TGF-beta/Smad
TGF-beta/Smad inhibitors are compounds that interfere with the TGF-beta (Transforming Growth Factor-beta) signaling pathway, which is mediated by Smad proteins. This pathway is involved in the regulation of cell growth, differentiation, apoptosis, and stem cell function. Dysregulation of TGF-beta/Smad signaling is associated with cancer, fibrosis, and other diseases. Inhibitors of this pathway are important tools for studying these conditions and developing potential therapies. At CymitQuimica, we provide TGF-beta/Smad inhibitors to support your research in cell signaling, oncology, and tissue repair.
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(E)-SIS3
CAS:521984-48-5
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding
Formula:
C28H27N3O3·HCl
Purity:
95.64% - 98.83%
Color and Shape:
Solid
Molecular weight:
489.99
Ref: TM-T3636
| 1mg | 43.00 € | ||
| 2mg | 57.00 € | ||
| 5mg | 111.00 € | ||
| 10mg | 167.00 € | ||
| 25mg | 344.00 € | ||
| 50mg | 512.00 € | ||
| 100mg | 730.00 € | ||
| 500mg | 1,473.00 € | ||
| 1mL*10mM (DMSO) | 120.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
R-268712
CAS:879487-87-3
R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type …
Formula:
C20H18FN5O
Purity:
99.61%
Color and Shape:
Solid
Molecular weight:
363.39
Ref: TM-T16708
| 1mg | 47.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 137.00 € | ||
| 25mg | 264.00 € | ||
| 50mg | 399.00 € | ||
| 100mg | 567.00 € | ||
| 200mg | 805.00 € | ||
| 1mL*10mM (DMSO) | 97.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
SRI-011381
CAS:1629138-41-5
SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of …
Formula:
C20H31N3O
Purity:
98.64%
Color and Shape:
Solid
Molecular weight:
329.48
Ref: TM-T4283
| 1mg | 35.00 € | ||
| 2mg | 48.00 € | ||
| 5mg | 70.00 € | ||
| 10mg | 111.00 € | ||
| 25mg | 227.00 € | ||
| 50mg | 378.00 € | ||
| 100mg | 622.00 € | ||
| 200mg | 873.00 € | ||
| 500mg | 1,293.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
SJ000291942
CAS:425613-09-8
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.
Formula:
C16H15FN2O4
Purity:
99.07%
Color and Shape:
Solid
Molecular weight:
318.3
Ref: TM-T4662
| 2mg | 46.00 € | ||
| 5mg | 66.00 € | ||
| 10mg | 105.00 € | ||
| 25mg | 230.00 € | ||
| 50mg | 401.00 € | ||
| 100mg | 595.00 € | ||
| 1mL*10mM (DMSO) | 74.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .
Formula:
C25H44F6N6O9
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
686.64
Ref: TM-T7676
| 2mg | 44.00 € | ||
| 5mg | 57.00 € | ||
| 10mg | 88.00 € | ||
| 25mg | 145.00 € | ||
| 50mg | 217.00 € | ||
| 100mg | 334.00 € | ||
| 200mg | 467.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Kartogenin
CAS:4727-31-5
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of …
Formula:
C20H15NO3
Purity:
96.25% - 97.79%
Color and Shape:
Solid
Molecular weight:
317.34
Ref: TM-T1748
| 2mg | 35.00 € | ||
| 5mg | 50.00 € | ||
| 10mg | 58.00 € | ||
| 25mg | 89.00 € | ||
| 50mg | 163.00 € | ||
| 100mg | 274.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Halofuginone
CAS:55837-20-2
Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.
Formula:
C16H17BrClN3O3
Purity:
97.67%
Color and Shape:
Off-White Solid
Molecular weight:
414.68
Ref: TM-T6856
| 1mg | 37.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 123.00 € | ||
| 25mg | 240.00 € | ||
| 50mg | 363.00 € | ||
| 100mg | 547.00 € | ||
| 500mg | 1,198.00 € |
Estimated delivery in United States, on Tuesday 20 May 2025
Halofuginone hydrobromide
CAS:64924-67-0
Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the …
Formula:
C16H17BrClN3O3·HBr
Purity:
97.01% - 98.5%
Color and Shape:
Solid
Molecular weight:
495.59
Ref: TM-T3524
| 1mg | 37.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 112.00 € | ||
| 25mg | 219.00 € | ||
| 50mg | 328.00 € | ||
| 100mg | 495.00 € | ||
| 500mg | 947.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Tuesday 3 Jun 2025
PF-06952229
CAS:1801333-55-0
PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the …
Formula:
C23H24ClFN4O3
Purity:
99.45%
Color and Shape:
Solid
Molecular weight:
458.91
Ref: TM-T12433
| 1mg | 111.00 € | ||
| 5mg | 274.00 € | ||
| 10mg | 439.00 € | ||
| 25mg | 747.00 € | ||
| 50mg | 1,035.00 € | ||
| 100mg | 1,406.00 € | ||
| 1mL*10mM (DMSO) | 303.00 € |
Estimated delivery in United States, on Tuesday 3 Jun 2025
CJJ300
CAS:1807631-83-9
CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, …
Formula:
C30H33N3
Purity:
99.41%
Color and Shape:
Liquid
Molecular weight:
435.6
Ref: TM-T62483
| 1mg | 42.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 137.00 € | ||
| 25mg | 264.00 € | ||
| 50mg | 432.00 € | ||
| 100mg | 655.00 € | ||
| 500mg | 1,359.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Tuesday 3 Jun 2025
Chromenone 1
CAS:1639929-29-5
Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).
Formula:
C18H10F3N3O2
Purity:
100% - 99.85%
Color and Shape:
Liquid
Molecular weight:
357.29
Ref: TM-T61301
| 1mg | 77.00 € | ||
| 5mg | 158.00 € | ||
| 10mg | 225.00 € | ||
| 25mg | 338.00 € | ||
| 50mg | 472.00 € | ||
| 100mg | 645.00 € | ||
| 200mg | 868.00 € | ||
| 1mL*10mM (DMSO) | 162.00 € |
Estimated delivery in United States, on Tuesday 3 Jun 2025
SJ000063181
CAS:945189-68-4
SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.
Formula:
C14H14ClFN2O2
Purity:
99.83%
Color and Shape:
Liquid
Molecular weight:
296.72
Ref: TM-T60644
| 1mg | 52.00 € | ||
| 5mg | 97.00 € | ||
| 10mg | 149.00 € | ||
| 25mg | 283.00 € | ||
| 50mg | 550.00 € | ||
| 100mg | 792.00 € | ||
| 500mg | 1,605.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Tuesday 3 Jun 2025
Pentabromophenol
CAS:608-71-9
Pentabromophenol (NSC-5717) suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.
Formula:
C6HBr5O
Purity:
98.89%
Color and Shape:
Monoclinic Prisms From Acetic Acid; Needles From Alcohol Physical Description Light Brown Powder Insoluble In Water (Ntp 1992)
Molecular weight:
488.59
Ref: TM-T20319
| 1g | 34.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Tuesday 3 Jun 2025
(Rac)-SIS3 free base
CAS:1009104-85-1
SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits …
Formula:
C28H27N3O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
453.53
Ref: TM-T12923
| 25mg | 697.00 € | ||
| 50mg | 907.00 € | ||
| 100mg | 1,454.00 € |
Estimated delivery in United States, on Tuesday 3 Jun 2025
TGFβ-IN-5
CAS:259870-32-1
TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative …
Formula:
C20H16N4
Purity:
99.29% - 99.5%
Color and Shape:
Liquid
Molecular weight:
312.37
Ref: TM-T77786
| 1mg | 57.00 € | ||
| 5mg | 120.00 € | ||
| 10mg | 175.00 € | ||
| 25mg | 303.00 € | ||
| 50mg | 439.00 € | ||
| 100mg | 628.00 € | ||
| 500mg | 1,301.00 € |
Estimated delivery in United States, on Tuesday 17 Jun 2025
3,7-DMF
CAS:20950-52-1
3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate …
Formula:
C17H14O4
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
282.29
Ref: TM-T79603
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 17 Jun 2025
TP0427736
CAS:864374-00-5
TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x >ALK3 selectivity; counters TGF-β in human cells, extends anagen …
Formula:
C14H10N4S2
Purity:
97.67%
Color and Shape:
Solid
Molecular weight:
298.39
Ref: TM-T24897
| 1mg | 96.00 € | ||
| 5mg | 226.00 € | ||
| 10mg | 369.00 € | ||
| 25mg | 630.00 € | ||
| 50mg | 898.00 € | ||
| 1mL*10mM (DMSO) | 255.00 € |
Estimated delivery in United States, on Tuesday 17 Jun 2025
DT-6
CAS:2414315-95-8
DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of …
Formula:
C89H130N20O29S2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
2008.23
Ref: TM-T79789
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 17 Jun 2025
Myristoyl tetrapeptide-12
CAS:959610-24-3
Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair …
Formula:
C32H63N7O5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
625.89
Ref: TM-T80628
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 17 Jun 2025
DCN1-IN-2
CAS:2543578-57-8
DCN1-IN-2, a DCN1 inhibitor, exhibits potent activity with an IC 50 of 2.96 nM. It …
Formula:
C18H14ClF3N4OS
Color and Shape:
Liquid
Molecular weight:
426.84
Ref: TM-T89956
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 15 Jul 2025
