MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
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B-Raf IN 1
CAS:950736-05-7
B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.
Formula:
C29H24F3N5O
Purity:
97.22% - 99.27%
Color and Shape:
Solid
Molecular weight:
515.53
Ref: TM-T1845
| 1mg | 93.00 € | ||
| 2mg | 118.00 € | ||
| 5mg | 188.00 € | ||
| 10mg | 330.00 € | ||
| 25mg | 560.00 € | ||
| 50mg | 801.00 € | ||
| 100mg | 1,103.00 € | ||
| 200mg | 867.00 € | ||
| 1mL*10mM (DMSO) | 222.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
NCB-0846
CAS:1792999-26-8
NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
Formula:
C21H21N5O2
Purity:
97.04% - 99.46%
Color and Shape:
Solid
Molecular weight:
375.42
Ref: TM-T4011
| 1mg | 36.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 245.00 € | ||
| 50mg | 418.00 € | ||
| 100mg | 615.00 € | ||
| 1mL*10mM (DMSO) | 86.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
VX-702
CAS:745833-23-2
VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.
Formula:
C19H12F4N4O2
Purity:
100% - 99%
Color and Shape:
Solid
Molecular weight:
404.32
Ref: TM-T2513
| 10mg | 54.00 € | ||
| 25mg | 83.00 € | ||
| 50mg | 131.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 18 Dec 2024
Sulindac sulfide
CAS:49627-27-2
Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid …
Formula:
C20H17FO2S
Purity:
99.68%
Color and Shape:
Solid
Molecular weight:
340.41
Ref: TM-T13037
| 10mg | 36.00 € | ||
| 25mg | 52.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
6H05
CAS:1469338-01-9
6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
Formula:
C20H30ClN3O2S3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
476.12
Ref: TM-T1931
| 5mg | 124.00 € | ||
| 10mg | 212.00 € | ||
| 25mg | 348.00 € | ||
| 50mg | 516.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
FMK
CAS:821794-92-7
FMK is an irreversible inhibitor of RSK2 kinase.
Formula:
C18H19FN4O2
Purity:
98.93%
Color and Shape:
Solid
Molecular weight:
342.37
Ref: TM-TQ0310
| 1mg | 73.00 € | ||
| 2mg | 94.00 € | ||
| 5mg | 171.00 € | ||
| 10mg | 295.00 € | ||
| 25mg | 502.00 € | ||
| 50mg | 722.00 € | ||
| 100mg | 1,016.00 € | ||
| 500mg | 2,023.00 € | ||
| 1mL*10mM (DMSO) | 186.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Vincristine
CAS:57-22-7
Vincristine, a microtubule disruptor, inhibits mitosis in cancer cells, useful in leukemia research.
Formula:
C46H56N4O10
Purity:
100%
Color and Shape:
Solid
Molecular weight:
824.96
Ref: TM-T3S0209
| 20mg | 143.00 € | ||
| 1mL*10mM (DMSO) | 118.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
PLX7904
CAS:1393465-84-3
PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it …
Formula:
C24H22F2N6O3S
Purity:
96.27% - 96.27%
Color and Shape:
Solid
Molecular weight:
512.53
Ref: TM-T6949
| 5mg | 49.00 € | ||
| 10mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
IM-54
CAS:861891-50-1
IM-54 is a cell-permeable, effective, and selective necrosis inhibitor.
Formula:
C19H23N3O2
Purity:
99.05%
Color and Shape:
Solid
Molecular weight:
325.4
Ref: TM-T24160
| 1mg | 57.00 € | ||
| 5mg | 125.00 € | ||
| 10mg | 181.00 € | ||
| 25mg | 306.00 € | ||
| 50mg | 456.00 € | ||
| 100mg | 653.00 € | ||
| 500mg | 1,328.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
RMC-0331
CAS:2488788-52-7
RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer …
Formula:
C22H25ClF3N5O3
Purity:
99.81%
Color and Shape:
Solid
Molecular weight:
499.91
Ref: TM-T38170
| 1mg | 143.00 € | ||
| 2mg | 207.00 € | ||
| 5mg | 346.00 € | ||
| 10mg | 616.00 € | ||
| 25mg | 1,273.00 € | ||
| 50mg | 1,977.00 € | ||
| 100mg | 2,935.00 € | ||
| 1mL*10mM (DMSO) | 375.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
ZINC12409120
CAS:1010888-06-8
ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 …
Formula:
C20H16N4O2
Purity:
98.69% - 99.84%
Color and Shape:
Liquid
Molecular weight:
344.37
Ref: TM-T61122
| 1mg | 325.00 € | ||
| 5mg | 769.00 € | ||
| 10mg | 1,049.00 € | ||
| 25mg | 1,476.00 € | ||
| 50mg | 1,838.00 € | ||
| 100mg | 2,336.00 € | ||
| 500mg | 4,549.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
M443
CAS:1820684-31-8
M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 …
Formula:
C31H30F3N7O2
Purity:
98.95%
Color and Shape:
Solid
Molecular weight:
589.61
Ref: TM-T15943
| 1mg | 185.00 € | ||
| 1mL*10mM (DMSO) | 355.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
JNK-IN-11
CAS:676594-38-0
JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.
Formula:
C12H11NO3S2
Purity:
98.82%
Color and Shape:
Solid
Molecular weight:
281.35
Ref: TM-T60534
| 1mg | 46.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 138.00 € | ||
| 25mg | 269.00 € | ||
| 50mg | 397.00 € | ||
| 100mg | 578.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
AKP-001
CAS:897644-83-6
AKP-001 is a selective inhibitor of MAPK of the p38α isoform and is used in …
Formula:
C21H13ClF2N4O2
Purity:
99.50% - 99.92%
Color and Shape:
Solid
Molecular weight:
426.8
Ref: TM-T25015
| 25mg | 1,410.00 € | ||
| 50mg | 1,845.00 € | ||
| 100mg | 2,329.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
EB1
CAS:42951-68-8
EB1 is an MNK kinase inhibitor that inhibits cancer cell growth, promotes apoptosis, and inhibits …
Formula:
C18H14N4
Purity:
99.82%
Color and Shape:
Liquid
Molecular weight:
286.33
Ref: TM-T73582
| 1g | 3,239.00 € | ||
| 1mg | 74.00 € | ||
| 5mg | 157.00 € | ||
| 10mg | 221.00 € | ||
| 25mg | 367.00 € | ||
| 50mg | 551.00 € | ||
| 100mg | 785.00 € | ||
| 500mg | 2,181.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
KRAS inhibitor-6
CAS:2022986-61-2
KRAS inhibitor-6 is a potent KRAS G12C inhibitor.
Formula:
C27H30ClF2N5O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
546.01
Ref: TM-T11773
| 25mg | 1,549.00 € | ||
| 50mg | 2,031.00 € | ||
| 100mg | 2,609.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
Jolkinolide B
CAS:37905-08-1
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud.
Formula:
C20H26O4
Purity:
99.39%
Color and Shape:
Solid
Molecular weight:
330.42
Ref: TM-T2S1040
| 1mg | 65.00 € | ||
| 5mg | 141.00 € | ||
| 10mg | 212.00 € | ||
| 25mg | 361.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
SR-3306
CAS:1128096-91-2
SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, …
Formula:
C28H26N8O
Purity:
99.50% - 99.81%
Color and Shape:
Solid
Molecular weight:
490.56
Ref: TM-T16927
| 1mg | 52.00 € | ||
| 5mg | 101.00 € | ||
| 10mg | 158.00 € | ||
| 25mg | 296.00 € | ||
| 50mg | 537.00 € | ||
| 100mg | 862.00 € | ||
| 500mg | 1,726.00 € | ||
| 1mL*10mM (DMSO) | 114.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
p38 MAPK Inhibitor
CAS:219138-24-6
p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase (IC50 = 35 nM). …
Formula:
C20H13ClFN3O
Purity:
99.24%
Color and Shape:
Liquid
Molecular weight:
365.79
Ref: TM-T36010
| 1mg | 94.00 € | ||
| 5mg | 290.00 € | ||
| 10mg | 452.00 € | ||
| 25mg | 660.00 € | ||
| 50mg | 906.00 € | ||
| 100mg | 1,204.00 € | ||
| 200mg | 1,639.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
MAPK13-IN-1
CAS:229002-10-2
MAPK13-IN-1 is a potent MAPK13 (p38δ) inhibitor (IC50: 620 nM).
Formula:
C20H23N5O2
Purity:
99.55%
Color and Shape:
Solid
Molecular weight:
365.43
Ref: TM-T11943
| 1mg | 98.00 € | ||
| 2mg | 144.00 € | ||
| 5mg | 233.00 € | ||
| 10mg | 351.00 € | ||
| 25mg | 607.00 € | ||
| 50mg | 879.00 € | ||
| 100mg | 1,267.00 € | ||
| 500mg | 2,565.00 € | ||
| 1mL*10mM (DMSO) | 257.00 € |
Estimated delivery in United States, on Tuesday 21 Jan 2025
