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JAK

JAK

JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.

Found 245 products of "JAK"

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  • 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
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    2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

    CAS:
    <p>2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.</p>
    Formula:C16H13Cl2N3O2
    Purity:98.77%
    Color and Shape:Solid
    Molecular weight:350.2

    Ref: TM-T22338

  • Fedratinib
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    Fedratinib

    CAS:
    <p>Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.</p>
    Formula:C27H36N6O3S
    Purity:97.31% - 99.96%
    Color and Shape:Solid
    Molecular weight:524.68

    Ref: TM-T1995

  • Gandotinib
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    Gandotinib

    CAS:
    <p>LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).</p>
    Formula:C23H25ClFN7O
    Purity:99.33% - 99.86%
    Color and Shape:Solid
    Molecular weight:469.94

    Ref: TM-T2638

  • Decernotinib
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    Decernotinib

    CAS:
    <p>Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.</p>
    Formula:C18H19F3N6O
    Purity:99.28% - >99.99%
    Color and Shape:Solid
    Molecular weight:392.38

    Ref: TM-T2636

  • RO495
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    RO495

    CAS:
    <p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>
    Formula:C17H14Cl2N6O
    Purity:97.94%
    Color and Shape:Solid
    Molecular weight:389.24

    Ref: TM-T22416

  • ZM39923 hydrochloride
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    ZM39923 hydrochloride

    CAS:
    <p>ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.</p>
    Formula:C23H25NO·HCl
    Purity:98.05%
    Color and Shape:Solid
    Molecular weight:367.91

    Ref: TM-T6145

  • WP1066
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    WP1066

    CAS:
    <p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>
    Formula:C17H14BrN3O
    Purity:98.92% - 99.73%
    Color and Shape:Solid
    Molecular weight:356.22

    Ref: TM-T2156

  • RGB-286638 free base
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    RGB-286638 free base

    CAS:
    <p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>
    Formula:C29H35N7O4
    Purity:98% - 99.91%
    Color and Shape:Solid
    Molecular weight:545.63

    Ref: TM-T2378

  • Oclacitinib maleate
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    Oclacitinib maleate

    CAS:
    <p>Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with no effect on 38 non-JAK kinases.</p>
    Formula:C15H23N5O2S·C4H4O4
    Purity:99.17%
    Color and Shape:Solid
    Molecular weight:453.51

    Ref: TM-T6914

  • Protosappanin A
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    Protosappanin A

    CAS:
    <p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>
    Formula:C15H12O5
    Purity:99.42% - 99.82%
    Color and Shape:Solid
    Molecular weight:272.25

    Ref: TM-TJS1779

  • Deucravacitinib
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    Deucravacitinib

    CAS:
    <p>Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.</p>
    Formula:C20H19D3N8O3
    Purity:98.52% - >99.99%
    Color and Shape:Solid
    Molecular weight:425.46

    Ref: TM-T14687

  • Pacritinib hydrochloride
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    Pacritinib hydrochloride

    CAS:
    <p>Pacritinib HCl: strong JAK2/Wild-type &amp; JAK2V617F inhibitor (IC50: 23/19 nM), used in AML &amp; MF research.</p>
    Formula:C28H32N4O3·xClH
    Color and Shape:Solid

    Ref: TM-T64283

  • XL019
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    XL019

    CAS:
    <p>XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.</p>
    Formula:C25H28N6O2
    Purity:99.19%
    Color and Shape:Solid
    Molecular weight:444.53

    Ref: TM-T3072

  • TG101209
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    TG101209

    CAS:
    <p>TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.</p>
    Formula:C26H35N7O2S
    Purity:99% - >99.99%
    Color and Shape:Solid
    Molecular weight:509.67

    Ref: TM-T3065

  • FM-381
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    FM-381

    CAS:
    <p>FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.</p>
    Formula:C24H24N6O2
    Purity:98.44%
    Color and Shape:Solid
    Molecular weight:428.49

    Ref: TM-T5091

  • Gusacitinib HCl
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    Gusacitinib HCl

    CAS:
    <p>Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.</p>
    Formula:C24H29ClN8O2
    Color and Shape:Solid
    Molecular weight:497

    Ref: TM-T69766

  • Baricitinib phosphate
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    Baricitinib phosphate

    CAS:
    <p>Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.</p>
    Formula:C16H20N7O6PS
    Purity:99.4% - 99.82%
    Color and Shape:Solid
    Molecular weight:469.41

    Ref: TM-T2360

  • BMS-911543
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    BMS-911543

    CAS:
    <p>BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.</p>
    Formula:C23H28N8O
    Purity:97.69% - 99.98%
    Color and Shape:Solid
    Molecular weight:432.52

    Ref: TM-T6790

  • AMG-47a
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    AMG-47a

    CAS:
    <p>AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.</p>
    Formula:C29H28F3N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:535.56

    Ref: TM-T7123

  • Atractylenolide I
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    Atractylenolide I

    CAS:
    <p>Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.</p>
    Formula:C15H18O2
    Purity:97.55% - 99.92%
    Color and Shape:Solid
    Molecular weight:230.3

    Ref: TM-T5S0167