STAT
STAT proteins are critical components of the JAK/STAT signaling pathway, which transmits extracellular signals from cytokines and growth factors to the cell nucleus, influencing gene expression. STAT proteins are involved in regulating immune responses, cell growth, differentiation, and survival. Dysregulation of STAT signaling is implicated in various diseases, including cancer, autoimmune disorders, and chronic inflammation. At CymitQuimica, we provide a comprehensive range of STAT pathway modulators to support your research in signal transduction, immunology, and therapeutic development.
Found 98 products of "STAT"
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Panaxadiol
CAS:<p>Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.</p>Formula:C30H52O3Purity:98% - 99.9%Color and Shape:SolidMolecular weight:460.73Tetramethylcurcumin
CAS:<p>Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also</p>Formula:C25H28O6Purity:97.69% - 99.94%Color and Shape:SolidMolecular weight:424.49Stattic
CAS:<p>Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation.</p>Formula:C8H5NO4SPurity:98.32% - 99.76%Color and Shape:SolidMolecular weight:211.19Homoharringtonine
CAS:<p>Homoharringtonine (HHT) is an alkaloid combatting myeloid cancers and potentially some myelodysplastic syndromes, may treat leukemia and resistant NSC-LC.</p>Formula:C29H39NO9Purity:98.21% - 99.78%Color and Shape:Off-White CrystMolecular weight:545.62inS3-54-A26
CAS:<p>inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.</p>Formula:C25H19ClN2O2Purity:99.57%Color and Shape:SolidMolecular weight:414.88STAT3-IN-B9
CAS:<p>STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.</p>Formula:C20H13NO5SPurity:98.19%Color and Shape:SolidMolecular weight:379.39inS3-54A18
CAS:<p>inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.</p>Formula:C23H16ClNO2Purity:99.68%Color and Shape:SolidMolecular weight:373.83Stafib-2
CAS:<p>Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,</p>Formula:C28H26N2O12P2Purity:98.48%Color and Shape:SolidMolecular weight:644.46ML115
CAS:<p>ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.</p>Formula:C15H15ClN2O4Purity:99.97%Color and Shape:SolidMolecular weight:322.74STAT6-IN-3
CAS:<p>STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain.</p>Formula:C32H35IN3O7PPurity:98%Color and Shape:SolidMolecular weight:731.51STAT3-IN-20
CAS:<p>STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear</p>Formula:C30H27F4N7SPurity:98%Color and Shape:SolidMolecular weight:593.64Antitumor agent-73
CAS:<p>Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.</p>Formula:C50H82BrO4PPurity:98%Color and Shape:SolidMolecular weight:858.06STAT6-IN-2
CAS:<p>STAT6-IN-2(R)-84 is a STAT6 inhibitor that inhibits the secretion of eotaxin-3 and the tyrosine phosphorylation of STAT6.</p>Formula:C28H31N5O2Purity:99.67%Color and Shape:SolidMolecular weight:469.58WZ-2-033
CAS:<p>WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.</p>Formula:C25H18F3N3O4SColor and Shape:SolidMolecular weight:513.49STAT3-IN-35
CAS:<p>STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.</p>Formula:C21H23NO4Color and Shape:SolidMolecular weight:353.41PMMB-187
CAS:<p>PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.</p>Formula:C27H23BrN2O6S2Color and Shape:SolidMolecular weight:615.52STAT3-IN-8
CAS:<p>"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."</p>Formula:C19H7F7N2O3Purity:98%Color and Shape:SolidMolecular weight:444.26STAT3-IN-36
CAS:<p>STAT3-IN-36 (compound 11g) is a tritarget inhibitor that selectively targets LRPPRC, STAT3, and CDK1, exhibiting potent anticancer activity. This compound binds to LRPPRC, STAT3, and CDK1, demonstrating more effective anticancer effects than those of TMF or Capecitabine. Additionally, STAT3-IN-36 exhibits an IC50 value of 1.8 μM in HGC27 cells.</p>Formula:C30H24F2N2O9S2Color and Shape:SolidMolecular weight:658.65
