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JAK/STAT signaling

JAK/STAT signaling

JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.

Subcategories of "JAK/STAT signaling"

Found 321 products of "JAK/STAT signaling"

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  • Ifidancitinib
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    Ifidancitinib

    CAS:
    <p>Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.</p>
    Formula:C20H18FN5O3
    Purity:98.05%
    Color and Shape:Solid
    Molecular weight:395.39

    Ref: TM-T38623

  • FLLL32
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    FLLL32

    CAS:
    <p>FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of &lt;5 μM).</p>
    Formula:C28H32O6
    Purity:97% - 97.90%
    Color and Shape:Solid
    Molecular weight:464.55

    Ref: TM-T6838

  • Filgotinib
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    Filgotinib

    CAS:
    <p>Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.</p>
    Formula:C21H23N5O3S
    Purity:98.03% - ≥95%
    Color and Shape:Solid
    Molecular weight:425.5

    Ref: TM-T1929

  • RGB-286638 free base
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    RGB-286638 free base

    CAS:
    <p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>
    Formula:C29H35N7O4
    Purity:98% - 99.91%
    Color and Shape:Solid
    Molecular weight:545.63

    Ref: TM-T2378

  • JAK3-IN-6
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    JAK3-IN-6

    CAS:
    <p>JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM</p>
    Formula:C19H18N4O3
    Purity:99.94% - 99.94%
    Color and Shape:Solid
    Molecular weight:350.37

    Ref: TM-T5492

  • Ritlecitinib
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    Ritlecitinib

    CAS:
    <p>Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.</p>
    Formula:C15H19N5O
    Purity:98.82% - 99.92%
    Color and Shape:Solid
    Molecular weight:285.34

    Ref: TM-T5382

  • SHR0302
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    SHR0302

    CAS:
    <p>SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,</p>
    Formula:C18H22N8O2S
    Purity:99.11%
    Color and Shape:Solid
    Molecular weight:414.48

    Ref: TM-T9195

  • AG490
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    AG490

    CAS:
    <p>AG490 inhibits EGFR (0.1 μM IC50), 135x &gt; selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>
    Formula:C17H14N2O3
    Purity:98.6% - 99.39%
    Color and Shape:Yellow Solid
    Molecular weight:294.3

    Ref: TM-T2600

  • RO8191
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    RO8191

    CAS:
    <p>RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.</p>
    Formula:C14H5F6N5O
    Purity:98% - 98.85%
    Color and Shape:Solid
    Molecular weight:373.21

    Ref: TM-T22142

  • SMI-16a
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    SMI-16a

    CAS:
    <p>SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (</p>
    Formula:C13H13NO3S
    Purity:99.99%
    Color and Shape:Solid
    Molecular weight:263.31

    Ref: TM-T3989

  • SAR-20347
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    SAR-20347

    CAS:
    <p>SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).</p>
    Formula:C21H18ClFN4O4
    Purity:98.99% - 99.77%
    Color and Shape:Solid
    Molecular weight:444.84

    Ref: TM-T4210

  • XL019
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    XL019

    CAS:
    <p>XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.</p>
    Formula:C25H28N6O2
    Purity:99.19%
    Color and Shape:Solid
    Molecular weight:444.53

    Ref: TM-T3072

  • Gandotinib
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    Gandotinib

    CAS:
    <p>LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).</p>
    Formula:C23H25ClFN7O
    Purity:99.33% - 99.86%
    Color and Shape:Solid
    Molecular weight:469.94

    Ref: TM-T2638

  • Momelotinib HCl
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    Momelotinib HCl

    CAS:
    <p>Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.</p>
    Formula:C23H24Cl2N6O2
    Color and Shape:Solid
    Molecular weight:487.38

    Ref: TM-T70823

  • Atractylenolide I
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    Atractylenolide I

    CAS:
    <p>Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.</p>
    Formula:C15H18O2
    Purity:97.55% - 99.92%
    Color and Shape:Solid
    Molecular weight:230.3

    Ref: TM-T5S0167

  • TCS-PIM-1-4a
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    TCS-PIM-1-4a

    CAS:
    <p>SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).</p>
    Formula:C11H6F3NO2S
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:273.23

    Ref: TM-T4215

  • Peficitinib
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    Peficitinib

    CAS:
    <p>Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.</p>
    Formula:C18H22N4O2
    Purity:98.67% - 99.4%
    Color and Shape:Solid
    Molecular weight:326.39

    Ref: TM-T6933

  • Tofacitinib Citrate
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    Tofacitinib Citrate

    CAS:
    <p>Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).</p>
    Formula:C22H28N6O8
    Purity:99.19% - 99.75%
    Color and Shape:Solid
    Molecular weight:504.49

    Ref: TM-T2398

  • Gusacitinib HCl
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    Gusacitinib HCl

    CAS:
    <p>Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.</p>
    Formula:C24H29ClN8O2
    Color and Shape:Solid
    Molecular weight:497

    Ref: TM-T69766

  • Ruxolitinib (S enantiomer)
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    Ruxolitinib (S enantiomer)

    CAS:
    <p>Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.</p>
    Formula:C17H18N6
    Purity:99.37% - 99.79%
    Color and Shape:Solid
    Molecular weight:306.36

    Ref: TM-T6156