Raf
Raf kinases are key components of the MAPK/ERK signaling pathway, playing a critical role in transmitting signals from the cell membrane to the nucleus. Raf activation leads to the phosphorylation of MEK, which subsequently activates ERK, influencing cell division, differentiation, and survival. Mutations in Raf, particularly in B-Raf, are associated with various cancers, making Raf a critical target in cancer therapy. At CymitQuimica, we provide a variety of Raf inhibitors and modulators to support your research in oncology, signal transduction, and therapeutic development.
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Sorafenib
CAS:284461-73-0
Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, …
Formula:
C21H16ClF3N4O3
Purity:
98% - 99.89%
Color and Shape:
Solid
Molecular weight:
464.82
Ref: TM-T0093L
| 1g | 96.00 € | ||
| 50mg | 39.00 € | ||
| 100mg | 51.00 € | ||
| 500mg | 67.00 € | ||
| 1mL*10mM (DMSO) | 35.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
LUT014
CAS:2274819-46-2
LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions …
Formula:
C27H19F3N8O
Purity:
99.03%
Color and Shape:
Solid
Molecular weight:
528.49
Ref: TM-T15794
| 1mg | 65.00 € | ||
| 5mg | 140.00 € | ||
| 10mg | 184.00 € | ||
| 25mg | 339.00 € | ||
| 50mg | 476.00 € | ||
| 100mg | 666.00 € | ||
| 1mL*10mM (DMSO) | 163.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Regorafénib N-oxyde (M2)
CAS:835621-11-9
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.
Formula:
C21H15ClF4N4O4
Purity:
98.03% - 99.48%
Color and Shape:
Solid
Molecular weight:
498.81
Ref: TM-T10157
| 1mg | 44.00 € | ||
| 2mg | 55.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 102.00 € | ||
| 25mg | 176.00 € | ||
| 50mg | 318.00 € | ||
| 100mg | 461.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Sorafenib tosylate
CAS:475207-59-1
Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
Formula:
C21H16ClF3N4O3·C7H8O3S
Purity:
99.2% - 99.81%
Color and Shape:
White To Off-White Crystalline Powder
Molecular weight:
637.03
Ref: TM-T0093
| 1g | 95.00 € | ||
| 50mg | 44.00 € | ||
| 100mg | 57.00 € | ||
| 200mg | 66.00 € | ||
| 500mg | 73.00 € | ||
| 1mL*10mM (DMSO) | 62.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
LXH254
CAS:1800398-38-2
LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM …
Formula:
C25H25F3N4O4
Purity:
98.3% - 99.92%
Color and Shape:
Solid
Molecular weight:
502.49
Ref: TM-T11898
| 1mg | 52.00 € | ||
| 5mg | 120.00 € | ||
| 10mg | 182.00 € | ||
| 25mg | 355.00 € | ||
| 50mg | 555.00 € | ||
| 100mg | 675.00 € | ||
| 200mg | 927.00 € | ||
| 500mg | 1,413.00 € | ||
| 1mL*10mM (DMSO) | 134.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
MEK/RAF-IN-1
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy …
Formula:
C28H29F3N6O5S
Color and Shape:
Liquid
Molecular weight:
618.63
Ref: TM-T200267
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
B-Raf IN 2
CAS:2649372-20-1
B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It …
Formula:
C20H17F2N5O4S
Purity:
98.2%
Color and Shape:
Liquid
Molecular weight:
461.44
Ref: TM-T40284
| 1mg | 56.00 € | ||
| 5mg | 122.00 € | ||
| 10mg | 184.00 € | ||
| 25mg | 328.00 € | ||
| 50mg | 460.00 € | ||
| 100mg | 647.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
GNE-9815
CAS:2729996-45-4
GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selective
Formula:
C26H22FN5O2
Purity:
98.19% - 98.73%
Color and Shape:
Liquid
Molecular weight:
455.48
Ref: TM-T9585
| 1mg | 63.00 € | ||
| 5mg | 143.00 € | ||
| 10mg | 221.00 € | ||
| 25mg | 369.00 € | ||
| 50mg | 527.00 € | ||
| 100mg | 713.00 € | ||
| 500mg | 1,430.00 € | ||
| 1mL*10mM (DMSO) | 145.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Vem-L-Cy5
Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), …
Formula:
C63H68F5N7O9S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
1194.31
Ref: TM-T78777
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
PROTAC B-Raf degrader 1
CAS:2364367-27-9
PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC …
Formula:
C36H37N5O12S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
763.77
Ref: TM-T12556
| 5mg | 407.00 € | ||
| 10mg | 651.00 € | ||
| 50mg | To inquire | ||
| 100mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
NST-628
CAS:3002056-30-3
NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK. NST-628 …
Formula:
C22H18F2N4O5S
Purity:
98.62%
Color and Shape:
Solid
Molecular weight:
488.46
Ref: TM-T87041
| 1mg | 219.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
SOS1-IN-11
CAS:2654741-64-5
SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).
Formula:
C22H24F3N5O
Purity:
98.79%
Color and Shape:
Solid
Molecular weight:
431.45
Ref: TM-T60029
| 1mg | 75.00 € | ||
| 5mg | 166.00 € | ||
| 10mg | 278.00 € | ||
| 25mg | 442.00 € | ||
| 50mg | 631.00 € | ||
| 100mg | 849.00 € | ||
| 1mL*10mM (DMSO) | 179.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
MRTX0902
CAS:2654743-22-1
MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 …
Formula:
C22H24N6O
Purity:
98.37%
Color and Shape:
Solid
Molecular weight:
388.47
Ref: TM-T9755
| 1mg | 94.00 € | ||
| 5mg | 199.00 € | ||
| 10mg | 292.00 € | ||
| 25mg | 618.00 € | ||
| 50mg | 989.00 € | ||
| 100mg | 1,613.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
KG5
CAS:877874-85-6
KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM …
Formula:
C20H16F3N7OS
Purity:
98.2%
Color and Shape:
Liquid
Molecular weight:
459.45
Ref: TM-T41003
| 1mg | 34.00 € | ||
| 2mg | 45.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 102.00 € | ||
| 25mg | 198.00 € | ||
| 50mg | 302.00 € | ||
| 100mg | 434.00 € | ||
| 200mg | 608.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Xl-281
CAS:870603-16-0
XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and …
Formula:
C24H19ClN4O4
Purity:
95.77% - 98.60%
Color and Shape:
Liquid
Molecular weight:
462.89
Ref: TM-T68170
| 1mg | 274.00 € | ||
| 5mg | 673.00 € | ||
| 10mg | 920.00 € | ||
| 25mg | 1,417.00 € | ||
| 50mg | 1,846.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Zabofloxacin hydrochloride
CAS:623574-00-5
Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has …
Formula:
C19H21ClFN5O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
437.86
Ref: TM-T13406L
| 10mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
Raf inhibitor 1
CAS:1093100-40-3
B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.
Formula:
C26H19ClN8
Purity:
98.05%
Color and Shape:
Solid
Molecular weight:
478.94
Ref: TM-T2074
| 1mg | 38.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 109.00 € | ||
| 25mg | 195.00 € | ||
| 50mg | 315.00 € | ||
| 100mg | 459.00 € | ||
| 1mL*10mM (DMSO) | 84.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
CCT241161
CAS:1163719-91-2
CCT241161: oral pan-RAF inhibitor; IC50s: LCK (3 nM), CRAF (6), SRC (10), V600E-BRAF (15), BRAF …
Formula:
C28H27N7O3S
Purity:
100% - 98.48%
Color and Shape:
Solid
Molecular weight:
541.62
Ref: TM-T9638
| 1mg | 134.00 € | ||
| 5mg | 319.00 € | ||
| 10mg | 455.00 € | ||
| 25mg | 697.00 € | ||
| 50mg | 917.00 € | ||
| 100mg | 1,263.00 € | ||
| 500mg | 2,535.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
RAS GTPase inhibitor 1
CAS:2252242-32-1
RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.
Formula:
C27H28ClF4N5O2
Purity:
99.66%
Color and Shape:
Solid
Molecular weight:
565.99
Ref: TM-T12692
| 1mg | 353.00 € | ||
| 5mg | 845.00 € | ||
| 10mg | 1,154.00 € | ||
| 25mg | 1,688.00 € | ||
| 50mg | 2,217.00 € | ||
| 100mg | 2,888.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
BI-882370
CAS:1392429-79-6
BI-882370 is a specific RAF kinase inhibitor.
Formula:
C28H33F2N7O2S
Purity:
97.33% - 99.07%
Color and Shape:
Solid
Molecular weight:
569.67
Ref: TM-TQ0048
| 1mg | 42.00 € | ||
| 2mg | 56.00 € | ||
| 5mg | 83.00 € | ||
| 10mg | 132.00 € | ||
| 25mg | 231.00 € | ||
| 50mg | 414.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
