Raf
Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.
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Uplarafenib
CAS:1425485-87-5
Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on …
Formula:
C22H21F3N4O4S
Purity:
99.85%
Color and Shape:
Liquid
Molecular weight:
494.49
Ref: TM-T63333
| 1mg | 94.00 € | ||
| 5mg | 199.00 € | ||
| 10mg | 291.00 € | ||
| 25mg | 618.00 € | ||
| 50mg | 930.00 € | ||
| 100mg | 1,613.00 € | ||
| 500mg | 3,232.00 € | ||
| 1mL*10mM (DMSO) | 220.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
B-Raf IN 16
CAS:2304746-24-3
B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used …
Formula:
C20H19N5O3S
Purity:
98.59% - 99.56%
Color and Shape:
Liquid
Molecular weight:
409.46
Ref: TM-T79830
| 1mg | 182.00 € | ||
| 5mg | 451.00 € | ||
| 10mg | 646.00 € | ||
| 25mg | 1,007.00 € | ||
| 50mg | 1,390.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
Raf inhibitor 3
CAS:1662682-11-2
Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 …
Formula:
C18H19FN8O2S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
430.46
Ref: TM-T79813
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Feb 2025
IHMT-RAF-128
CAS:2479289-15-9
IHMT-RAF-128 is a potent pan-RAF inhibitor that demonstrates robust antitumor activity in xenograft mouse tumor …
Formula:
C27H24F3N5O2
Color and Shape:
Liquid
Molecular weight:
507.51
Ref: TM-T89984
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Mar 2025
SKLB646
CAS:1970149-05-3
SKLB646 is an orally active multitarget kinase inhibitor that exhibits potent suppression of several kinases. …
Formula:
C28H26F3N7O
Color and Shape:
Liquid
Molecular weight:
533.55
Ref: TM-T200104
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Mar 2025
LSN3074753
CAS:1455031-68-1
LSN3074753, a derivative of LY3009120, acts as a pan-RAF and Raf dimer inhibitor. This compound …
Formula:
C24H30FN5O2
Color and Shape:
Liquid
Molecular weight:
439.53
Ref: TM-T89906
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Wednesday 5 Mar 2025
BMS-214662
CAS:195987-41-8
BMS-214662: potent, selective farnesyl transferase inhibitor; triggers apoptosis in CML stem cells; antitumor effects.
Formula:
C25H23N5O2S2
Color and Shape:
Solid
Molecular weight:
489.61
Ref: TM-T10567
| 25mg | 2,106.00 € | ||
| 50mg | 2,789.00 € | ||
| 100mg | 3,744.00 € |
Estimated delivery in United States, on Wednesday 5 Mar 2025
Rineterkib
CAS:1715025-32-3
Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
Formula:
C26H27BrF3N5O2
Purity:
98.4%
Color and Shape:
Solid
Molecular weight:
578.42
Ref: TM-T11224
| 1mg | 96.00 € | ||
| 5mg | 190.00 € | ||
| 10mg | 357.00 € | ||
| 25mg | 604.00 € | ||
| 50mg | 860.00 € | ||
| 100mg | 1,170.00 € | ||
| 1mL*10mM (DMSO) | 252.00 € |
Estimated delivery in United States, on Wednesday 19 Mar 2025
I-37 free base( 2359690-13-2(free base))
I-37 free base is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.
Formula:
C22H24ClF3N4O
Purity:
99.75%
Color and Shape:
Solid
Molecular weight:
452.9
Ref: TM-T8721L
| 1mg | Discontinued | Request information | |
| 1ml | Discontinued | Request information | |
| 5mg | Discontinued | Request information | |
| 10mg | Discontinued | Request information | |
| 25mg | Discontinued | Request information | |
| 50mg | Discontinued | Request information | |
| 100mg | Discontinued | Request information | |
| 1ml*10 (DMSO) | Discontinued | Request information |
I-37
CAS:2359690-13-2
I-37 (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-) is a novel benzylamino
Formula:
C22H23F3N4O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
416.44
Ref: TM-T8721
| 5mg | Discontinued | Request information | |
| 10mg | Discontinued | Request information | |
| 25mg | Discontinued | Request information | |
| 50mg | Discontinued | Request information | |
| 100mg | Discontinued | Request information |
