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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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  • JAK3-IN-1
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    JAK3-IN-1

    CAS:
    <p>JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.</p>
    Formula:C26H30ClN7O2
    Color and Shape:Solid
    Molecular weight:508.02

    Ref: TM-T15607

  • JAK3/BTK-IN-1
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    JAK3/BTK-IN-1

    CAS:
    <p>JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important</p>
    Formula:C25H28N8O
    Purity:97.89%
    Color and Shape:Solid
    Molecular weight:456.54

    Ref: TM-T9814

  • JAK-IN-30
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    JAK-IN-30

    CAS:
    <p>JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50</p>
    Formula:C19H26N8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:398.53

    Ref: TM-T79235

  • JAK-IN-28
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    JAK-IN-28

    CAS:
    <p>JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].</p>
    Formula:C20H18ClN7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:407.86

    Ref: TM-T79116

  • AZD-1897
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    AZD-1897

    CAS:
    <p>AZD-1897 is a highly efficient ATP-competitive pan-PIM inhibitor with anti-cancer and anti-leukemia activity, used in multiple myeloma research.</p>
    Formula:C18H23N3O3S
    Purity:99.49%
    Color and Shape:Solid
    Molecular weight:361.46

    Ref: TM-T71242

  • M-110
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    M-110

    CAS:
    <p>M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).</p>
    Formula:C22H28ClN5O3
    Purity:99.55%
    Color and Shape:Solid
    Molecular weight:445.94

    Ref: TM-T15830

  • JAK1-IN-4
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    JAK1-IN-4

    CAS:
    <p>JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).</p>
    Formula:C26H32FN9O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:521.59

    Ref: TM-T15606

  • JAK3/BTK-IN-2
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    JAK3/BTK-IN-2

    CAS:
    <p>JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.</p>
    Formula:C25H32N8O2
    Purity:99.64% - 99.87%
    Color and Shape:Solid
    Molecular weight:476.57

    Ref: TM-T9813

  • Lorpucitinib
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    Lorpucitinib

    CAS:
    <p>Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.</p>
    Formula:C22H28N6O2
    Purity:99.72%
    Color and Shape:Solid
    Molecular weight:408.5

    Ref: TM-T62053

  • JAK3i
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    JAK3i

    CAS:
    <p>JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.</p>
    Formula:C18H15FN4O3
    Purity:98.61% - 99.81%
    Color and Shape:Solid
    Molecular weight:354.34

    Ref: TM-T27650

  • Jaspamycin
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    Jaspamycin

    CAS:
    <p>Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.</p>
    Formula:C12H12N4O5
    Color and Shape:Solid
    Molecular weight:292.25

    Ref: TM-T11711

  • PIM-1 Inhibitor 2
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    PIM-1 Inhibitor 2

    CAS:
    <p>PIM-1 Inhibitor 2 (PIM1-IN-2) is a potent Pim-1 inhibitor with potential anti-cancer activity, used in cancer research.</p>
    Formula:C17H11ClN4O
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:322.75

    Ref: TM-T23158

  • JAK1-IN-8
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    JAK1-IN-8

    CAS:
    <p>JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50&lt;500 nM).</p>
    Formula:C22H23FN4O3S
    Purity:98.4%
    Color and Shape:Solid
    Molecular weight:442.51

    Ref: TM-T35899

  • STS-E412
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    STS-E412

    CAS:
    <p>STS-E412 is a tissue-protective and selective EPOR/CD131 receptor activator for the study of neurological disorders.</p>
    Formula:C15H15ClN4O2
    Purity:99.01%
    Color and Shape:Solid
    Molecular weight:318.76

    Ref: TM-T24840

  • Izencitinib
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    Izencitinib

    CAS:
    <p>Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.</p>
    Formula:C22H26N8
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:402.50

    Ref: TM-T35898

  • JAK-STAT-IN-1
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    JAK-STAT-IN-1

    CAS:
    <p>JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.</p>
    Formula:C21H21N5O2
    Purity:99.59%
    Color and Shape:Solid
    Molecular weight:375.42

    Ref: TM-T78607

  • Butyzamide
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    Butyzamide

    CAS:
    <p>Butyzamide: oral Mpl activator, non-peptide, antagonizes TPO receptors, boosts hMpl, Ba/F3 cells, and enhances platelets in mice.</p>
    Formula:C29H32Cl2N2O5S
    Purity:99.51% - 99.83%
    Color and Shape:Soild
    Molecular weight:591.55

    Ref: TM-T67894

  • NT219
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    NT219

    CAS:
    <p>NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.</p>
    Formula:C16H14BrNO5S
    Purity:98.06% - 99.72%
    Color and Shape:Solid
    Molecular weight:412.26

    Ref: TM-T62105

  • Brepocitinib
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    Brepocitinib

    CAS:
    <p>Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).</p>
    Formula:C18H21F2N7O
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:389.4

    Ref: TM-TQ0010

  • Lepzacitinib
    Targetmol
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    Lepzacitinib

    CAS:
    <p>Lepzacitinib is a selective, inflammatory, small molecule JAK1/3(Janus kinase) inhibitor primarily used for the treatment of atopic dermatitis.</p>
    Formula:C18H21N5O3
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:355.39

    Ref: TM-T78207