MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 901 products for "MAPK". Showing the first 500.
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TAT-PAK18 R192A
TAT-PAK18 R192A is an inactive Tat-Pak peptide. It does not influence Rac1 translocation triggered by any tested proteins.Formula:C143H247N55O37Molecular weight:3326.91369PROTAC MEK1 Degrader-1
CAS:PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Formula:C53H66FIN8O11S2Purity:98%Color and Shape:SolidMolecular weight:1201.17KRAS G12C inhibitor 60
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, andFormula:C31H30F5N7O2Purity:98%Color and Shape:SolidMolecular weight:627.61Tagarafdeg
CAS:Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.Formula:C45H49F2N11O9SPurity:>99.99% - ＞99.99%Color and Shape:SolidMolecular weight:958ERK2 IN-5
CAS:ERK2IN-5 (Compound 5g) is an inhibitor of ERK2 and demonstrates good affinity for both ERK2 and JNK3, with Ki values of 86 nM and 550 nM, respectively.Formula:C21H17ClN4OMolecular weight:376.84R18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Formula:C101H157N27O29S3Purity:98%Color and Shape:SolidMolecular weight:2309.69BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Formula:C47H62N8O4SColor and Shape:SolidMolecular weight:835.11GNE-9815
CAS:GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selectiveFormula:C26H22FN5O2Purity:99.08% - 99.1%Color and Shape:SolidMolecular weight:455.48Ref: TM-T9585
1mg60.00€5mg138.00€1mL*10mM (DMSO)138.00€10mg215.00€25mg358.00€50mg510.00€100mg692.00€500mg1,386.00€HPK1-IN-4
CAS:HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.Formula:C23H26N6O3Purity:97.06%Color and Shape:Yellow SolidMolecular weight:434.49Ref: TM-T40350
1mg123.00€5mg295.00€1mL*10mM (DMSO)326.00€10mg447.00€25mg782.00€50mg1,071.00€100mg1,468.00€MS432
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.Formula:C50H65F3IN7O6SPurity:98%Color and Shape:SolidMolecular weight:1076.06AM-001
CAS:AM-001, a non-competitive inhibitor of Epac1, effectively blocks the activation of Rap1, a downstream effector of Epac1, in cultured cells, and is commonly used in heart disease-related research.Formula:C24H16FN3OS2Purity:99.92%Color and Shape:Yellow SolidMolecular weight:445.53Antimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFormula:C18H13N3OSPurity:99.82%Color and Shape:SolidMolecular weight:319.38Ref: TM-T67942
1mg54.00€5mg116.00€10mg172.00€1mL*10mM (DMSO)180.00€25mg278.00€50mg371.00€100mg510.00€200mg687.00€LYMTAC-2
LYMTAC-2 is a lysosome-targeting chimera (LYMTAC) developed to degrade membrane-associated proteins through lysosomal membrane proteins (LMP) such as RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with target proteins like KRASG12D, facilitating their relocation to lysosomes and resulting in ubiquitin-dependent degradation. This compound has potential for studying membrane protein regulation and devising strategies to counter resistance in KRAS-driven signaling pathways.Color and Shape:SolidMolecular weight:1248.44(S,R,S)-AHPC-Me-C10-Br
CAS:(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate and ligand-linker for E3 ligase, MS432 for MEK1/2 inhibitors and a VHL E3 ligase linker.Formula:C34H51BrN4O4SPurity:98.89%Color and Shape:SolidMolecular weight:691.76JTP10-△-TATi TFA
JTP10-△-TATi TFA is a selective inhibitor of JNK2 peptide (IC50: 92 nM), exhibiting 10-fold selectivity for JNK2 over JNK1 and JNK3.Formula:C120H213F3N48O28Purity:98%Color and Shape:SolidMolecular weight:2833.28Fluconazole-PEG6-XMU-MP-9
Fluconazole-PEG6-XMU-MP-9, PEG-linked conjugate, fluconazole antifungal plus XMU-MP-9, promotes Nedd4-1 mediated K-Ras mutant degradation.Formula:C48H53F3N10O10SPurity:98.73%Molecular weight:1019.06MEK/RAF-IN-1
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.Formula:C28H29F3N6O5SColor and Shape:SolidMolecular weight:618.63Cobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Formula:C21H21F3IN3O2Purity:98%Color and Shape:SolidMolecular weight:531.318NK7-902 TFA
NK7-902 TFA is a CRBN molecular glue degrader of NEK7. It effectively degrades NEK7 in human primary monocytes and whole blood, yet only partially inhibits NLRP3-dependent IL-1β production. While NK7-902 TFA achieves deep and lasting NEK7 degradation, it temporarily blocks NLRP3 inflammasome activation in non-human primates when administered orally. Additionally, NK7-902 TFA demonstrates activity in mouse systems.Color and Shape:Odour Solid(RS)-G12Di-1
(RS)-G12Di-1 is a selective covalent inhibitor of K-Ras-G12D.Formula:C37H35FN6O4Molecular weight:646.27038
