STAT
STAT proteins are critical components of the JAK/STAT signaling pathway, which transmits extracellular signals from cytokines and growth factors to the cell nucleus, influencing gene expression. STAT proteins are involved in regulating immune responses, cell growth, differentiation, and survival. Dysregulation of STAT signaling is implicated in various diseases, including cancer, autoimmune disorders, and chronic inflammation. At CymitQuimica, we provide a comprehensive range of STAT pathway modulators to support your research in signal transduction, immunology, and therapeutic development.
Found 98 products of "STAT"
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STAT3-IN-41
<p>STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.</p>Formula:C22H30F3NO7Color and Shape:SolidMolecular weight:477.471STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Formula:C19H16N2O4SColor and Shape:SolidMolecular weight:368.41MNK8
CAS:<p>MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.</p>Formula:C15H12N2O2Purity:99.74%Color and Shape:SolidMolecular weight:252.27STX-0119
CAS:<p>STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.</p>Formula:C22H14N4O3Purity:99.61%Color and Shape:SolidMolecular weight:382.37STAT5-IN-3
<p>STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.</p>Formula:C25H27N5OColor and Shape:SolidMolecular weight:413.51JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Color and Shape:Odour SolidEupalinolide K
CAS:<p>Eupalinolide K is a natural product</p>Formula:C20H26O6Purity:98%Color and Shape:SolidMolecular weight:362.42Stafib-1
CAS:<p>Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.</p>Formula:C26H24N2O11P2Purity:97.18%Color and Shape:SolidMolecular weight:602.42Balsalazide
CAS:<p>Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.</p>Formula:C17H15N3O6Purity:99.31%Color and Shape:Yellow To Orange Crystalline PowderMolecular weight:357.32C188-9
CAS:<p>C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.</p>Formula:C27H21NO5SPurity:98.07% - >99.99%Color and Shape:SolidMolecular weight:471.52AS1517499
CAS:<p>AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM). High-Quality, Low-Cost!</p>Formula:C20H20ClN5O2Purity:98.27% - 98.7%Color and Shape:SolidMolecular weight:397.86Protosappanin A
CAS:<p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>Formula:C15H12O5Purity:99.42% - 99.82%Color and Shape:SolidMolecular weight:272.25Atractylenolide I
CAS:<p>Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.</p>Formula:C15H18O2Purity:97.55% - 99.92%Color and Shape:SolidMolecular weight:230.3Picroside I
CAS:<p>Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B.</p>Formula:C24H28O11Purity:99.70%Color and Shape:SolidMolecular weight:492.47RO8191
CAS:<p>RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.</p>Formula:C14H5F6N5OPurity:98% - 98.85%Color and Shape:SolidMolecular weight:373.211-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
CAS:<p>SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.</p>Formula:C21H13ClF3N3O2Purity:99.41%Color and Shape:SolidMolecular weight:431.8Saikosaponin D
CAS:<p>Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.</p>Formula:C42H68O13Purity:98.34% - 99.73%Color and Shape:White PowderMolecular weight:780.98HJC0152 hydrochloride
CAS:<p>HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.</p>Formula:C15H14Cl3N3O4Purity:99.01% - 99.06%Color and Shape:SolidMolecular weight:406.64AS1810722
CAS:<p>AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM.</p>Formula:C25H25F2N7OPurity:99.13%Color and Shape:SolidMolecular weight:477.51TPCA-1
CAS:<p>TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases</p>Formula:C12H10FN3O2SPurity:95.03% - 97.86%Color and Shape:SolidMolecular weight:279.29
