Raf
Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.
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NVP-BHG712
CAS:940310-85-0
NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR …
Formula:
C26H20F3N7O
Purity:
97.96%
Color and Shape:
Solid
Molecular weight:
503.48
Ref: TM-T6348
| 1mg | 36.00 € | ||
| 2mg | 57.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 114.00 € | ||
| 25mg | 212.00 € | ||
| 50mg | 389.00 € | ||
| 100mg | 582.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
RAF709
CAS:1628838-42-5
RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for …
Formula:
C28H29F3N4O4
Purity:
99.43% - 99.83%
Color and Shape:
Solid
Molecular weight:
542.55
Ref: TM-T3711
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 130.00 € | ||
| 25mg | 256.00 € | ||
| 50mg | 419.00 € | ||
| 100mg | 618.00 € | ||
| 500mg | 1,287.00 € | ||
| 1mL*10mM (DMSO) | 93.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Locostatin
CAS:133812-16-5
Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase …
Formula:
C14H15NO3
Purity:
97.13%
Color and Shape:
Solid
Molecular weight:
245.27
Ref: TM-T8823
| 5mg | 46.00 € | ||
| 10mg | 64.00 € | ||
| 25mg | 110.00 € | ||
| 50mg | 167.00 € | ||
| 100mg | 234.00 € | ||
| 200mg | 350.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Regorafenib monohydrate
CAS:1019206-88-2
Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, …
Formula:
C21H17ClF4N4O4
Purity:
99.69%
Color and Shape:
Solid
Molecular weight:
500.83
Ref: TM-T1792L
| 5mg | 36.00 € | ||
| 10mg | 49.00 € | ||
| 25mg | 69.00 € | ||
| 50mg | 87.00 € | ||
| 100mg | 138.00 € | ||
| 200mg | 204.00 € | ||
| 500mg | 348.00 € | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
ZM 336372
CAS:208260-29-1
ZM 336372 is a potent and selective c-Raf inhibitor.
Formula:
C23H23N3O3
Purity:
97.24% - 97.51%
Color and Shape:
Solid
Molecular weight:
389.45
Ref: TM-T1851
| 2mg | 40.00 € | ||
| 5mg | 58.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 160.00 € | ||
| 50mg | 281.00 € | ||
| 100mg | 492.00 € | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
GW 5074
CAS:220904-83-6
GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor.
Formula:
C15H8Br2INO2
Purity:
97.49%
Color and Shape:
Solid
Molecular weight:
520.94
Ref: TM-T6525
| 2mg | 42.00 € | ||
| 5mg | 59.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 131.00 € | ||
| 50mg | 165.00 € | ||
| 100mg | 193.00 € | ||
| 200mg | 276.00 € | ||
| 1mL*10mM (DMSO) | 73.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
L-779450
CAS:303727-31-3
L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and …
Formula:
C20H14ClN3O
Purity:
≥95%
Color and Shape:
Solid
Molecular weight:
347.8
Ref: TM-T1953
| 2mg | 54.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 111.00 € | ||
| 25mg | 190.00 € | ||
| 50mg | 353.00 € | ||
| 100mg | 562.00 € | ||
| 1mL*10mM (DMSO) | 82.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PLX-4720
CAS:918505-84-7
PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site …
Formula:
C17H14ClF2N3O3S
Purity:
97.78% - 99.89%
Color and Shape:
Solid
Molecular weight:
413.83
Ref: TM-T2473
| 5mg | 38.00 € | ||
| 10mg | 52.00 € | ||
| 25mg | 86.00 € | ||
| 50mg | 98.00 € | ||
| 100mg | 122.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CCT196969
CAS:1163719-56-9
CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, …
Formula:
C27H24FN7O3
Purity:
98.58% - 99.65%
Color and Shape:
Solid
Molecular weight:
513.52
Ref: TM-T4133
| 2mg | 35.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 157.00 € | ||
| 50mg | 245.00 € | ||
| 100mg | 398.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Belvarafenib
CAS:1446113-23-0
Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and …
Formula:
C23H16ClFN6OS
Purity:
99.44% - ≥98%
Color and Shape:
Solid
Molecular weight:
478.93
Ref: TM-T5634
| 2mg | 40.00 € | ||
| 5mg | 62.00 € | ||
| 10mg | 99.00 € | ||
| 25mg | 165.00 € | ||
| 50mg | 237.00 € | ||
| 100mg | 353.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novel
Formula:
C23H26ClF3N4O2
Purity:
99.64% - 99.88%
Color and Shape:
Solid
Molecular weight:
482.92
Ref: TM-T8746L
| 1mg | 128.00 € | ||
| 5mg | 281.00 € | ||
| 10mg | 424.00 € | ||
| 25mg | 698.00 € | ||
| 50mg | 981.00 € | ||
| 1mL*10mM (DMSO) | 348.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Effusanin A
CAS:30220-43-0
Effusanin A: antibacterial, damages DNA, inhibits DU145 cells at 3.16 μM and LoVo cells at …
Formula:
C20H28O5
Purity:
98.00%
Color and Shape:
Solid
Molecular weight:
348.43
Ref: TM-TN3920
| 1mg | 169.00 € | ||
| 5mg | 347.00 € | ||
| 10mg | 520.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
B-Raf IN 1
CAS:950736-05-7
B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.
Formula:
C29H24F3N5O
Purity:
97.22% - 99.27%
Color and Shape:
Solid
Molecular weight:
515.53
Ref: TM-T1845
| 1mg | 93.00 € | ||
| 2mg | 118.00 € | ||
| 5mg | 188.00 € | ||
| 10mg | 330.00 € | ||
| 25mg | 560.00 € | ||
| 50mg | 801.00 € | ||
| 100mg | 1,103.00 € | ||
| 1mL*10mM (DMSO) | 222.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SGX-523
CAS:1022150-57-7
SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, …
Formula:
C18H13N7S
Purity:
100% - 99.6%
Color and Shape:
Solid
Molecular weight:
359.41
Ref: TM-T2293
| 1mg | 52.00 € | ||
| 2mg | 66.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 138.00 € | ||
| 25mg | 272.00 € | ||
| 50mg | 439.00 € | ||
| 100mg | 648.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Vemurafenib
CAS:918504-65-1
Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and …
Formula:
C23H18ClF2N3O3S
Purity:
98% - 99.65%
Color and Shape:
Solid
Molecular weight:
489.92
Ref: TM-T2382
| 10mg | 54.00 € | ||
| 50mg | 78.00 € | ||
| 100mg | 97.00 € | ||
| 200mg | 168.00 € | ||
| 500mg | 284.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
LY3009120
CAS:1454682-72-4
LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and …
Formula:
C23H29FN6O
Purity:
96.96% - ≥95%
Color and Shape:
Solid
Molecular weight:
424.51
Ref: TM-T6882
| 2mg | 35.00 € | ||
| 5mg | 50.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 168.00 € | ||
| 50mg | 306.00 € | ||
| 100mg | 516.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PROTAC BRAF-V600E degrader-1
CAS:2417296-84-3
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.
Formula:
C48H54F2N10O10S
Purity:
99.43%
Color and Shape:
Solid
Molecular weight:
1001.07
Ref: TM-T8745
| 1mg | 109.00 € | ||
| 5mg | 292.00 € | ||
| 10mg | 383.00 € | ||
| 25mg | 625.00 € | ||
| 50mg | 844.00 € | ||
| 100mg | 1,126.00 € | ||
| 200mg | 1,528.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Dabrafenib
CAS:1195765-45-7
Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is …
Formula:
C23H20F3N5O2S2
Purity:
100% - 99.83%
Color and Shape:
Solid
Molecular weight:
519.56
Ref: TM-T1903
| 5mg | 48.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 78.00 € | ||
| 50mg | 92.00 € | ||
| 100mg | 113.00 € | ||
| 200mg | 153.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Dabrafenib Mesylate
CAS:1195768-06-9
Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E …
Formula:
C24H24F3N5O5S3
Purity:
99.45% - 99.62%
Color and Shape:
Solid
Molecular weight:
615.67
Ref: TM-T8474
| 5mg | 47.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 78.00 € | ||
| 50mg | 92.00 € | ||
| 100mg | 113.00 € | ||
| 500mg | 221.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Doramapimod
CAS:285983-48-4
Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but …
Formula:
C31H37N5O3
Purity:
97.73% - 99.65%
Color and Shape:
Solid
Molecular weight:
527.66
Ref: TM-T6277
| 1g | 552.00 € | ||
| 5mg | 36.00 € | ||
| 10mg | 54.00 € | ||
| 25mg | 78.00 € | ||
| 50mg | 90.00 € | ||
| 100mg | 124.00 € | ||
| 200mg | 220.00 € | ||
| 500mg | 371.00 € | ||
| 1mL*10mM (DMSO) | 44.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
