Raf
Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.
Found 86 products for "Raf".
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AZ 628
CAS:AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.Formula:C27H25N5O2Purity:99.50%Color and Shape:SolidMolecular weight:451.52Raf inhibitor 1 dihydrochloride
CAS:Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.Formula:C26H21Cl3N8Purity:98.75% - 99.54%Color and Shape:SolidMolecular weight:551.858Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Formula:C26H19ClN8Purity:99.91%Color and Shape:SolidMolecular weight:478.936TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Formula:C27H23F2N7O3Purity:99.28% - 99.58%Color and Shape:Yellow SolidMolecular weight:531.5134PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Formula:C24H22F2N6O3SPurity:99.51% - 99.66%Color and Shape:SolidMolecular weight:512.532Kobe2601
CAS:Kobe2601 is a water-soluble structural analog of Kobe0065. Kobe2601 inhibits Ras-Raf binding.Formula:C13H10FN5O4SPurity:99.24%Color and Shape:SolidMolecular weight:351.31PLX7683
CAS:PLX7683 is a RAF pathway paradox breaker used in MAPK signaling and resistance mutation research.Formula:C23H19ClF2N4O3SPurity:97.60%Color and Shape:SolidMolecular weight:504.94MCP110
CAS:MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Formula:C33H36N2O3Purity:97.23%Color and Shape:OilMolecular weight:508.6505RAF-IN-1
CAS:RAF-IN-1 inhibits cRAF, BRAF and BRAFV600E, with GI50 3.4 and 2.9 nM in mutant cell lines.Formula:C26H22F3N3O4Purity:99.62%Color and Shape:White SolidMolecular weight:497.47GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Formula:C19H18N4O2Purity:99.62%Color and Shape:SolidMolecular weight:334.37BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Formula:C22H18F2N4O3SPurity:98.2% - 98.41%Color and Shape:SolidMolecular weight:456.465K-Ras G12C-IN-3
CAS:K-Ras G12C-IN-3 covalently binds G12C mutant cysteine, locking K-Ras in an inactive GDP-bound state and blocking MAPK/ERK signaling.Formula:C21H19Cl3N2O3Color and Shape:SolidMolecular weight:453.746B-Raf IN 13
CAS:B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.Formula:C19H19ClFN3O4SPurity:99.41% - >99.99%Color and Shape:SolidMolecular weight:439.89SOS1-IN-15
CAS:SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.Formula:C28H27F3N6O2Purity:98.32%Color and Shape:SolidMolecular weight:536.548GSK2008607
CAS:GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.Formula:C31H28F3N7O3S2Purity:99.99%Color and Shape:SolidMolecular weight:667.724B-Raf IN 15
CAS:B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Formula:C19H15N3OSPurity:98%Color and Shape:SolidMolecular weight:333.41B-Raf IN 16
CAS:B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Formula:C20H19N5O3SPurity:99.78% - 99.85%Color and Shape:SolidMolecular weight:409.46Lifirafenib
CAS:Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFormula:C25H17F3N4O3Purity:97.99% - 98%Color and Shape:SolidMolecular weight:478.4227Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Formula:C18H19FN8O2SPurity:98%Color and Shape:SolidMolecular weight:430.46Uplarafenib
CAS:Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.Formula:C22H21F3N4O4SPurity:99.98%Color and Shape:SolidMolecular weight:494.487
