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STAT

STAT

STAT proteins are critical components of the JAK/STAT signaling pathway, which transmits extracellular signals from cytokines and growth factors to the cell nucleus, influencing gene expression. STAT proteins are involved in regulating immune responses, cell growth, differentiation, and survival. Dysregulation of STAT signaling is implicated in various diseases, including cancer, autoimmune disorders, and chronic inflammation. At CymitQuimica, we provide a comprehensive range of STAT pathway modulators to support your research in signal transduction, immunology, and therapeutic development.

Found 110 products for "STAT".

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  • STAT3-IN-20
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    STAT3-IN-20

    CAS:
    STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear
    Formula:C30H27F4N7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:593.64

    Ref: TM-T79662

  • STAT3-IN-B9
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    STAT3-IN-B9

    CAS:
    STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.
    Formula:C20H13NO5S
    Purity:98.19%
    Color and Shape:Yellow Solid
    Molecular weight:379.386

    Ref: TM-T28865

  • Stafib-2
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    Stafib-2

    CAS:
    Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,
    Formula:C28H26N2O12P2
    Purity:98.48%
    Color and Shape:White Solid
    Molecular weight:644.46

    Ref: TM-T9646

  • STAT6-IN-2
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    STAT6-IN-2

    CAS:
    STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.
    Formula:C28H31N5O2
    Purity:99.94%
    Color and Shape:Solid
    Molecular weight:469.58

    Ref: TM-T79185

  • PMMB-187
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    PMMB-187

    CAS:
    PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.
    Formula:C27H23BrN2O6S2
    Color and Shape:Solid
    Molecular weight:615.52

    Ref: TM-T200126

  • STAT3-IN-35
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    STAT3-IN-35

    CAS:
    STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.
    Formula:C21H23NO4
    Color and Shape:Solid
    Molecular weight:353.41

    Ref: TM-T200468

  • WZ-2-033
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    WZ-2-033

    CAS:
    WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.
    Formula:C25H18F3N3O4S
    Color and Shape:Solid
    Molecular weight:513.49

    Ref: TM-T200925

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    STAT6-IN-13

    CAS:
    STAT6-IN-13 (Compound 22) is a STAT6 inhibitor with an IC50 value of ≤300 nM, demonstrating weak inhibition of STAT3. It can be utilized for research in cancer, inflammation, and immunology.
    Formula:C32H33F2N4O6PS
    Molecular weight:670.66

    Ref: TM-T217884

  • STAT3-IN-8
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    STAT3-IN-8

    CAS:
    "STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."
    Formula:C19H7F7N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:444.26

    Ref: TM-T71550

  • KT621 Analog 2
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    KT621 Analog 2

    CAS:
    KT621 Analog 2 also measured the DC50 value of STAT6 to be > 1 µM through the Meso Scale Discovery Assay (MSDA) method. This detection was derived after culturing the human cell line A549 at 37°C for 24 hours.
    Formula:C55H67N11O6S
    Color and Shape:Solid
    Molecular weight:1010.26

    Ref: TM-T212786

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