TRP/TRPV Channel
TRP (Transient Receptor Potential) channels, including the TRPV subfamily, are a group of ion channels involved in various sensory processes, such as temperature sensation, pain perception, and osmoregulation. TRP channels are widely expressed in different tissues and play a role in physiological responses to environmental stimuli. The TRPV channels, in particular, are involved in detecting temperature changes and are implicated in conditions such as chronic pain, inflammation, and cancer. At CymitQuimica, we offer a comprehensive range of TRP/TRPV channel modulators to support your research in sensory biology, pain management, and signal transduction.
Found 96 products of "TRP/TRPV Channel"
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PF-4840154
CAS:PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.
Formula:C26H38N6O2Purity:>99.99%Color and Shape:SolidMolecular weight:466.62Pyr10
CAS:Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.Formula:C18H13F6N3O2SPurity:99.69% - 99.7%Color and Shape:SolidMolecular weight:449.37SB-705498
CAS:SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.Formula:C17H16BrF3N4OPurity:99.57% - ≥95%Color and Shape:SolidMolecular weight:429.23Vanilloid receptor antagonist 1
CAS:Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.Formula:C18H15N3O2Purity:98.14%Color and Shape:SolidMolecular weight:305.33AMG9810
CAS:AMG 9810 blocks capsaicin's action on TRPV1; human IC50=24.5 nM, rat IC50=85.6 nM.Formula:C21H23NO3Purity:99.79% - 99.95%Color and Shape:SolidMolecular weight:337.41Ref: TM-T7189
2mg34.00€5mg48.00€10mg58.00€25mg110.00€50mg177.00€100mg286.00€200mg425.00€1mL*10mM (DMSO)50.00€Optovin
CAS:Optovin is a TRPA1 activator, which is reversibly photoactivated.Formula:C15H13N3OS2Purity:99.47% - 99.67%Color and Shape:SolidMolecular weight:315.41Ref: TM-T6617
2mg39.00€5mg57.00€10mg93.00€25mg160.00€50mg250.00€100mg406.00€200mg592.00€1mL*10mM (DMSO)64.00€MDR-652
CAS:MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM forFormula:C22H23ClFN3O2SPurity:99.96%Color and Shape:SolidMolecular weight:447.95Ref: TM-T22360
1mg60.00€2mg87.00€5mg130.00€10mg178.00€25mg331.00€50mg512.00€100mg707.00€200mg973.00€1mL*10mM (DMSO)142.00€RN-1747
CAS:RN-1747: TRPV4 agonist (EC50: human 0.77 μM, mouse 4.0 μM, rat 4.1 μM), TRPM8 antagonist (IC50: 4 μM).Formula:C17H18ClN3O4SPurity:99.29%Color and Shape:SolidMolecular weight:395.86AMTB hydrochloride
CAS:AMTB HCl: Novel TRPM8 blocker, relieves pain, treats urinary issues, moderates bladder reflexes in rats.Formula:C23H27ClN2O2SPurity:99.08%Color and Shape:SolidMolecular weight:430.99Ref: TM-T19723
1mg34.00€5mg74.00€10mg119.00€25mg250.00€50mg424.00€100mg627.00€200mg890.00€1mL*10mM (DMSO)87.00€TRPM8 antagonist 2
CAS:TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.Formula:C26H26N2O2Purity:98.1%Color and Shape:SolidMolecular weight:398.5Ref: TM-T5698
1mg34.00€5mg66.00€10mg99.00€25mg167.00€50mg260.00€100mg416.00€200mg600.00€1mL*10mM (DMSO)73.00€AC1903
CAS:AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.Formula:C19H17N3OPurity:98.45%Color and Shape:SolidMolecular weight:303.36JNJ-28583113
CAS:JNJ-28583113 is a TRPM2 antagonist, inducing phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death.Formula:C19H21F3N2O2Purity:98.57%Color and Shape:SolidMolecular weight:366.38Ref: TM-T74779
1mg89.00€5mg204.00€10mg254.00€25mg409.00€50mg624.00€100mg795.00€200mg1,103.00€1mL*10mM (DMSO)225.00€SAR7334
CAS:SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).Formula:C21H22ClN3OPurity:99.62% - 99.71%Color and Shape:SolidMolecular weight:367.87Ref: TM-T12849
1mg67.00€2mg88.00€5mg152.00€10mg236.00€25mg295.00€50mg349.00€100mg439.00€200mg628.00€1mL*10mM (DMSO)166.00€JYL 1421
CAS:JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).Formula:C20H26FN3O2S2Purity:98.83%Color and Shape:SolidMolecular weight:423.57Ref: TM-T15634
1mg66.00€5mg177.00€10mg289.00€25mg580.00€50mg888.00€100mg1,414.00€200mg1,882.00€1mL*10mM (DMSO)170.00€Asivatrep
CAS:Asivatrep (PAC14028) is a selective and potent antagonist of transient receptor potential vanilloid subtype 1 (TRPV1) for the study of atopic dermatitis.Formula:C21H22F5N3O3SPurity:95.13%Color and Shape:SolidMolecular weight:491.48TRPV4 agonist-1
CAS:TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).Formula:C25H23ClF2N4O2Purity:98%Color and Shape:SolidMolecular weight:484.93TRPC6-PAM-C20
CAS:TRPC6-PAM-C20, a selective enhancer for TRPC6, boosts calcium in HEK cells and OAG-related platelet clumping, EC50: 2.37μM.Formula:C22H21NO4Purity:98.16%Color and Shape:SolidMolecular weight:363.41D-3263 hydrochloride
CAS:D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.
Formula:C21H32ClN3O3Purity:99.93%Color and Shape:SolidMolecular weight:409.95TRPV3 antagonist 74a
CAS:TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.Formula:C17H17F3N2O2Purity:≥98.0%Color and Shape:SolidMolecular weight:338.32GSK1702934A
CAS:GSK1702934A is a TRPC3 agonist with pro-arrhythmic and positive inotropic effects and is used in the study of diabetes mellitus.Formula:C22H25N3O2SPurity:98.15%Color and Shape:SolidMolecular weight:395.52N-Oleoyl Valine
CAS:N-Oleoyl valine, an N-acyl amine, antagonizes TRPV3 for thermoregulation; rises post-cold exposure; elevates in mouse lung injury.Formula:C23H43NO3Molecular weight:381.59TRPM4-IN-2
CAS:NBA, or TRPM4-IN-2, is a potent TRPM4 inhibitor with IC50 of 0.16 μM, used in prostate and colorectal cancer research.Formula:C19H14ClNO4Purity:99.21%Color and Shape:SolidMolecular weight:355.77AM12
CAS:AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).Formula:C15H9BrO5Purity:98%Color and Shape:SolidMolecular weight:349.13RN9893
CAS:RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.Formula:C21H23F3N4O5SPurity:99.99%Color and Shape:SolidMolecular weight:500.49HC-070
CAS:HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).Formula:C22H20Cl2N4O4Purity:98.48%Color and Shape:SolidMolecular weight:475.32Ref: TM-T15465
1mg84.00€5mg160.00€10mg236.00€25mg406.00€50mg572.00€100mg772.00€200mg1,035.00€1mL*10mM (DMSO)165.00€ABT 102
CAS:ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.Formula:C21H24N4OPurity:98.38% - 99.86%Color and Shape:SolidMolecular weight:348.44Ref: TM-T29522
1mg109.00€5mg235.00€10mg349.00€25mg532.00€50mg745.00€100mg999.00€200mg1,333.00€1mL*10mM (DMSO)245.00€Olvanil
CAS:Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.Formula:C26H43NO3Purity:99.58%Color and Shape:SolidMolecular weight:417.62Ref: TM-T23106
2mg34.00€5mg49.00€10mg75.00€25mg145.00€50mg236.00€100mg385.00€200mg560.00€1mL*10mM (DMSO)50.00€Elismetrep
CAS:Elismetrep (MT-8554) is an orally available TRPM8 inhibitor with potential analgesic activity for the study of vasomotor symptoms in postmenopausal women.Formula:C27H21F3N2O5SPurity:99.37% - 99.93%Color and Shape:SolidMolecular weight:542.53TC-I 2014
CAS:TC-I 2014 shows antiallodynic properties in pain models.Formula:C23H19F6N3OPurity:99.07%Color and Shape:SolidMolecular weight:467.41Ref: TM-T17006
1mg57.00€5mg120.00€10mg192.00€25mg385.00€50mg620.00€100mg1,018.00€200mg1,378.00€1mL*10mM (DMSO)126.00€MSP3
CAS:MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.Formula:C16H19NO3SPurity:99.89%Color and Shape:SolidMolecular weight:305.39Ref: TM-T28118
2mg33.00€5mg50.00€10mg80.00€25mg161.00€50mg243.00€100mg358.00€200mg505.00€1mL*10mM (DMSO)71.00€Pyr3
CAS:Pyr3 selectively blocks TRPC3 channels, reducing Ca2+ influx; it's effective at 700 nM.Formula:C16H11Cl3F3N3O3Purity:98.04%Color and Shape:SolidMolecular weight:456.63Ref: TM-T16687
1mg35.00€2mg52.00€5mg77.00€10mg97.00€25mg215.00€50mg363.00€100mg512.00€200mg738.00€500mg1,121.00€1mL*10mM (DMSO)86.00€Mavatrep
CAS:Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain.Formula:C25H21F3N2OPurity:98.51% - 99.31%Color and Shape:SolidMolecular weight:422.44Ref: TM-T16014
1mg63.00€2mg90.00€5mg137.00€10mg215.00€25mg385.00€50mg618.00€100mg888.00€200mg1,243.00€1mL*10mM (DMSO)150.00€FEMA-4809
CAS:FEMA-4809 activates TRPM8, the ion channel for cold sensation, and is used as a cooling agent.Formula:C17H17N3O2SPurity:99.9%Color and Shape:SolidMolecular weight:327.4Ref: TM-T27308
1mg34.00€5mg73.00€10mg110.00€25mg180.00€50mg255.00€100mg363.00€200mg497.00€1mL*10mM (DMSO)84.00€SET 2
CAS:SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.Formula:C17H21F3N4O2SPurity:99.77%Color and Shape:SolidMolecular weight:402.43Ref: TM-T37097
5mg55.00€10mg92.00€25mg168.00€50mg284.00€100mg414.00€500mgTo inquire1mL*10mM (DMSO)67.00€MK-2295
CAS:MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.Formula:C27H31FN6O2Purity:98.83% - 99.44%Color and Shape:SolidMolecular weight:490.57Mesendogen
CAS:Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7Formula:C18H16ClF3N2OSPurity:99.66%Color and Shape:SolidMolecular weight:400.85GSK3395879
CAS:GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).Formula:C20H15F4N3O5SPurity:98%Color and Shape:SolidMolecular weight:485.41PF-05105679
CAS:PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.Formula:C26H21FN2O3Purity:99.84%Color and Shape:SolidMolecular weight:428.45Ref: TM-T16483
1mg47.00€2mg60.00€5mg87.00€10mg145.00€25mg279.00€50mg425.00€100mg645.00€200mg895.00€1mL*10mM (DMSO)96.00€JT010
CAS:JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).Formula:C16H19ClN2O3SPurity:99.75%Color and Shape:SolidMolecular weight:354.85A-1165442
CAS:A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.Formula:C22H20ClF2N3O2Color and Shape:SolidMolecular weight:431.86AMG-0347
CAS:AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.Formula:C24H26F3N3O2Purity:99.93%Color and Shape:SolidMolecular weight:445.48Ref: TM-T29968
1mg215.00€5mg523.00€10mg695.00€25mg1,054.00€50mg1,414.00€100mg1,900.00€200mg2,565.00€1mL*10mM (DMSO)537.00€AMG2850
CAS:AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).Formula:C19H17F6N3OPurity:99.84%Color and Shape:SolidMolecular weight:417.35Ref: TM-T10300
1mg71.00€5mg161.00€10mg235.00€25mg423.00€50mg627.00€100mg803.00€1mL*10mM (DMSO)172.00€ELP-004
CAS:ELP-004 is a TRPC channel inhibitor that blocks Ca2+ entry mediated by TRPC channels. It serves as an osteoclast inhibitor by preventing osteoclast differentiation. ELP-004 also hinders basal Ca2+ levels and the associated translocation of NFATc1 in inflammatory osteoclastogenesis. Additionally, it reduces bone erosion in mouse models of rheumatoid arthritis.Formula:C10H11Cl2NOColor and Shape:SolidMolecular weight:232.106TRPA1 Antagonist 1
CAS:TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.Formula:C24H20F6N5Na2O7PSPurity:98%Color and Shape:SolidMolecular weight:713.45Apcin A HCL
CAS:Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].
Formula:C10H15Cl4N5O2Purity:99.30%Color and Shape:SolidMolecular weight:379.07Motugivatrep
CAS:Motugivatrep is a potent and selective TRPV1 antagonist that can be used to study TRPV1-related respiratory diseases.
Formula:C22H20F3NO3Purity:99.22%Color and Shape:SolidMolecular weight:403.39Ref: TM-T64312
Discontinued product
