MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 886 products of "MAPK"
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Divarasib adipate
CAS:<p>Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of <0.01 μM, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].</p>Formula:C35H42ClF4N7O6Color and Shape:SolidMolecular weight:768.2TUS-007
CAS:<p>TUS-007, a non-proteasome inhibiting CANDDY, is an oral KRAS G12D/V degrader for cell-free chemical knockdown and tumor suppression.</p>Formula:C44H54Cl2N8O5Color and Shape:SolidMolecular weight:845.86Anti-inflammatory agent 31
<p>Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.</p>Formula:C19H30O3Color and Shape:SolidMolecular weight:306.44PROTAC KRAS G12C degrader-1
<p>PROTAC KRAS G12C degrader-1, a cereblon-based degrader, promotes CRBN/KRAS G12C dimerization and facilitates the degradation of GFP-KRAS G12C in reporter cells</p>Formula:C50H54ClFN8O6Purity:98%Color and Shape:SolidMolecular weight:917.47SOS1-IN-17
<p>SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.</p>Formula:C29H34F3N5O2Color and Shape:SolidMolecular weight:541.61KRAS inhibitor-33
<p>KRAS inhibitor-33 (compound 115a) is a pyrido[2,3-d]pyrimidine derivative that serves as an effective inhibitor of KRAS, exhibiting an IC50 value of ≤ 100nM.</p>Formula:C33H39ClF2N6O3Color and Shape:SolidMolecular weight:641.15Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Color and Shape:Odour SolidHPK1-IN-39
<p>HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes the</p>Formula:C26H27N7O2Color and Shape:SolidMolecular weight:469.54YN14
<p>YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low</p>Purity:98%Color and Shape:Odour SolidPROTAC MLKL Degrader-1
<p>PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.</p>Formula:C46H55F2N9O9SColor and Shape:SolidMolecular weight:948.05PROTAC SOS1 degrader-3
<p>PROTAC SOS1 degrader-3 efficiently targets and breaks down SOS1 via ubiquitin-proteasome.</p>Formula:C34H32F3N7O6Color and Shape:SolidMolecular weight:691.66KRAS G12D inhibitor 6
CAS:<p>KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D.</p>Formula:C32H37ClN8O2Color and Shape:SolidMolecular weight:601.15RTIL 13
CAS:<p>RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).</p>Formula:C30H55BrN2O3Color and Shape:SolidMolecular weight:571.685G12Si-5
CAS:<p>G12Si-5: covalent K-RasG12S inhibitor, Ki 26 μM, targets S-IIP domain, hinders oncogenic signaling, lowers ERK phosphorylation in mutant cells.</p>Formula:C31H29ClFN5O3Color and Shape:SolidMolecular weight:574.05BI1701963
<p>BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.</p>Formula:C47H62N8O4SColor and Shape:SolidMolecular weight:835.11Debromohymenialdisine
CAS:<p>Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.</p>Formula:C11H11N5O2Color and Shape:SolidMolecular weight:245.242BAY-6035
CAS:<p>BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.</p>Formula:C22H28N4O3Purity:99.97%Color and Shape:SolidMolecular weight:396.48KRpep-2d
CAS:KRpep-2d, a potent inhibitor of K-Ras, effectively suppresses the proliferation of cancer cells driven by K-Ras.Formula:C109H183N43O25S2Color and Shape:SolidMolecular weight:2560.02KRAS inhibitor-24
CAS:<p>KRAS inhibitor-24 (compound 115c), a pyrido-pyridine class KRAS inhibitor, exhibits potent activity against KRas G12V, KRas WT, and KRas G12R, with IC50 values all below 100 nM.</p>Formula:C33H39ClF2N6O3Color and Shape:SolidMolecular weight:641.15G12 TFA
<p>G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.</p>Formula:C54H96F3N15O17Molecular weight:1283.70607
