Raf
Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.
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K-Ras(G12C) inhibitor 9
CAS:1469337-91-4
K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).
Formula:
C16H21ClIN3O4S
Purity:
97.33% - 97.45%
Color and Shape:
Solid
Molecular weight:
513.78
Ref: TM-T6556
| 1mg | 52.00 € | ||
| 2mg | 73.00 € | ||
| 5mg | 122.00 € | ||
| 10mg | 181.00 € | ||
| 25mg | 373.00 € | ||
| 50mg | 541.00 € | ||
| 100mg | 740.00 € | ||
| 1mL*10mM (DMSO) | 181.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SB-590885
CAS:405554-55-4
SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).
Formula:
C27H27N5O2
Purity:
95.42% - 99.06%
Color and Shape:
Solid
Molecular weight:
453.54
Ref: TM-T2295
| 1mg | 43.00 € | ||
| 5mg | 92.00 € | ||
| 10mg | 129.00 € | ||
| 25mg | 249.00 € | ||
| 50mg | 477.00 € | ||
| 100mg | 697.00 € | ||
| 1mL*10mM (DMSO) | 145.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Plx-4032
CAS:1029872-54-5
Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.
Formula:
C23H18ClF2N3O3S
Purity:
99.36% - 99.94%
Color and Shape:
Solid
Molecular weight:
489.92
Ref: TM-T8654
| 10mg | 54.00 € | ||
| 50mg | 78.00 € | ||
| 100mg | 97.00 € | ||
| 200mg | 167.00 € | ||
| 500mg | 286.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Regorafenib
CAS:755037-03-7
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, …
Formula:
C21H15ClF4N4O3
Purity:
98% - 99.95%
Color and Shape:
Solid
Molecular weight:
482.82
Ref: TM-T1792
| 5mg | 35.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 79.00 € | ||
| 50mg | 94.00 € | ||
| 100mg | 142.00 € | ||
| 200mg | 181.00 € | ||
| 500mg | 304.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Raf inhibitor 1 dihydrochloride
CAS:1191385-19-9
Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.
Formula:
C26H19ClN8HCl
Purity:
98.19% - 98.44%
Color and Shape:
Solid
Molecular weight:
551.86
Ref: TM-T4167
| 1mg | 49.00 € | ||
| 2mg | 65.00 € | ||
| 5mg | 105.00 € | ||
| 10mg | 182.00 € | ||
| 25mg | 304.00 € | ||
| 50mg | 450.00 € | ||
| 100mg | 659.00 € | ||
| 500mg | 1,347.00 € | ||
| 1mL*10mM (DMSO) | 190.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PLX8394
CAS:1393466-87-9
Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective …
Formula:
C25H21F3N6O3S
Purity:
100% - 98.22%
Color and Shape:
Solid
Molecular weight:
542.53
Ref: TM-T3579
| 1mg | 52.00 € | ||
| 2mg | 59.00 € | ||
| 5mg | 89.00 € | ||
| 10mg | 139.00 € | ||
| 25mg | 242.00 € | ||
| 50mg | 360.00 € | ||
| 100mg | 525.00 € | ||
| 1mL*10mM (DMSO) | 120.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Ro 5126766
CAS:946128-88-7
RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 …
Formula:
C21H18FN5O5S
Purity:
98.13% - 98.3%
Color and Shape:
Solid
Molecular weight:
471.46
Ref: TM-T6971
| 1mg | 57.00 € | ||
| 2mg | 81.00 € | ||
| 5mg | 113.00 € | ||
| 10mg | 169.00 € | ||
| 25mg | 324.00 € | ||
| 50mg | 515.00 € | ||
| 100mg | 744.00 € | ||
| 1mL*10mM (DMSO) | 118.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Kobe2602
CAS:454453-49-7
Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.
Formula:
C14H9F4N5O4S
Purity:
98.36% - 99.39%
Color and Shape:
Solid
Molecular weight:
419.31
Ref: TM-T1892
| 10mg | 40.00 € | ||
| 25mg | 52.00 € | ||
| 50mg | 81.00 € | ||
| 100mg | 122.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Agerafenib
CAS:1188910-76-0
Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.
Formula:
C24H22F3N5O5
Purity:
95.78% - 99.23%
Color and Shape:
Solid
Molecular weight:
517.46
Ref: TM-T2070
| 1mg | 42.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 128.00 € | ||
| 25mg | 227.00 € | ||
| 50mg | 369.00 € | ||
| 100mg | 553.00 € | ||
| 200mg | 790.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Takeda-6d
CAS:1125632-93-0
Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with …
Formula:
C27H19ClFN5O3S
Purity:
98.27%
Color and Shape:
Solid
Molecular weight:
547.99
Ref: TM-T22436
| 1mg | 93.00 € | ||
| 2mg | 130.00 € | ||
| 5mg | 182.00 € | ||
| 10mg | 272.00 € | ||
| 25mg | 446.00 € | ||
| 50mg | 621.00 € | ||
| 100mg | 835.00 € | ||
| 200mg | 1,116.00 € | ||
| 1mL*10mM (DMSO) | 247.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
AZ304
CAS:942507-42-8
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and …
Formula:
C27H25N5O2
Purity:
99.83%
Color and Shape:
Solid
Molecular weight:
451.52
Ref: TM-T5172
| 10mg | 41.00 € | ||
| 25mg | 63.00 € | ||
| 50mg | 93.00 € | ||
| 100mg | 150.00 € | ||
| 1mL*10mM (DMSO) | 43.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TAK-632
CAS:1228591-30-7
TAK-632 is a potent pan-Raf inhibitor.
Formula:
C27H18F4N4O3S
Purity:
98% - 98.92%
Color and Shape:
Solid
Molecular weight:
554.52
Ref: TM-T1886
| 5mg | 41.00 € | ||
| 10mg | 49.00 € | ||
| 25mg | 84.00 € | ||
| 50mg | 121.00 € | ||
| 100mg | 208.00 € | ||
| 200mg | 270.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
RAF265
CAS:927880-90-8
RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 …
Formula:
C24H16F6N6O
Purity:
99.56%
Color and Shape:
Solid
Molecular weight:
518.41
Ref: TM-T6296
| 1mg | 46.00 € | ||
| 2mg | 62.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 145.00 € | ||
| 25mg | 261.00 € | ||
| 50mg | 425.00 € | ||
| 100mg | 625.00 € | ||
| 1mL*10mM (DMSO) | 99.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
NVP-BAW2881
CAS:861875-60-7
NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor with activity to inhibit chronic and …
Formula:
C22H15F3N4O2
Purity:
98.19% - 99.97%
Color and Shape:
Solid
Molecular weight:
424.38
Ref: TM-T3641
| 1mg | 36.00 € | ||
| 2mg | 50.00 € | ||
| 5mg | 74.00 € | ||
| 10mg | 114.00 € | ||
| 25mg | 210.00 € | ||
| 50mg | 338.00 € | ||
| 100mg | 490.00 € | ||
| 500mg | 1,087.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
AD80
CAS:1384071-99-1
AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
Formula:
C22H19F4N7O
Purity:
100% - 99.9%
Color and Shape:
Solid
Molecular weight:
473.43
Ref: TM-T4301
| 1mg | 46.00 € | ||
| 5mg | 92.00 € | ||
| 10mg | 146.00 € | ||
| 25mg | 283.00 € | ||
| 50mg | 465.00 € | ||
| 100mg | 682.00 € | ||
| 500mg | 1,375.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Raf inhibitor 2
CAS:220904-99-4
Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.
Formula:
C15H8Br2ClNO2
Purity:
98.53%
Color and Shape:
Solid
Molecular weight:
429.49
Ref: TM-T4194
| 2mg | 39.00 € | ||
| 5mg | 60.00 € | ||
| 10mg | 93.00 € | ||
| 25mg | 159.00 € | ||
| 50mg | 232.00 € | ||
| 100mg | 337.00 € | ||
| 200mg | 474.00 € | ||
| 1mL*10mM (DMSO) | 62.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TBAP-001
CAS:1777832-90-2
TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E …
Formula:
C27H23F2N7O3
Purity:
99.3%
Color and Shape:
Solid
Molecular weight:
531.51
Ref: TM-T9693
| 1mg | 74.00 € | ||
| 5mg | 159.00 € | ||
| 10mg | 247.00 € | ||
| 25mg | 447.00 € | ||
| 50mg | 671.00 € | ||
| 100mg | 932.00 € | ||
| 1mL*10mM (DMSO) | 181.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Encorafenib
CAS:1269440-17-6
Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.
Formula:
C22H27ClFN7O4S
Purity:
98.64% - 99.74%
Color and Shape:
Solid
Molecular weight:
540.01
Ref: TM-T6487
| 1mg | 51.00 € | ||
| 5mg | 93.00 € | ||
| 10mg | 120.00 € | ||
| 25mg | 184.00 € | ||
| 50mg | 350.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
B-Raf IN 11
CAS:918504-27-5
B-Raf IN 11 is a novel selective inhibitor.
Formula:
C17H14BrF2N3O3S
Purity:
99.46%
Color and Shape:
Solid
Molecular weight:
458.28
Ref: TM-T19802
| 50mg | 36.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
BAY-293
CAS:2244904-70-7
BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).
Formula:
C25H28N4O2S
Purity:
96.8%
Color and Shape:
Solid
Molecular weight:
448.58
Ref: TM-T5418
| 1mg | 52.00 € | ||
| 5mg | 109.00 € | ||
| 10mg | 183.00 € | ||
| 25mg | 368.00 € | ||
| 50mg | 547.00 € | ||
| 100mg | 786.00 € | ||
| 1mL*10mM (DMSO) | 123.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
