Raf
Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.
Found 82 products of "Raf"
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AZ 628
CAS:AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.Formula:C27H25N5O2Purity:99.50%Color and Shape:SolidMolecular weight:451.52Raf inhibitor 1 dihydrochloride
CAS:Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.Formula:C26H19ClN8HClPurity:98.19% - 99.54%Color and Shape:SolidMolecular weight:551.86Ref: TM-T4167
1mg47.00€2mg60.00€5mg98.00€10mg170.00€1mL*10mM (DMSO)178.00€25mg284.00€50mg423.00€100mg618.00€500mg1,305.00€Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Formula:C26H19ClN8Purity:99.91%Color and Shape:SolidMolecular weight:478.94TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Formula:C27H23F2N7O3Purity:99.58%Color and Shape:SolidMolecular weight:531.51Ref: TM-T9693
1mg46.00€5mg92.00€1mL*10mM (DMSO)107.00€10mg147.00€25mg258.00€50mg386.00€100mg537.00€200mg710.00€PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Formula:C24H22F2N6O3SPurity:99.51% - 99.66%Color and Shape:SolidMolecular weight:512.53BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Formula:C22H18F2N4O3SPurity:98.2% - 98.41%Color and Shape:SolidMolecular weight:456.47Ref: TM-T10599
1mg44.00€5mg87.00€1mL*10mM (DMSO)99.00€10mg137.00€25mg236.00€50mg371.00€100mg530.00€200mg770.00€MCP110
CAS:MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Formula:C33H36N2O3Purity:97.23%Color and Shape:OilMolecular weight:508.65Ref: TM-T24437
1mg34.00€5mg92.00€1mL*10mM (DMSO)103.00€10mg160.00€25mg276.00€50mg400.00€100mg532.00€500mg1,063.00€B-Raf IN 13
CAS:B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.
Formula:C19H19ClFN3O4SPurity:99.41% - >99.99%Color and Shape:SoildMolecular weight:439.89GDC-0879
CAS:GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.Formula:C19H18N4O2Purity:99.62%Color and Shape:SolidMolecular weight:334.37Ref: TM-T6320
1mg35.00€2mg50.00€5mg74.00€1mL*10mM (DMSO)82.00€10mg105.00€25mg205.00€50mg334.00€100mg537.00€200mg765.00€GSK2008607
CAS:GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.
Formula:C31H28F3N7O3S2Purity:99.36%Color and Shape:SolidMolecular weight:667.72Ref: TM-T27454
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€SOS1-IN-15
CAS:SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.Formula:C28H27F3N6O2Purity:98.32%Color and Shape:SolidMolecular weight:536.548B-Raf IN 15
CAS:B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Formula:C19H15N3OSPurity:98%Color and Shape:SolidMolecular weight:333.41Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Formula:C18H19FN8O2SPurity:98%Color and Shape:SolidMolecular weight:430.46Lifirafenib
CAS:Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFormula:C25H17F3N4O3Purity:97.99% - 98%Color and Shape:SolidMolecular weight:478.42Ref: TM-T22272
50mgTo inquire100mgTo inquire1mg34.00€5mg65.00€10mg92.00€1mL*10mM (DMSO)94.00€25mg180.00€Uplarafenib
CAS:Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on solid cancers.Formula:C22H21F3N4O4SPurity:99.98%Color and Shape:SolidMolecular weight:494.49Ref: TM-T63333
1mg54.00€5mg119.00€1mL*10mM (DMSO)131.00€10mg170.00€25mg359.00€50mg538.00€100mg928.00€B-Raf IN 16
CAS:B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Formula:C20H19N5O3SPurity:99.31% - 99.78%Color and Shape:SolidMolecular weight:409.46HG6-64-1
CAS:HG6-64-1 (HMSL 10017-101-1, compound 9 (XI-1)) is a potent and selective B-Raf inhibitor with an IC50 = 0.09 μM in B-raf V600E-transformed Ba/F3 cells.Formula:C32H34F3N5O2Purity:99.89%Color and Shape:SolidMolecular weight:577.64Ref: TM-T15480
1mg69.00€5mg147.00€1mL*10mM (DMSO)178.00€10mg215.00€25mg371.00€50mg522.00€100mg708.00€Brimarafenib
CAS:Brimarafenib is a selective RAF dimerization inhibitor, which can inhibit BRAF and CRAF, and exhibits inhibitory effects on a variety of RAF mutations.Formula:C24H17F3N4O4Purity:98.32%Color and Shape:SolidMolecular weight:482.41pan-Raf/RTK inhibitor 1
CAS:Pan-Raf/RTK inhibitor 1 (compound I-16) is a potent pan-Raf inhibitor with IC50 values of 3.49 nM (BRafV600E), 8.86 nM (ARaf), 5.78 nM (BRafWT), and 1.65 nM (CRaf). It exhibits antiproliferative activity against various cancer cell lines and can be utilized in cancer research.Formula:C29H28F3N7O3Color and Shape:SolidMolecular weight:579.573Rineterkib
CAS:Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.Formula:C26H27BrF3N5O2Purity:99.73%Color and Shape:SolidMolecular weight:578.42Ref: TM-T11224
1mg87.00€5mg170.00€1mL*10mM (DMSO)224.00€10mg318.00€25mg538.00€50mg765.00€100mg1,035.00€
