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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 885 products of "MAPK"

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  • GSK-114
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    GSK-114

    CAS:
    <p>GSK-114, a TNNI3K inhibitor with a 25 nM IC50, is 40x more selective than B-Raf and good for in vivo studies.</p>
    Formula:C19H23N5O4S
    Purity:99.51%
    Color and Shape:Solid
    Molecular weight:417.48

    Ref: TM-T22341

  • Talmapimod
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    Talmapimod

    CAS:
    <p>Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), &gt;2000-fold selectivity over 20 kinases.</p>
    Formula:C27H30ClFN4O3
    Purity:98% - 99.9%
    Color and Shape:Solid
    Molecular weight:513

    Ref: TM-T12871

  • CC-90001
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    CC-90001

    CAS:
    <p>CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.</p>
    Formula:C16H27N5O2
    Purity:99.96%
    Color and Shape:Solid
    Molecular weight:321.42

    Ref: TM-T9688

  • IACS-13909
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    IACS-13909

    CAS:
    <p>IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.</p>
    Formula:C17H18Cl2N6
    Purity:98.8%
    Color and Shape:Solid
    Molecular weight:377.27

    Ref: TM-T9196

  • ARS-1620
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    ARS-1620

    CAS:
    <p>ARS-1620 is a covalent inhibitor of K-RASG12C.</p>
    Formula:C21H17ClF2N4O2
    Purity:98.86%
    Color and Shape:Solid
    Molecular weight:430.84

    Ref: TM-T7609

  • Neflamapimod
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    Neflamapimod

    CAS:
    <p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>
    Formula:C19H9Cl2F2N3OS
    Purity:97.88% - 99.75%
    Color and Shape:Solid
    Molecular weight:436.26

    Ref: TM-T6089

  • CymitQuimica logo
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    Belvarafenib TFA

    <p>Belvarafenib TFA (HM95573 TFA) inhibits RAF: B-RAF (56 nM), B-RAFv600E (7 nM), C-RAF (5 nM) effectively.</p>
    Formula:C25H17ClF4N6O3S
    Color and Shape:Solid
    Molecular weight:592.95

    Ref: TM-T64194

  • K-Ras-IN-1
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    K-Ras-IN-1

    CAS:
    <p>K-Ras-IN-1 is a K-Ras inhibitor.</p>
    Formula:C11H13NOS
    Purity:98.72%
    Color and Shape:Solid
    Molecular weight:207.29

    Ref: TM-T5469

  • PF-06260933 HCl
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    PF-06260933 HCl

    CAS:
    <p>PF-06260933 Dihydrochloride, a MAP4K4 inhibitor, hinders HGK, Mink, Tnik (IC50s: 140, 8, 13 nM) and lessens mouse fasting hyperglycemia.</p>
    Formula:C16H15Cl3N4
    Color and Shape:Solid
    Molecular weight:369.68

    Ref: TM-T33945

  • JNK-IN-8
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    JNK-IN-8

    CAS:
    <p>JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).</p>
    Formula:C29H29N7O2
    Purity:99.24% - >99.99%
    Color and Shape:Solid
    Molecular weight:507.59

    Ref: TM-T2668

  • SUN11602
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    SUN11602

    CAS:
    <p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>
    Formula:C26H37N5O2
    Purity:99.36%
    Color and Shape:Solid
    Molecular weight:451.6

    Ref: TM-T3714

  • L-779450
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    L-779450

    CAS:
    <p>L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays &gt;7, &gt;30 and &gt;70-fold selectivity over p38α, GSK3β and Lck respectively.</p>
    Formula:C20H14ClN3O
    Purity:≥95%
    Color and Shape:Solid
    Molecular weight:347.8

    Ref: TM-T1953

  • GW 284543 hydrochloride
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    GW 284543 hydrochloride

    CAS:
    <p>GW 284543 hydrochloride is a selective inhibitor of MEK5 .</p>
    Formula:C23H21ClN2O3
    Purity:99.73%
    Color and Shape:Solid
    Molecular weight:408.87

    Ref: TM-T7742

  • BI-D1870
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    BI-D1870

    CAS:
    <p>BI-D1870 is a highly specific, blood-brain-permeable, and ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK.Cost-effective and quality-assured.</p>
    Formula:C19H23F2N5O2
    Purity:98.51% - 99.43%
    Color and Shape:Solid
    Molecular weight:391.42

    Ref: TM-T6171

  • SLV-2436
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    SLV-2436

    CAS:
    <p>SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).</p>
    Formula:C19H15ClN4O
    Purity:98.56%
    Color and Shape:Solid
    Molecular weight:350.8

    Ref: TM-T4424

  • 6H05 (TFA)
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    6H05 (TFA)

    CAS:
    <p>6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.</p>
    Formula:C22H31ClF3N3O4S3
    Purity:98.83%
    Color and Shape:Solid
    Molecular weight:590.14

    Ref: TM-T7326

  • ML-098
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    ML-098

    CAS:
    <p>ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).</p>
    Formula:C19H19NO3
    Purity:99.06% - 99.23%
    Color and Shape:Solid
    Molecular weight:309.36

    Ref: TM-T4619

  • MK2-IN-3
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    MK2-IN-3

    CAS:
    <p>MK2-IN-3 is a potent MK-2 inhibitor, cell-permeable, for rheumatoid arthritis treatment.</p>
    Formula:C21H16N4O
    Purity:99.01%
    Color and Shape:Solid
    Molecular weight:340.38

    Ref: TM-T9034

  • 1-(4-methansulfinylphenyl)ethanone
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    1-(4-methansulfinylphenyl)ethanone

    CAS:
    <p>The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.</p>
    Formula:C9H10O2S
    Purity:99.48%
    Color and Shape:Solid
    Molecular weight:182.24

    Ref: TM-T8870

  • Cichoric Acid
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    Cichoric Acid

    CAS:
    <p>Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues.</p>
    Formula:C22H18O12
    Purity:97.87% - 98.77%
    Color and Shape:Solid
    Molecular weight:474.37

    Ref: TM-TL0006