TGF-beta/Smad
TGF-beta/Smad inhibitors are compounds that interfere with the TGF-beta (Transforming Growth Factor-beta) signaling pathway, which is mediated by Smad proteins. This pathway is involved in the regulation of cell growth, differentiation, apoptosis, and stem cell function. Dysregulation of TGF-beta/Smad signaling is associated with cancer, fibrosis, and other diseases. Inhibitors of this pathway are important tools for studying these conditions and developing potential therapies. At CymitQuimica, we provide TGF-beta/Smad inhibitors to support your research in cell signaling, oncology, and tissue repair.
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BIO-013077-01
CAS:746667-48-1
BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.
Formula:
C17H13N5
Purity:
99.87%
Color and Shape:
Solid
Molecular weight:
287.32
Ref: TM-T8330
| 1mg | 50.00 € | ||
| 5mg | 89.00 € | ||
| 10mg | 137.00 € | ||
| 25mg | 266.00 € | ||
| 50mg | 382.00 € | ||
| 100mg | 542.00 € | ||
| 200mg | 733.00 € | ||
| 1mL*10mM (DMSO) | 134.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Trimethylamine N-oxide dihydrate
CAS:62637-93-8
TMANO Dihydrate, from trimethylamine oxidation, stabilizes proteins against sharks' urea.
Formula:
C3H13NO3
Purity:
98%
Color and Shape:
White Crystal
Molecular weight:
111.14
Ref: TM-T5247
| 1g | 48.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
LY3200882
CAS:1898283-02-7
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
Formula:
C24H29N5O3
Purity:
98.37% - 99.46%
Color and Shape:
Solid
Molecular weight:
435.52
Ref: TM-T5125
| 1mg | 45.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 140.00 € | ||
| 25mg | 265.00 € | ||
| 50mg | 417.00 € | ||
| 100mg | 631.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SD-208
CAS:627536-09-8
SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity …
Formula:
C17H10ClFN6
Purity:
98.72% - ≥95%
Color and Shape:
Solid
Molecular weight:
352.75
Ref: TM-T2109
| 1mg | 40.00 € | ||
| 2mg | 51.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 100.00 € | ||
| 25mg | 203.00 € | ||
| 50mg | 307.00 € | ||
| 100mg | 480.00 € | ||
| 1mL*10mM (DMSO) | 110.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SRI-011381
CAS:1629138-41-5
SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of …
Formula:
C20H31N3O
Purity:
98.64%
Color and Shape:
Solid
Molecular weight:
329.48
Ref: TM-T4283
| 1mg | 35.00 € | ||
| 2mg | 47.00 € | ||
| 5mg | 69.00 € | ||
| 10mg | 109.00 € | ||
| 25mg | 223.00 € | ||
| 50mg | 371.00 € | ||
| 100mg | 611.00 € | ||
| 200mg | 856.00 € | ||
| 500mg | 1,268.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Halofuginone
CAS:55837-20-2
Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.
Formula:
C16H17BrClN3O3
Purity:
97.67%
Color and Shape:
Off-White Solid
Molecular weight:
414.68
Ref: TM-T6856
| 1mg | 37.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | 121.00 € | ||
| 25mg | 235.00 € | ||
| 50mg | 355.00 € | ||
| 100mg | 534.00 € | ||
| 500mg | 1,170.00 € |
Estimated delivery in United States, on Wednesday 8 Jan 2025
PF-06952229
CAS:1801333-55-0
PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the …
Formula:
C23H24ClFN4O3
Purity:
99.45%
Color and Shape:
Solid
Molecular weight:
458.91
Ref: TM-T12433
| 1mg | 107.00 € | ||
| 5mg | 269.00 € | ||
| 10mg | 424.00 € | ||
| 25mg | 720.00 € | ||
| 50mg | 997.00 € | ||
| 100mg | 1,353.00 € | ||
| 1mL*10mM (DMSO) | 301.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
SJ000063181
CAS:945189-68-4
SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.
Formula:
C14H14ClFN2O2
Purity:
99.83%
Color and Shape:
Liquid
Molecular weight:
296.72
Ref: TM-T60644
| 1mg | 52.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 146.00 € | ||
| 25mg | 278.00 € | ||
| 50mg | 540.00 € | ||
| 100mg | 774.00 € | ||
| 500mg | 1,570.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Chromenone 1
CAS:1639929-29-5
Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).
Formula:
C18H10F3N3O2
Purity:
100% - 99.85%
Color and Shape:
Liquid
Molecular weight:
357.29
Ref: TM-T61301
| 1mg | 113.00 € | ||
| 5mg | 250.00 € | ||
| 10mg | 367.00 € | ||
| 25mg | 551.00 € | ||
| 50mg | 771.00 € | ||
| 100mg | 1,052.00 € | ||
| 500mg | 2,103.00 € | ||
| 1mL*10mM (DMSO) | 259.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Pentabromophenol
CAS:608-71-9
Pentabromophenol (NSC-5717) suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.
Formula:
C6HBr5O
Purity:
98.89%
Color and Shape:
Monoclinic Prisms From Acetic Acid; Needles From Alcohol Physical Description Light Brown Powder Insoluble In Water (Ntp 1992)
Molecular weight:
488.59
Ref: TM-T20319
| 1g | 34.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
(Rac)-SIS3 free base
CAS:1009104-85-1
SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits …
Formula:
C28H27N3O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
453.53
Ref: TM-T12923
| 25mg | 681.00 € | ||
| 50mg | 893.00 € | ||
| 100mg | 1,432.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
CJJ300
CAS:1807631-83-9
CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, …
Formula:
C30H33N3
Purity:
99.41%
Color and Shape:
Liquid
Molecular weight:
435.6
Ref: TM-T62483
| 1mg | 41.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 135.00 € | ||
| 25mg | 260.00 € | ||
| 50mg | 425.00 € | ||
| 100mg | 644.00 € | ||
| 500mg | 1,336.00 € | ||
| 1mL*10mM (DMSO) | 94.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Halofuginone hydrobromide
CAS:64924-67-0
Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the …
Formula:
C16H17BrClN3O3·HBr
Purity:
97.01% - 98.5%
Color and Shape:
Solid
Molecular weight:
495.59
Ref: TM-T3524
| 1mg | 36.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 110.00 € | ||
| 25mg | 214.00 € | ||
| 50mg | 321.00 € | ||
| 100mg | 483.00 € | ||
| 500mg | 925.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Myristoyl tetrapeptide-12
CAS:959610-24-3
Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair …
Formula:
C32H63N7O5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
625.89
Ref: TM-T80628
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Feb 2025
TGFβ-IN-5
CAS:259870-32-1
TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative …
Formula:
C20H16N4
Purity:
99.29% - 99.5%
Color and Shape:
Liquid
Molecular weight:
312.37
Ref: TM-T77786
| 1mg | 56.00 € | ||
| 5mg | 119.00 € | ||
| 10mg | 172.00 € | ||
| 25mg | 295.00 € | ||
| 50mg | 430.00 € | ||
| 100mg | 615.00 € | ||
| 500mg | 1,271.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
DT-6
CAS:2414315-95-8
DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of …
Formula:
C89H130N20O29S2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
2008.23
Ref: TM-T79789
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Feb 2025
3,7-DMF
CAS:20950-52-1
3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate …
Formula:
C17H14O4
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
282.29
Ref: TM-T79603
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Feb 2025
TP0427736
CAS:864374-00-5
TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x >ALK3 selectivity; counters TGF-β in human cells, extends anagen …
Formula:
C14H10N4S2
Purity:
97.67%
Color and Shape:
Solid
Molecular weight:
298.39
Ref: TM-T24897
| 1mg | 94.00 € | ||
| 5mg | 221.00 € | ||
| 10mg | 361.00 € | ||
| 25mg | 618.00 € | ||
| 50mg | 881.00 € | ||
| 1mL*10mM (DMSO) | 254.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
DCN1-IN-2
CAS:2543578-57-8
DCN1-IN-2, a DCN1 inhibitor, exhibits potent activity with an IC 50 of 2.96 nM. It …
Formula:
C18H14ClF3N4OS
Color and Shape:
Liquid
Molecular weight:
426.84
Ref: TM-T89956
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Mar 2025
TGFβ1-IN-1
CAS:2348795-14-0
TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and …
Formula:
C22H24N2O3
Purity:
99.89%
Color and Shape:
Liquid
Molecular weight:
364.438
Ref: TM-T61389
| 2mg | 90.00 € |
Estimated delivery in United States, on Wednesday 5 Mar 2025
