Raf
Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.
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TBAP-001
CAS:1777832-90-2
TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E …
Formula:
C27H23F2N7O3
Purity:
99.3%
Color and Shape:
Solid
Molecular weight:
531.51
Ref: TM-T9693
| 1mg | 48.00 € | ||
| 5mg | 97.00 € | ||
| 10mg | 156.00 € | ||
| 25mg | 271.00 € | ||
| 50mg | 408.00 € | ||
| 100mg | 567.00 € | ||
| 200mg | 748.00 € | ||
| 1mL*10mM (DMSO) | 113.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Encorafenib
CAS:1269440-17-6
Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.
Formula:
C22H27ClFN7O4S
Purity:
98.64% - 99.74%
Color and Shape:
Solid
Molecular weight:
540.01
Ref: TM-T6487
| 1mg | 51.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 122.00 € | ||
| 25mg | 187.00 € | ||
| 50mg | 355.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
B-Raf IN 11
CAS:918504-27-5
B-Raf IN 11 is a novel selective inhibitor.
Formula:
C17H14BrF2N3O3S
Purity:
99.46%
Color and Shape:
Solid
Molecular weight:
458.28
Ref: TM-T19802
| 50mg | 35.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
BAY-293
CAS:2244904-70-7
BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).
Formula:
C25H28N4O2S
Purity:
96.8%
Color and Shape:
Solid
Molecular weight:
448.58
Ref: TM-T5418
| 1mg | 52.00 € | ||
| 5mg | 111.00 € | ||
| 10mg | 187.00 € | ||
| 25mg | 376.00 € | ||
| 50mg | 560.00 € | ||
| 100mg | 800.00 € | ||
| 1mL*10mM (DMSO) | 123.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
NVP-BHG712
CAS:940310-85-0
NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR …
Formula:
C26H20F3N7O
Purity:
97.32%
Color and Shape:
Solid
Molecular weight:
503.48
Ref: TM-T6348
| 1mg | 35.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 111.00 € | ||
| 25mg | 212.00 € | ||
| 50mg | 393.00 € | ||
| 100mg | 587.00 € | ||
| 200mg | 833.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
RAF709
CAS:1628838-42-5
RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for …
Formula:
C28H29F3N4O4
Purity:
99.43% - 99.83%
Color and Shape:
Solid
Molecular weight:
542.55
Ref: TM-T3711
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 131.00 € | ||
| 25mg | 259.00 € | ||
| 50mg | 424.00 € | ||
| 100mg | 625.00 € | ||
| 500mg | 1,311.00 € | ||
| 1mL*10mM (DMSO) | 94.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Locostatin
CAS:133812-16-5
Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase …
Formula:
C14H15NO3
Purity:
97.13%
Color and Shape:
Solid
Molecular weight:
245.27
Ref: TM-T8823
| 5mg | 47.00 € | ||
| 10mg | 65.00 € | ||
| 25mg | 111.00 € | ||
| 50mg | 169.00 € | ||
| 100mg | 236.00 € | ||
| 200mg | 354.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
BI-882370
CAS:1392429-79-6
BI-882370 is a specific RAF kinase inhibitor.
Formula:
C28H33F2N7O2S
Purity:
97.33% - 99.07%
Color and Shape:
Solid
Molecular weight:
569.67
Ref: TM-TQ0048
| 1mg | 43.00 € | ||
| 2mg | 57.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | 135.00 € | ||
| 25mg | 235.00 € | ||
| 50mg | 423.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
PLX-4720
CAS:918505-84-7
PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site …
Formula:
C17H14ClF2N3O3S
Purity:
97.78% - 99.83%
Color and Shape:
Solid
Molecular weight:
413.83
Ref: TM-T2473
| 5mg | 38.00 € | ||
| 10mg | 52.00 € | ||
| 25mg | 87.00 € | ||
| 50mg | 99.00 € | ||
| 100mg | 124.00 € | ||
| 1mL*10mM (DMSO) | 49.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
CCT196969
CAS:1163719-56-9
CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, …
Formula:
C27H24FN7O3
Purity:
98.58% - 98.93%
Color and Shape:
Solid
Molecular weight:
513.52
Ref: TM-T4133
| 2mg | 35.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 160.00 € | ||
| 50mg | 250.00 € | ||
| 100mg | 406.00 € | ||
| 1mL*10mM (DMSO) | 59.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Belvarafenib
CAS:1446113-23-0
Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and …
Formula:
C23H16ClFN6OS
Purity:
99.44% - ≥98%
Color and Shape:
Solid
Molecular weight:
478.93
Ref: TM-T5634
| 2mg | 40.00 € | ||
| 5mg | 64.00 € | ||
| 10mg | 101.00 € | ||
| 25mg | 170.00 € | ||
| 50mg | 245.00 € | ||
| 100mg | 363.00 € | ||
| 1mL*10mM (DMSO) | 65.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
K-Ras(G12C) Inhibitor 6
CAS:2060530-16-5
Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.
Formula:
C17H22Cl2N2O3S
Purity:
89.07% - 97.09%
Color and Shape:
Solid
Molecular weight:
405.33
Ref: TM-T3725
| 1mg | 63.00 € | ||
| 2mg | 88.00 € | ||
| 5mg | 133.00 € | ||
| 10mg | 230.00 € | ||
| 25mg | 477.00 € | ||
| 50mg | 667.00 € | ||
| 100mg | 932.00 € | ||
| 1mL*10mM (DMSO) | 133.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Effusanin A
CAS:30220-43-0
Effusanin A: antibacterial, damages DNA, inhibits DU145 cells at 3.16 μM and LoVo cells at …
Formula:
C20H28O5
Purity:
98.00%
Color and Shape:
Solid
Molecular weight:
348.43
Ref: TM-TN3920
| 1mg | 170.00 € | ||
| 5mg | 349.00 € | ||
| 10mg | 523.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
B-Raf IN 1
CAS:950736-05-7
B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.
Formula:
C29H24F3N5O
Purity:
97.22% - 99.27%
Color and Shape:
Solid
Molecular weight:
515.53
Ref: TM-T1845
| 1mg | 92.00 € | ||
| 2mg | 119.00 € | ||
| 5mg | 187.00 € | ||
| 10mg | 329.00 € | ||
| 25mg | 560.00 € | ||
| 50mg | 800.00 € | ||
| 100mg | 1,103.00 € | ||
| 1mL*10mM (DMSO) | 221.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
SGX-523
CAS:1022150-57-7
SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, …
Formula:
C18H13N7S
Purity:
100% - 99.49%
Color and Shape:
Solid
Molecular weight:
359.41
Ref: TM-T2293
| 1mg | 52.00 € | ||
| 2mg | 66.00 € | ||
| 5mg | 97.00 € | ||
| 10mg | 140.00 € | ||
| 25mg | 279.00 € | ||
| 50mg | 449.00 € | ||
| 100mg | 658.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Vemurafenib
CAS:918504-65-1
Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and …
Formula:
C23H18ClF2N3O3S
Purity:
98% - 99.65%
Color and Shape:
Solid
Molecular weight:
489.92
Ref: TM-T2382
| 10mg | 55.00 € | ||
| 50mg | 79.00 € | ||
| 100mg | 99.00 € | ||
| 200mg | 172.00 € | ||
| 500mg | 290.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
LY3009120
CAS:1454682-72-4
LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and …
Formula:
C23H29FN6O
Purity:
96.96% - ≥95%
Color and Shape:
Solid
Molecular weight:
424.51
Ref: TM-T6882
| 2mg | 35.00 € | ||
| 5mg | 50.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 171.00 € | ||
| 50mg | 311.00 € | ||
| 100mg | 527.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
PROTAC BRAF-V600E degrader-1
CAS:2417296-84-3
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.
Formula:
C48H54F2N10O10S
Purity:
99.43%
Color and Shape:
Solid
Molecular weight:
1001.07
Ref: TM-T8745
| 1mg | 113.00 € | ||
| 5mg | 304.00 € | ||
| 10mg | 398.00 € | ||
| 25mg | 648.00 € | ||
| 50mg | 875.00 € | ||
| 100mg | 1,169.00 € | ||
| 200mg | 1,586.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Dabrafenib
CAS:1195765-45-7
Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is …
Formula:
C23H20F3N5O2S2
Purity:
100% - 99.83%
Color and Shape:
Solid
Molecular weight:
519.56
Ref: TM-T1903
| 5mg | 48.00 € | ||
| 10mg | 63.00 € | ||
| 25mg | 79.00 € | ||
| 50mg | 93.00 € | ||
| 100mg | 115.00 € | ||
| 200mg | 156.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
Dabrafenib Mesylate
CAS:1195768-06-9
Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E …
Formula:
C24H24F3N5O5S3
Purity:
99.45% - 99.62%
Color and Shape:
Solid
Molecular weight:
615.67
Ref: TM-T8474
| 5mg | 48.00 € | ||
| 10mg | 63.00 € | ||
| 25mg | 79.00 € | ||
| 50mg | 93.00 € | ||
| 100mg | 115.00 € | ||
| 500mg | 226.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Tuesday 22 Apr 2025
