Chloride channel
Chloride channels are membrane proteins that control the movement of chloride ions across cellular membranes, playing a vital role in maintaining cell volume, electrical excitability, and acid-base balance. Dysregulation of chloride channels is linked to diseases such as cystic fibrosis, epilepsy, and kidney disorders. At CymitQuimica, we offer a variety of chloride channel modulators to support your research in ion transport, cellular homeostasis, and disease mechanisms.
Found 54 products of "Chloride channel"
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Eact
CAS:Eact is a potent TMEM16A activator that also triggers TRPV1, causing itch, pain, and heat sensitivity.
Formula:C22H24N2O5SPurity:98.14%Color and Shape:SolidMolecular weight:428.5Endovion
CAS:Endovion (NS3728) is a pharmacological anion channel and an Anoctamin-1 (ANO 1) channel inhibitor. Endovion is also the specific VRAC/VSOAC blocker.Formula:C16H9BrF6N6OPurity:98.51%Color and Shape:SolidMolecular weight:495.18T16Ainh-A01
CAS:T16Ainh-A01 is a potent TMEM16A chloride channel inhibitor with a 1 μM IC50, targeting CaCC.Formula:C19H20N4O3S2Purity:97.18% - 98.15%Color and Shape:SolidMolecular weight:416.52Meticrane
CAS:Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.Formula:C10H13NO4S2Purity:99.16%Color and Shape:SolidMolecular weight:275.34Flufenamic acid
CAS:Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.Formula:C14H10F3NO2Purity:98.68%Color and Shape:White To Light Yellow Crystalline PowderMolecular weight:281.23Afoxolaner
CAS:Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.Formula:C26H17ClF9N3O3Purity:99.1% - 99.38%Color and Shape:SolidMolecular weight:625.87Niflumic acid
CAS:Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.Formula:C13H9F3N2O2Purity:99.47%Color and Shape:SolidMolecular weight:282.22NS1652
CAS:NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
Formula:C15H11F3N2O3Purity:99.62%Color and Shape:SolidMolecular weight:324.25DCPIB
CAS:DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μMFormula:C22H28Cl2O4Purity:99.79% - 99.87%Color and Shape:SolidMolecular weight:427.36Ref: TM-T10979
2mg39.00€5mg57.00€1mL*10mM (DMSO)63.00€10mg87.00€25mg177.00€50mg301.00€100mg485.00€200mg690.00€Halothane
CAS:Halothane (Anestan) 可以减弱内皮依赖性舒张作用。Formula:C2HBrClF3Purity:99.80% - >99.99%Color and Shape:Colorless Volatile Liquid Density 1 875 G / Cm3 Boiling Point 122 4°F (50 2°C) NoncombustibleMolecular weight:197.38ANO1-IN-4
CAS:ANO1-IN-4 (Compound 10bm) is a reversible inhibitor of the calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1), with an IC50 of 0.030 µM. It demonstrates good metabolic stability in rat liver microsomes and can inhibit spontaneous contractions in isolated mouse ileum.Formula:C19H19BrF2N2O2SColor and Shape:SolidMolecular weight:457.33Ion Channel Targeted Library
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;
Color and Shape:Odour SolidChlorotoxin TFA
Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.Formula:C160H250F3N53O49S11Color and Shape:SolidMolecular weight:4109.74Chlorotoxin
CAS:Chlorotoxin: 36-amino acid peptide from deathstalker scorpion venom; blocks small chloride channels.Formula:C158H249N53O47S11Purity:98%Color and Shape:SolidMolecular weight:3995.71GaTx2
CAS:High-affinity ClC-2 blocker (KD ~50 pM), selective over other ClCs/CFTR/GABAC/CaCC/KV1.2; slows activation, no effect on open channels.Formula:C125H199N39O47S6Purity:98%Color and Shape:SolidMolecular weight:3192.54Chlorotoxin(linear)
Chlorotoxin(linear): 36-amino-acid peptide from Egyptian scorpion venom, used in research as chloride channel blocker.Formula:C158H256N52O48S11Purity:98%Color and Shape:SolidMolecular weight:4004.76Umifoxolaner
CAS:Umifoxolaner is an anti-parasitic agent (veterinary).Formula:C26H16ClF10N3O3Color and Shape:SolidMolecular weight:643.87Lubiprostone hemiketal
CAS:Lubiprostone (hemiketal) (RU-0211 (hemiketal)), a selective activator of the chloride channel 2 (CLCN2), facilitates the treatment of chronic idiopathic constipation and opioid-induced constipation. It functions by enhancing CLCN2 channel activity, which boosts chloride ion secretion in the intestines, subsequently increasing fluid secretion and improving intestinal peristalsis. Additionally, Lubiprostone (hemiketal) may be utilized in research related to chronic constipation and cancer.Formula:C20H32F2O5Color and Shape:SolidMolecular weight:390.46Afoxolaner (Standard)
CAS:Afoxolaner (Standard) is the standard substance of Afoxolaner, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.Formula:C26H17ClF9N3O3Molecular weight:625.87Fenamic acid
CAS:Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats.Formula:C13H11NO2Purity:99.6%Color and Shape:White To Off-White Crystalline PowderMolecular weight:213.2319Phenyl benzoate
CAS:Phenyl benzoate is a benzoate ester obtained by the formal condensation of phenol with benzoic acid.It is an important organic synthesis intermediate.Formula:C13H10O2Purity:99.63%Color and Shape:White Crystalline PowderMolecular weight:198.22Irisolidone
CAS:Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
Formula:C17H14O6Purity:99.41% - 99.87%Color and Shape:SolidMolecular weight:314.29Anthracene-9-carboxylic acid
CAS:Anthracene-9-carboxylic acid is an inhibitor of chloride transport with a moderate to strong inhibitory action on PKA activated cardiac IcI.Formula:C15H10O2Purity:99.05%Color and Shape:Yellow Cystalline PowderMolecular weight:222.24Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormula:C43H63NO11Purity:99.84%Color and Shape:SolidMolecular weight:769.96MONNA
CAS:MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.Formula:C18H14N2O5Purity:98.29%Color and Shape:SolidMolecular weight:338.31Lubiprostone
CAS:Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.Formula:C20H32F2O5Purity:97.31% - 98.54%Color and Shape:White Odorless Crystals Or Crystalline PowderMolecular weight:390.46Talniflumate
CAS:Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell
Formula:C21H13F3N2O4Purity:98% - 99.81%Color and Shape:White To Pale Yellow Crystalline PowderMolecular weight:414.33NPPB
CAS:NPPB is a chloride channel blocker with IC50 of 80 nM .Formula:C16H16N2O4Purity:99.95%Color and Shape:Light Yellow To Yellow SolidMolecular weight:300.31Guanidinoethyl sulfonate
CAS:Guanidinoethyl sulfonate (Taurocyamine) is a competitive glycine receptor antagonist.Formula:C3H9N3O3SPurity:99.43% - 99.47%Color and Shape:SolidMolecular weight:167.19Org 25543
CAS:Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.Formula:C24H32N2O4Purity:99.13%Color and Shape:SolidMolecular weight:412.52Ref: TM-T50082
1mg55.00€5mg114.00€1mL*10mM (DMSO)129.00€10mg170.00€25mg274.00€50mg371.00€100mg522.00€200mg687.00€CaCCinh-A01
CAS:CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).Formula:C18H21NO4SPurity:99.36% - >99.99%Color and Shape:SolidMolecular weight:347.43Adjudin
CAS:Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.Formula:C15H12Cl2N4OPurity:96.51% - ≥95%Color and Shape:SolidMolecular weight:335.19Hydroflumethiazide
CAS:Hydroflumethiazide is a thiazide diuretic. It has also shown the activity of anti-hypertensive.Formula:C8H8F3N3O4S2Color and Shape:Crystals SolidMolecular weight:331.29Bts 39542
CAS:Bts 39542 is a diuretic that plays a major role in the Henle circulation and increases renal blood flow without affecting glomerular filtration rate.Formula:C16H11ClN4O3SColor and Shape:SolidMolecular weight:374.8NS5818
CAS:NS5818 inhibits ClC.Formula:C23H19Cl2N7O2Purity:98%Color and Shape:SolidMolecular weight:496.35Alilusem
CAS:Alilusem is a new diuretic that is beneficial to the clinical treatment of hypertension.Formula:C17H15ClKN2O5SColor and Shape:SolidMolecular weight:433.92H100
CAS:H100 inhibits Cl- transport, mildly affects NaK2Cl cotransporter and Band 3 anion exchanger, not KCl cotransporter.Formula:C18H16N2O6SPurity:98%Color and Shape:SolidMolecular weight:388.4BTG-1640
CAS:BTG-1640 is used potentially for the treatment of anxiety and panic disorder.Formula:C15H19NO2Color and Shape:SolidMolecular weight:245.32NS-3736
CAS:NS-3736 is a chloride channel inhibitor that has been shown to prevent osteoclastic acidification and resorption.Formula:C15H9BrClF3N6OColor and Shape:SolidMolecular weight:461.62IAA-94
CAS:IAA-94 is an inhibitor of chloride channels, it binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM.Formula:C17H18Cl2O4Color and Shape:SolidMolecular weight:357.23ANO1-IN-2
CAS:ANO1-IN-2: potent ANO1 blocker (IC50: 1.75 μM), less effective on ANO2 (IC50: 7.43 μM), inhibits glioblastoma cell growth.Formula:C16H14ClN3O2S2Color and Shape:SolidMolecular weight:379.88ANO1-IN-1
CAS:ANO1-IN-1 blocks ANO1/2 channels (IC50: 2.56/15.43 μM) and hinders glioma cell growth.Formula:C18H28N2O2SPurity:99.93%Color and Shape:SolidMolecular weight:336.49Ani9
CAS:Ani9 selectively blocks ANO1/TMEM16A with a 77 nM IC50, useful for ANO1 research and treating cancer, hypertension, pain, diarrhea, asthma.
Formula:C17H17ClN2O3Purity:99.73%Color and Shape:SolidMolecular weight:332.78Stepronin
CAS:Stepronin (TTPG) shows expectorant activities and inhibits airway secretion.Formula:C10H11NO4S2Purity:99.59%Color and Shape:White Or Off White CrystallineMolecular weight:273.33Ref: TM-T21433
5mg48.00€1mL*10mM (DMSO)48.00€10mg71.00€25mg111.00€50mg187.00€100mg290.00€200mg410.00€Losigamone
CAS:Losigamone (AO-33) is an agonist of GABA receptor and can be used in studies about the treatment of partial seizures.Formula:C12H11ClO4Purity:99.98%Color and Shape:SolidMolecular weight:254.67R(+)-IAA-94
CAS:R(+)-IAA-94 (Methylindazone) blocks epithelial chloride channels; inhibits Nef-sdAb19 binding.Formula:C17H18Cl2O4Purity:98.95% - 99.17%Color and Shape:SolidMolecular weight:357.23PAT1inh-B01
CAS:PAT1inh-B01, a selective SLC26A6 inhibitor, impedes PAT1 (a Cl-/HCO3- exchanger) activity, with an IC50 of 350 nM, effectively inhibiting anion exchange.Formula:C22H18BrF3N6O2Color and Shape:SolidMolecular weight:535.32ARN 11391
CAS:ARN 11391 enhances the function of the IP3-gated calcium channel ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1), boosting intracellular calcium ionFormula:C22H29N3O3Color and Shape:SolidMolecular weight:383.49DIOA
CAS:DIOA acts as a potent antagonist of acid-sensitive outwardly rectifying (ASOR) anion channels [1].Formula:C20H24Cl2O4Color and Shape:SolidMolecular weight:399.31OADS
CAS:OADS is an inhibitor of ClC-ec1 with low micromolar affinity. OADS has no specific effect on a CLC channel (ClC-1).Formula:C30H42N2O8S2Color and Shape:SolidMolecular weight:622.79DFBTA
DFBTA inhibits ANO1 with IC50 of 24 nM, effectively treating inflammatory pain orally.Formula:C18H10ClF2NO3SColor and Shape:SolidMolecular weight:393.79S9-A13
CAS:S9-A13 is a potent and selective inhibitor of SLC26A9, exhibiting an IC50 of 90.9 nM without inhibiting other members of the SLC26 family, such as SLC26A3, SLC26A4, and SLC26A6. It also inhibits the SLC26A9 Cl- current in cells lacking CFTR expression.Formula:C20H18ClN3O2SColor and Shape:SolidMolecular weight:399.89NMD670
CAS:NMD670 is an orally active, partial inhibitor of the skeletal muscle-specific chloride channel ClC-1. It enhances muscle excitability and neuromuscular transmission, restoring muscle function and mobility. NMD670 has a favorable safety profile and improves muscle function in rats, particularly in an MG rat model [1].Formula:C12H10BrNO4Color and Shape:SolidMolecular weight:312.12T16A(inh)-C01
CAS:T16A(inh)-C01 is the Ca(2+)-activated Cl(-) Channel, Ano1 class C inhibitor.Formula:C18H16O5Purity:98%Color and Shape:SolidMolecular weight:312.32
