JNK
JNKs are a subgroup of the MAPK family that respond to stress stimuli, such as cytokines, ultraviolet irradiation, and heat shock, and are involved in controlling apoptosis, inflammation, and immune responses. JNK signaling is crucial for the regulation of cellular stress responses and has been implicated in various diseases, including neurodegenerative disorders, cancer, and inflammatory conditions. At CymitQuimica, we provide a range of JNK pathway modulators to support your research in stress signaling, apoptosis, and disease pathology.
Found 96 products of "JNK"
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IQ-1S
CAS:<p>IQ-1S is an inhibitor of NF-κB/activating protein 1 (AP-1) with an IC50 of 1.8 μM. It exhibits high binding affinity to all three JNKs, with Kd values for JNK3, JNK2, and JNK1 being 87 nM, 360 nM, and 390 nM, respectively.</p>Formula:C15H8N3NaOColor and Shape:SolidMolecular weight:269.23L-JNKI-1
<p>L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.</p>Formula:C164H286N66O40Purity:98%Color and Shape:SolidMolecular weight:3822.44JNK-IN-18
<p>JNK-IN-18 (compound 23b) is a potent inhibitor of JNK1, boasting an IC50 of 2 nM. It demonstrates superior efficacy when compared to its IC50 values of 125 nM for JNK2 and 98 nM for BRAF(V600E).</p>Color and Shape:Odour SolidJNK3 inhibitor-8
<p>JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.</p>Formula:C32H30FN7O3Color and Shape:SolidMolecular weight:579.62Vacquinol-1
CAS:<p>Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.</p>Formula:C21H21ClN2OPurity:98.67%Color and Shape:SolidMolecular weight:352.86JNK2-IN-1
<p>JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α and</p>Formula:C30H26N4O5Purity:98%Color and Shape:SolidMolecular weight:522.55JNK-1-IN-3
CAS:<p>JNK-1-IN-3 (Compound 9e) downregulates JNK1 and phosphorylated JNK1, reduces c-Jun and c-Fos expression in tumours, and restores p53 activity.</p>Formula:C19H17FN4O3Purity:97.551%Color and Shape:SolidMolecular weight:368.36Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Color and Shape:Odour SolidD-JBD19
CAS:<p>D-JBD19 is a non-permeable peptide with neuroprotective effects.</p>Formula:C99H164N32O28Purity:98%Color and Shape:SolidMolecular weight:2250.597MAPK Inhibitor Library
<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>Color and Shape:Odour SolidPROTAC JNK1-targeted-1
<p>PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]</p>Formula:C35H32BrN9O6Color and Shape:SolidMolecular weight:754.589JNK-IN-14
<p>JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.</p>Formula:C27H31N5O4SPurity:98%Color and Shape:SolidMolecular weight:521.63CC-401
CAS:<p>CC-401 is a specific inhibitor of JNK (Ki: 25-50nM).</p>Formula:C22H24N6OPurity:98%Color and Shape:SolidMolecular weight:388.47JIP-1(153-163)
CAS:<p>Peptide based on JIP-1(153-163) inhibits JNK with micromolar affinity; barely affects p38, ERK.</p>Formula:C61H104N20O14Purity:98%Color and Shape:SolidMolecular weight:1341.6JNK1 Protein, Human, Recombinant (GST)
<p>Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family.</p>Color and Shape:Lyophilized PowderMolecular weight:75 kDa (predicted); 65 kDa (reducing conditions)Ezatiostat
CAS:<p>Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.</p>Formula:C27H35N3O6SPurity:97.95%Color and Shape:SolidMolecular weight:529.65Loureirin B
CAS:<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Formula:C18H20O5Purity:99.33% - 99.86%Color and Shape:SolidMolecular weight:316.35Taurochenodeoxycholic Acid
CAS:<p>Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.</p>Formula:C26H45NO6SPurity:99.53% - 99.86%Color and Shape:SolidMolecular weight:499.7Ro 31-8220 Mesylate
CAS:<p>Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.</p>Formula:C25H23N5O2S·CH4O3SPurity:98.79% - 99.02%Color and Shape:SolidMolecular weight:553.65Astragaloside IV
CAS:<p>Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.</p>Formula:C41H68O14Purity:99% - 99.84%Color and Shape:Hydroscopic Brown Or Yellow PowderMolecular weight:784.97
