<p>Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.</p>Formula:C103H192N14O17S2Purity:98%Color and Shape:SolidMolecular weight:1962.85Pam2CSK4
CAS:<p>TLR2/6 agonist; boosts TNF-α in human cells & mouse B cell growth/activation.</p>Formula:C65H126N10O12SPurity:98%Color and Shape:SolidMolecular weight:1271.83MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA
<p>MC-Val-Cit-PAB-Amide-TLR7 agonist 4 TFA is the trifluoroacetate form of MC-Val-Cit-PAB-Amide-TLR7 agonist 4,a HER2-TLR7 and HER2- TLR8 immune agonist complexes.</p>Formula:C54H73F3N12O13Purity:99.67%Color and Shape:SolidMolecular weight:1155.22CRX 527
CAS:<p>CRX 527 is a TLR4 ligand and serves as an adjuvant for peptide cancer vaccines, enhancing anti-tumor immune responses. CRX 527 also induces hematopoietic stem cell (HSC) differentiation, increasing the proportion and number of LSK cells, and promotes their differentiation into macrophages. This activation bolsters immune defense and protects intestinal epithelium from radiation damage.</p>Formula:C81H151N2O19PColor and Shape:SolidMolecular weight:1488.04MTvkPABC-P5 TFA
<p>MTvkPABC-P5d TFA, a TLR7 agonist, functions as an immune stimulant. It is applicable in the synthesis of immune-stimulating antibody conjugates (ISAC).</p>Color and Shape:Odour SolidDesethyl chloroquine diphosphate
CAS:<p>Desethyl chloroquine diphosphate is the active metabolite of Desethylchloroquine, an inhibitor of TLRs with antiplasmodial activity and inhibition of autophagy.</p>Formula:C16H28ClN3O8P2Purity:99.72%Color and Shape:SolidMolecular weight:487.81TLR7 agonist 3
CAS:<p>TLR7 agonist 3 is a Toll-like receptor 7 (TLR7) agonist that has anticancer activity and is used in the study of diseases of the immune system.</p>Formula:C18H24N4OPurity:99.27%Color and Shape:SolidMolecular weight:312.41Neoseptin-3
CAS:<p>Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.</p>Formula:C29H34N2O4Purity:98%Color and Shape:SolidMolecular weight:474.59Toll-like receptor modulator
CAS:<p>Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.</p>Formula:C15H13F5N2O2Purity:98%Color and Shape:SolidMolecular weight:348.27Pam3CSK4
CAS:<p>Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.</p>Formula:C81H156N10O13SPurity:98%Color and Shape:SolidMolecular weight:1510.23Bropirimine
CAS:<p>Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.</p>Formula:C10H8BrN3OPurity:99.01%Color and Shape:SolidMolecular weight:266.09TLR7 agonist 2
CAS:<p>TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).</p>Formula:C17H16N6O2Purity:99.33%Color and Shape:SolidMolecular weight:336.35TLR7/8 agonist 1
CAS:<p>TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.</p>Formula:C22H25N5Purity:99.4%Color and Shape:SolidMolecular weight:359.47Telratolimod
CAS:<p>Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.</p>Formula:C36H59N5O2Purity:98.61%Color and Shape:SolidMolecular weight:593.89Enpatoran
CAS:<p>Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM).</p>Formula:C16H15F3N4Purity:97.08% - 99.38%Color and Shape:SolidMolecular weight:320.31Gardiquimod
CAS:<p>Gardiquimod, an imidazoquinoline TLR7 agonist, inhibits HIV-1 in macrophages and PBMCs under 10μM.</p>Formula:C17H23N5OPurity:98.02% - 99.68%Color and Shape:SolidMolecular weight:313.4CU-CPT-8m
CAS:<p>CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)</p>Formula:C14H12N4OPurity:99.00%Color and Shape:SolidMolecular weight:252.27SM-324405
CAS:<p>SM-324405 is an agonist of TLR7.</p>Formula:C19H23N5O4Purity:97.83%Color and Shape:SolidMolecular weight:385.42CU-CPT9b
CAS:<p>CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).</p>Formula:C16H13NO2Purity:98.1%Color and Shape:SolidMolecular weight:251.28MD2-IN-1
CAS:<p>MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM for the recombinant human MD2 (rhMD2).</p>Formula:C20H22O6Purity:99.87%Color and Shape:SolidMolecular weight:358.39C29
CAS:<p>C29 inhibits TLR2/1 and TLR2/6 in human cells, but only TLR2/1 in mouse macrophages.</p>Formula:C16H15NO4Purity:96.34% - 97.37%Color and Shape:SolidMolecular weight:285.29TLR3-IN-1
CAS:<p>TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor. It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the TNF-α and IL-1β.</p>Formula:C18H13ClFNO3SPurity:98.56%Color and Shape:SolidMolecular weight:377.82CU-CPT-9a
CAS:<p>CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-</p>Formula:C17H15NO2Purity:99.01%Color and Shape:SolidMolecular weight:265.31TLR7/8/9-IN-1
CAS:<p>TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.</p>Formula:C27H37N3O2Purity:99.56%Color and Shape:SolidMolecular weight:435.6Pam3CSK4 TFA (112208-00-1 free base)
CAS:<p>Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2.Cost-effective and quality-assured.</p>Formula:C87H159F9N10O19SPurity:96.4% - 99.01%Color and Shape:SolidMolecular weight:1852.33TLR4-IN-C34
CAS:<p>TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis</p>Formula:C17H27NO9Purity:99.69%Color and Shape:SolidMolecular weight:389.41V209
CAS:<p>1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.</p>Formula:C16H17N5O5Purity:99.61%Color and Shape:SolidMolecular weight:359.34TH1020
CAS:<p>TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.</p>Formula:C23H15N7S2Purity:99.23%Color and Shape:SolidMolecular weight:453.54Motolimod
CAS:<p>Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.</p>Formula:C28H34N4O2Purity:97.43% - 99.66%Color and Shape:SolidMolecular weight:458.6TLR7/8 agonist 1 dihydrochloride
CAS:<p>TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.</p>Formula:C22H27Cl2N5Purity:98.33%Color and Shape:SolidMolecular weight:432.39Robinin
CAS:<p>Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.</p>Formula:C33H40O19Purity:98.78% - 99.13%Color and Shape:SolidMolecular weight:740.66Paridiprubart
CAS:<p>Paridiprubart (NI-0101) is a humanised monoclonal antibody targeting TLR4, ameliorative effects in COVID-19 patients with ARDS and rheumatoid arthritis.</p>Purity:95% - 95%Color and Shape:LiquidCL264
CAS:<p>CL264, a selective agonist of TLR7, can be used in studies about innate immune signals.</p>Formula:C19H23N7O4Purity:98.01%Color and Shape:SolidMolecular weight:413.43AXC-715 trihydrochloride
CAS:<p>AXC-715 trihydrochloride is a TLR7/8 agonist used to make PD-L1 adjuvanted antibody immunocouplings.</p>Formula:C18H28Cl3N5Purity:99.74%Color and Shape:SolidMolecular weight:420.81TLR7 agonist 1
CAS:<p>TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).</p>Formula:C21H25N5OPurity:98%Color and Shape:SolidMolecular weight:363.46AZD8848
CAS:<p>AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.</p>Formula:C29H43N7O5Color and Shape:SolidMolecular weight:569.7TL8-506
CAS:<p>TL8-506 is a selective and potent TLR8 agonist that induces cytokine and chemokine production.TL8-506 alleviates inflammatory and autoimmune diseases.</p>Formula:C20H17N3O2Purity:95% - 99.97%Color and Shape:SolidMolecular weight:331.37DSR-6434
CAS:<p>DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.</p>Formula:C19H28N8O2Purity:99.78%Color and Shape:SolidMolecular weight:400.48AT791
CAS:<p>AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.</p>Formula:C23H31N3O3Purity:99.88%Color and Shape:SolidMolecular weight:397.51Rabeximod
CAS:<p>Rabeximod, an immunomodulator, eases autoimmune diseases, inhibits arthritis, and aids brain recovery post-injury by blocking inflammation.</p>Formula:C22H24ClN5OPurity:99.99%Color and Shape:SolidMolecular weight:409.91BBIQ
CAS:<p>BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1</p>Formula:C21H22N4Purity:99.71%Color and Shape:SolidMolecular weight:330.43M62812
CAS:<p>TLR4 inhibitor blocks LPS-induced NF-κB (IC50=2.4μg/mL), cytokines in PBMCs/HUVECs, and extends life in septic shock mice.</p>Formula:C13H13Cl2N3OSPurity:99.07%Color and Shape:SolidMolecular weight:330.23SM360320
CAS:<p>SM360320 (CL-087) is a selective TLR7 agonist that blocks HCV replication in hepatocytes and aids immunology research.</p>Formula:C15H17N5O3Purity:99.13%Color and Shape:SolidMolecular weight:315.33TLR7/8-IN-1
CAS:<p>TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research.Cost-effective and quality-assured.</p>Formula:C29H40N8O2Purity:99.83%Color and Shape:SolidMolecular weight:532.68TLR7 agonist 23
CAS:<p>TLR7 agonist23 (compound 12b) is a potent agonist of Toll-like receptor-7 (TLR7), with an EC50 value of 0.15 uM. It is suitable for research in immune diseases.</p>Formula:C21H22N4O2Color and Shape:SolidMolecular weight:362.42TLR9-IN-1
CAS:<p>TLR9-IN-1: selective, potent human TLR9 inhibitor (IC50: 7 nM), useful for researching immune-related diseases.</p>Formula:C23H31N7OColor and Shape:SolidMolecular weight:421.54ABR-238901
CAS:<p>ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products</p>Formula:C11H9BrClN3O4SPurity:98.63% - 98.71%Color and Shape:SolidMolecular weight:394.63CU-CPD107
CAS:<p>CU-CPD107 selectively activates TLR8 and ssRNA, inhibits TLR8 with R848 (IC50=13.7 μM), and coactivates with ssRNA.</p>Formula:C16H21IN2O2Purity:98%Color and Shape:SolidMolecular weight:400.25TLR7 agonist 28
CAS:<p>TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.</p>Formula:C26H25N9O7Color and Shape:SolidMolecular weight:575.533Creatine ethyl ester
CAS:<p>Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.</p>Formula:C6H13N3O2Color and Shape:SolidMolecular weight:159.186SARM1-IN-4
CAS:<p>SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.</p>Formula:C13H17F2N3O2Color and Shape:SolidMolecular weight:285.29LHC-165
CAS:<p>LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.</p>Formula:C29H32F2N3O7PPurity:98%Color and Shape:SolidMolecular weight:603.55TLR7/8/9 antagonist 2
CAS:<p>TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.</p>Formula:C23H31N7Purity:98%Color and Shape:SoildMolecular weight:405.54
