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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 885 products of "MAPK"

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  • ASK1-IN-1
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    ASK1-IN-1

    CAS:
    <p>ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.</p>
    Formula:C19H19N9O2
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:405.41

    Ref: TM-T9697

  • PROTAC BRAF-V600E degrader-1
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    PROTAC BRAF-V600E degrader-1

    CAS:
    <p>PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.</p>
    Formula:C48H54F2N10O10S
    Purity:99.43%
    Color and Shape:Solid
    Molecular weight:1001.07

    Ref: TM-T8745

  • R1487
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    R1487

    CAS:
    <p>R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.</p>
    Formula:C19H18F2N4O3
    Purity:99.77%
    Color and Shape:Solid
    Molecular weight:388.37

    Ref: TM-T7667

  • ASP2453
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    ASP2453

    CAS:
    <p>ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.</p>
    Formula:C40H48F3N7O4
    Purity:99.71%
    Color and Shape:Solid
    Molecular weight:747.85

    Ref: TM-T39738

  • PLX-4720
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    PLX-4720

    CAS:
    <p>PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.</p>
    Formula:C17H14ClF2N3O3S
    Purity:97.78% - 99.83%
    Color and Shape:Solid
    Molecular weight:413.83

    Ref: TM-T2473

  • ERK-IN-3
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    ERK-IN-3

    CAS:
    <p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>
    Formula:C22H25ClFN7O2
    Purity:99.55% - 99.76%
    Color and Shape:Solid
    Molecular weight:473.93

    Ref: TM-T9141

  • GNE-495
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    GNE-495

    CAS:
    <p>GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).</p>
    Formula:C22H20FN5O2
    Purity:99.22% - 99.57%
    Color and Shape:Solid
    Molecular weight:405.42

    Ref: TM-TQ0079

  • BAY-293
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    BAY-293

    CAS:
    <p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>
    Formula:C25H28N4O2S
    Purity:97.16%
    Color and Shape:Solid
    Molecular weight:448.58

    Ref: TM-T5418

  • (S)-AMG-510
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    (S)-AMG-510

    CAS:
    <p>(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.</p>
    Formula:C30H30F2N6O3
    Purity:99.05% - 99.76%
    Color and Shape:Solid
    Molecular weight:560.594

    Ref: TM-T22258

  • B-Raf IN 11
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    B-Raf IN 11

    CAS:
    <p>B-Raf IN 11 is a novel selective inhibitor.</p>
    Formula:C17H14BrF2N3O3S
    Purity:99.947%
    Color and Shape:Solid
    Molecular weight:458.28

    Ref: TM-T19802

  • Compound 3344 hydrochloride
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    Compound 3344 hydrochloride

    <p>Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>
    Formula:C24H27ClN2O3
    Purity:99.23%
    Color and Shape:Solid
    Molecular weight:426.94

    Ref: TM-T9184L

  • Locostatin
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    Locostatin

    CAS:
    <p>Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.</p>
    Formula:C14H15NO3
    Purity:97.13%
    Color and Shape:Solid
    Molecular weight:245.27

    Ref: TM-T8823

  • SB 239063
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    SB 239063

    CAS:
    <p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>
    Formula:C20H21FN4O2
    Purity:99.42% - 99.81%
    Color and Shape:Solid
    Molecular weight:368.4

    Ref: TM-T6976

  • AZ7550
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    AZ7550

    CAS:
    <p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>
    Formula:C27H31N7O2
    Purity:97.07% - 99.75%
    Color and Shape:Solid
    Molecular weight:485.58

    Ref: TM-T13564

  • IQ-3
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    IQ-3

    CAS:
    <p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>
    Formula:C20H11N3O3
    Purity:≥98%
    Color and Shape:Solid
    Molecular weight:341.32

    Ref: TM-T8477

  • BMS582949
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    BMS582949

    CAS:
    <p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>
    Formula:C22H26N6O2
    Purity:98.11%
    Color and Shape:Solid
    Molecular weight:406.48

    Ref: TM-T6789

  • CC-401 Hydrochloride
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    CC-401 Hydrochloride

    CAS:
    <p>CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.</p>
    Formula:C22H25ClN6O
    Purity:99.71% - ≥95%
    Color and Shape:Solid
    Molecular weight:424.93

    Ref: TM-T5833

  • Maohuoside A
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    Maohuoside A

    CAS:
    <p>Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.</p>
    Formula:C27H32O12
    Purity:98.91% - 99.57%
    Color and Shape:Solid
    Molecular weight:548.54

    Ref: TM-TN2081

  • BI-78D3
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    BI-78D3

    CAS:
    <p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays &gt; 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>
    Formula:C13H9N5O5S2
    Purity:97.89% - >99.99%
    Color and Shape:Solid
    Molecular weight:379.37

    Ref: TM-T6784

  • Sotorasib
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    Sotorasib

    CAS:
    <p>Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.</p>
    Formula:C30H30F2N6O3
    Purity:98% - 99.95%
    Color and Shape:Solid
    Molecular weight:560.594

    Ref: TM-T8684