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Raf

Raf

Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.

Found 83 products of "Raf"

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  • BI-882370
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    BI-882370

    CAS:
    <p>BI-882370 is a specific RAF kinase inhibitor.</p>
    Formula:C28H33F2N7O2S
    Purity:97.33% - 99.07%
    Color and Shape:Solid
    Molecular weight:569.67

    Ref: TM-TQ0048

  • K-Ras(G12C) inhibitor 9
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    K-Ras(G12C) inhibitor 9

    CAS:
    <p>K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).</p>
    Formula:C16H21ClIN3O4S
    Purity:97.33% - 97.45%
    Color and Shape:Solid
    Molecular weight:513.78

    Ref: TM-T6556

  • SB-590885
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    SB-590885

    CAS:
    <p>SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).</p>
    Formula:C27H27N5O2
    Purity:95.42% - 99.06%
    Color and Shape:Solid
    Molecular weight:453.54

    Ref: TM-T2295

  • Plx-4032
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    Plx-4032

    CAS:
    <p>Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.</p>
    Formula:C23H18ClF2N3O3S
    Purity:98.53% - 99.36%
    Color and Shape:Solid
    Molecular weight:489.92

    Ref: TM-T8654

  • K-Ras(G12C) inhibitor 6
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    K-Ras(G12C) inhibitor 6

    CAS:
    <p>Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.</p>
    Formula:C17H22Cl2N2O3S
    Purity:89.07% - 97.09%
    Color and Shape:Solid
    Molecular weight:405.34

    Ref: TM-T3725

  • L-779450
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    L-779450

    CAS:
    <p>L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays &gt;7, &gt;30 and &gt;70-fold selectivity over p38α, GSK3β and Lck respectively.</p>
    Formula:C20H14ClN3O
    Purity:≥95%
    Color and Shape:Solid
    Molecular weight:347.8

    Ref: TM-T1953

  • PLX-4720
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    PLX-4720

    CAS:
    <p>PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.</p>
    Formula:C17H14ClF2N3O3S
    Purity:97.78% - 99.83%
    Color and Shape:Solid
    Molecular weight:413.83

    Ref: TM-T2473

  • CCT196969
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    CCT196969

    CAS:
    <p>CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.</p>
    Formula:C27H24FN7O3
    Purity:98.93% - 99.65%
    Color and Shape:Solid
    Molecular weight:513.52

    Ref: TM-T4133

  • Belvarafenib
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    Belvarafenib

    CAS:
    <p>Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.</p>
    Formula:C23H16ClFN6OS
    Purity:98% - 99.65%
    Color and Shape:Solid
    Molecular weight:478.93

    Ref: TM-T5634

  • I-49 free base
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    I-49 free base

    <p>I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novel</p>
    Formula:C23H26ClF3N4O2
    Purity:99.64% - 99.88%
    Color and Shape:Solid
    Molecular weight:482.92

    Ref: TM-T8746L

  • B-Raf IN 1
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    B-Raf IN 1

    CAS:
    <p>B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.</p>
    Formula:C29H24F3N5O
    Purity:97.22% - 99.27%
    Color and Shape:Solid
    Molecular weight:515.53

    Ref: TM-T1845

  • SGX-523
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    SGX-523

    CAS:
    <p>SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.</p>
    Formula:C18H13N7S
    Purity:99% - >99.99%
    Color and Shape:Solid
    Molecular weight:359.41

    Ref: TM-T2293

  • Vemurafenib
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    Vemurafenib

    CAS:
    <p>Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.</p>
    Formula:C23H18ClF2N3O3S
    Purity:98% - 99.65%
    Color and Shape:Solid
    Molecular weight:489.92

    Ref: TM-T2382

  • LY3009120
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    LY3009120

    CAS:
    <p>LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.</p>
    Formula:C23H29FN6O
    Purity:96.96% - ≥95%
    Color and Shape:Solid
    Molecular weight:424.51

    Ref: TM-T6882

  • PROTAC BRAF-V600E degrader-1
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    PROTAC BRAF-V600E degrader-1

    CAS:
    <p>PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.</p>
    Formula:C48H54F2N10O10S
    Purity:99.43%
    Color and Shape:Solid
    Molecular weight:1001.07

    Ref: TM-T8745

  • Dabrafenib
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    Dabrafenib

    CAS:
    <p>Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive.</p>
    Formula:C23H20F3N5O2S2
    Purity:99.62% - >99.99%
    Color and Shape:Solid
    Molecular weight:519.56

    Ref: TM-T1903

  • Dabrafenib Mesylate
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    Dabrafenib Mesylate

    CAS:
    <p>Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).</p>
    Formula:C24H24F3N5O5S3
    Purity:99.45% - 99.82%
    Color and Shape:Solid
    Molecular weight:615.67

    Ref: TM-T8474

  • Doramapimod
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    Doramapimod

    CAS:
    <p>Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.</p>
    Formula:C31H37N5O3
    Purity:97.14% - 98.80%
    Color and Shape:Solid
    Molecular weight:527.66

    Ref: TM-T6277

  • TAK-580
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    TAK-580

    CAS:
    <p>TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.</p>
    Formula:C17H12Cl2F3N7O2S
    Purity:99.25% - 99.77%
    Color and Shape:Solid
    Molecular weight:506.29

    Ref: TM-T6895

  • Regorafenib Hydrochloride
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    Regorafenib Hydrochloride

    CAS:
    <p>Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.</p>
    Formula:C21H16Cl2F4N4O3
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:519.28

    Ref: TM-T8402