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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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  • PM-43I
    Targetmol
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    PM-43I

    CAS:
    <p>PM-43I is a potent inhibitor of both STAT5- and STAT6-dependent allergic airway disease in mice.</p>
    Formula:C38H50F2N3O10P
    Color and Shape:Solid
    Molecular weight:777.79

    Ref: TM-T70333

  • JAK-IN-26
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    JAK-IN-26

    CAS:
    <p>JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in</p>
    Formula:C22H24N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:420.46

    Ref: TM-T78189

  • TCS 21311
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    TCS 21311

    CAS:
    <p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ &amp; GSK3β; &gt;100x selective over JAK1, JAK2, TYK2.</p>
    Formula:C27H25F3N4O4
    Purity:99.39% - ≥98%
    Color and Shape:Solid
    Molecular weight:526.51

    Ref: TM-T17019

  • STAT3-IN-14
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    STAT3-IN-14

    CAS:
    <p>STAT3-IN-14 is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 can directly bind to the hinge region of STAT3 .</p>
    Formula:C14H10O5
    Color and Shape:Solid
    Molecular weight:258.23

    Ref: TM-T73070

  • Pim-1 kinase inhibitor 5
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    Pim-1 kinase inhibitor 5

    CAS:
    <p>Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-</p>
    Formula:C22H13Cl2N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:406.26

    Ref: TM-T78980

  • JAK-IN-24
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    JAK-IN-24

    CAS:
    <p>JAK-IN-24: JAK inhibitor, IC50: 0.534 nM (4 μM ATP), 24 nM (1mM ATP), STAT5 phosphorylation IC50: 86.171 nM.</p>
    Formula:C20H25N5O2
    Color and Shape:Solid
    Molecular weight:367.44

    Ref: TM-T73330

  • JAK kinase-IN-1
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    JAK kinase-IN-1

    CAS:
    <p>JAK kinase-IN-1 (Example 1) functions as a potent inhibitor targeting the JAK family, which includes TYK2, JAK1, JAK2, and JAK3, with IC50 values of 4.2 nM, 32</p>
    Formula:C17H19F2N7OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:407.44

    Ref: TM-T79807

  • PIM1-IN-4
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    PIM1-IN-4

    CAS:
    <p>PIM1-IN-4: strong PIM1 inhibitor, also blocks SGK-1, PKA, CaMK-1, GSK3β, MSK1; promising for cancer studies.</p>
    Formula:C27H25BrCl2CuN6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:663.88

    Ref: TM-T73247

  • JAK-IN-1
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    JAK-IN-1

    CAS:
    <p>JAK-IN-1 shows improved selectivity for JAK3 over JAK1. JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively.</p>
    Formula:C20H24N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:380.44

    Ref: TM-T11703

  • GNE-955
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    GNE-955

    CAS:
    <p>GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).</p>
    Formula:C22H24N8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:416.48

    Ref: TM-T15406

  • PIM1-IN-1
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    PIM1-IN-1

    CAS:
    <p>PIM1-IN-1 inhibits PIM1/3 with IC50s: PIM1 (7 nM), PIM2 (5530 nM), PIM3 (70 nM); it has anti-cancer properties.</p>
    Formula:C25H30N8O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474.56

    Ref: TM-T12474

  • Tubulin/JAK2-IN-1
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    Tubulin/JAK2-IN-1

    CAS:
    <p>Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant</p>
    Formula:C22H20N6O3
    Color and Shape:Solid
    Molecular weight:416.43

    Ref: TM-T80921

  • Ginsenoside Rk1
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    Ginsenoside Rk1

    CAS:
    <p>Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.</p>
    Formula:C42H70O12
    Purity:98.46% - 99.13%
    Color and Shape:Solid
    Molecular weight:767

    Ref: TM-T4S1499

  • Upadacitinib tartrate
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    Upadacitinib tartrate

    CAS:
    <p>Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.</p>
    Formula:C21H33F3N6O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:602.521

    Ref: TM-T7503L

  • JAK-IN-25
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    JAK-IN-25

    CAS:
    <p>JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.</p>
    Formula:C19H17N5O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:379.37

    Ref: TM-T78175

  • Tyk2-IN-9
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    Tyk2-IN-9

    CAS:
    <p>Tyk2-IN-9: selective Tyk-2 inhibitor, IC50 of 0.076 nM (TYK2-JH2), 1.8 nM (JAK1-JH2), for inflammation/autoimmune research.</p>
    Formula:C20H17N9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:383.41

    Ref: TM-T13237

  • JAK-IN-4
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    JAK-IN-4

    CAS:
    <p>JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.</p>
    Formula:C18H21N4Na2O6P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:466.341

    Ref: TM-T11705

  • Nezulcitinib
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    Nezulcitinib

    CAS:
    <p>Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.</p>
    Formula:C30H37N7O2
    Color and Shape:Solid
    Molecular weight:527.66

    Ref: TM-T63709

  • JAK2-IN-4
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    JAK2-IN-4

    CAS:
    <p>JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.</p>
    Formula:C23H27N5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.56

    Ref: TM-T11708

  • JAK-IN-5
    Targetmol
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    JAK-IN-5

    CAS:
    <p>JAK-IN-5 is a JAK inhibitor.</p>
    Formula:C27H31FN6O
    Purity:98.1% - 99.37%
    Color and Shape:Solid
    Molecular weight:474.57

    Ref: TM-T11710