MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 893 products of "MAPK"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
KRAS inhibitor-38
CAS:KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.Formula:C53H68ClF2N9O8SColor and Shape:SolidMolecular weight:1064.68JNK3 inhibitor-8
JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.Formula:C32H30FN7O3Color and Shape:SolidMolecular weight:579.62DB-10
DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.Color and Shape:Odour SolidNUCC-0200808
NUCC-0200808 (Compound 12g) is an MNK1 inhibitor with an IC50 of 42 nM. It reduces eIF4E phosphorylation and cell viability in AML cells and induces apoptosis. NUCC-0200808 shows potential for research in the field of leukemia.Color and Shape:Odour SolidKRAS G12D inhibitor 6
CAS:KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.Formula:C32H37ClN8O2Color and Shape:SolidMolecular weight:601.15KRAS G12C inhibitor 18
CAS:KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.Formula:C25H20ClFN4O3SColor and Shape:SolidMolecular weight:510.97Tagarafdeg
CAS:Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.Formula:C45H49F2N11O9SPurity:>99.99% - ＞99.99%Color and Shape:SolidMolecular weight:958Rac1 Inhibitor W56
CAS:Peptide (45-60) blocks Rac1 binding with TrioN, GEF-H1, Tiam1 GEFs.Formula:C74H117N19O23SPurity:98%Color and Shape:SolidMolecular weight:1671.93MEK/RAF-IN-1
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.Formula:C28H29F3N6O5SColor and Shape:SolidMolecular weight:618.63NecroX-2
CAS:NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.Formula:C25H32N4O4S2Purity:97.12%Color and Shape:SolidMolecular weight:516.68GNE-9815
CAS:GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selectiveFormula:C26H22FN5O2Purity:99.08% - 99.1%Color and Shape:SolidMolecular weight:455.48Ref: TM-T9585
1mg60.00€5mg138.00€10mg215.00€25mg358.00€50mg510.00€100mg692.00€500mg1,386.00€1mL*10mM (DMSO)138.00€KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formula:C51H65F4N9O9S2Color and Shape:SolidMolecular weight:1088.24BAS 00489700
CAS:BAS 00489700 is a N-UTR interaction inhibitor. BAS 00489700 inhibits virus replication in cell culture.Formula:C19H16N2O4Purity:99.78%Color and Shape:SolidMolecular weight:336.34Ref: TM-T67854
1mg85.00€5mg170.00€10mg250.00€25mg371.00€50mg522.00€100mg712.00€200mg954.00€1mL*10mM (DMSO)170.00€LC 2 Epimer
CAS:Negative control for LC 2.Formula:C59H71ClFN11O7SColor and Shape:SolidMolecular weight:1132.8Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Color and Shape:Odour SolidRef: TM-L1600
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireMAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Color and Shape:Odour SolidRef: TM-L1400
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquire12-Oxo phytodienoic acid
CAS:12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.
Formula:C18H28O3Purity:98%Color and Shape:SolidMolecular weight:292.41FAM49B (190-198) mouse
CAS:FAM49B (190-198) mouse represents a peptide fragment of the mitochondria-localized protein FAM49B, which is instrumental in regulating mitochondrial fission, function, and integrity, in addition to influencing tumor progression. Beyond its role in mitochondrial dynamics, FAM49B serves as a negative regulator of T cell activation by inhibiting GTPase Rac activity and affecting cytoskeleton reorganization.Formula:C49H71N9O14SColor and Shape:SolidMolecular weight:1042.2Z16078526
CAS:Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.Formula:C18H17N3O4SPurity:99.18%Color and Shape:SolidMolecular weight:371.41HPK1-IN-8
CAS:HPK1-IN-8 is an allosteric, inactive, conformation-selective triazolopyrimidine ketone HPK1 inhibitor.Formula:C19H17FN6O2SPurity:99.68%Color and Shape:SolidMolecular weight:412.44
