MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 892 products of "MAPK"
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RAF709
CAS:RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.Formula:C28H29F3N4O4Purity:99.28% - 99.8%Color and Shape:SolidMolecular weight:542.55Ref: TM-T3711
1mg38.00€2mg50.00€5mg82.00€10mg124.00€25mg245.00€50mg401.00€100mg592.00€500mg1,243.00€1mL*10mM (DMSO)88.00€Sodium new houttuyfonate
CAS:Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.Formula:C14H27NaO5SPurity:≥98% - ≥98%Color and Shape:SolidMolecular weight:330.41AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formula:C16H17FIN3O4Purity:98.72%Color and Shape:SolidMolecular weight:461.23NG25
CAS:NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.Formula:C29H30F3N5O2Purity:98.32% - ≥95%Color and Shape:SolidMolecular weight:537.58XMD17-109
CAS:XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).
Formula:C36H46N8O3Purity:98.75% - 99.7%Color and Shape:SolidMolecular weight:638.8HPK1-IN-34
CAS:HPK1-IN-34 (Compound 143) is an inhibitor of HPK1 (Haematopoietic progenitor kinase 1) with an IC₅₀ < 0.1 μM, suitable for cancer and immunology research.Formula:C25H28N4O2SPurity:99.39%Color and Shape:SolidMolecular weight:448.58Ref: TM-T72052
1mg136.00€5mg326.00€10mg522.00€25mg1,044.00€50mg1,674.00€100mg2,682.00€1mL*10mM (DMSO)353.00€ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Formula:C40H48F3N7O4Purity:99.71%Color and Shape:SolidMolecular weight:747.85Theaflavin 3,3′-digallate
CAS:Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFormula:C43H32O20Purity:98.71% - 99.86%Color and Shape:SolidMolecular weight:868.70Ref: TM-T5429
1mg87.00€5mg169.00€10mg268.00€25mg462.00€50mg647.00€100mg873.00€200mg1,153.00€1mL*10mM (DMSO)268.00€Cephradine sodium
CAS:Cephradine sodium, a semi-synthetic cephalosporin antibiotic, disrupts bacterial cell wall synthesis, causing lysis.Formula:C16H18N3NaO4SColor and Shape:SolidMolecular weight:371.39Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Formula:C17H20F3N7O2Purity:97.58% - 98.92%Color and Shape:SolidMolecular weight:411.38B-Raf IN 1
CAS:B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.Formula:C29H24F3N5OPurity:97.22% - 99.27%Color and Shape:SolidMolecular weight:515.53Ref: TM-T1845
1mg87.00€2mg113.00€5mg177.00€10mg313.00€25mg530.00€50mg757.00€100mg1,044.00€1mL*10mM (DMSO)210.00€(S)-AMG-510
CAS:(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Formula:C30H30F2N6O3Purity:99.05% - 99.76%Color and Shape:SolidMolecular weight:560.594Ref: TM-T22258
2mg34.00€5mg50.00€10mg80.00€25mg147.00€50mg259.00€100mg404.00€500mg888.00€1mL*10mM (DMSO)73.00€KRPEP-2D acetate
KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.Formula:C110H186N44O27S2Purity:98.94%Color and Shape:SolidMolecular weight:2621.06ASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Formula:C19H19N9O2Purity:99.92%Color and Shape:SolidMolecular weight:405.41Ref: TM-T9697
1mg90.00€5mg215.00€10mg321.00€25mg582.00€50mg873.00€100mg1,216.00€1mL*10mM (DMSO)236.00€PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Formula:C17H14ClF2N3O3SPurity:97.78% - 99.83%Color and Shape:SolidMolecular weight:413.83N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Formula:C11H15NOPurity:99.46% - 99.84%Color and Shape:SolidMolecular weight:177.24Locostatin
CAS:Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.Formula:C14H15NO3Purity:97.13%Color and Shape:SolidMolecular weight:245.27K-Ras(G12C) inhibitor 6
CAS:Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.
Formula:C17H22Cl2N2O3SPurity:89.07% - 97.09%Color and Shape:SolidMolecular weight:405.34CAY10404
CAS:CAY10404: potent COX-1/2 inhibitor; blocks PKB/Akt, MAPK pathways; triggers NSC-LC apoptosis; analgesic, anti-inflammatory, anti-cancer.Formula:C17H12F3NO3SPurity:99.02%Color and Shape:SolidMolecular weight:367.34PLX8394
CAS:Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.Formula:C25H21F3N6O3SPurity:98.75% - >99.99%Color and Shape:SolidMolecular weight:542.53BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Formula:C25H28N4O2SPurity:97.16%Color and Shape:SolidMolecular weight:448.58Ref: TM-T5418
1mg50.00€5mg105.00€10mg177.00€25mg321.00€50mg482.00€100mg710.00€200mg982.00€1mL*10mM (DMSO)116.00€ERK-IN-3
CAS:ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Formula:C22H25ClFN7O2Purity:99.55% - 99.76%Color and Shape:SolidMolecular weight:473.93Pimasertib HCl
CAS:Pimasertib HCl, an oral MEK1/2 inhibitor, may thwart tumor growth by blocking RAS/RAF/MEK/ERK signaling.Formula:C15H16ClFIN3O3Color and Shape:SolidMolecular weight:467.66AS601245
CAS:AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.Formula:C20H16N6SPurity:98% - 99.02%Color and Shape:SolidMolecular weight:372.45Ulixertinib
CAS:Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.Formula:C21H22Cl2N4O2Purity:99.31% - 99.95%Color and Shape:SolidMolecular weight:433.33CC-401 Hydrochloride
CAS:CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Formula:C22H25ClN6OPurity:99.71% - ≥95%Color and Shape:SolidMolecular weight:424.93BI-78D3
CAS:BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.Formula:C13H9N5O5S2Purity:97.89% - >99.99%Color and Shape:SolidMolecular weight:379.37I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFormula:C23H26ClF3N4O2Purity:99.64% - 99.88%Color and Shape:SolidMolecular weight:482.92Deltarasin HCl
CAS:Deltarasin hinders KRAS-PDEδ, impairs cancer cell growth via a PDEδ pocket, disrupting RAS/RAF signaling and autophagy.Formula:C40H37N5O·xHClColor and Shape:SolidMolecular weight:713.144Talmapimod
CAS:Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.Formula:C27H30ClFN4O3Purity:98% - 99.9%Color and Shape:SolidMolecular weight:513Ref: TM-T12871
1mg50.00€2mg73.00€5mg109.00€10mg168.00€25mg358.00€50mg530.00€100mg758.00€1mL*10mM (DMSO)124.00€JNK Inhibitor VIII
CAS:JNK Inhibitor VIII (TCS JNK 6o) is an ATP-competitive selective inhibitor of c-Jun N-terminal kinase (JNK)(IC50 values of 45 nM and 160 nM for JNK-1 and -2,Formula:C18H20N4O4Purity:98.93%Color and Shape:SolidMolecular weight:356.38Refametinib
CAS:Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).Formula:C19H20F3IN2O5SPurity:99.85% - >99.99%Color and Shape:SolidMolecular weight:572.34Ref: TM-T6636
2mg43.00€5mg63.00€10mg93.00€25mg147.00€50mg222.00€100mg326.00€200mg485.00€1mL*10mM (DMSO)79.00€Cefotetan
CAS:Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.Formula:C17H17N7O8S4Purity:95.72% - 99.38%Color and Shape:SolidMolecular weight:575.62Sotorasib
CAS:Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.Formula:C30H30F2N6O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:560.594Ref: TM-T8684
1g1,359.00€1mg37.00€2mg52.00€5mg79.00€10mg126.00€25mg225.00€50mg374.00€100mg459.00€500mg1,026.00€1mL*10mM (DMSO)87.00€Pyridoxal 5'-phosphate hydrate
CAS:Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,Formula:C8H10NO6PPurity:97.52%Color and Shape:SolidMolecular weight:247.14Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Formula:C21H18FN5O5SPurity:98.3% - 98.81%Color and Shape:SolidMolecular weight:471.46Ref: TM-T6971
1mg54.00€2mg78.00€5mg109.00€10mg169.00€25mg311.00€50mg500.00€100mg718.00€1mL*10mM (DMSO)112.00€GSK-114
CAS:GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.Formula:C19H23N5O4SPurity:99.51%Color and Shape:SolidMolecular weight:417.48CK1-IN-1
CAS:CK1-IN-1, a CK1 inhibitor with IC50: 15nM CK1δ, 16nM CK1ε, 73nM p38σ; patent WO2015119579A1.Formula:C24H15F2N3Purity:98.79%Color and Shape:SolidMolecular weight:383.39Ref: TM-T5393
1mg47.00€2mg62.00€5mg92.00€10mg152.00€25mg289.00€50mg447.00€100mg670.00€1mL*10mM (DMSO)101.00€PF-06260933 HCl
CAS:PF-06260933 Dihydrochloride, a MAP4K4 inhibitor, hinders HGK, Mink, Tnik (IC50s: 140, 8, 13 nM) and lessens mouse fasting hyperglycemia.Formula:C16H15Cl3N4Color and Shape:SolidMolecular weight:369.68SCH54292
CAS:SCH-54292 is a GDP exchange inhibitor.Formula:C24H28N2O9SPurity:95.65%Color and Shape:SolidMolecular weight:520.55K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formula:C16H21ClIN3O4SPurity:97.33% - 97.45%Color and Shape:SolidMolecular weight:513.78Ref: TM-T6556
1mg34.00€5mg78.00€10mg108.00€25mg215.00€50mg311.00€100mg425.00€200mg597.00€1mL*10mM (DMSO)108.00€Compound 3344 hydrochloride
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.Formula:C24H27ClN2O3Purity:99.23%Color and Shape:SolidMolecular weight:426.94Ref: TM-T9184L
1mg136.00€5mg269.00€10mg404.00€25mg665.00€50mg888.00€100mg1,243.00€1mL*10mM (DMSO)318.00€BMS582949
CAS:BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.Formula:C22H26N6O2Purity:98.11%Color and Shape:SolidMolecular weight:406.48Ref: TM-T6789
1mg82.00€2mg114.00€5mg200.00€10mg284.00€25mg477.00€50mg692.00€100mg973.00€1mL*10mM (DMSO)200.00€SB 239063
CAS:SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.
Formula:C20H21FN4O2Purity:99.42% - 99.81%Color and Shape:SolidMolecular weight:368.4p-Cresyl sulfate potassium
CAS:p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanineFormula:C7H7KO4SPurity:99.38% - 99.90%Color and Shape:SolidMolecular weight:226.29ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Formula:C21H31N5O2Purity:99.56%Color and Shape:SolidMolecular weight:385.5Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Formula:C23H24ClN3O3Purity:97.98%Color and Shape:SolidMolecular weight:425.91Ref: TM-T9407
1mg38.00€5mg75.00€10mg110.00€25mg193.00€50mg323.00€100mg460.00€200mg620.00€1mL*10mM (DMSO)84.00€Milnacipran
CAS:Milnacipran, an SNRI with 85% bioavailability, treats fibromyalgia and is well absorbed orally.Formula:C15H22N2OColor and Shape:SolidMolecular weight:246.35IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Formula:C17H18Cl2N6Purity:98.8%Color and Shape:SolidMolecular weight:377.27CC-90001
CAS:CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.Formula:C16H27N5O2Purity:99.96%Color and Shape:SolidMolecular weight:321.42
