MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 885 products of "MAPK"
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LC-2
CAS:<p>LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a</p>Formula:C59H71ClFN11O7SPurity:98%Color and Shape:SolidMolecular weight:1132.78Tunlametinib
CAS:<p>Tunlametinib is a MEK1/2 inhibitor (IC50=1.9 nM) for treating RAS/RAF-driven cancers.</p>Formula:C16H12F2IN3O3SPurity:98.72%Color and Shape:SolidMolecular weight:491.25Anti-ERK2 Antibody (5V598)
<p>Anti-ERK2 Antibody (5V598) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (5V598) can be used in ELISA.</p>Color and Shape:Odour LiquidAnti-ERK2 Antibody (4F551)
<p>Anti-ERK2 Antibody (4F551) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (4F551) can be used in ELISA,FCM.</p>Color and Shape:Odour LiquidAnti-ERK2 Antibody (9C922)
<p>Anti-ERK2 Antibody (9C922) is a Mouse antibody targeting ERK2. Anti-ERK2 Antibody (9C922) can be used in WB,ELISA.</p>Color and Shape:Odour LiquidTAK1-IN-3
CAS:<p>TAK1-IN-3 is a novel ATP-competitive TAK1 inhibitor for the study of cancer.</p>Formula:C16H19N3O2SPurity:98.88%Color and Shape:SolidMolecular weight:317.41Enniatin B
CAS:<p>Enniatins B decreases the activation of ERK (p44/p42).</p>Formula:C33H57N3O9Purity:98%Color and Shape:SolidMolecular weight:639.831TRPM4 inhibitor 8
CAS:<p>TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.</p>Formula:C11H17BrN2Purity:97%Color and Shape:SolidMolecular weight:257.17JH295
CAS:<p>JH295: potent, selective Nek2 inhibitor (IC50 = 770 nM), irreversibly targets Cys22, no effect on Cdk1, Aurora B, Plk1, or spindle mechanisms.</p>Formula:C18H16N4O2Color and Shape:SolidMolecular weight:320.352EM127
CAS:<p>EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.</p>Formula:C14H18ClN3O3Purity:97.61%Color and Shape:SolidMolecular weight:311.76RAS GTPase inhibitor 1
CAS:<p>RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.</p>Formula:C27H28ClF4N5O2Purity:98.43%Color and Shape:SolidMolecular weight:565.99IACS-13909
CAS:<p>IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.</p>Formula:C17H18Cl2N6Purity:98.8%Color and Shape:SolidMolecular weight:377.27Gypenoside L
CAS:<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Formula:C42H72O14Purity:99.42% - 99.65%Color and Shape:SolidMolecular weight:801.01L-779450
CAS:<p>L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.</p>Formula:C20H14ClN3OPurity:≥95%Color and Shape:SolidMolecular weight:347.8CC-90001
CAS:<p>CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.</p>Formula:C16H27N5O2Purity:99.96%Color and Shape:SolidMolecular weight:321.42A-674563 2HCl(552325-73-2(fb-2hcl))
<p>A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.</p>Formula:C22H24Cl2N4OPurity:94.66%Color and Shape:SolidMolecular weight:431.36NG25
CAS:<p>NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.</p>Formula:C29H30F3N5O2Purity:98.32% - ≥95%Color and Shape:SolidMolecular weight:537.58K-Ras(G12C) inhibitor 6
CAS:<p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>Formula:C17H22Cl2N2O3SPurity:89.07% - 97.09%Color and Shape:SolidMolecular weight:405.34K-Ras(G12C) inhibitor 9
CAS:<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Formula:C16H21ClIN3O4SPurity:97.33% - 97.45%Color and Shape:SolidMolecular weight:513.78Cichoric Acid
CAS:<p>Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues.</p>Formula:C22H18O12Purity:97.87% - 98.77%Color and Shape:SolidMolecular weight:474.37methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
CAS:<p>methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.</p>Formula:C13H13NO5Purity:97.69%Color and Shape:SolidMolecular weight:263.25AZD8330
CAS:<p>AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.</p>Formula:C16H17FIN3O4Purity:98.72%Color and Shape:SolidMolecular weight:461.23Kobe2602
CAS:<p>Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.</p>Formula:C14H9F4N5O4SPurity:98.36% - 99.39%Color and Shape:SolidMolecular weight:419.31GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Formula:C16H11N5O2SPurity:98.86%Color and Shape:SolidMolecular weight:337.36Belvarafenib
CAS:<p>Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.</p>Formula:C23H16ClFN6OSPurity:98% - 99.65%Color and Shape:SolidMolecular weight:478.93Agerafenib
CAS:<p>Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.</p>Formula:C24H22F3N5O5Purity:95.78% - 99.23%Color and Shape:SolidMolecular weight:517.46SCH772984
CAS:<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Formula:C33H33N9O2Purity:97.565% - 98.75%Color and Shape:SolidMolecular weight:587.67Deltarasin HCl
CAS:<p>Deltarasin hinders KRAS-PDEδ, impairs cancer cell growth via a PDEδ pocket, disrupting RAS/RAF signaling and autophagy.</p>Formula:C40H37N5O·xHClColor and Shape:SolidMolecular weight:713.144RAF709
CAS:<p>RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.</p>Formula:C28H29F3N4O4Purity:99.28% - 99.8%Color and Shape:SolidMolecular weight:542.55NVP-BHG712
CAS:<p>NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and</p>Formula:C26H20F3N7OPurity:97.32% - 98.63%Color and Shape:SolidMolecular weight:503.48ASK1-IN-1
CAS:<p>ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.</p>Formula:C19H19N9O2Purity:99.92%Color and Shape:SolidMolecular weight:405.41PROTAC BRAF-V600E degrader-1
CAS:<p>PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.</p>Formula:C48H54F2N10O10SPurity:99.43%Color and Shape:SolidMolecular weight:1001.07R1487
CAS:<p>R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.</p>Formula:C19H18F2N4O3Purity:99.77%Color and Shape:SolidMolecular weight:388.37ASP2453
CAS:<p>ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.</p>Formula:C40H48F3N7O4Purity:99.71%Color and Shape:SolidMolecular weight:747.85PLX-4720
CAS:<p>PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.</p>Formula:C17H14ClF2N3O3SPurity:97.78% - 99.83%Color and Shape:SolidMolecular weight:413.83ERK-IN-3
CAS:<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Formula:C22H25ClFN7O2Purity:99.55% - 99.76%Color and Shape:SolidMolecular weight:473.93GNE-495
CAS:<p>GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).</p>Formula:C22H20FN5O2Purity:99.22% - 99.57%Color and Shape:SolidMolecular weight:405.42BAY-293
CAS:<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Formula:C25H28N4O2SPurity:97.16%Color and Shape:SolidMolecular weight:448.58(S)-AMG-510
CAS:<p>(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.</p>Formula:C30H30F2N6O3Purity:99.05% - 99.76%Color and Shape:SolidMolecular weight:560.594B-Raf IN 11
CAS:<p>B-Raf IN 11 is a novel selective inhibitor.</p>Formula:C17H14BrF2N3O3SPurity:99.947%Color and Shape:SolidMolecular weight:458.28Compound 3344 hydrochloride
<p>Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Formula:C24H27ClN2O3Purity:99.23%Color and Shape:SolidMolecular weight:426.94Locostatin
CAS:<p>Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.</p>Formula:C14H15NO3Purity:97.13%Color and Shape:SolidMolecular weight:245.27SB 239063
CAS:<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formula:C20H21FN4O2Purity:99.42% - 99.81%Color and Shape:SolidMolecular weight:368.4AZ7550
CAS:<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formula:C27H31N7O2Purity:97.07% - 99.75%Color and Shape:SolidMolecular weight:485.58IQ-3
CAS:<p>IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.</p>Formula:C20H11N3O3Purity:≥98%Color and Shape:SolidMolecular weight:341.32BMS582949
CAS:<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Formula:C22H26N6O2Purity:98.11%Color and Shape:SolidMolecular weight:406.48CC-401 Hydrochloride
CAS:<p>CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.</p>Formula:C22H25ClN6OPurity:99.71% - ≥95%Color and Shape:SolidMolecular weight:424.93Maohuoside A
CAS:<p>Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.</p>Formula:C27H32O12Purity:98.91% - 99.57%Color and Shape:SolidMolecular weight:548.54BI-78D3
CAS:<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Formula:C13H9N5O5S2Purity:97.89% - >99.99%Color and Shape:SolidMolecular weight:379.37Sotorasib
CAS:<p>Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.</p>Formula:C30H30F2N6O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:560.594
