CymitQuimica logo
P-gp

P-gp

P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.

Found 64 products for "P-gp".

products per page.
  • DM-4103
    Targetmol
    + Info

    DM-4103

    CAS:
    DM-4103 is a primary metabolite of Tolvaptan, predominantly metabolized by the CYP3A4 enzyme in the liver. In SCHH cells, DM-4103 inhibits the human liver transport proteins NTCP, BSEP, MRP2, MRP3, and MRP4 with IC50 values of 16.3, 4.15, 51.0, 44.6, and 4.26 μM, respectively, and affects bile acid transport. DM-4103 is applicable for research in autosomal dominant polycystic kidney disease (ADPKD).
    Formula:C26H23ClN2O5
    Molecular weight:478.92

    Ref: TM-T210591

  • P-gp-IN-30
    Targetmol
    + Info

    P-gp-IN-30

    CAS:
    P-gp-IN-30 (Compound 13) is an inhibitor of P-glycoprotein (P-gp) that targets YB-1. It reduces the expression of total YB-1 protein and nuclear YB-1 protein, thereby inhibiting the expression and function of downstream P-gp, which significantly enhances sensitivity to paclitaxel by inhibiting its efflux rate. When combined with paclitaxel, P-gp-IN-30 effectively suppresses tumor growth in A549/Taxol xenograft mouse models. This compound is useful for research on non-small cell lung cancer (NSCLC).
    Formula:C34H36N2O9
    Molecular weight:616.66

    Ref: TM-T211609

  • NSC73306
    Targetmol
    + Info

    NSC73306

    CAS:
    NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.
    Formula:C16H14N4O2S
    Purity:98.10%
    Color and Shape:Solid
    Molecular weight:326.373

    Ref: TM-T204744

  • CymitQuimica logo
    Targetmol
    + Info

    Doxorubamine

    CAS:
    Doxorubamine, a derivative of Doxorubicin, serves as a weak substrate for P-glycoprotein and is effective in killing reagent-sensitive ovarian cancer.
    Formula:C27H30N2O10
    Molecular weight:542.54

    Ref: TM-T214791