JAK/STAT signaling
JAK/STAT signaling inhibitors are compounds that disrupt the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, which is involved in cytokine signaling, cell growth, and immune response. These inhibitors are important tools in studying the regulation of this pathway and its role in various diseases, including cancers, immune disorders, and inflammatory conditions. JAK/STAT inhibitors are also being developed as targeted therapies for these diseases. At CymitQuimica, we provide a wide selection of high-quality JAK/STAT signaling inhibitors to support your research in molecular biology, oncology, and immunology.
Subcategories of "JAK/STAT signaling"
Found 361 products of "JAK/STAT signaling"
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NVP-BSK805
CAS:NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.Formula:C27H28F2N6OPurity:98%Color and Shape:SolidMolecular weight:490.55TLC1566-0618
CAS:TLC1566-0618 shows antitumor activity and targets stat.Formula:C20H15NO3S3Purity:98%Color and Shape:SolidMolecular weight:413.53Golotimod TFA
CAS:Golotimod TFA (SCV 07 TFA) is a dipeptide exhibiting immunomodulatory and antibacterial activity, alleviates radiation-induced oral mucositis.Formula:C18H20F3N3O7Purity:98%Color and Shape:SoildMolecular weight:447.36(3S,4S)-Tofacitinib
CAS:(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.Formula:C16H20N6OPurity:98%Color and Shape:SolidMolecular weight:312.37JAK3-IN-12
CAS:JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.Formula:C19H19N5O4SColor and Shape:SolidMolecular weight:413.45K00135
CAS:K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.Formula:C18H18N4OPurity:98.16%Color and Shape:SolidMolecular weight:306.36JAK-IN-11
CAS:JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.Formula:C23H22FN5O4SPurity:99.75%Color and Shape:SolidMolecular weight:483.52CX-6258
CAS:CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.Formula:C26H24ClN3O3Purity:97.46%Color and Shape:SolidMolecular weight:461.94Ref: TM-T1834
1mg34.00€5mg75.00€10mg101.00€25mg197.00€50mg295.00€100mg447.00€200mg623.00€1mL*10mM (DMSO)77.00€JAK-IN-20
CAS:JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.Formula:C28H30FN7O2Color and Shape:SolidMolecular weight:515.58Niclosamide monohydrate
CAS:Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication.Formula:C13H10Cl2N2O5Purity:98%Color and Shape:SolidMolecular weight:345.14Peficitinib hydrochloride
CAS:Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).Formula:C18H23ClN4O2Color and Shape:SolidMolecular weight:362.86TK4b
CAS:TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).Formula:C21H22N2O2Color and Shape:SolidMolecular weight:334.41TK4g
CAS:TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) & 15.80 nM (JAK3); promising for lymphoid diseases & leukemia research.Formula:C19H19N3O4SColor and Shape:SolidMolecular weight:385.44JAK-2/3-IN-2
CAS:JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).Formula:C19H19ClN2OSColor and Shape:SolidMolecular weight:358.89XZH-5
CAS:XZH-5 is an inhibitor of STAT3.Formula:C22H25F6N5O4Purity:98%Color and Shape:SolidMolecular weight:537.46JAK-IN-14
CAS:JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.Formula:C19H15FN4OPurity:98.27%Color and Shape:SolidMolecular weight:334.35Ref: TM-T9764
1mg81.00€5mg170.00€10mg268.00€25mg555.00€50mg888.00€100mg1,414.00€200mg1,882.00€1mL*10mM (DMSO)178.00€TyK2-IN-2
CAS:TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).Formula:C16H18N6OPurity:98%Color and Shape:SolidMolecular weight:310.35JAK-IN-18
CAS:"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."Formula:C27H28F2N6O3Color and Shape:SolidMolecular weight:522.55Tyk2-IN-5
CAS:Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).Formula:C21H19FN8O2Purity:98%Color and Shape:SolidMolecular weight:434.43Tyk2-IN-7
CAS:Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).Formula:C18H15D3N6O3SPurity:98%Color and Shape:SolidMolecular weight:401.46MS-1020
CAS:MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.Formula:C21H18N2O3Purity:98%Color and Shape:SolidMolecular weight:346.381,2,3,4,5,6-Hexabromocyclohexane
CAS:Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.Formula:C6H6Br6Purity:98%Color and Shape:SolidMolecular weight:557.54OICR-0547
CAS:OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.Formula:C28H29F3N4O4Purity:98%Color and Shape:SolidMolecular weight:542.55JAK3-IN-9
CAS:JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.Formula:C17H23N5O4SColor and Shape:SolidMolecular weight:393.46EP009
CAS:EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies.Formula:C14H24O2Color and Shape:SolidMolecular weight:224.34INCB16562
CAS:INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.Formula:C19H11Cl2N5Color and Shape:SolidMolecular weight:380.23BP-5-087
CAS:BP-5-087 is a STAT3 inhibitor, combining with BCR-ABL1 inhibition to overcome kinase-independent resistance in chronic myeloid leukemia.Formula:C36H30F8N2O6SColor and Shape:SolidMolecular weight:770.69Galiellalactone
CAS:inhibits IL-6-mediated JAK/STAT signal transductionFormula:C11H14O3Purity:98%Color and Shape:SolidMolecular weight:194.23CP-690550A
CAS:Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.Formula:C15H21N5O2Color and Shape:SolidMolecular weight:303.36GDC-4379
CAS:GDC-4379 is a JAK1 inhibitor that can be used to study asthma.Formula:C21H18ClF2N7O3Color and Shape:SolidMolecular weight:489.86Peficitinib hydrobromide
CAS:Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.Formula:C18H23BrN4O2Color and Shape:SolidMolecular weight:407.312Povorcitinib
CAS:Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).Formula:C23H22F5N7OColor and Shape:SolidMolecular weight:507.469(2R,5S)-Ritlecitinib
CAS:(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].Formula:C15H19N5OColor and Shape:SolidMolecular weight:285.34YM-341619
CAS:YM-341619 (AS1617612), potent STAT6 inhibitor; IC50: 0.70 nM; hinders IL-4-induced Th2 in mice; may aid allergic disease research.Formula:C22H21F3N6O2Color and Shape:SolidMolecular weight:458.44TUL01101
CAS:TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.Formula:C22H25F2N5O2Color and Shape:SolidMolecular weight:429.46Stafia-1-dipivaloyloxymethyl ester
CAS:Stafia-1 suppresses pSTAT5a in a dose-dependent manner (0-200 μM) without affecting pSTAT5b.Formula:C37H48FO13PColor and Shape:SolidMolecular weight:750.74MM-206
CAS:MM-206, a cell-permeable, non-cytotoxic naphthalene sulfonamide compound, it effectively inhibits STAT3 DNA-binding activity.Formula:C22H12F5NO3S2Color and Shape:SolidMolecular weight:497.46MC0704
MC0704: STAT3 inhibitor, IC50=2.13μM, promotes apoptosis & cell arrest, anti-breast cancer, for mTNBC research.Formula:C29H21BrN4O2Color and Shape:SolidMolecular weight:537.41STAT3-IN-15
STAT3-IN-15: Potent, oral STAT3 inhibitor for IPF, blocks STAT3 phosphorylation, cell migration, and EMT.Formula:C20H17F3N2O3SColor and Shape:SolidMolecular weight:422.42Thi-DPPY
CAS:Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.Formula:C28H28ClN5O4SColor and Shape:SolidMolecular weight:566.07HJC0149
CAS:HJC0149 is a potent orally bioavailable signal transducer and activator of transcription 3 inhibitor.Formula:C15H10ClNO4SColor and Shape:SolidMolecular weight:335.76TYK2-IN-11
CAS:TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.Formula:C18H17N5O3SColor and Shape:SolidMolecular weight:383.42SYK/JAK-IN-1
CAS:SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.Formula:C24H26N8O3Color and Shape:SolidMolecular weight:474.52PF-00956980
CAS:PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.Formula:C18H26N6OColor and Shape:SolidMolecular weight:342.44LLL12
CAS:LLL12 inhibits STAT3 phosphorylation, boosting Cisplatin and Paclitaxel effects against ovarian cancer cell activities.Formula:C14H9NO5SColor and Shape:SolidMolecular weight:303.29JAK-IN-10
CAS:JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.Formula:C20H18FN5O3SPurity:99.53%Color and Shape:SolidMolecular weight:427.45Ref: TM-T13571
1mg82.00€5mg167.00€10mg246.00€25mg405.00€50mg572.00€100mg772.00€500mg1,539.00€1mL*10mM (DMSO)178.00€JAK3-IN-1
CAS:JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.Formula:C26H30ClN7O2Color and Shape:SolidMolecular weight:508.02JMS-053
CAS:JMS-053 is a phosphatase DUSP3 inhibitor that inhibits CDC25B and prevents VEGF from disrupting the microvascular endothelial barrier.Formula:C13H8N2O2SPurity:≥98.0%Color and Shape:SolidMolecular weight:256.28TP-5801
CAS:TP-5801 is an orally active non-receptor tyrosine kinase (TNK1) inhibitor with an IC50 value of 1.40 nM and antitumor effects.Formula:C24H31BrN8OColor and Shape:SolidMolecular weight:527.46AC430
CAS:AC430, a specific JAK2 inhibitor for cancer and autoimmune therapy, excels in preclinical trials with low doses. Developed by Ambit.Formula:C19H16FN5OColor and Shape:SolidMolecular weight:349.36
