TLR
Toll-like receptors (TLRs) are a class of proteins that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. TLRs are involved in detecting a wide range of pathogens, including bacteria, viruses, and fungi, and are essential for the activation of inflammatory signaling pathways. Dysregulation of TLR signaling is associated with chronic inflammatory diseases, autoimmune disorders, and cancer. At CymitQuimica, we offer a variety of high-quality TLR modulators to support your research in innate immunity, inflammation, and infectious disease.
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MD2-TLR4-IN-1
CAS:2249801-12-3
MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
Formula:
C22H14Cl2N4O
Purity:
97.74%
Color and Shape:
Solid
Molecular weight:
421.28
Ref: TM-T7672
| 1mg | 60.00 € | ||
| 5mg | 131.00 € | ||
| 10mg | 207.00 € | ||
| 25mg | 353.00 € | ||
| 50mg | 496.00 € | ||
| 100mg | 655.00 € | ||
| 200mg | 881.00 € | ||
| 1mL*10mM (DMSO) | 146.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
E6446 dihydrochloride
CAS:1345675-25-3
E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation …
Formula:
C27H37Cl2N3O3
Purity:
99.44%
Color and Shape:
Solid
Molecular weight:
522.51
Ref: TM-T4068
| 1mg | 105.00 € | ||
| 2mg | 156.00 € | ||
| 5mg | 300.00 € | ||
| 10mg | 368.00 € | ||
| 25mg | 615.00 € | ||
| 50mg | 875.00 € | ||
| 100mg | 1,189.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Telratolimod
CAS:1359993-59-1
Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.
Formula:
C36H59N5O2
Purity:
98.61%
Color and Shape:
Solid
Molecular weight:
593.89
Ref: TM-T17032
| 1mg | 169.00 € | ||
| 2mg | 232.00 € | ||
| 5mg | 347.00 € | ||
| 10mg | 519.00 € | ||
| 25mg | 832.00 € | ||
| 50mg | 1,133.00 € | ||
| 100mg | 1,532.00 € | ||
| 1mL*10mM (DMSO) | 460.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Enpatoran
CAS:2101938-42-3
Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM).
Formula:
C16H15F3N4
Purity:
99.38%
Color and Shape:
Solid
Molecular weight:
320.31
Ref: TM-T9570
| 1mg | 118.00 € | ||
| 5mg | 230.00 € | ||
| 10mg | 346.00 € | ||
| 25mg | 580.00 € | ||
| 50mg | 868.00 € | ||
| 100mg | 1,291.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Gardiquimod
CAS:1020412-43-4
Gardiquimod, an imidazoquinoline TLR7 agonist, inhibits HIV-1 in macrophages and PBMCs under 10μM.
Formula:
C17H23N5O
Purity:
98% - 98.02%
Color and Shape:
Solid
Molecular weight:
313.4
Ref: TM-T15371
| 1mg | 36.00 € | ||
| 2mg | 50.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 109.00 € | ||
| 25mg | 176.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CU-CPT-8m
CAS:125079-83-6
CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
Formula:
C14H12N4O
Purity:
98.97%
Color and Shape:
Solid
Molecular weight:
252.27
Ref: TM-T7347
| 1mg | 52.00 € | ||
| 2mg | 73.00 € | ||
| 5mg | 100.00 € | ||
| 10mg | 164.00 € | ||
| 25mg | 290.00 € | ||
| 50mg | 532.00 € | ||
| 100mg | 763.00 € | ||
| 1mL*10mM (DMSO) | 105.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SM-324405
CAS:677773-91-0
SM-324405 is an agonist of TLR7.
Formula:
C19H23N5O4
Purity:
97.83%
Color and Shape:
Solid
Molecular weight:
385.42
Ref: TM-T7860
| 1mg | 36.00 € | ||
| 5mg | 75.00 € | ||
| 10mg | 109.00 € | ||
| 25mg | 195.00 € | ||
| 50mg | 311.00 € | ||
| 100mg | 446.00 € | ||
| 200mg | 622.00 € | ||
| 1mL*10mM (DMSO) | 84.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CU-CPT9b
CAS:2162962-69-6
CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 …
Formula:
C16H13NO2
Purity:
98.10%
Color and Shape:
Solid
Molecular weight:
251.28
Ref: TM-T7302
| 1mg | 52.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 159.00 € | ||
| 25mg | 256.00 € | ||
| 50mg | 373.00 € | ||
| 100mg | 559.00 € | ||
| 1mL*10mM (DMSO) | 130.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
MD2-IN-1
CAS:111797-22-9
MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM …
Formula:
C20H22O6
Purity:
99.43%
Color and Shape:
Solid
Molecular weight:
358.39
Ref: TM-T4231
| 1mg | 57.00 € | ||
| 5mg | 122.00 € | ||
| 10mg | 180.00 € | ||
| 25mg | 341.00 € | ||
| 50mg | 514.00 € | ||
| 100mg | 773.00 € | ||
| 1mL*10mM (DMSO) | 135.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
C29
CAS:363600-92-4
C29 inhibits TLR2/1 and TLR2/6 in human cells, but only TLR2/1 in mouse macrophages.
Formula:
C16H15NO4
Purity:
96.34%
Color and Shape:
Solid
Molecular weight:
285.29
Ref: TM-T3502
| 1mg | 51.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 177.00 € | ||
| 25mg | 276.00 € | ||
| 50mg | 423.00 € | ||
| 100mg | 640.00 € | ||
| 1mL*10mM (DMSO) | 150.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Afimetoran
CAS:2171019-55-7
Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of …
Formula:
C26H32N6O
Purity:
99.89%
Color and Shape:
Solid
Molecular weight:
444.57
Ref: TM-T39654
| 1mg | 90.00 € | ||
| 5mg | 183.00 € | ||
| 10mg | 305.00 € | ||
| 25mg | 518.00 € | ||
| 50mg | 737.00 € | ||
| 100mg | 1,041.00 € | ||
| 1mL*10mM (DMSO) | 213.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TLR3-IN-1
CAS:1279713-77-7
TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor. It can inhibit TLR3/dsRNA complex-mediated downstream …
Formula:
C18H13ClFNO3S
Purity:
97.77%
Color and Shape:
Solid
Molecular weight:
377.82
Ref: TM-T22698
| 1mg | 52.00 € | ||
| 2mg | 73.00 € | ||
| 5mg | 112.00 € | ||
| 10mg | 183.00 € | ||
| 25mg | 389.00 € | ||
| 50mg | 581.00 € | ||
| 100mg | 826.00 € | ||
| 500mg | 1,672.00 € | ||
| 1mL*10mM (DMSO) | 125.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
E6446
CAS:1219925-73-1
E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling.
Formula:
C27H35N3O3
Purity:
99.41%
Color and Shape:
Solid
Molecular weight:
449.59
Ref: TM-T4206
| 1mg | 91.00 € | ||
| 5mg | 184.00 € | ||
| 10mg | 300.00 € | ||
| 25mg | 500.00 € | ||
| 50mg | 714.00 € | ||
| 100mg | 976.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CU-CPT-9a
CAS:2165340-32-7
CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling …
Formula:
C17H15NO2
Purity:
99.01%
Color and Shape:
Solid
Molecular weight:
265.31
Ref: TM-T7317
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 124.00 € | ||
| 25mg | 233.00 € | ||
| 50mg | 425.00 € | ||
| 100mg | 624.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TLR7/8/9-IN-1
CAS:2180127-82-4
TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 …
Formula:
C27H37N3O2
Purity:
98.31%
Color and Shape:
Solid
Molecular weight:
435.6
Ref: TM-T39669
| 1mg | 51.00 € | ||
| 2mg | 71.00 € | ||
| 5mg | 113.00 € | ||
| 10mg | 182.00 € | ||
| 25mg | 296.00 € | ||
| 50mg | 433.00 € | ||
| 100mg | 588.00 € | ||
| 200mg | 840.00 € | ||
| 1mL*10mM (DMSO) | 169.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TLR4-IN-C34
CAS:40592-88-9
TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and …
Formula:
C17H27NO9
Purity:
99.77%
Color and Shape:
Solid
Molecular weight:
389.4
Ref: TM-T8503
| 2mg | 45.00 € | ||
| 5mg | 66.00 € | ||
| 10mg | 92.00 € | ||
| 25mg | 128.00 € | ||
| 50mg | 201.00 € | ||
| 100mg | 297.00 € | ||
| 1mL*10mM (DMSO) | 75.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Bropirimine
CAS:56741-95-8
Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the …
Formula:
C10H8BrN3O
Purity:
99.01%
Color and Shape:
Solid
Molecular weight:
266.09
Ref: TM-T5521
| 2mg | 35.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 74.00 € | ||
| 25mg | 113.00 € | ||
| 50mg | 159.00 € | ||
| 100mg | 228.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
1V209
CAS:1062444-54-5
1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
Formula:
C16H17N5O5
Purity:
99.61%
Color and Shape:
Solid
Molecular weight:
359.34
Ref: TM-T8316
| 1mg | 38.00 € | ||
| 2mg | 49.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 123.00 € | ||
| 25mg | 267.00 € | ||
| 50mg | 425.00 € | ||
| 100mg | 625.00 € | ||
| 1mL*10mM (DMSO) | 86.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Polyinosinic-polycytidylic acid
CAS:24939-03-5
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog and an immunostimulant that acts …
Formula:
(C10H13N4O8P)x·(C9H14N3O8P)x
Purity:
90%
Color and Shape:
Solid
Molecular weight:
671.4
Ref: TM-T23171
| 5mg | 49.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 144.00 € | ||
| 50mg | 263.00 € | ||
| 100mg | 410.00 € | ||
| 500mg | 936.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TH1020
CAS:1841460-82-9
TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 …
Formula:
C23H15N7S2
Purity:
99.23%
Color and Shape:
Solid
Molecular weight:
453.54
Ref: TM-T8727
| 2mg | 46.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 186.00 € | ||
| 50mg | 349.00 € | ||
| 100mg | 522.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
