MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 885 products of "MAPK"
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ERK-IN-3
CAS:<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Formula:C22H25ClFN7O2Purity:99.55% - 99.76%Color and Shape:SolidMolecular weight:473.93Talmapimod
CAS:<p>Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.</p>Formula:C27H30ClFN4O3Purity:98% - 99.9%Color and Shape:SolidMolecular weight:513JNK Inhibitor VIII
CAS:<p>JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,</p>Formula:C18H20N4O4Purity:98.93%Color and Shape:SolidMolecular weight:356.38BAY-293
CAS:<p>BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).</p>Formula:C25H28N4O2SPurity:97.16%Color and Shape:SolidMolecular weight:448.58(S)-AMG-510
CAS:<p>(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.</p>Formula:C30H30F2N6O3Purity:99.05% - 99.76%Color and Shape:SolidMolecular weight:560.594Locostatin
CAS:<p>Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.</p>Formula:C14H15NO3Purity:97.13%Color and Shape:SolidMolecular weight:245.27CCT196969
CAS:<p>CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.</p>Formula:C27H24FN7O3Purity:98.93% - 99.65%Color and Shape:SolidMolecular weight:513.52SB 239063
CAS:<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formula:C20H21FN4O2Purity:99.42% - 99.81%Color and Shape:SolidMolecular weight:368.4Dabrafenib
CAS:<p>Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.</p>Formula:C23H20F3N5O2S2Purity:99.62% - >99.99%Color and Shape:SolidMolecular weight:519.56Cefotetan
CAS:<p>Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.</p>Formula:C17H17N7O8S4Purity:95.72% - 99.38%Color and Shape:SolidMolecular weight:575.62CC-401 Hydrochloride
CAS:<p>CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.</p>Formula:C22H25ClN6OPurity:99.71% - ≥95%Color and Shape:SolidMolecular weight:424.93K-Ras(G12C) inhibitor 9
CAS:<p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>Formula:C16H21ClIN3O4SPurity:97.33% - 97.45%Color and Shape:SolidMolecular weight:513.78BI-78D3
CAS:<p>BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.</p>Formula:C13H9N5O5S2Purity:97.89% - >99.99%Color and Shape:SolidMolecular weight:379.37Sotorasib
CAS:<p>Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.</p>Formula:C30H30F2N6O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:560.594SB 242235
CAS:<p>SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.</p>Formula:C19H20FN5OPurity:99.13% - 99.68%Color and Shape:SolidMolecular weight:353.39Refametinib
CAS:<p>Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).</p>Formula:C19H20F3IN2O5SPurity:99.53% - >99.99%Color and Shape:SolidMolecular weight:572.34S6K-18
CAS:<p>S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.</p>Formula:C17H18N4O3SPurity:98.99%Color and Shape:SolidMolecular weight:358.41GW 284543 hydrochloride
CAS:<p>GW 284543 hydrochloride is a selective inhibitor of MEK5 .</p>Formula:C23H21ClN2O3Purity:99.73%Color and Shape:SolidMolecular weight:408.87Ro 5126766
CAS:<p>RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.</p>Formula:C21H18FN5O5SPurity:98.3% - 98.81%Color and Shape:SolidMolecular weight:471.46PF-06260933 HCl
CAS:<p>PF-06260933 Dihydrochloride, a MAP4K4 inhibitor, hinders HGK, Mink, Tnik (IC50s: 140, 8, 13 nM) and lessens mouse fasting hyperglycemia.</p>Formula:C16H15Cl3N4Color and Shape:SolidMolecular weight:369.68SCH54292
CAS:<p>SCH-54292 is a GDP exchange inhibitor.</p>Formula:C24H28N2O9SPurity:95.65%Color and Shape:SolidMolecular weight:520.55SL327
CAS:<p>SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.</p>Formula:C16H12F3N3SPurity:97.98% - >99.99%Color and Shape:SolidMolecular weight:335.35Pyridoxal 5'-phosphate hydrate
CAS:<p>Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,</p>Formula:C8H10NO6PPurity:97.52%Color and Shape:SolidMolecular weight:247.14CK1-IN-1
CAS:<p>CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.</p>Formula:C24H15F2N3Purity:98.79%Color and Shape:SolidMolecular weight:383.39TAK-715
CAS:<p>TAK-715 is a p38 MAPK inhibitor for p38α.</p>Formula:C24H21N3OSPurity:99.83%Color and Shape:SolidMolecular weight:399.51L-779450
CAS:<p>L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.</p>Formula:C20H14ClN3OPurity:≥95%Color and Shape:SolidMolecular weight:347.8IACS-13909
CAS:<p>IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.</p>Formula:C17H18Cl2N6Purity:98.8%Color and Shape:SolidMolecular weight:377.27DB07268
CAS:<p>DB07268 is a potent and selective JNK1 inhibitor.</p>Formula:C17H15N5O2Purity:98.2% - 98.91%Color and Shape:SolidMolecular weight:321.33p-Cresyl sulfate potassium
CAS:<p>p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanine</p>Formula:C7H7KO4SPurity:99.38%Color and Shape:SolidMolecular weight:226.29XMD17-109
CAS:<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Formula:C36H46N8O3Purity:98.75% - 99.7%Color and Shape:SolidMolecular weight:638.8CC-90001
CAS:<p>CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.</p>Formula:C16H27N5O2Purity:99.96%Color and Shape:SolidMolecular weight:321.42Rasarfin
CAS:<p>Rasarfin inhibits Ras and ARF6.</p>Formula:C23H24ClN3O3Purity:97.98%Color and Shape:SolidMolecular weight:425.91BMS582949
CAS:<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Formula:C22H26N6O2Purity:98.11%Color and Shape:SolidMolecular weight:406.48Cichoric Acid
CAS:<p>Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues.</p>Formula:C22H18O12Purity:97.87% - 98.77%Color and Shape:SolidMolecular weight:474.37SB-590885
CAS:<p>SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).</p>Formula:C27H27N5O2Purity:95.42% - 99.06%Color and Shape:SolidMolecular weight:453.54ZT-12-037-01
CAS:<p>Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).</p>Formula:C21H31N5O2Purity:99.56%Color and Shape:SolidMolecular weight:385.5JNK-IN-7
CAS:<p>JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).</p>Formula:C28H27N7O2Purity:98.02% - 99.53%Color and Shape:SolidMolecular weight:493.56GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Formula:C16H11N5O2SPurity:98.86%Color and Shape:SolidMolecular weight:337.36ARS-1620
CAS:<p>ARS-1620 is a covalent inhibitor of K-RASG12C.</p>Formula:C21H17ClF2N4O2Purity:98.86%Color and Shape:SolidMolecular weight:430.84Neflamapimod
CAS:<p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>Formula:C19H9Cl2F2N3OSPurity:97.88% - 99.75%Color and Shape:SolidMolecular weight:436.26Belvarafenib TFA
<p>Belvarafenib TFA (HM95573 TFA) inhibits RAF: B-RAF (56 nM), B-RAFv600E (7 nM), C-RAF (5 nM) effectively.</p>Formula:C25H17ClF4N6O3SColor and Shape:SolidMolecular weight:592.95Compound 3344 hydrochloride
<p>Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.</p>Formula:C24H27ClN2O3Purity:99.23%Color and Shape:SolidMolecular weight:426.94K-Ras-IN-1
CAS:<p>K-Ras-IN-1 is a K-Ras inhibitor.</p>Formula:C11H13NOSPurity:98.72%Color and Shape:SolidMolecular weight:207.29SCH772984
CAS:<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Formula:C33H33N9O2Purity:97.565% - 98.75%Color and Shape:SolidMolecular weight:587.67JNK-IN-8
CAS:<p>JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).</p>Formula:C29H29N7O2Purity:99.24% - >99.99%Color and Shape:SolidMolecular weight:507.59SUN11602
CAS:<p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>Formula:C26H37N5O2Purity:99.36%Color and Shape:SolidMolecular weight:451.6GSK-114
CAS:<p>GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.</p>Formula:C19H23N5O4SPurity:99.51%Color and Shape:SolidMolecular weight:417.48TA-02
CAS:<p>TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.</p>Formula:C20H13F2N3Purity:99.35% - 99.79%Color and Shape:SolidMolecular weight:333.33ERK5-IN-1
CAS:<p>ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).</p>Formula:C25H29N7O2Purity:97.70%Color and Shape:SolidMolecular weight:459.54Binimetinib
CAS:<p>Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C17H15BrF2N4O3Purity:98.03% - >99.99%Color and Shape:SolidMolecular weight:441.23
