TLR
Toll-like receptors (TLRs) are a class of proteins that play a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs) and initiating immune responses. TLRs are involved in detecting a wide range of pathogens, including bacteria, viruses, and fungi, and are essential for the activation of inflammatory signaling pathways. Dysregulation of TLR signaling is associated with chronic inflammatory diseases, autoimmune disorders, and cancer. At CymitQuimica, we offer a variety of high-quality TLR modulators to support your research in innate immunity, inflammation, and infectious disease.
Found 74 products of "TLR"
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PVP-037.2
CAS:PVP-037.2 is a TLR7/8 agonist that acts as an adjuvant to enhance vaccine-induced TH1 immune responses and boost the production of antigen-specific antibodies IgG1 and IgG2c.Formula:C23H20F3N5OColor and Shape:SoildMolecular weight:439.43(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 serves as the E3 ubiquitin ligase ligand and linker for PROTAC(R)-NX-2127, utilized in cancer research.Formula:C29H33N5O4Color and Shape:SolidMolecular weight:515.6Ezeprogind
CAS:Ezeprogind, TLR9 inhibitor for Alzheimer's. Affordable Excellence: Reliable Quality You Can TrustFormula:C25H44N6Purity:99.28%Color and Shape:SolidMolecular weight:428.66TLR8 agonist 8
CAS:TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.Formula:C53H63N11O10Color and Shape:SolidMolecular weight:1014.14TLR8 agonist 7
CAS:TLR8 agonist7 is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of less than 250 nM. It remains stable in human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist7 demonstrates antitumor activity, achieving a tumor growth inhibition (TGI) rate of 98%.Formula:C54H63N9O16Color and Shape:SolidMolecular weight:1094.13TLR7 agonist 17
CAS:TLR7 agonist 17 (compound 20) functions as a highly effective TLR7 agonist, exhibiting EC 50 values of 12 nM for hTLR7 and 17 nM for mTLR7. Additionally, this compound has demonstrated anticancer activity [1].Formula:C25H37N7O3Color and Shape:SolidMolecular weight:483.61TLR7 agonist 24
TLR7 agonist24 (Compound 21) is an agonist of TLR7 with an EC50 of 3.72 μM. When combined with Aluminum Hydroxide, it can be employed as a vaccine adjuvant to enhance the immune response to antigens from SARS-CoV-2 and hepatitis B.Color and Shape:Odour SolidPam3CSK4
CAS:Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.Formula:C81H156N10O13SPurity:98%Color and Shape:SolidMolecular weight:1510.23TLR7 agonist 3
CAS:TLR7 agonist 3 is a Toll-like receptor 7 (TLR7) agonist that has anticancer activity and is used in the study of diseases of the immune system.
Formula:C18H24N4OPurity:99.27%Color and Shape:SolidMolecular weight:312.41Toll-like receptor modulator
CAS:Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.Formula:C15H13F5N2O2Purity:98%Color and Shape:SolidMolecular weight:348.27Neoseptin-3
CAS:Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.Formula:C29H34N2O4Purity:98%Color and Shape:SolidMolecular weight:474.59Motolimod
CAS:Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.Formula:C28H34N4O2Purity:97.43% - 99.66%Color and Shape:SolidMolecular weight:458.6TLR7 agonist 2
CAS:TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
Formula:C17H16N6O2Purity:99.33%Color and Shape:SolidMolecular weight:336.35TLR7/8 agonist 1
CAS:TLR7/8 agonist 1 is a toll-like receptor TLR7/TLR8 agonist with anticancer and antiviral activities and can be used to study immune-related diseases.Formula:C22H25N5Purity:99.4%Color and Shape:SolidMolecular weight:359.47Telratolimod
CAS:Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.Formula:C36H59N5O2Purity:98.61%Color and Shape:SolidMolecular weight:593.89Enpatoran
CAS:Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM).Formula:C16H15F3N4Purity:97.08% - 99.38%Color and Shape:SolidMolecular weight:320.31Ref: TM-T9570
1mg113.00€5mg222.00€10mg334.00€25mg552.00€50mg782.00€100mg1,054.00€200mg1,414.00€1mL*10mM (DMSO)161.00€CU-CPT-8m
CAS:CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)Formula:C14H12N4OPurity:99.00%Color and Shape:SolidMolecular weight:252.27SM-324405
CAS:SM-324405 is an agonist of TLR7.Formula:C19H23N5O4Purity:97.83%Color and Shape:SolidMolecular weight:385.42Ref: TM-T7860
2mg34.00€5mg52.00€10mg84.00€25mg138.00€50mg215.00€100mg306.00€200mg427.00€1mL*10mM (DMSO)57.00€CU-CPT9b
CAS:CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM).Formula:C16H13NO2Purity:98.1%Color and Shape:SolidMolecular weight:251.28Ref: TM-T7302
1mg49.00€5mg92.00€10mg152.00€25mg245.00€50mg340.00€100mg504.00€200mg717.00€1mL*10mM (DMSO)105.00€MD2-IN-1
CAS:MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM for the recombinant human MD2 (rhMD2).Formula:C20H22O6Purity:99.87%Color and Shape:SolidMolecular weight:358.39
