MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
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K-Ras G12C-IN-4
CAS:2376328-55-9
K-Ras G12C-IN-4 is a potent co-valent Inhibitor of KRAS G12C..
Formula:
C31H33ClN4O4
Purity:
99.00%
Color and Shape:
Solid
Molecular weight:
561.07
Ref: TM-T11738
| 1mg | 72.00 € | ||
| 5mg | 164.00 € | ||
| 10mg | 241.00 € | ||
| 25mg | 410.00 € | ||
| 50mg | 543.00 € | ||
| 100mg | 797.00 € | ||
| 200mg | 1,072.00 € | ||
| 1mL*10mM (DMSO) | 196.00 € |
Estimated delivery in United States, on Tuesday 3 Dec 2024
LUT014
CAS:2274819-46-2
LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions …
Formula:
C27H19F3N8O
Purity:
99.03%
Color and Shape:
Solid
Molecular weight:
528.49
Ref: TM-T15794
| 1mg | 65.00 € | ||
| 5mg | 140.00 € | ||
| 10mg | 184.00 € | ||
| 25mg | 339.00 € | ||
| 50mg | 476.00 € | ||
| 100mg | 666.00 € | ||
| 1mL*10mM (DMSO) | 163.00 € |
Estimated delivery in United States, on Tuesday 3 Dec 2024
AX-15836
CAS:2035509-96-5
AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).
Formula:
C32H40N8O5S
Purity:
98.96%
Color and Shape:
Solid
Molecular weight:
648.78
Ref: TM-T14360
| 1mg | 57.00 € | ||
| 2mg | 81.00 € | ||
| 5mg | 120.00 € | ||
| 10mg | 169.00 € | ||
| 25mg | 295.00 € | ||
| 50mg | 421.00 € | ||
| 100mg | 593.00 € | ||
| 500mg | 1,216.00 € | ||
| 1mL*10mM (DMSO) | 172.00 € |
Estimated delivery in United States, on Tuesday 3 Dec 2024
MAP4K4-IN-3
CAS:1811510-58-3
MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.
Formula:
C15H12ClN5
Purity:
98.07%
Color and Shape:
Solid
Molecular weight:
297.74
Ref: TM-T11942
| 5mg | 46.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 149.00 € | ||
| 50mg | 230.00 € | ||
| 100mg | 365.00 € | ||
| 200mg | 540.00 € | ||
| 500mg | 827.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Tuesday 3 Dec 2024
BI-3406
CAS:2230836-55-0
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless …
Formula:
C23H25F3N4O3
Purity:
99.20% - 99.66%
Color and Shape:
Solid
Molecular weight:
462.46
Ref: TM-T12979
| 1mg | 72.00 € | ||
| 5mg | 157.00 € | ||
| 10mg | 245.00 € | ||
| 25mg | 453.00 € | ||
| 50mg | 649.00 € | ||
| 100mg | 903.00 € | ||
| 500mg | 1,793.00 € | ||
| 1mL*10mM (DMSO) | 168.00 € |
Estimated delivery in United States, on Tuesday 3 Dec 2024
ARS-1630
CAS:1698055-86-5
ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.
Formula:
C21H17ClF2N4O2
Purity:
97.81%
Color and Shape:
Solid
Molecular weight:
430.84
Ref: TM-T10376
| 1mg | 51.00 € | ||
| 5mg | 113.00 € | ||
| 10mg | 164.00 € | ||
| 25mg | 314.00 € | ||
| 50mg | 451.00 € | ||
| 100mg | 593.00 € | ||
| 1mL*10mM (DMSO) | 129.00 € |
Estimated delivery in United States, on Tuesday 3 Dec 2024
Allicin
CAS:539-86-6
Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal …
Formula:
C6H10OS2
Purity:
≥98%
Color and Shape:
Clear To Slightly Yellow Liquid
Molecular weight:
162.27
Ref: TM-T3123
| 1g | 276.00 € | ||
| 25mg | 47.00 € | ||
| 50mg | 60.00 € | ||
| 100mg | 91.00 € | ||
| 500mg | 184.00 € | ||
| 1mL*10mM (DMSO) | 65.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
GNE-9815
CAS:2729996-45-4
GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selective
Formula:
C26H22FN5O2
Purity:
98.19% - 98.73%
Color and Shape:
Solid
Molecular weight:
455.48
Ref: TM-T9585
| 1mg | 63.00 € | ||
| 5mg | 143.00 € | ||
| 10mg | 221.00 € | ||
| 25mg | 369.00 € | ||
| 50mg | 527.00 € | ||
| 100mg | 713.00 € | ||
| 500mg | 1,430.00 € | ||
| 1mL*10mM (DMSO) | 145.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
STE-MEK1(13)
CAS:566872-15-9
STE-MEK1(13), a cell-permeable ERK1/2 inhibitor with IC50 values ranging from 13 to 30 μM, impedes …
Formula:
C86H153N19O17S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
1757.32
Ref: TM-T80543
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 2 Dec 2024
HPK1-IN-4
CAS:2739844-28-9
HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is …
Formula:
C23H26N6O3
Purity:
97.2%
Color and Shape:
Liquid
Molecular weight:
434.49
Ref: TM-T40350
| 1mg | 127.00 € | ||
| 5mg | 305.00 € | ||
| 10mg | 460.00 € | ||
| 25mg | 805.00 € | ||
| 50mg | 1,103.00 € | ||
| 100mg | 1,511.00 € | ||
| 1mL*10mM (DMSO) | 343.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
Cyclorasin 9A5
CAS:1782098-79-6
Cyclorasin 9A5 is a cell-permeable, 11-residue cyclic peptide that orthosterically disrupts the Ras-Raf protein interaction, …
Formula:
C75H108FN25O13
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
1586.82
Ref: TM-T82637
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 2 Dec 2024
JNK-IN-12
JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor with an IC50 value of 66.3 nM, …
Formula:
C56H82N16O7
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
1091.35
Ref: TM-T79296
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 2 Dec 2024
Endothelin-1 (1-31) (Human) TFA
Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from the chymase-mediated selective …
Formula:
C164H237F3N38O49S5
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
3742.18
Ref: TM-T78063
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 2 Dec 2024
n-Butyl α-D-fructofuranoside
CAS:80971-59-1
N-Butyl α-D-fructofuranoside, extracted from the root barks of Ulmus davidiana var.
Formula:
C10H20O6
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
236.26
Ref: TM-T80005
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Monday 2 Dec 2024
MLKL-IN-2
CAS:899759-16-1
MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related …
Formula:
C26H25N5O
Purity:
98.61%
Color and Shape:
Solid
Molecular weight:
423.51
Ref: TM-T41027
| 1mg | 90.00 € | ||
| 5mg | 184.00 € | ||
| 10mg | 305.00 € | ||
| 25mg | 631.00 € | ||
| 50mg | 993.00 € | ||
| 100mg | 1,532.00 € | ||
| 200mg | 2,070.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
Lup-20(29)-en-28-oic acid
CAS:848784-85-0
Lup-20(29)-en-28-oic acid: Anticancer, blocks autophagy, boosts chemotherapeutics in HeLa cells. Pulsatilla saponin D: Has haemolytic …
Formula:
C47H76O17
Purity:
98%
Color and Shape:
Solid
Molecular weight:
913.1
Ref: TM-TN2118
| 5mg | 519.00 € | ||
| 1mL*10mM (DMSO) | 803.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
Opnurasib
CAS:2653994-08-0
Opnurasib (JDQ-443) is an orally available and selective and potent covalent KRAS G12C inhibitor with …
Formula:
C29H28ClN7O
Purity:
98% - 98.88%
Color and Shape:
Solid
Molecular weight:
526.03
Ref: TM-T40292
| 1mg | 103.00 € | ||
| 5mg | 348.00 € | ||
| 10mg | 517.00 € | ||
| 25mg | 835.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 401.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
ERK5-IN-6
CAS:2734916-64-2
ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study …
Formula:
C23H21N3
Purity:
98.59%
Color and Shape:
Soild
Molecular weight:
339.43
Ref: TM-T77731
| 1mg | 181.00 € | ||
| 5mg | 449.00 € | ||
| 10mg | 643.00 € | ||
| 25mg | 1,003.00 € | ||
| 50mg | 1,383.00 € | ||
| 100mg | 1,841.00 € | ||
| 500mg | 3,647.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
Ro-3201195
CAS:249937-52-8
Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.
Formula:
C19H18FN3O4
Purity:
100%
Color and Shape:
Liquid
Molecular weight:
371.36
Ref: TM-T68134
| 1mg | 125.00 € | ||
| 5mg | 299.00 € | ||
| 10mg | 446.00 € | ||
| 25mg | 735.00 € | ||
| 50mg | 1,009.00 € | ||
| 100mg | 1,374.00 € | ||
| 500mg | 2,747.00 € | ||
| 1mL*10mM (DMSO) | 326.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
KG5
CAS:877874-85-6
KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM …
Formula:
C20H16F3N7OS
Purity:
98.2%
Color and Shape:
Liquid
Molecular weight:
459.45
Ref: TM-T41003
| 1mg | 34.00 € | ||
| 2mg | 45.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 102.00 € | ||
| 25mg | 198.00 € | ||
| 50mg | 302.00 € | ||
| 100mg | 434.00 € | ||
| 200mg | 608.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Monday 2 Dec 2024
