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Raf

Raf

Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.

Found 83 products of "Raf"

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  • RAS GTPase inhibitor 1
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    RAS GTPase inhibitor 1

    CAS:
    <p>RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.</p>
    Formula:C27H28ClF4N5O2
    Purity:98.43%
    Color and Shape:Solid
    Molecular weight:565.99

    Ref: TM-T12692

  • AZ304
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    AZ304

    CAS:
    <p>AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).</p>
    Formula:C27H25N5O2
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:451.52

    Ref: TM-T5172

  • PLX8394
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    PLX8394

    CAS:
    <p>Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.</p>
    Formula:C25H21F3N6O3S
    Purity:98.75% - >99.99%
    Color and Shape:Solid
    Molecular weight:542.53

    Ref: TM-T3579

  • L-779450
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    L-779450

    CAS:
    <p>L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays &gt;7, &gt;30 and &gt;70-fold selectivity over p38α, GSK3β and Lck respectively.</p>
    Formula:C20H14ClN3O
    Purity:≥95%
    Color and Shape:Solid
    Molecular weight:347.8

    Ref: TM-T1953

  • Takeda-6d
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    Takeda-6d

    CAS:
    <p>Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.</p>
    Formula:C27H19ClFN5O3S
    Purity:98.27%
    Color and Shape:Solid
    Molecular weight:547.99

    Ref: TM-T22436

  • GW 5074
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    GW 5074

    CAS:
    <p>GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor.</p>
    Formula:C15H8Br2INO2
    Purity:99.32%
    Color and Shape:Solid
    Molecular weight:520.94

    Ref: TM-T6525

  • PLX-4720
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    PLX-4720

    CAS:
    <p>PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.</p>
    Formula:C17H14ClF2N3O3S
    Purity:97.78% - 99.83%
    Color and Shape:Solid
    Molecular weight:413.83

    Ref: TM-T2473

  • Raf inhibitor 2
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    Raf inhibitor 2

    CAS:
    <p>Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.</p>
    Formula:C15H8Br2ClNO2
    Purity:98.53%
    Color and Shape:Solid
    Molecular weight:429.49

    Ref: TM-T4194

  • Kobe2602
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    Kobe2602

    CAS:
    <p>Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.</p>
    Formula:C14H9F4N5O4S
    Purity:98.36% - 99.39%
    Color and Shape:Solid
    Molecular weight:419.31

    Ref: TM-T1892

  • Encorafenib
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    Encorafenib

    CAS:
    <p>Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.</p>
    Formula:C22H27ClFN7O4S
    Purity:99.51% - 99.83%
    Color and Shape:Solid
    Molecular weight:540.01

    Ref: TM-T6487

  • Plx-4032
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    Plx-4032

    CAS:
    <p>Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.</p>
    Formula:C23H18ClF2N3O3S
    Purity:98.53% - 99.36%
    Color and Shape:Solid
    Molecular weight:489.92

    Ref: TM-T8654

  • Regorafenib
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    Regorafenib

    CAS:
    <p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>
    Formula:C21H15ClF4N4O3
    Purity:98% - 99.95%
    Color and Shape:Solid
    Molecular weight:482.82

    Ref: TM-T1792

  • Regorafenib monohydrate
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    Regorafenib monohydrate

    CAS:
    <p>Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine</p>
    Formula:C21H17ClF4N4O4
    Purity:99.69%
    Color and Shape:Solid
    Molecular weight:500.83

    Ref: TM-T1792L

  • K-Ras(G12C) inhibitor 9
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    K-Ras(G12C) inhibitor 9

    CAS:
    <p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>
    Formula:C16H21ClIN3O4S
    Purity:97.33% - 97.45%
    Color and Shape:Solid
    Molecular weight:513.78

    Ref: TM-T6556

  • AD80
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    AD80

    CAS:
    <p>AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.</p>
    Formula:C22H19F4N7O
    Purity:99.49% - 99.75%
    Color and Shape:Solid
    Molecular weight:473.43

    Ref: TM-T4301

  • BI-882370
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    BI-882370

    CAS:
    <p>BI-882370 is a specific RAF kinase inhibitor.</p>
    Formula:C28H33F2N7O2S
    Purity:97.33% - 99.07%
    Color and Shape:Solid
    Molecular weight:569.67

    Ref: TM-TQ0048

  • RAF709
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    RAF709

    CAS:
    <p>RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.</p>
    Formula:C28H29F3N4O4
    Purity:99.28% - 99.8%
    Color and Shape:Solid
    Molecular weight:542.55

    Ref: TM-T3711

  • SB-590885
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    SB-590885

    CAS:
    <p>SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).</p>
    Formula:C27H27N5O2
    Purity:95.42% - 99.06%
    Color and Shape:Solid
    Molecular weight:453.54

    Ref: TM-T2295

  • RAF265
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    RAF265

    CAS:
    <p>RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.</p>
    Formula:C24H16F6N6O
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:518.41

    Ref: TM-T6296

  • Ro 5126766
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    Ro 5126766

    CAS:
    <p>RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.</p>
    Formula:C21H18FN5O5S
    Purity:98.3% - 98.81%
    Color and Shape:Solid
    Molecular weight:471.46

    Ref: TM-T6971